Research

Publications

Below you can find a list of our published research.

9618 results

Cited 101 times since 2002 (4.3 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 87, Issue 4, 1 1 2002, Pages 356-362 Health related quality of life and health status in adult survivors with previously operated complex congenital heart disease. Kamphuis M, Ottenkamp J, Vliegen HW, Vogels T, Zwinderman KH, Kamphuis RP, Verloove-Vanhorick SP

Objective: To examine the impact of previously operated complex congenital heart disease on health related quality of life and subjective health status and to determine the relation between these parameters and physical status. Design: Cross sectional; information on medical follow up was sought retrospectively. Setting: Patients were randomly selected from the archives of the paediatric cardiology department, Leiden University Medical Centre, Leiden, The Netherlands, and approached irrespective... Abstract

Cited 77 times since 2002 (3.3 per year) source: EuropePMC

Radiology, Volume 223, Issue 1, 1 1 2002, Pages 204-211 Exercise MR imaging in the assessment of pulmonary regurgitation and biventricular function in patients after tetralogy of fallot repair. Roest AA, Helbing WA, Kunz P, van den Aardweg JG, Lamb HJ, Vliegen HW, van der Wall EE, de Roos A

Purpose: To assess the responses of pulmonary regurgitation (PR) and biventricular function to submaximal exercise by using a magnetic resonance (MR) imaging exercise protocol with young adult patients who underwent tetralogy of Fallot repair at a young age. Materials and methods: Fifteen patients with corrected tetralogy of Fallot (mean age, 17.5 years +/- 2.5 [SD]) underwent MR imaging at rest and during exercise for the evaluation of PR and biventricular function. Results were compared with f... Abstract

Cited 38 times since 2002 (1.6 per year) source: EuropePMC

Journal of dairy science, Volume 85, Issue 4, 1 1 2002, Pages 782-789 Trends in somatic cell counts, bacterial counts, and antibiotic residue violations in New York State during 1999-2000. van Schaik G, Lotem M, Schukken YH

Milk quality data on a month-by-month basis from March 1999 to December 2000 were studied from five of the largest milk plants operating in New York State. The analyses focused on bulk tank somatic cell count (SCC), bacterial counts in the form of plate loop count (PLC), and antibiotic residue violations in the pool of milk of New York State, their mutual relation, and the influence of farm size. The average SCC was 363,000 cells/ml, the average PLC was 24,400 bacteria/ml, and the average number... Abstract

Cited 73 times since 2002 (3.1 per year) source: EuropePMC

American journal of physiology. Heart and circulatory physiology, Volume 282, Issue 4, 1 1 2002, Pages H1350-8 Indexes of diastolic RV function: load dependence and changes after chronic RV pressure overload in lambs. Leeuwenburgh BP, Steendijk P, Helbing WA, Baan J

Diastolic function is a major determinant of ventricular performance, especially when loading conditions are altered. We evaluated biventricular diastolic function in lambs and studied possible load dependence of diastolic parameters [minimum first derivative of pressure vs. time (dP/dt(min)) and time constant of isovolumic relaxation (tau)] in normal (n = 5) and chronic right ventricular (RV) pressure-overloaded (n = 5) hearts by using an adjustable band on the pulmonary artery (PAB). Pressure-... Abstract

Cited 2 times since 2002 (0.1 per year) source: EuropePMC

Nederlands tijdschrift voor geneeskunde, Volume 146, Issue 10, 1 1 2002, Pages 473-477 [Surgery and referral for subsequent 131I therapy for patients with differentiated thyroid carcinoma in the south-east of the Netherlands, 1983-1996, compared to the consensus guidelines from 1987]. Kuijpens JL, Hoekstra OS, Hamming JF, Haak HR, Ribot JG, Coebergh JW

Objective: To evaluate the treatment of patients with differentiated (papillary or follicular) thyroid cancer in general hospitals in the south-east of the Netherlands during the period 1983-1996, in relation to the 1987 national consensus recommendations. Design: Population-based, retrospective, descriptive. Method: For the period 1 January 1983-31 December 1996, data on the histology, TNM-stage and treatment (hospital, specialist, type of operation, referral for 131I therapy) of all 236 patien... Abstract

Cited 24 times since 2002 (1 per year) source: EuropePMC

British journal of cancer, Volume 86, Issue 5, 1 1 2002, Pages 811-818 A fully human anti-Ep-CAM scFv-beta-glucuronidase fusion protein for selective chemotherapy with a glucuronide prodrug. de Graaf M, Boven E, Oosterhoff D, van der Meulen-Muileman IH, Huls GA, Gerritsen WR, Haisma HJ, Pinedo HM

Monoclonal antibodies against tumour-associated antigens could be useful to deliver enzymes selectively to the site of a tumour for activation of a non-toxic prodrug. A completely human fusion protein may be advantageous for repeated administration, as host immune responses may be avoided. We have constructed a fusion protein consisting of a human single chain Fv antibody, C28, against the epithelial cell adhesion molecule and the human enzyme beta-glucuronidase. The sequences encoding C28 and h... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 10, Issue 3, 1 1 2002, Pages 109-110 Vitamins C. E and β-carotene fired and statins for president? Jukema JW, Liem AH

Abstract

Cited 6 times since 2002 (0.3 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 29, Issue 4, 19 3 2002, Pages 452-457 Feasibility, safety and image quality of cardiac FDG studies during hyperinsulinaemic-euglycaemic clamping. Bax JJ, Visser FC, Poldermans D, van Lingen A, Elhendy A, Boersma E, Visser CA

Fluorine-18 fluorodeoxyglucose (FDG) imaging for the assessment of myocardial viability has become an integral part of the diagnostic and prognostic work-up of patients with ischaemic cardiomyopathy. To ensure good image quality, in particular in patients with diabetes mellitus, hyperinsulinaemic-euglycaemic clamping has been proposed. In this study we evaluated the safety and the image quality of cardiac FDG imaging during clamping in a large group of patients, including a subgroup with diabete... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 10, Issue 2, 1 1 2002, Pages 101-103 Einthoven meeting 2002: 9-11 June, Leiden. Schalij MJ, Van der Wall EE

Abstract

Cited 1 times since 2002 (0 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 10, Issue 2, 1 1 2002, Pages 43-47 Rhythmic sensory stimulation improves fitness by conditioning the autonomic nervous system. Frederiks J, Swenne CA, Ghafoerkhan A, Lalmahomed H, Maan AC, Schalij MJ, Bruschke AV, van der Wall EE

Background: Endurance training is known to alter the functioning of the autonomic nervous system, a major goal when pursuing fitness. Here, we test the hypothesis that the training-associated rhythmic sensations alone, hence without the usual accompanying physical exercise, accomplish this effect. Method: We studied sixteen resting healthy male volunteers, age (mean±SD) 25.9±3.7 years. During one hour we applied, at marching pace (2 bursts per second), bipolar transcutaneous electrical sensory n... Abstract

Cited 16 times since 2002 (0.7 per year) source: EuropePMC

British journal of cancer, Volume 86, Issue 3, 1 1 2002, Pages 436-442 Prerequisites for effective adenovirus mediated gene therapy of colorectal liver metastases in the rat using an intracellular neutralizing antibody fragment to p21-Ras. van Etten B, ten Hagen TL, de Vries MR, Ambagtsheer G, Huet T, Eggermont AM

Ras mutations are present in 40-50% of colorectal cancers. Inactivating this oncogene may therefore reduce proliferation capacity. In order to target ras we studied the transduction efficacy and anti tumour activity of an adenoviral vector expressing an intracellular, neutralizing single chain antibody to p21-ras (Y28). In in vitro studies transfection levels of the K-ras mutated rat colon carcinoma cell line CC531 were studied using the LacZ marker gene. In our in vivo liver metastases model di... Abstract

Cited 12 times since 2002 (0.5 per year) source: EuropePMC

Cardiovascular surgery (London, England), Volume 10, Issue 1, 1 1 2002, Pages 62-64 Organized thrombus in the ascending aorta originating from the ostium of the right coronary artery. Shahin GM, Bosker HA, Knaepen PJ, Morshuis WJ, Lindeboom JE

This case report describes the rare finding of a pedunculate thrombus in the ascending aorta originating from the ostium of the right coronary artery (RCA) detected after an inferior wall myocardial infarction in a young female. The thrombus was removed surgically during an emergency cardiopulmonary bypass procedure Abstract

The Annals of thoracic surgery, Volume 73, Issue 2, 1 1 2002, Pages 699 Double-inlet left ventricle: successfully staged ventricular septation with 12.5 years follow-up. Ottenkamp J, Hazekamp MG

Abstract

Cited 35 times since 2002 (1.5 per year) source: EuropePMC

Investigative ophthalmology & visual science, Volume 43, Issue 2, 1 1 2002, Pages 300-307 Rectus extraocular muscle paths and decompression surgery for Graves orbitopathy: mechanism of motility disturbances. Abràmoff MD, Kalmann R, de Graaf ME, Stilma JS, Mourits MP

Purpose: To study possible causes of motility disturbances that may result from orbital decompression surgery in patients with Graves orbitopathy and especially the role of rectus extraocular muscle paths. Methods: Sixteen patients with Graves orbitopathy were studied before and 3 to 6 months after translid (6 patients) and coronal (10 patients) orbital decompression surgery for disfiguring proptosis. Ocular motility changes were measured by comparing maximum ductions and severity of diplopia, a... Abstract

Cited 4 times since 2002 (0.2 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 123, Issue 2, 1 1 2002, Pages 348-349 Quadricuspid aortic valve in transposition of the great arteries. Portela FA, Hazekamp MG, Bartelings MM, Gittenberger-De Groot AC

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Cited 17 times since 2002 (0.7 per year) source: EuropePMC

Experimental cell research, Volume 273, Issue 1, 1 1 2002, Pages 107-117 Synergistic proliferative action of insulin-like growth factor I and 17 beta-estradiol in MCF-7S breast tumor cells. Hamelers IH, van Schaik RF, van Teeffelen HA, Sussenbach JS, Steenbergh PH

We have analyzed the mechanism by which the combination of insulin-like growth factor I (IGF-I) and 17 beta-estradiol (E2) induces cell cycle progression in MCF-7S cells. This cell line differs from many other breast cancer-derived cell lines in that E2 (1 nM) does not induce cell cycle progression, whereas the combination of submitogenic concentrations of IGF-I (2 ng/ml) and E2 does. We find that addition of IGF-I to MCF-7S cells leads to a dose-dependent activation of the IGF type I receptor a... Abstract

Cited 90 times since 2002 (3.8 per year) source: EuropePMC

Circulation, Volume 105, Issue 6, 1 1 2002, Pages 702-706 Cardiac autonomic dysfunction in Brugada syndrome. Wichter T, Matheja P, Eckardt L, Kies P, Schäfers K, Schulze-Bahr E, Haverkamp W, Borggrefe M, Schober O, Breithardt G, Schäfers M

Background: Patients with Brugada syndrome present with characteristic ECG abnormalities (atypical right bundle-branch block and ST-segment elevation) and life-threatening ventricular tachyarrhythmias despite structurally normal hearts. Involvement of the autonomic nervous system is suggested by the occurrence of ventricular tachyarrhythmias and sudden death at rest or during sleep and by changes of typical ECG signs under pharmacological modulation of the myocardial autonomic tone. Methods and... Abstract

Cited 71 times since 2002 (3 per year) source: EuropePMC

Clinical genetics, Volume 61, Issue 2, 1 1 2002, Pages 115-125 ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels. Zwarts KY, Clee SM, Zwinderman AH, Engert JC, Singaraja R, Loubser O, James E, Roomp K, Hudson TJ, Jukema JW, Kastelein JJ, Hayden MR

The authors have previously shown that individuals heterozygous for ABCA1 mutations have decreased high density lipoprotein cholesterol, increased triglycerides and an increased frequency of coronary artery disease (CAD), and that single nucleotide polymorphisms (SNPs) in the coding region of the ABCA1 gene significantly impact plasma lipid levels and the severity of CAD in the general population. They have now identified several SNPs in non-coding regions of ABCA1 which may be important for the... Abstract

Cited 5 times since 2002 (0.2 per year) source: EuropePMC

Cardiovascular and interventional radiology, Volume 25, Issue 1, 17 3 2002, Pages 72-73 Successful emergency stenting of acute ruptured false iliac aneurysm. Bierdrager E, Lohle PN, Schoemaker CM, Lampmann LE, van Berge Henegouwen DP, Hamming JF

A 75-year-old man complaining of acute abdominal pain, 1 month after elective surgical repair of an abdominal aortic aneurysm by an aortabi-iliac bypass graft, was referred and admitted to the emergency room. Imaging by sonography and computed tomography scan revealed a ruptured iliac pseudoaneurysm at the right iliac anastomotic site with associated large retroperitoneal hematoma. We inserted a self-expanding covered Z-stent graft by a transfemoral approach and the iliac anastomotic pseudoaneur... Abstract

Cited 26 times since 2002 (1.1 per year) source: EuropePMC

Radiology, Volume 222, Issue 1, 1 1 2002, Pages 127-135 MR flow mapping in coronary artery bypass grafts: a validation study with Doppler flow measurements. Langerak SE, Kunz P, Vliegen HW, Jukema JW, Zwinderman AH, Steendijk P, Lamb HJ, van der Wall EE, de Roos A

Purpose: To validate fast magnetic resonance (MR) flow mapping with intravascular Doppler flow measurements in vitro and in patients with nonstenotic and stenotic coronary artery bypass grafts. Materials and methods: MR and Doppler flow measurements were performed in a small-diameter flow phantom with physiologic flow conditions and at baseline and during adenosine stress in 27 grafts in 23 patients, who were scheduled for cardiac catheterization. At invasive analysis, the grafts were divided in... Abstract