9549 results
Cited 6 times since 2024 (3.1 per year)
source: EuropePMC
Vascular biology (Bristol, England),
Volume 6, Issue 1, 1 1 2024, Pages e240009
Therapeutic angiogenesis for patients with chronic limb-threatening ischemia: promising or hoax?
Peeters JAHM, Schepers A, Hamming JF, Quax PHA
Chronic limb-threatening ischemia (CLTI) is a critical end-stage disease that leads to high amputation rates. Over the past few decades, therapeutic angiogenesis has attracted a lot of attention as a means to reduce the necessity for amputations. Especially gene- and cell therapy are regarded to as possible treatment modalities to restore the hampered blood flow. So far, early-phase clinical trials often fail to prove a significant clinical improvement in mortality, amputation rate, and ulcer he...
Abstract
Cited 12 times since 2024 (6.3 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 83, Issue 1, 1 1 2024, Pages 47-59
Lung-to-Heart Nano-in-Micro Peptide Promotes Cardiac Recovery in a Pig Model of Chronic Heart Failure.
Alogna A, Berboth L, Faragli A, Faragli A, Ötvös J, Lo Muzio FP, di Mauro V, Modica J, Quarta E, Semmler L, Deißler PM, Berger YW, Tran KL, de Marchi B, Longinotti-Buitoni G, Degli Esposti L, Guillot E, Bazile D, Iafisco M, Dotti A, Bang ML, de Luca C, Brandenberger C, Benazzi L, di Silvestre D, de Palma A, Primeßnig U, Hohendanner F, Perna S, Buttini F, Colombo P, Mühlfeld C, Steendijk P, Mauri P, Tschöpe C, Borlaug B, Pieske BM, Attanasio P, Post H, Heinzel FR, Catalucci D
Background: The lack of disease-modifying drugs is one of the major unmet needs in patients with heart failure (HF). Peptides are highly selective molecules with the potential to act directly on cardiomyocytes. However, a strategy for effective delivery of therapeutics to the heart is lacking. Objectives: In this study, the authors sought to assess tolerability and efficacy of an inhalable lung-to-heart nano-in-micro technology (LungToHeartNIM) for cardiac-specific targeting of a mimetic peptide...
Abstract
Cited 2 times since 2024 (1 per year)
source: EuropePMC
European heart journal. Imaging methods and practice,
Volume 2, Issue 1, 1 1 2024, Pages qyae029
Cardiovascular imaging research and innovation in 2023.
Barison A, Timoteo AT, Liga R, Borodzicz-Jazdzyk S, El Messaoudi S, Luong C, Mandoli GE, Moscatelli S, Ramkisoensing AA, Moharem-Elgamal S, Pontone G, Neglia D
In 2023, cardiovascular imaging has made significant advancements, in terms of technology, pathophysiology, and clinical application. In this review, the most recent research findings in the field of cardiovascular imaging are discussed. Artificial intelligence and large population cohorts, together with several technical improvements, have had a crucial impact on the technological advancements of echocardiography, cardiovascular magnetic resonance, computed tomography (CT), and nuclear medicine...
Abstract
Advances in experimental medicine and biology,
Volume 1441, 1 1 2024, Pages 593-598
Total Anomalous Pulmonary Venous Connections, Human Genetics.
Poelmann RE, Jongbloed MRM, DeRuiter MC
Partial anomalous pulmonary venous connections (PAVC) have been found after abnormal gene expressions involving several syndromes. Total anomalous pulmonary venous connection (TAPVC) is found in conjunction with heterotaxia syndrome as well as several other syndromes. It has been reported with an autosomal dominance with variable expression and incomplete penetrance. The occurrence is also related to environmental factors which may superimpose on a familial susceptibility for TAPVC. Many pathway...
Abstract
Cited 7 times since 2023 (3.7 per year)
source: EuropePMC
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
Volume 54, Issue 4, 30 5 2023, Pages 294-296
Differential dynamics of TARC during JAK-inhibitor therapy compared to biological therapies targeting type 2 inflammation.
Boesjes CM, Bakker DS, Knol EF, de Graaf M, van Wijk F, de Bruin-Weller MS
Abstract
Cited 6 times since 2023 (3.1 per year)
source: EuropePMC
JACC. Advances,
Volume 3, Issue 2, 27 4 2023, Pages 100772
Clinical Course of TGA After Arterial Switch Operation in the Current Era.
Engele LJ, van der Palen RLF, Joosen RS, Sieswerda GT, Schoof PH, van Melle JP, Berger RMF, Accord RE, Rammeloo LAJ, Konings TC, Helbing WA, Roos-Hesselink JW, van de Woestijne PC, Frerich S, van Dijk APJ, Kuipers IM, Hazekamp MGH, Mulder BJM, Breur JMPJ, Blom N, Jongbloed MRM, Bouma BJ
Background: The number of patients with an arterial switch operation (ASO) for transposition of the great arteries (TGA) is steadily growing; limited information is available regarding the clinical course in the current era. Objectives: The purpose was to describe clinical outcome late after ASO in a national cohort, including survival, rates of (re-)interventions, and clinical events. Methods: A total of 1,061 TGA-ASO patients (median age 10.7 years [IQR: 2.0-18.2 years]) from a nationwide pros...
Abstract
Cited 2 times since 2023 (1 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 40, Issue 3, 27 4 2023, Pages 499-508
The value of serial echocardiography in risk assessment of patients with paroxysmal atrial fibrillation.
Leung M, van Rosendael PJ, van der Bijl P, Regeer MV, van Wijngaarden SE, Leung DY, Delgado V, Marsan NA, Ng ACT, Bax JJ
Progression from paroxysmal to persistent atrial fibrillation (AF) is associated with increased morbidity and mortality. We examined the association of left atrial (LA) remodeling by serial echocardiography, and AF progression over an extended follow-up period. Two-hundred ninety patients (mean age 61 ± 11 years, 73% male) who underwent transthoracic echocardiography performed at first presentation for non-valvular paroxysmal AF (PAF) and repeat echocardiogram 1-year later, were followed for p...
Abstract
Journal of bodywork and movement therapies,
Volume 38, 23 4 2023, Pages 211-253
Empowering patients with persistent pain: The potential of cognitive functional therapy in interdisciplinary care: A single-case experimental design.
Zingg S, de Graaf M, Hilfiker R
Introduction and purpose: Persistent musculoskeletal pain (PMP) is multifactorial and causes both societal and financial burdens. Integration of multifactorial management in patients with PMP remains challenging. A single-case experimental design was performed on three patients suffering from high impact PMP (lumbar spine, shoulder and knee) to i) assess the potential for Cognitive Functional Therapy (CFT) in interdisciplinary care, ii) describe in detail the clinical journey patients experience...
Abstract
Cited 3 times since 2023 (1.6 per year)
source: EuropePMC
The Pediatric infectious disease journal,
Volume 43, Issue 4, 22 4 2023, Pages 365-370
Epidemiology and Outcomes of Neonatal Meningitis: Results of the Turkish Neo-Meningitis Nationwide Study.
Oncel MY, Cizmeci MN, Karadag-Oncel E, Elvan-Tuz A, Canpolat FE, Akin MA, Uslu S, Cetinkaya M, Erdeve O, Koc E, Neo-Meningitis Study Group
Objective: To investigate the incidence and etiology of neonatal meningitis and to assess the associated risk factors, complications and outcomes in a nationwide multicenter retrospective descriptive study. Method: Twenty-seven centers from 7 geographical regions participated in the study. Newborns with a positive cerebrospinal fluid culture and/or cerebrospinal fluid polymerase chain reaction were included in the study. Demographic characteristics, clinical, laboratory and neuroimaging findings...
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
Frontiers in nutrition,
Volume 10, 22 4 2023, Pages 1178134
Identifying barriers and facilitators to adopting healthier dietary choices in clinical care: a cross-sectional observational study.
de Frel DL, Wicks H, Bakk Z, van Keulen N, Atsma DE, Janssen VR
Background and aims: Adopting healthier diets can drastically improve societal health. Our environment plays a crucial role in daily dietary choices and hospitals in particular can stimulate patients to adopt healthier eating habits. Unfortunately, no robust clinically applicable cuing tools exist to help guide in-hospital dietary interventions. The purpose of this study was to identify patient-related barriers and facilitators to adopting healthier dietary choices. Methods and results: This cro...
Abstract
Journal of the Society for Cardiovascular Angiography & Interventions,
Volume 3, Issue 2, 22 4 2023, Pages 101263
A Tumor-Feeding Artery Towards a Cardiac Glomus Tumor.
Kalkman DN, van der Kley F, Dekkers P, Wierda E, Kuipers RS, van de Klippe HA
Abstract
Cited 2 times since 2023 (1 per year)
source: EuropePMC
Journal of general internal medicine,
Volume 39, Issue 4, 22 4 2023, Pages 683-689
How to Use Costs in Value-Based Healthcare: Learning from Real-life Examples.
van der Poort EKJ, Kidanemariam M, Moriates C, Rakers MM, Tsevat J, Schroijen M, Atsma DE, van den Akker-van Marle ME, Bos WJW, van den Hout WB
Background: Healthcare organizations measure costs for business operations but do not routinely incorporate costs in decision-making on the value of care. Aim: Provide guidance on how to use costs in value-based healthcare (VBHC) delivery at different levels of the healthcare system. Setting and participants: Integrated practice units (IPUs) for diabetes mellitus (DM) and for acute myocardial infarction (AMI) at the Leiden University Medical Center and a collaboration of seven breast cancer IPUs...
Abstract
Journal of cardiovascular medicine (Hagerstown, Md.),
Volume 25, Issue 2, 22 4 2023, Pages 176-177
Statin pretreatment and cardiac surgery: end of a myth?
Oliveri F, Meretta A, Schaerli N, Montero-Cabezas J, Jukema JW
Abstract
Cited 6 times since 2023 (3.1 per year)
source: EuropePMC
BMC health services research,
Volume 23, Issue 1, 21 3 2023, Pages 1455
An iterative approach to developing a multifaceted implementation strategy for a complex eHealth intervention within clinical practice.
IJzerman RVH, van der Vaart R, Breeman LD, Arkenbout K, Keesman M, Kraaijenhagen RA, Evers AWM, Scholte Op Reimer WJM, Janssen VR
Background: The number of complex eHealth interventions has increased considerably. Despite available implementation theory outlining well-designed strategies, implementing complex interventions within practice proves challenging and often does not lead to sustainable use. To improve sustainability, theory and practice should be addressed during the development of an implementation strategy. By subsequently transparently reporting the executed theory-based steps and their corresponding practice...
Abstract
Cited 2 times since 2023 (1 per year)
source: EuropePMC
European urology open science,
Volume 59, 20 3 2023, Pages 50-54
Treatment Patterns and Use of Immune Checkpoint Inhibitors Among Patients with Metastatic Bladder Cancer in a Dutch Nationwide Cohort.
Richters A, Robbrecht DGJ, Meijer RP, van der Heijden AG, Kiemeney LALM, van den Bosch J, Suelmann BBM, Özdemir BC, ProBCI Study Group, Mehra N, Aben KKH
Since 2017, two immune checkpoint inhibitors (ICIs) have become the standard of care for the treatment of metastatic urothelial carcinoma in Europe: pembrolizumab as second-line therapy and avelumab as maintenance therapy. Our aim was to describe the use of ICIs as first and later lines of treatment in patients with metastatic bladder cancer (mBC) in the Netherlands. We identified all patients diagnosed with primary mBC between 2018 and 2021 in the Netherlands from the Netherlands Cancer Registr...
Abstract
Cited 24 times since 2023 (12.4 per year)
source: EuropePMC
European journal of heart failure,
Volume 26, Issue 4, 20 3 2023, Pages 754-771
European Society of Cardiology Core Curriculum for cardio-oncology.
López-Fernández T, Farmakis D, Ameri P, Asteggiano R, de Azambuja E, Aznar M, Barac A, Bayes-Genis A, Bax JJ, Bergler-Klein J, Boriani G, Celutkiene J, Coats A, Cohen-Solal A, Córdoba R, Cosyns B, Filippatos G, Fox K, Gulati G, Inciardi RM, Lee G, Mamas MA, Novo G, Plummer C, Psyrri A, Rakisheva A, Suter T, Tini G, Tocchetti CG, Toutouzas K, Wilhelm M, Metra M, Lyon AR, Rosano GMC
Cardio-oncology is a rapidly growing field of cardiovascular (CV) medicine that has resulted from the continuously increasing clinical demand for specialized CV evaluation, prevention and management of patients suffering or surviving from malignant diseases. Dealing with CV disease in patients with cancer requires special knowledge beyond that included in the general core curriculum for cardiology. Therefore, the European Society of Cardiology (ESC) has developed a special core curriculum for ca...
Abstract
Cited 6 times since 2023 (3.1 per year)
source: EuropePMC
JACC. Clinical electrophysiology,
Volume 10, Issue 3, 20 3 2023, Pages 585-603
Mapping and Ablation of Ventricular Tachycardia in Inherited Left Ventricular Cardiomyopathies.
Zeppenfeld K, Kimura Y, Ebert M
Advances in the field of human genetics have led to an accumulating understanding of the genetic basis of distinct nonischemic cardiomyopathies associated with ventricular tachycardias (VTs) and sudden cardiac death. To date, there is an increasing proportion of patients with inherited cardiomyopathies requiring catheter ablation for VTs. This review provides an overview of disease-causing gene mutations frequently encountered and relevant for clinical electrophysiologists. Available data on VT...
Abstract
Cited 2 times since 2023 (1 per year)
source: EuropePMC
PloS one,
Volume 18, Issue 12, 19 3 2023, Pages e0292645
Differences in the gut microbiota between Gurkhas and soldiers of British origin.
Troth TD, McInnes RS, Dunn SJ, Mirza J, Whittaker AH, Goodchild SA, Loman NJ, Harding SV, van Schaik W
Previous work indicated that the incidence of travellers' diarrhoea (TD) is higher in soldiers of British origin, when compared to soldiers of Nepalese descent (Gurkhas). We hypothesise that the composition of the gut microbiota may be a contributing factor in the risk of developing TD in soldiers of British origin. This study aimed to characterise the gut microbial composition of Gurkha and non-Gurkha soldiers of the British Army. Recruitment of 38 soldiers (n = 22 Gurkhas, n = 16 non-Gurk...
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
BMC ecology and evolution,
Volume 23, Issue 1, 19 3 2023, Pages 77
Does the expensive brain hypothesis apply to amphibians and reptiles?
Song Z, Griesser M, Schuppli C, van Schaik CP
Vertebrate brains show extensive variation in relative size. The expensive brain hypothesis argues that one important source of this variation is linked to a species' ability to generate the energy required to sustain the brain, especially during periods of unavoidable food scarcity. Here we ask whether this hypothesis, tested so far in endothermic vertebrates, also applies to ectotherms, where ambient temperature is an additional major aspect of energy balance. Phylogenetic comparative ana...
Abstract
BMJ open,
Volume 13, Issue 12, 18 3 2023, Pages e064335
New methodology to assess the excess burden of antibiotic resistance using country-specific parameters: a case study regarding <i>E. coli</i> urinary tract infections.
Godijk NG, McDonald SA, Altorf-van der Kuil W, Schoffelen AF, Franz E, Bootsma MCJ
Objectives: Antimicrobial resistant (AMR) infections are a major public health problem and the burden on population level is not yet clear. We developed a method to calculate the excess burden of resistance which uses country-specific parameter estimates and surveillance data to compare the mortality and morbidity due to resistant infection against a counterfactual (the expected burden if infection was antimicrobial susceptible). We illustrate this approach by estimating the excess burden for AM...
Abstract
