9549 results
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 53, 9 2 2025, Pages 102470
Stenosis degree and plaque burden differ between the major epicardial coronary arteries supplying ischemic territories.
Kero T, Knuuti J, Bär S, Bax JJ, Saraste A, Maaniitty T
Background: It is unclear whether coronary artery stenosis, plaque burden, and composition differ between major epicardial arteries supplying ischemic myocardial territories. Methods: We studied 837 symptomatic patients undergoing coronary computed tomography angiography (CTA) and 15O-water positron emission tomography (PET) myocardial perfusion imaging for suspected obstructive coronary artery disease. Coronary CTA was analyzed using artificial intelligence-guided quantitative computed tomograp...
Abstract
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
Volume 225, 8 2 2025, Pages 112089
Albedo parameter-based characterization of surface roughness in chemically etched zirconium samples.
Yılmaz D, Pathman AF, Kalecik S, Kurucu Y, Demir L
In this study, we investigate the potential of gamma-ray albedo parameters as a non-contact and radiation-based technique to characterize surface roughness variations in zirconium foils subjected to chemical etching. Zirconium samples were etched in 20 % hydrofluoric acid (HF) for different durations (30, 60, 90, and 120 s), and their surface morphology was evaluated using profilometry and gamma spectrometry. Albedo parameters were derived from the intensities of Compton and coherent scattering...
Abstract
Thrombosis research,
Volume 255, 7 1 2025, Pages 109420
Thrombectomy in high-risk pulmonary embolism - device versus thrombolysis: rationale and design of the TORPEDO-NL investigator-initiated, academically-sponsored, multicenter, open-label randomized controlled trial.
Stenger WJE, den Uil CA, Rietdijk WJR, Al Amri I, Montero-Cabezas JM, Elzo Kraemer CV, van Mens TE, Meuwese CL, van Mieghem NMDA, Lauw MN, van den Toorn LM, Levolger S, van de Luijtgaarden KM, Sprenger RA, van Dongen JM, Imani F, Meuwissen M, Kant KM, Aarts RAHM, Winckers K, Brans RJB, Kuiper GJAJM, Schnabel R, Ende-Verhaar YM, Urlings TAJ, Ruys TA, Slot S, Scheffer HJ, Adriaansens SOJH, Boomsma MF, Nijholt IM, Walen S, Leentjens J, Jenniskens S, van Geuns RJ, Griffioen A, Nijkeuter M, Ruigrok D, Vos JA, Kies DA, Tuinman PR, Lely RJ, van der Meijs BB, Hovens MMC, Konstantinides SV, Mol MS, Kraaijeveld AO, Klok FA, Contributing authors
Background: Catheter-directed thrombectomy (CDT) is a promising alternative to full dose thrombolysis in patients with acute high-risk pulmonary embolism (PE), expected to have a more direct effect on pulmonary artery clot burden and a better safety profile. Randomized trials evaluating the safety and efficacy of CDT in high-risk patients are currently unavailable. Methods and results: The TORPEDO-NL study is an investigator-initiated, publicly-funded, multicenter, open-label randomized controll...
Abstract
Applied neuropsychology. Child,
6 1 2025, Pages 1-7
Cognitive function and inflammatory markers of survivors of MIS-C.
Üstündağ G, Özyurt G, Elvan Tüz A, Argüz Çıldır D, Akman S, Kara Aksay A, Yılmaz D, Karadağ Öncel E
Background: Multisystem inflammatory syndrome in children (MIS-C) presents severe clinical challenges due to its severe outcomes and diagnostic complexities. Recent studies suggest cognitive functions may also be affected. This study evaluates cognitive functions in MIS-C survivors over 12 months and explores the relationship with inflammatory markers. Methods: This prospective observational cohort study included children diagnosed with MIS-C hospitalized in a tertiary pediatric care unit. Follo...
Abstract
BMC psychology,
Volume 13, Issue 1, 6 1 2025, Pages 872
Effects of demographic characteristics on burnout, psychological resilience, and family functioning in parents of children with disabilities.
Yildirim MS, Firat MÖ, Atay ME, Yilmaz DA, Dege G
Background: Parents of children with disabilities face unique challenges beyond typical parenting responsibilities. The ongoing demands of caregiving can increase burnout, negatively affecting psychological well-being and family functionality. Psychological resilience is crucial in managing stress and maintaining family dynamics, yet the relationship between burnout, resilience, and family functionality remains underexplored. Objective: This study aims to examine the effects of demographic chara...
Abstract
Cited 1 times since 2025 (3.3 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
5 1 2025, Pages S0022-5223(25)00648-8
Personalized external aortic root support: The Dutch experience.
Kougioumtzoglou AM, Lam BCY, Bouma BJ, Groenink M, Scholte AJHA, Dolmaci OB, Corsmit OT, Pandey AK, de Blok ACJ, Noter SL, Austin C, Klautz RJM, Hazekamp MG, Koolbergen D
Introduction: Patients with connective tissue disease and aortic root aneurysm are at risk of dissection and progression of the dilatation. Standard treatment of aortic root aneurysm is either a total root replacement or valve-sparing root replacement. Both procedures have drawbacks, such as the need for anticoagulation and long-term exposure to the chance of reoperation or endocarditis. The ExoVasc personalized external aortic root support (PEARS) is a perivascular stent that has been introduce...
Abstract
Cited 2 times since 2025 (6.5 per year)
source: EuropePMC
Virchows Archiv : an international journal of pathology,
5 1 2025
Diagnosing the silent: the molecular landscape of non-functional parathyroid carcinoma.
Jentus MM, Corver WE, Snel M, van Haalen FM, van Wezel T, Ruano D, Kapiteijn E, Crobach S, Appelman-Dijkstra NM, Schepers A, Morreau H
Non-functional parathyroid carcinoma (NFPC) is an exceptionally rare malignancy, with approximately 50 cases reported since the parathyroid glands were first described in the late nineteenth century. Unlike functional parathyroid carcinomas (PC), which typically present with severe hyperparathyroidism (HPT) and are monitored via serum calcium and parathyroid hormone (PTH) levels, NFPC lacks biochemical markers and is monitored solely through imaging. In this study, we present two new cases of pr...
Abstract
Cited 4 times since 2025 (12.6 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 67, Issue 8, 1 1 2025, Pages ezaf276
2025 ESC/EACTS Guidelines for the management of valvular heart disease.
Praz F, Borger MA, Lanz J, Marin-Cuartas M, Abreu A, Adamo M, Marsan NA, Barili F, Bonaros N, Cosyns B, De Paulis R, Gamra H, Jahangiri M, Jeppsson A, Klautz RJM, Mores B, Pérez-David E, Pöss J, Prendergast BD, Rocca B, Rossello X, Suzuki M, Thiele H, Tribouilloy CM, Wojakowski W, ESC/EACTS Scientific Document Group
Abstract
Clinical and translational science,
Volume 18, Issue 8, 1 1 2025, Pages e70303
Recommendations for (Pharmaco)Genetic Sampling in Patients Following Allogeneic Hematopoietic Stem Cell Transplantation.
Bokma A, Matic M, Ralf A, van den Bosch BJC, Kayser M, van Schaik RHN, Lafeber M, Coenen MJH, Atrafi F
In patients receiving allogenic hematopoietic stem cell transplantation (aHSCT) complete chimerism is desired. However, this brings a challenge when non-invasive assessment of recipient germline DNA is required for genetic testing. Here, we aim to create awareness for (pharmaco)genetic sampling in patients following aHSCT based on a case report of a patient following aHSCT in which pharmacogenetic analysis was performed. Six pharmacogenetic genes were analyzed in DNA extracted from peripheral bl...
Abstract
Journal of experimental botany,
Volume 76, Issue 12, 1 1 2025, Pages 3560-3576
Gpa2 detects the potato cyst nematode effector GpRBP-1 in the cytoplasm but requires a balanced nucleocytoplasmic distribution to trigger cell death.
Zheng Q, Putker V, Slootweg EJ, Overmars H, van Leeuwen F, van Schaik CC, Sterken MG, Sukarta OCA, Smant G, Goverse A
The potato immune receptor Gpa2 confers host-specific resistance to the cyst nematode Globodera pallida. When transiently expressed in Nicotiana benthamiana it triggers cell death upon recognition of the matching effector GpRBP-1. Effector-triggered immunity by Gpa2 depends on the host factor RanGAP2, which is known to regulate the nucleocytoplasmic distribution and functioning of the highly homologous potato immune receptor Rx1. However, the subcellular localisation of Gpa2 and the role of RanG...
Abstract
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 8, 1 1 2025, Pages euaf136
Different underlying aetiologies in patients presenting with ventricular tachycardia fulfilling task force criteria for arrhythmogenic right ventricular cardiomyopathy: initial suspicion based on the 12-lead electrocardiogram.
Hoogendoorn JC, Bosman LP, van der Heijden JF, Wilde AA, van den Berg MP, Yap SC, van Tintelen JP, Dooijes D, Te Riele ASJM, Zeppenfeld K
Aims: The task force criteria (TFC) for arrhythmogenic right ventricular cardiomyopathy (ARVC) are highly sensitive but lack specificity. Atypical RV involvement (aRVi) may indicate different underlying aetiologies and prognosis, requiring specific therapeutic interventions. We aimed to evaluate the role of the baseline 12-lead ECG for initial suspicion of aRVi. Methods: From the Netherlands Heart Institute Arrhythmogenic Cardiomyopathy (NHI-ACM) registry, patients were selected who (i) fulfille...
Abstract
The journal of vascular access,
1 1 2025, Pages 11297298251350745
Cephalic vein dilatation at the elbow by preoperative supervised forearm exercise depends on adherence to therapy: Results from the randomized controlled single-blind PINCH trial.
Wilschut ED, de Winter EP, Bos EJ, de Vries MR, Putter H, van der Steenhoven TJ, Eefting D, Hamming JF, Rotmans JI, van der Bogt KEA
Background: Maturation failure may be as high as 30%-60% of arteriovenous fistulas (AVF). Forearm exercise postoperatively has shown potential in increasing blood vessel size in patients with end-stage renal disease and may promote maturation of AVFs. Little evidence exists on the impact of pre-operative forearm exercises on the increase of vascular diameters. Aim of this study was to evaluate the effect of supervised forearm exercises on vascular diameters and AVF maturation. Methods: The PINCH...
Abstract
European heart journal,
1 1 2025, Pages ehaf480
Heart failure with reduced ejection fraction and ventricular secondary mitral regurgitation: a holistic approach.
Adamo M, Pagnesi M, Ajmone Marsan N, Bauersachs J, Hausleiter J, Zieroth S, Metra M
Optimal management of patients with heart failure with reduced ejection fraction (HFrEF) and secondary mitral regurgitation (SMR) requires the integration of multiple competencies with the interplay of guideline-directed medical therapy (GDMT) for HFrEF, devices, namely cardiac resynchronization therapy (CRT), when indicated, and mitral transcatheter edge-to-edge repair (M-TEER). Both GDMT and CRT can reduce SMR severity. However, GDMT may not be tolerated in patients with HFrEF who develop hypo...
Abstract
Cited 2 times since 2025 (6.3 per year)
source: EuropePMC
European heart journal. Quality of care & clinical outcomes,
Volume 11, Issue 5, 1 1 2025, Pages 691-697
Key priorities for the implementation of the 2023 ESC Guidelines for the management of endocarditis in low-resource settings.
Borger MA, de Waha S, Marsan NA, Zühlke L, Mestres CA, Fosbol E, Bonaros N, Pizzi MN, Brida M, Sionis A, Delgado V, Members of the Task Force for the 2023 ESC Guidelines for the management of endocarditis
European Society of Cardiology (ESC) Guidelines provide best practice, evidence-based recommendations for diagnosing and treating patients with cardiovascular diseases. It is not always possible for best practices to be followed, however, particularly in low-resource settings. To address this issue, a set of guideline-related documents were created to identify key priorities for users in these settings. The documents highlight the related recommendations and describe key strategies for clinician...
Abstract
Cited 1 times since 2025 (3.1 per year)
source: EuropePMC
Alimentary pharmacology & therapeutics,
Volume 62, Issue 5, 31 5 2025, Pages 553-554
Letter: Efficacy Versus Effectiveness-An Important Nuance Among Real-World Studies.
Naber MR, Ubbink D, van Schaik FDM, Löwenberg M
Abstract
The Journal of asthma : official journal of the Association for the Care of Asthma,
Volume 62, Issue 11, 31 5 2025, Pages 2002-2008
Inhaled muscarinic antagonists during pregnancy in women with asthma: case series from a Dutch prospective observational cohort study.
Kathiravetpillai N, van Buul AR, Ezinga M, Koehorst-Ter Huurne K, Van Nederveen-Bendien SA
Introduction: A large proportion of women with asthma experience worsening of asthma during pregnancy. Well-controlled asthma during pregnancy decreases the risk of maternal and fetal complications. Long-acting muscarinic antagonists (LAMAs) are part of treatment guidelines for poorly controlled asthma. There are no clinical safety data available on LAMA and short-acting muscarinic antagonists (SAMAs) use in pregnancy.Objective: The aim was to evaluate asthma control and pregnancy outcomes in pr...
Abstract
The Journal of dermatological treatment,
Volume 36, Issue 1, 30 5 2025, Pages 2539282
Upadacitinib in daily practice for refractory atopic dermatitis in adolescents: a case series of the BioDay registry.
Vroman F, van der Rijst LP, Bacoş-Cosma OI, Zuithoff NPA, Kamsteeg M, van Lumig PPM, Loman L, Schuttelaar MLA, de Bruin-Weller MS, de Graaf M
Purpose: Upadacitinib is approved for treating moderate-to-severe atopic dermatitis (AD) aged ≥12 years. We evaluated upadacitinib's effectiveness and safety in AD adolescents in daily practice. Materials and methods: Fifteen adolescent AD patients from the BioDay registry, treated with upadacitinib 15 mg once daily were evaluated at baseline and after 4, 8, 16, and 28 weeks. Effectiveness was assessed using Eczema Area and Severity Index (EASI) score and Investigator Global Assessment (IGA...
Abstract
Immuno-oncology technology,
Volume 27, 29 5 2025, Pages 101065
Comprehensive analysis of the systemic immune landscape across breast cancer subtypes and disease stages.
Bakker NAM, Garner H, Geurts VCM, Champanhet E, Klaver C, Duijst M, Nederlof I, Gielen RCAM, de Graaf M, Voorthuis R, Liefaard MC, Lips EH, Oosterkamp HM, Kok M, de Visser KE
Background: Breast cancer is a systemic disease, yet the impact of tumor molecular subtype and disease stage on the systemic immune landscape remains poorly understood. In this study, we comprehensively analyzed the systemic immune landscape in a large cohort of breast cancer patients, encompassing all molecular subtypes and disease stages, alongside a control group of healthy donors. Materials and methods: Using multi-parameter flow cytometry, we assessed the abundance, phenotype, and activatio...
Abstract
Journal of orthopaedics,
Volume 68, 29 5 2025, Pages 283-286
Indomethacin versus Ketorolac for the prevention of heterotopic ossification in hip arthroscopy patients.
Frey CS, Spears TM, Puczko D, Hymel AM, Mathews CG, Luchini PM, Van Schaik KD, Leschied JR, Sullivan J
Background: Nonsteroidal anti-inflammatory drugs are commonly utilized to reduce the risk of developing heterotopic ossification (HO) after hip arthroscopy. However, it is not known which regimen is optimal. Purpose: The purpose of this study is to determine the rate of HO formation after hip arthroscopy in response to different NSAID protocols. Methods: Consecutive cases of a single fellowship-trained surgeon at a tertiary referral center were retrospectively reviewed. Patients received a regim...
Abstract
JACC. Basic to translational science,
Volume 10, Issue 8, 29 5 2025, Pages 101323
CD137 Signaling Modulates Vein Graft Atherosclerosis by Driving T-Cell Activation and Regulating Intraplaque Angiogenesis.
de Jong A, Sluiter TJ, Peters HAB, Lamens A, Jukema JW, Arens R, Quax PHA, de Vries MR
Atherosclerotic vein graft failure still presents a major problem. T-cells have been identified as one of the most abundant immune cell subset in atherosclerotic plaques. Their role, however, remains only partly understood. Using a murine vein graft model for advanced, unstable atherosclerotic lesions, we find that T-cells accumulate over time in atherosclerotic vein grafts, and appear to be activated rapidly after engraftment, demonstrated by increased expression of CD137 on plaque T-cells. Tar...
Abstract
