9549 results
Cited 1 times since 2025 (2.3 per year)
source: EuropePMC
Gut microbes,
Volume 17, Issue 1, 22 4 2025, Pages 2519700
<i>Staphylococcus haemolyticus</i> is a reservoir of antibiotic resistance genes in the preterm infant gut.
Lamberte LE, Darby EM, Kiu R, Moran RA, Acuna-Gonzalez A, Sim K, Shaw AG, Kroll JS, Belteki G, Clarke P, Felgate H, Webber MA, Rowe W, Hall LJ, Van Schaik W
Staphylococcus haemolyticus is an important cause of sepsis in preterm infants, with gut colonization being recognized as a risk factor for infection. To better understand the diversity of S. haemolyticus among preterm infants, we generated genome sequences of S. haemolyticus strains (n = 140) from 44 stool samples of 22 preterm infants from four hospitals in England. Core genome phylogenetic analyses, incorporating 126 publicly available S. haemolyticus genome sequences, showed that 85/140 (60....
Abstract
Acta biomaterialia,
Volume 202, 21 3 2025, Pages 262-275
Multilayered trabecular meshwork for dynamic in vitro studies in glaucoma research.
Gładysz MZ, Fernandes M, Li X, Koch M, Marchena F, Hofman A, de Graaf M, Wolters JC, Kamperman M, Nagelkerke A, Włodarczyk-Biegun MK
Glaucoma, an eye disease causing incremental vision loss, currently has no cure. Its primary cause is the malfunction of the trabecular meshwork (TM), a multilayered tissue in the eye responsible for draining aqueous humor (AH) from the anterior chamber. TM clogging increases outflow resistance, elevates intraocular pressure (IOP), and damages optic nerves, leading to irreversible blindness. Existing in vitro TM models are suboptimal, as they lack the hierarchical structure of the TM. This artic...
Abstract
Cited 1 times since 2025 (2.3 per year)
source: EuropePMC
International journal of cardiology. Congenital heart disease,
Volume 21, 21 3 2025, Pages 100603
Echocardiographic effects of sodium-glucose cotransporter 2 inhibitors in single ventricle circulatory failure.
Neijenhuis RML, Regeer MV, Walker NL, Hunter A, Kiès P, Holman ER, Jukema JW, Jongbloed MRM, Veldtman GR, Egorova AD
Background: Single ventricle patients are at high risk of developing circulatory failure. There is limited evidence for pharmacological treatment. This study assessed the echocardiographic changes in ventricular function during sodium-glucose cotransporter 2 inhibitor (SGLT2i) therapy in patients with single ventricle failure (SVF). Methods: SVF patients with a baseline transthoracic echocardiogram within six months before starting SGLT2i and at least one echocardiographic examination within twe...
Abstract
Critical reviews in oncology/hematology,
Volume 214, 20 3 2025, Pages 104815
Trimodal treatment vs radical cystectomy for muscle-invasive bladder cancer: The neglected impact of informative censoring. A systematic review and meta-analysis.
Robesti D, Micheli F, Rai SN, Fallara G, Gallina A, Montorsi F, Briganti A, Fossati N, van der Heijden AG, Ploussard G, Malavaud B, Martini A
Introduction: Informative censoring (IC) is a statistical bias that occurs when there is an imbalance in the dropout rate among study arms and this imbalance is not random, but can be ascribed to information that is not accounted for. Studies on trimodal therapy (TMT) versus radical cystectomy (RC) yielded conflicting results. We conducted a meta-analysis to assess the potential impact of informative censoring in influencing study outcomes. Materials and methods: A systematic literature search i...
Abstract
Frontiers in big data,
Volume 8, 19 3 2025, Pages 1596615
Conceptualization and scale development for big data-based learning organization capability.
Alkan N, Yilmaz DE, Alkan BB
Introduction: In today's competitive business landscape, organizations must enhance learning and adaptability to gain a strategic edge. While big data significantly influences organizational learning, a comprehensive tool to measure this capability has been lacking in the literature. This study aims to develop a valid and reliable scale to assess big data-based learning organization capability. Methods: A two-phase research design was employed. In the first phase, Exploratory Factor Analysi...
Abstract
Cited 1 times since 2025 (2.3 per year)
source: EuropePMC
International journal of cardiology,
Volume 438, 19 3 2025, Pages 133526
Sex-specific response to cardiac resynchronization therapy: the BIO|WOMEN trial.
Zamorano JL, Vörös G, Calvi V, Osca J, Quesada A, Vernooy K, Martinez JG, Maass AH, Nof E, Tolosana JM, Pardo M, Barr C, Fernández I, Merino JL, Ellery S, Ricoy-Martínez E, Belotti G, Seidlmayer L, Garcia S, Tönnis T, Campbell NG, Foley P, Brockmeier J, Nürnberg M, Ruiz-Granell R, Prinzen FW, Lorente-Ros Á, Moreno A, Pinart M, Ver Heyen M, Van Erven L
Background: Variable evidence exists about the efficacy of Cardiac resynchronization therapy (CRT) in women vs. men with reduced left ventricular ejection fraction (LVEF) and wide QRS complex. Current guidelines, hindered by underrepresentation of women in clinical trials, lack definitive recommendations. The present study was designed to achieve an equal distribution of women and men to prospectively evaluate sex-specific response to CRT. Methods: The primary endpoint was the absolute increase...
Abstract
Archives of microbiology,
Volume 207, Issue 8, 13 2 2025, Pages 174
Biochemical characterization of lipase from Cryptococcus albidus (D24) and its application in sugar fatty acid ester synthesis.
Yilmaz DE, Kula C, Demirci H
Microbial lipases are widely used in industrial applications. The lipase enzyme from Cryptococcus albidus (D24) strain was biochemically characterized and evaluated for its potential in catalyzing esterification reactions, particularly in the synthesis of sugar fatty acid esters. The enzyme demonstrated enhanced activity in solvents like acetone, isopropanol, and dimethylformamide. The effects of different metal ions on the stability of the enzyme were also evaluated, and the results revealed an...
Abstract
Journal of vascular surgery cases and innovative techniques,
Volume 11, Issue 6, 13 2 2025, Pages 101880
Left renal vein transposition as a treatment of refractory hypertension in nutcracker syndrome.
Hofman AB, Ooms S, Rotmans JI, van der Vorst JR
Nutcracker syndrome is a rare condition that describes compression of the left renal vein in between the proximal superior mesenteric artery and the abdominal aorta. Nutcracker syndrome is diagnosed by combining the typical anamnesis with ultrasound findings, demonstrating left renal vein compression. Hypertension, although rare, can be a serious feature of nutcracker syndrome. There has been a long-standing controversy surrounding possible treatment options for nutcracker syndrome. This case re...
Abstract
Open medicine (Warsaw, Poland),
Volume 20, Issue 1, 12 2 2025, Pages 20251219
Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults.
Uysal O, Yılmaz D
Objectives: The aim of the study was to examine peripheral oxygen saturation values in the index and middle fingers of the dominant hand in healthy young adults measured while lying in a supine position or sitting straight up. Methods: This study was a non-randomized and non-controlled, quasi-experimental repeated measures study. It was conducted with 200 healthy young adults in Turkey. A pulse oximeter was located at the same time on the index and middle fingers of the active hand of each parti...
Abstract
Cited 1 times since 2025 (2.2 per year)
source: EuropePMC
Therapeutic advances in chronic disease,
Volume 16, 12 2 2025, Pages 20406223251333570
Systematic review: the use of tacrolimus in steroid-refractory ulcerative colitis.
Jangra V, Yilmaz D, Soares D, Taylor F, Andreani S, Hotouras A
Background: Steroid-refractory ulcerative colitis (SR-UC) is a severe form of ulcerative colitis (UC) that persists despite high-dose corticosteroid therapy. Management is challenging and often requires biologics, immunosuppressants or colectomy. Tacrolimus, a calcineurin inhibitor with immunomodulatory effects, has emerged as a potential alternative, though its efficacy, safety and long-term outcomes remain uncertain. Objectives: This systematic review evaluates the efficacy and safety of tacro...
Abstract
Microbiology spectrum,
Volume 13, Issue 7, 10 2 2025, Pages e0062825
Transposon-directed insertion-site sequencing (TraDIS) analysis of <i>Enterococcus faecium</i> using nanopore sequencing and a WebAssembly analysis platform.
Krause AL, Wirth W, Turner AM, Judd L, Li L, van Schaik W, Howden BP, Carter GP, Seemann T, Wick R, Stinear TP, Buultjens AH, Monk IR
Vancomycin-resistant Enterococcus faecium (VREfm) are healthcare-associated opportunistic pathogens of global significance. Genetic tools are needed to understand the molecular basis for VREfm clinically relevant phenotypes, such as persistence within the human gut or antimicrobial resistance. Here, we present a transposon-directed insertion-site sequencing (TraDIS) platform optimized for E. faecium. We engineered a transposon delivery plasmid, pIMTA(tetM), that can generate high-density transpo...
Abstract
Cited 1 times since 2025 (2.2 per year)
source: EuropePMC
Human vaccines & immunotherapeutics,
Volume 21, Issue 1, 10 2 2025, Pages 2516949
A new quadrivalent meningococcal tetanus toxoid conjugate vaccine: Menquadfi® (MENACWY-TT).
Dinleyici EC, Ciftci E, Somer A, Yilmaz D, Tezer H
Neisseria meningitidis (Nm) remains a major global health concern, causing invasive meningococcal disease (IMD) with significant morbidity and mortality. Despite vaccination efforts, Nm serogroup prevalence and antibiotic resistance continue to evolve, necessitating ongoing surveillance and novel immunization strategies. This review aims to assess the role of MenACWY-TT, a quadrivalent meningococcal conjugate vaccine, in IMD prevention by evaluating its immunogenicity, safety, and real-world eff...
Abstract
Cited 1 times since 2025 (2.1 per year)
source: EuropePMC
International journal of cardiology,
Volume 437, 8 2 2025, Pages 133493
Prognostic utility of hybrid coronary computed tomography angiography and myocardial perfusion imaging in elderly patients with suspected coronary artery disease.
Nammas W, Ajosenpää I, Maaniitty T, Stenström I, Bax JJ, Knuuti J, Saraste A
Background: The prognostic utility of sequential hybrid imaging strategy (coronary computed tomography angiography (CCTA) followed by positron emission tomography (PET) myocardial perfusion imaging in those with obstruction) in the elderly remains unclear. We explored the predictors of adverse outcome in patients ≥65, versus those
Abstract
Cited 2 times since 2025 (4.3 per year)
source: EuropePMC
Communications biology,
Volume 8, Issue 1, 7 1 2025, Pages 890
Observational social learning of "know-how" and "know-what" in wild orangutans: evidence from nest-building skill acquisition.
Permana AL, Permana JJ, Nellissen L, Prayogi ES, Prasetyo D, Wich SA, van Schaik CP, Schuppli C
Immature great apes learn how to build their nests over multiple years, yet how they do so has remained largely unclear. We investigated the detailed role of social learning in the acquisition of nest-building skills in wild Sumatran orangutans (Pongo abelii) using data on nest-building, nest practice, and nest peering behaviour from 44 individuals, collected over 17 years. We found that nest peering (but not being close to a nesting individual without peering) is associated with a significant i...
Abstract
Cited 1 times since 2025 (2.1 per year)
source: EuropePMC
JCI insight,
Volume 10, Issue 13, 5 1 2025, Pages e190992
Distinct cell types along thick ascending limb express pathways for monovalent and divalent cation transport.
Demirci H, Bahena-Lopez JP, Smorodchenko A, Su XT, Nelson JW, Yang CL, Curry JN, Duan XP, Wang WH, Sharkovska Y, Liu R, Yilmaz DE, Quintanova C, Emberley K, Emery B, Himmerkus N, Bleich M, Ellison DH, Bachmann S
Kidney thick ascending limb (TAL) cells reabsorb sodium, potassium, calcium, and magnesium and contribute to urinary concentration. These cells are typically viewed as a single type that recycles potassium across the apical membrane and generates a lumen-positive transepithelial voltage driving calcium and magnesium reabsorption, though variability in potassium channel expression has been reported. Additionally, recent transcriptomic analyses suggest that different cell types exist along this se...
Abstract
Biological cybernetics,
Volume 119, Issue 2-3, 4 1 2025, Pages 12
Decreased spinal inhibition leads to undiversified locomotor patterns.
de Graaf ML, Wagner H, Mochizuki L, Le Mouel C
During walking and running, animals display rich and coordinated motor patterns that are generated and controlled within the central nervous system. Previous computational and experimental results suggest that the balance between excitation and inhibition in neural circuits may be critical for generating such structured motor patterns. In this paper, we explore the influence of this balance on the ability of a reservoir computing artificial neural network to learn human locomotor patterns, using...
Abstract
Expert review of respiratory medicine,
Volume 19, Issue 8, 4 1 2025, Pages 887-897
The relation between visceral fat and lung function in the general population is in part mediated by CRP and leptin.
Oosterom-Eijmael MJP, le Cessie S, Slats AM, Hiemstra PS, Thijs W, Lamb HJ, Willems van Dijk K, Rosendaal FR, de Mutsert R
Background: Abdominal obesity is associated with reduced lung function. It remains unclear whether this results from mechanical pressure or whether visceral fat also plays a role via inflammation. Our aim was to examine the association between visceral fat and lung function, and the role of inflammation. Methods: In this cross-sectional analysis, visceral fat was measured by magnetic resonance imaging and lung function by spirometry. We examined the association between visceral fat and lung func...
Abstract
Cited 1 times since 2025 (2.1 per year)
source: EuropePMC
Neurology,
Volume 104, Issue 12, 3 1 2025, Pages e213673
Epigenetic Aging in Pediatric-Onset Multiple Sclerosis.
Goyne C, Fair AE, Yilmaz D, Race J, Schuette A, Caillier SJ, Aaen GS, Abrams AW, Benson LA, Casper TC, Chitnis T, Gorman MP, Lotze TE, Krupp LB, Mar SS, Ness JM, Rensel M, Rodriguez M, Rose JW, Schreiner TL, Tillema JM, Waldman AT, Wheeler YS, Barcellos LF, Waubant E, Graves JS, as the US Network of Pediatric MS Centers
Background and objectives: Older chronological age is associated with decreased multiple sclerosis (MS) relapse rates and increased risk of progressive disease. Measurement of biological age may be more precise than birthdate in understanding these aging effects. In addition to normal aging, MS-related accelerated aging may contribute. Measurement of biological age in adults may be confounded by the effects of natural aging and age-related comorbidities. Examining age extremes can be informative...
Abstract
Animals : an open access journal from MDPI,
Volume 15, Issue 11, 3 1 2025, Pages 1653
Prospects for Data Collection to Optimise Kid Rearing in Dutch Dairy Goat Herds.
Dijkstra E, Santman-Berends I, de Haan T, van Schaik G, van den Brom R, Stegeman A
Optimising kid rearing is essential for sustainable dairy goat farming, yet validated parameters and practical benchmark data are lacking. This study aimed to develop and evaluate a set of key performance indicators (KPIs) for monitoring kid-rearing practices through a participatory approach. Researchers, veterinarians and five dairy goat farms participated developed a prototype set of KPIs covering birth, colostrum management, average daily gain (ADG), and mortality, which were stratified acros...
Abstract
Cited 1 times since 2025 (2.1 per year)
source: EuropePMC
American heart journal plus : cardiology research and practice,
Volume 56, 3 1 2025, Pages 100562
Impact of aortic valve calcification volume on left ventricular systolic function in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation.
Anwar HS, Algowhary M, Abdelmegid MAF, Helmy HA, Montero-Cabezas JM, Van Der Kley F
Background: Aortic valve calcification (AVC) has been linked to negative cardiac outcomes in patients with aortic stenosis (AS). Given the limited understanding of its specific contributions, we aimed to investigate the interaction between AVC and the left ventricular (LV) systolic function in patients with severe AS and LV systolic dysfunction who underwent transcatheter aortic valve implantation (TAVI). Materials and methods: An observational study of 75 patients with severe AS and LV ejection...
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