9549 results
Cited 132 times since 2020 (26 per year)
source: EuropePMC
European heart journal,
Volume 41, Issue 44, 1 1 2020, Pages 4245-4255
Lipoprotein(a) lowering by alirocumab reduces the total burden of cardiovascular events independent of low-density lipoprotein cholesterol lowering: ODYSSEY OUTCOMES trial.
Szarek M, Bittner VA, Aylward P, Baccara-Dinet M, Bhatt DL, Diaz R, Fras Z, Goodman SG, Halvorsen S, Harrington RA, Jukema JW, Moriarty PM, Pordy R, Ray KK, Sinnaeve P, Tsimikas S, Vogel R, White HD, Zahger D, Zeiher AM, Steg PG, Schwartz GG, ODYSSEY OUTCOMES Investigators
Aims: Lipoprotein(a) concentration is associated with first cardiovascular events in clinical trials. It is unknown if this relationship holds for total (first and subsequent) events. In the ODYSSEY OUTCOMES trial in patients with recent acute coronary syndrome (ACS), the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab reduced lipoprotein(a), low-density lipoprotein cholesterol (LDL-C), and cardiovascular events compared with placebo. This post hoc analysis determined whether...
Abstract
Cited 35 times since 2020 (6.9 per year)
source: EuropePMC
European heart journal,
Volume 41, Issue 42, 1 1 2020, Pages 4114-4123
Effect of alirocumab on major adverse cardiovascular events according to renal function in patients with a recent acute coronary syndrome: prespecified analysis from the ODYSSEY OUTCOMES randomized clinical trial.
Tuñón J, Steg PG, Bhatt DL, Bittner VA, Díaz R, Goodman SG, Jukema JW, Kim YU, Li QH, Mueller C, Parkhomenko A, Pordy R, Sritara P, Szarek M, White HD, Zeiher AM, Schwartz GG, ODYSSEY OUTCOMES Investigators
Aims: Statins reduce cardiovascular risk in patients with acute coronary syndrome (ACS) and normal-to-moderately impaired renal function. It is not known whether proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors provide similar benefit across a range of renal function. We determined whether effects of the PCSK9 inhibitor alirocumab to reduce cardiovascular events and death after ACS are influenced by renal function. Methods and results: ODYSSEY OUTCOMES compared alirocumab with pl...
Abstract
Cited 5 times since 2020 (1 per year)
source: EuropePMC
Journal of cardiovascular development and disease,
Volume 7, Issue 4, 1 1 2020, Pages E48
Assessment of D-Shaped Annulus of Mitral Valve in Patients with Severe MR Using Semi-Automated 4-Dimensional Analysis: Implications for Transcatheter Interventions.
Vo NM, van Wijngaarden SE, Marsan NA, Bax JJ, Delgado V
The development of transcatheter mitral valve replacement therapies requires accurate post-processing analysis tools to provide D-shaped mitral annulus dimensions from 3-dimensional (3D) data. The agreement between two semi-automated, software packages to process 3D transesophageal echocardiography (TEE) data for the measurement of the mitral valve annulus dimensions was evaluated. 3DTEE data of patients with moderate-severe mitral regurgitation (MR) were postprocessed with semi-automated, vendo...
Abstract
Cited 20 times since 2020 (3.9 per year)
source: EuropePMC
Journal of orthopaedic trauma,
Volume 34 Suppl 3, 1 1 2020, Pages S70-S75
Venous Thromboembolism in Hip Fracture Patients: A Subanalysis of the FAITH and HEALTH Trials.
MacDonald DRW, Neilly D, Schneider PS, Bzovsky S, Sprague S, Axelrod D, Poolman RW, Frihagen F, Bhandari M, Swiontkowski M, Schemitsch EH, Stevenson IM, FAITH Investigators, HEALTH Investigators
Background: The primary objective of this study was to determine the incidence of symptomatic venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT), in the hip fracture population. Secondary objectives included determining timing of VTE diagnosis, VTE thromboprophylaxis given, and identifying any factors associated with VTE. Methods: Using data from the FAITH and HEALTH trials, the incidence of VTE, including DVT and PE, and the timing of VTE were determi...
Abstract
Cited 4 times since 2020 (0.8 per year)
source: EuropePMC
Journal of orthopaedic trauma,
Volume 34 Suppl 3, 1 1 2020, Pages S76-S80
Clockwise Torque of Sliding Hip Screws: Is There a Right Side?
Würdemann FS, Poolman RW, Krijnen P, Bzovsky S, Sprague S, Kaptein BL, Hegeman JH, Schemitsch EH, Bhandari M, Swiontkowski M, Schipper IB, Dutch Hip Fracture Audit Group and FAITH Investigators
Objectives: This study evaluated whether patients with a left-sided femoral neck fracture (FNF) treated with a sliding hip screw (SHS) had a higher implant failure rate than patients treated for a right-sided FNF. This was performed to determine the clinical relevance of the clockwise rotational torque of the femoral neck lag screw in a SHS, in relation to the rotational stability of left and right-sided FNFs after fixation. Methods: Data were derived from the FAITH trial and Dutch Hip Fracture...
Abstract
Journal of orthopaedic trauma,
Volume 34 Suppl 3, 1 1 2020, Pages Sii-Siii
Study Summaries.
FAITH Investigators, HEALTH Investigators
Abstract
Cited 3 times since 2020 (0.6 per year)
source: EuropePMC
Journal of pediatric hematology/oncology,
Volume 42, Issue 8, 1 1 2020, Pages e712-e717
High-mobility Group Box 1 Protein in Pediatric Trauma Patients With Acute Traumatic Coagulopathy or Disseminated Intravascular Coagulation.
Ulusoy E, Duman M, Çağlar A, Küme T, Er A, Akgül F, Çitlenbik H, Yilmaz D, Ören H
Objectives: Trauma can induce the release of high-mobility group box 1 (HMGB1), which plays an important role in the activation of coagulation. In this study, we aimed to evaluate the role of HMGB1 in the early diagnosis of acute traumatic coagulopathy (ATC), disseminated intravascular coagulation, and clinical course. Materials and methods: One hundred pediatric trauma patients and 50 healthy controls were enrolled. Demographic data, physical examination results, trauma scores, International So...
Abstract
Cited 5 times since 2020 (1 per year)
source: EuropePMC
Journal of orthopaedic trauma,
Volume 34 Suppl 3, 1 1 2020, Pages S22-S28
Predictors of Loss to Follow-up in Hip Fracture Trials: A Secondary Analysis of the FAITH and HEALTH Trials.
Sivaratnam S, Comeau-Gauthier M, Sprague S, Schemitsch EH, Poolman RW, Frihagen F, Bhandari M, Swiontkowski M, Bzovsky S, FAITH Investigators, HEALTH Investigators
Background: Hip fracture trials often suffer substantial loss to follow-up due to difficulties locating and communicating with participants or when participants, or their family members, withdraw their consent. We aimed to determine which factors were associated with being unable to contact FAITH and HEALTH participants for their 24-month follow-up and to also determine which factors were associated with their withdrawal of consent. Methods: We conducted 2 multivariable logistic regression analy...
Abstract
Cited 11 times since 2020 (2.2 per year)
source: EuropePMC
Journal of orthopaedic trauma,
Volume 34 Suppl 3, 1 1 2020, Pages S9-S14
Arthroplasty Versus Internal Fixation for the Treatment of Undisplaced Femoral Neck Fractures: A Retrospective Cohort Study.
Afaq S, OʼHara NN, Schemitsch EH, Bzovsky S, Sprague S, Poolman RW, Frihagen F, Heels-Ansdell D, Bhandari M, Swiontkowski M, Slobogean GP, FAITH Investigators, HEALTH Investigators
Objective: To compare the 24-month risk of mortality between arthroplasty and internal fixation for undisplaced femoral neck fractures (FNFs). Design: Retrospective cohort study. Setting: Secondary data analysis of 2 multinational randomized controlled trials. Participants: Patients aged 50 years or older with a FNF. Intervention: Arthroplasty (n = 1441), including total hip arthroplasty and hemiarthroplasty, performed for a displaced FNF versus internal fixation (n = 734), including sliding hip...
Abstract
Cited 3 times since 2020 (0.6 per year)
source: EuropePMC
Journal of orthopaedic trauma,
Volume 34 Suppl 3, 1 1 2020, Pages S1-S8
The FAITH and HEALTH Trials: Are We Studying Different Hip Fracture Patient Populations?
Blankstein M, Schemitsch EH, Bzovsky S, Axelrod D, Poolman RW, Frihagen F, Bhandari M, Swiontkowski M, Sprague S, Schottel PC, FAITH Investigators, HEALTH Investigators
Background: Over the past decade, 2 randomized controlled trials were performed to evaluate 2 surgical strategies (internal fixation and arthroplasty) for the treatment of low-energy femoral neck fractures in patients aged ≥50 years. We evaluated whether patient populations in both the FAITH and HEALTH trials had different baseline characteristics and compared the displaced femoral neck fracture cohort from the FAITH trial to HEALTH trial patients. Methods: Patient demographics, medical comorbid...
Abstract
Cited 16 times since 2020 (3.2 per year)
source: EuropePMC
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
Volume 71, Issue 8, 1 1 2020, Pages 1847-1855
Dynamics of Intestinal Carriage of Extended-Spectrum Beta-lactamase-Producing Enterobacteriaceae in the Dutch General Population, 2014-2016.
van den Bunt G, Fluit AC, Bootsma MCJ, van Duijkeren E, Scharringa J, van Pelt W, Bonten MJM
Background: In the Netherlands, the prevalence of intestinal extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) carriage in community-dwelling subjects is ~5%. Little is known about the dynamics of ESBL-E carriage. Methods: In a nationwide, population-based study (2014-2016) with 4177 community-dwelling subjects, fecal samples from 656 subjects were collected after 1 (time point [T] = 1) and 6 (T = 2) months. The growth of ESBL-E was quantified and a whole-genome sequence ana...
Abstract
Cited 7 times since 2020 (1.4 per year)
source: EuropePMC
American journal of respiratory cell and molecular biology,
Volume 63, Issue 5, 1 1 2020, Pages 710-713
Decreased Glycolysis as Metabolic Fingerprint of Endothelial Cells in Chronic Thromboembolic Pulmonary Hypertension.
Smolders VFED, Rodríguez C, Morén C, Blanco I, Osorio J, Piccari L, Bonjoch C, Quax PHA, Peinado VI, Castellà M, Barberà JA, Cascante M, Tura-Ceide O
Abstract
Cited 3 times since 2020 (0.6 per year)
source: EuropePMC
World journal for pediatric & congenital heart surgery,
Volume 11, Issue 6, 1 1 2020, Pages 742-747
Long-Term Follow-Up of Pericardium for the Ventricular Component in Atrioventricular Septal Defect Repair.
IJsselhof RJ, Duchateau SDR, Schouten RM, Slieker MG, Hazekamp MG, Schoof PH
Background: Despite the improved outcome in complete atrioventricular septal defect (AVSD) repair, reoperations for left atrioventricular valve (LAVV) dysfunction are common. The aim of this study was to evaluate the effect of fresh untreated autologous pericardium for ventricular septal defect (VSD) closure on atrioventricular valve function and compare the results with the use of treated bovine pericardial patch material. Methods: Clinical and echocardiographic data were collected of patients...
Abstract
Cited 17 times since 2020 (3.3 per year)
source: EuropePMC
Journal of orthopaedic trauma,
Volume 34 Suppl 3, 1 1 2020, Pages S15-S21
Factors Associated With Mortality After Surgical Management of Femoral Neck Fractures.
Bzovsky S, Comeau-Gauthier M, Schemitsch EH, Swiontkowski M, Heels-Ansdell D, Frihagen F, Bhandari M, Sprague S, FAITH Investigators, HEALTH Investigators
Background: Hip fractures are recognized as one of the most devastating injuries impacting older adults because of the complications that follow. Mortality rates postsurgery can range from 14% to 58% within one year of fracture. We aimed to identify factors associated with increased risk of mortality within 24 months of a femoral neck fracture in patients aged ≥50 years enrolled in the FAITH and HEALTH trials. Methods: Two multivariable Cox proportional hazards regressions were used to investiga...
Abstract
Cited 55 times since 2020 (10.8 per year)
source: EuropePMC
European heart journal,
Volume 41, Issue 43, 1 1 2020, Pages 4181-4187
Long-term clinical outcomes of losartan in patients with Marfan syndrome: follow-up of the multicentre randomized controlled COMPARE trial.
van Andel MM, Indrakusuma R, Jalalzadeh H, Balm R, Timmermans J, Scholte AJ, van den Berg MP, Zwinderman AH, Mulder BJM, de Waard V, Groenink M
Aims: The COMPARE trial showed a small but significant beneficial effect of 3-year losartan treatment on aortic root dilatation rate in adults with Marfan syndrome (MFS). However, no significant effect was found on clinical endpoints, possibly due to a short follow-up period. The aim of the current study was therefore to investigate the long-term clinical outcomes after losartan treatment. Methods and results: In the original COMPARE study (inclusion 2008-2009), adult patients with MFS (n = 233)...
Abstract
Cited 1 times since 2020 (0.2 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 58, Issue 5, 1 1 2020, Pages 1105
What we see depends on what we look for.
Tomšič A, Klautz RJM
Abstract
Cited 28 times since 2020 (5.5 per year)
source: EuropePMC
Molecular oncology,
Volume 15, Issue 1, 31 5 2020, Pages 57-66
Comparison of variant allele frequency and number of mutant molecules as units of measurement for circulating tumor DNA.
Bos MK, Nasserinejad K, Jansen MPHM, Angus L, Atmodimedjo PN, de Jonge E, Dinjens WNM, van Schaik RHN, Del Re M, Dubbink HJ, Sleijfer S, Martens JWM
Quantification of tumor-specific variants (TSVs) in cell-free DNA is rapidly evolving as a prognostic and predictive tool in patients with cancer. Currently, both variant allele frequency (VAF) and number of mutant molecules per mL plasma are used as units of measurement to report those TSVs. However, it is unknown to what extent both units of measurement agree and what are the factors underlying an existing disagreement. To study the agreement between VAF and mutant molecules in current clinica...
Abstract
Cited 10 times since 2020 (2 per year)
source: EuropePMC
Pediatric nephrology (Berlin, Germany),
Volume 36, Issue 5, 31 5 2020, Pages 1195-1205
Predictors of poor kidney outcome in children with C3 glomerulopathy.
Pınarbaşı AS, Dursun I, Gokce I, Çomak E, Saygılı S, Bayram MT, Donmez O, Melek E, Tekcan D, Çiçek N, Yılmaz D, Tabel Y, Yıldırım ZY, Bahat E, Koyun M, Soylu A, Canpolat N, Aksu B, Çelakıl ME, Taşdemir M, Benzer M, Özçelik G, Bakkaloğlu SA, Düşünsel R
Background: C3 glomerulopathy (C3G) is characterized by heterogeneous clinical presentation, outcome, and predominant C3 accumulation in glomeruli without significant IgG. There is scarce outcome data regarding childhood C3G. We describe clinical and pathological features, treatment and outcomes, and risk factors for progression to chronic kidney disease stage 5 (CKD5) in the largest pediatric series with biopsy-proven C3G. Methods: Sixty pediatric patients with C3G from 21 referral centers in T...
Abstract
Cited 11 times since 2020 (2.2 per year)
source: EuropePMC
Cancers,
Volume 12, Issue 11, 29 5 2020, Pages E3179
Plasma Predictive Features in Treating EGFR-Mutated Non-Small Cell Lung Cancer.
Steendam CMJ, Veerman GDM, Pruis MA, Atmodimedjo P, Paats MS, van der Leest C, von der Thüsen JH, Yick DCY, Oomen-de Hoop E, Koolen SLW, Dinjens WNM, van Schaik RHN, Mathijssen RHJ, Aerts JGJV, Dubbink HJ, Dingemans AC
Although epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are the preferred treatment for patients with EGFR-mutated non-small cell lung cancer (NSCLC), not all patients benefit. We therefore explored the impact of the presence of mutations found in cell-free DNA (cfDNA) and TKI plasma concentrations during treatment on progression-free survival (PFS). In the prospective START-TKI study blood samples from 41 patients with EGFR-mutated NSCLC treated with EGFR-TKIs were av...
Abstract
Cited 13 times since 2020 (2.6 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 14, Issue 4, 28 4 2020, Pages 756-765
Insufficient Mitral Leaflet Remodeling in Relation to Annular Dilation and Risk of Residual Mitral Regurgitation After MitraClip Implantation.
Hirasawa K, Namazi F, Milhorini Pio S, Vo NM, Ajmone Marsan N, Bax JJ, Delgado V
Objectives: The purpose of this study was to determine whether the mitral valve (MV) total leaflet area (TLA)-to-mitral annular area (MAA) (TLA/MAA) ratio measured using 3-dimensional (3D) transesophageal echocardiography (TEE) was associated with residual mitral regurgitation (MR) after MitraClip implantation in patients with secondary MR. Background: The factors influencing the results of MitraClip implantation for secondary MR are controversial. This study hypothesized that insufficient remod...
Abstract
