Research

Publications

Below you can find a list of our published research.

6131 results

Cited 33 times since 2011 (2.4 per year) source: EuropePMC

Pediatric dermatology, Volume 28, Issue 2, 1 1 2011, Pages 169-171 Hypoglycemia as a result of propranolol during treatment of infantile hemangioma: a case report. Breur JM, de Graaf M, Breugem CC, Pasmans SG

Propranolol is a new and promising treatment for hemangiomas of infancy. We report of a patient in whom steroid maintenance therapy is successfully tapered after introduction of propranolol. This patient, however, developed symptomatic hypoglycemic events presumably because of a concurrent deficiency of epinephrine and cortisol as a direct result of both beta-blockage by propranolol and adrenal insufficiency as a result of prednisone use. Extreme care should be taken in patients treated with bot... Abstract

Cited 7 times since 2011 (0.5 per year) source: EuropePMC

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, Volume 17, Issue 3, 1 1 2011, Pages 261-269 Clinical value of myocardial perfusion scintigraphy as a screening tool in liver transplant candidates. Oprea-Lager DE, Sorgdrager BJ, Jukema JW, Scherptong RW, Ringers J, Coenraad MJ, van Hoek B, Stokkel MP

A cardiac evaluation before orthotopic liver transplantation (OLT) is imperative. Previous investigations have demonstrated that mild to moderate reversible perfusion defects on myocardial perfusion scintigraphy (MPS) in general are associated with a low risk for perioperative cardiac events. The objective of this study was to assess any perfusion defects in consecutive patients with chronic liver disease who were undergoing OLT. OLT candidates underwent extensive cardiovascular screening that i... Abstract

Cited 21 times since 2011 (1.5 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 4, Issue 3, 1 1 2011, Pages 246-256 Feasibility of diastolic function assessment with cardiac CT: feasibility study in comparison with tissue Doppler imaging. Boogers MJ, van Werkhoven JM, Schuijf JD, Delgado V, El-Naggar HM, Boersma E, Nucifora G, van der Geest RJ, Paelinck BP, Kroft LJ, Reiber JH, de Roos A, Bax JJ, Lamb HJ

Objectives: This study aimed to demonstrate the feasibility of multidetector row computed tomography (CT) for assessment of diastolic function in comparison with 2-dimensional (2D) echocardiography using tissue Doppler imaging (TDI). Background: Diastolic left ventricular (LV) function plays an important role in patients with cardiovascular disease. 2D echocardiography using TDI has been used most commonly to evaluate diastolic LV function. Although the role of cardiac CT imaging for evaluation... Abstract

Cited 7 times since 2011 (0.5 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 27, Issue 8, 26 4 2011, Pages 1179-1193 Role of computed tomography imaging for transcatheter valvular repair/insertion. Ewe SH, Klautz RJ, Schalij MJ, Delgado V

During the last decade, the development of transcatheter based therapies has provided feasible therapeutic options for patients with symptomatic severe valvular heart disease who are deemed inoperable. The promising results of many nonrandomized series and recent landmark trials have increased the number of percutaneous transcatheter valve procedures in high operative risk patients. Pre-procedural imaging of the anatomy of the aortic or mitral valve and their spatial relationships is crucial to... Abstract

Cited 68 times since 2011 (4.8 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 97, Issue 22, 25 4 2011, Pages 1847-1851 Impact of left atrial fibrosis and left atrial size on the outcome of catheter ablation for atrial fibrillation. den Uijl DW, Delgado V, Bertini M, Tops LF, Trines SA, van de Veire NR, Zeppenfeld K, Schalij MJ, Bax JJ

Background: Left atrial (LA) dilatation is an important risk factor for recurrence of atrial fibrillation (AF) after radiofrequency catheter ablation (RFCA). However, the clinical applications to select patients eligible for RFCA according to LA size is limited. Additional pre-procedural assessment of LA fibrosis might improve patient selection for RFCA. Objective: To investigate the impact of LA size and LA fibrosis on the outcome of RFCA for AF. Methods: One hundred and seventy consecutive pat... Abstract

Cited 9 times since 2011 (0.6 per year) source: EuropePMC

Atherosclerosis, Volume 216, Issue 2, 24 4 2011, Pages 365-369 Exercise ankle brachial index adds important prognostic information on long-term out-come only in patients with a normal resting ankle brachial index. de Liefde II, Klein J, Bax JJ, Verhagen HJ, van Domburg RT, Poldermans D

Background: The clinical value of exercise ankle brachial index (ABI) is still unclear, especially in patients with normal resting ABI. Method: 2164 patients performed a single-stage treadmill exercise test to diagnose or evaluate PAD. The population was divided into two groups: a normal resting ABI (resting ABI≥0.90) and PAD (resting ABI Abstract

Cited 42 times since 2011 (3 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 24, Issue 4, 24 4 2011, Pages 405-413 Quantitative analysis of mitral valve apparatus in mitral valve prolapse before and after annuloplasty: a three-dimensional intraoperative transesophageal study. Maffessanti F, Marsan NA, Tamborini G, Sugeng L, Caiani EG, Gripari P, Alamanni F, Jeevanandam V, Lang RM, Pepi M

Background: Intraoperative real-time three-dimensional transesophageal echocardiography has been shown useful in the evaluation of the mitral valve (MV) apparatus, and dedicated commercial software allows its quantitative assessment. The aims of this study were to (1) quantify the effects induced by prolapse on MV anatomy in the presence of fibroelastic deficiency (FED) or Barlow's disease (BD), (2) assess the effect of surgery on the MV apparatus, and (3) investigate the potential role of... Abstract

Cited 117 times since 2011 (8.3 per year) source: EuropePMC

Circulation research, Volume 108, Issue 5, 24 4 2011, Pages 582-592 Lack of fibronectin-EDA promotes survival and prevents adverse remodeling and heart function deterioration after myocardial infarction. Arslan F, Smeets MB, Riem Vis PW, Karper JC, Quax PH, Bongartz LG, Peters JH, Hoefer IE, Doevendans PA, Pasterkamp G, de Kleijn DP

Rationale: The extracellular matrix may induce detrimental inflammatory responses on degradation, causing adverse cardiac remodeling and heart failure. The extracellular matrix protein fibronectin-EDA (EIIIA; EDA) is upregulated after tissue injury and may act as a "danger signal" for leukocytes to cause adverse cardiac remodeling after infarction. Objective: In the present study, we evaluated the role of EDA in regulation of postinfarct inflammation and repair after myocardial infarct... Abstract

Cited 12 times since 2011 (0.9 per year) source: EuropePMC

BMC geriatrics, Volume 11, 22 4 2011, Pages 8 Incident venous thromboembolic events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Freeman DJ, Robertson M, Brown EA, Rumley A, Tobias ES, Frölich M, Slagboom PE, Jukema JW, de Craen AJ, Sattar N, Ford I, Gaw A, Greer IA, Lowe GD, Stott DJ

Background: Venous thromboembolic events (VTE), including deep venous thrombosis and pulmonary embolism, are common in older age. It has been suggested that statins might reduce the risk of VTE however positive results from studies of middle aged subjects may not be generalisable to elderly people. We aimed to determine the effect of pravastatin on incident VTE in older people; we also studied the impact of clinical and plasma risk variables. Methods: This study was an analysis of incident VTE u... Abstract

Cited 33 times since 2011 (2.3 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 31, Issue 5, 17 3 2011, Pages 1033-1040 Toll-like receptor 4 is involved in human and mouse vein graft remodeling, and local gene silencing reduces vein graft disease in hypercholesterolemic APOE*3Leiden mice. Karper JC, de Vries MR, van den Brand BT, Hoefer IE, Fischer JW, Jukema JW, Niessen HW, Quax PH

Objective: The goal of this study was to explore the role of Toll-like receptor 4 (TLR4) in vein graft remodeling and disease. Methods and results: First, expression of TLR4 was analyzed in freshly isolated human saphenous veins (huSV), in freshly isolated huSV ex vivo perfused in an extracorporeal circulation, or in huSV used as coronary vein grafts. Marked induction of focal TLR4 expression was observed in perfused fresh huSV. Moreover, TLR4 was abundantly present in lesions in fresh huSV or i... Abstract

Cited 51 times since 2011 (3.6 per year) source: EuropePMC

Injury, Volume 42, Issue 10, 16 3 2011, Pages 1125-1129 Increased rates of wound complications with locking plates in distal fibular fractures. Schepers T, Van Lieshout EM, De Vries MR, Van der Elst M

Introduction: There is a growing use of locking compression plates in fracture surgery. The current study was undertaken to investigate the wound complication rates of locking versus non-locking plates in distal fibular fractures. Patients and methods: During a 6-year study period all consecutive, closed distal fibular fractures treated with either a locking or a non-locking plate were included and retrospectively analysed for complication related to the fibula. Results: A total of 165 patients... Abstract

Cited 40 times since 2011 (2.8 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 13, Issue 5, 16 3 2011, Pages 634-639 The incidence and risk factors for new onset atrial fibrillation in the PROSPER study. Macfarlane PW, Murray H, Sattar N, Stott DJ, Ford I, Buckley B, Jukema JW, Westendorp RG, Shepherd J

Aims: Atrial fibrillation/flutter (AF) is the most common arrhythmia in older people. It associates with reduced exercise capacity, increased risk of stroke, and mortality. We aimed to determine retrospectively whether pravastatin reduces the incidence of AF and whether any electrocardiographic measures or clinical conditions might be risk factors for its development. Methods and results: The PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) was a randomized, double-blind control... Abstract

Cited 5 times since 2011 (0.4 per year) source: EuropePMC

International journal of cardiology, Volume 158, Issue 3, 12 2 2011, Pages 359-363 Exercise capacity and ventricular function in patients treated for isolated pulmonary valve stenosis or tetralogy of Fallot. Luijnenburg SE, de Koning WB, Romeih S, van den Berg J, Vliegen HW, Mulder BJ, Helbing WA

Background: We hypothesized 1) that long-term ventricular outcome and exercise capacity would be better in patients with isolated pulmonary valve stenosis (PS) treated with balloon pulmonary valvuloplasty (BPV) than in patients operated for tetralogy of Fallot (TOF), and 2) that ventricular outcome and exercise capacity would not be different in PS patients and healthy controls. Methods: We included 21 PS patients after BPV (16.2 ± 5.2 years) and 21 patients operated for TOF (16.6 ± 5.6 years),... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 19, Issue 3, 12 2 2011, Pages 151-152 The quest for an atrium-specific biomarker. van der Laarse A, de Vries AA

Abstract

Cited 1 times since 2011 (0.1 per year) source: EuropePMC

Critical care (London, England), Volume 15, Issue 1, 9 2 2011, Pages 119 Cardiovascular consequences of cooling in critical care. Steendijk P

This commentary discusses a paper by Filseth and colleagues in a previous issue of Critical Care. The authors describe the cardiovascular effects of induced hypothermia, focusing particularly on post-hypothermic ventricular function. The findings indicate that the treatment resulted in reduced systolic but unchanged diastolic left ventricular function with compensatory effects on heart rate and systemic vascular resistance. The novel aspects of this study are the registration of ventricular func... Abstract

Cited 3 times since 2011 (0.2 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 13, Issue 6, 4 1 2011, Pages 770-772 The infarct characteristics on magnetic resonance imaging and ventricular tachycardia: do we see what we need to see? Zeppenfeld K, van der Geest RJ

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Cited 26 times since 2011 (1.8 per year) source: EuropePMC

The Journal of surgical research, Volume 174, Issue 2, 2 1 2011, Pages 266-271 Near-infrared fluorescence imaging of liver metastases in rats using indocyanine green. van der Vorst JR, Hutteman M, Mieog JS, de Rooij KE, Kaijzel EL, Löwik CW, Putter H, Kuppen PJ, Frangioni JV, van de Velde CJ, Vahrmeijer AL

Background: Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) is a promising technique to obtain real-time assessment of the extent and number of colorectal liver metastases during surgery. The current study aims to optimize dosage and timing of ICG administration. Materials and methods: Liver tumors were induced in 18 male WAG/Rij rats by subcapsular inoculation of CC531 rat colorectal cancer cells into three distinct liver lobes. Rats were divided in two groups: imaging af... Abstract

Cited 25 times since 2011 (1.8 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 4, Issue 2, 1 1 2011, Pages 195-201 Early reperfusion therapy affects inducibility, cycle length, and occurrence of ventricular tachycardia late after myocardial infarction. Piers SR, Wijnmaalen AP, Borleffs CJ, van Huls van Taxis CF, Thijssen J, van Rees JB, Cannegieter SC, Bax JJ, Schalij MJ, Zeppenfeld K

Background: This study aimed to evaluate the impact of early reperfusion during acute myocardial infarction (MI) on ventricular tachycardia (Vt) inducibility, inducible Vt cycle length (CL), and occurrence of spontaneous Vt late after MI. Methods and results: Five hundred six patients (440 men; age, 63±11 years) with prior MI who underwent electrophysiology study before implantation of an implantable cardioverter-defibrillator for primary or secondary prevention were assessed. Patients were clas... Abstract

Cited 6 times since 2011 (0.4 per year) source: EuropePMC

Circulation. Cardiovascular interventions, Volume 4, Issue 1, 1 1 2011, Pages 112-113 Percutaneous tricuspid valve implantation in a Fontan patient with congestive heart failure and protein-losing enteropathy. Straver B, Wagenaar LJ, Blom NA, Mulder BJ, Bouma BJ, Hazekamp MG, de Winter RJ

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Cited 36 times since 2011 (2.6 per year) source: EuropePMC

Circulation, Volume 123, Issue 6, 1 1 2011, Pages 640-655 Assessment of systolic dyssynchrony for cardiac resynchronization therapy is clinically useful. Delgado V, Bax JJ

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