Research

Publications

Below you can find a list of our published research.

7154 results

Cited 2 times since 2014 (0.2 per year) source: EuropePMC

Heart, lung & circulation, Volume 23, Issue 8, 2 1 2014, Pages e169-71 Transcatheter mitral valve repair in osteogenesis imperfecta associated mitral valve regurgitation. van der Kley F, Delgado V, Ajmone Marsan N, Schalij MJ

Objectives: Osteogenesis imperfecta is associated with increased prevalence of significant mitral valve regurgitation. Surgical mitral valve repair and replacement are feasible but are associated with increased risk of bleeding and dehiscence of implanted valves may occur more frequently. The present case report describes the outcomes of transcatheter mitral valve repair in a patient with osteogenesis imperfecta. Patients/methods: A 60 year-old patient with osteogenesis imperfecta and associated... Abstract

Cited 1 times since 2014 (0.1 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 21, Issue 2, 1 1 2014, Pages 245-247 The importance of heart rate response during myocardial perfusion imaging. Bax JJ, Delgado V

Abstract

Cited 27 times since 2014 (2.5 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 16 Suppl 1, 1 1 2014, Pages i1-78 Statistics on the use of cardiac electronic devices and electrophysiological procedures in 55 ESC countries: 2013 report from the European Heart Rhythm Association (EHRA). Arribas F, Auricchio A, Boriani G, Brugada J, Deharo JC, Hindriks G, Kuck KH, Merino JL, Vardas P, Wolpert C, Zeppenfeld K

Abstract

Cited 17 times since 2014 (1.6 per year) source: EuropePMC

The American journal of cardiology, Volume 113, Issue 12, 1 1 2014, Pages 1947-1955 Feasibility of an automated quantitative computed tomography angiography-derived risk score for risk stratification of patients with suspected coronary artery disease. de Graaf MA, Broersen A, Ahmed W, Kitslaar PH, Dijkstra J, Kroft LJ, Delgado V, Bax JJ, Reiber JH, Scholte AJ

Coronary computed tomography angiography (CTA) has important prognostic value. Additionally, quantitative CTA (QCT) provides a more detailed accurate assessment of coronary artery disease (CAD) on CTA. Potentially, a risk score incorporating all quantitative stenosis parameters allows accurate risk stratification. Therefore, the purpose of this study was to determine if an automatic quantitative assessment of CAD using QCT combined into a CTA risk score allows risk stratification of patients. In... Abstract

Cited 78 times since 2014 (7.1 per year) source: EuropePMC

Surgical endoscopy, Volume 28, Issue 4, 1 1 2014, Pages 1076-1082 Optimization of near-infrared fluorescence cholangiography for open and laparoscopic surgery. Verbeek FP, Schaafsma BE, Tummers QR, van der Vorst JR, van der Made WJ, Baeten CI, Bonsing BA, Frangioni JV, van de Velde CJ, Vahrmeijer AL, Swijnenburg RJ

Background: During laparoscopic cholecystectomy, common bile duct (CBD) injury is a rare but severe complication. To reduce the risk of injury, near-infrared (NIR) fluorescent cholangiography using indocyanine green (ICG) has recently been introduced as a novel method of visualizing the biliary system during surgery. To date, several studies have shown feasibility of this technique; however, liver background fluorescence remains a major problem during fluorescent cholangiography. The aim of the... Abstract

Cited 11 times since 2014 (1 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 22, Issue 4, 1 1 2014, Pages 186-189 Using genetic variation for establishing causality of cardiovascular risk factors: overcoming confounding and reverse causality. Smit RA, Trompet S, de Craen AJ, Jukema JW

Cardiovascular disease (CVD) remains the leading cause of death in developed countries, despite the decline of CVD mortality over the last two decades. From observational, predictive research, efforts have been made to find causal risk factors for CVD. However, in recent years, some of these findings have been shown to be mistaken. Possible explanations for the discrepant findings are confounding and reverse causation. Genetic epidemiology has tried to address these problems through the use of M... Abstract

Cited 195 times since 2014 (17.8 per year) source: EuropePMC

Cell, Volume 157, Issue 2, 1 1 2014, Pages 329-339 Identification, characterization, and natural selection of mutations driving airborne transmission of A/H5N1 virus. Linster M, van Boheemen S, de Graaf M, Schrauwen EJA, Lexmond P, Mänz B, Bestebroer TM, Baumann J, van Riel D, Rimmelzwaan GF, Osterhaus ADME, Matrosovich M, Fouchier RAM, Herfst S

Recently, A/H5N1 influenza viruses were shown to acquire airborne transmissibility between ferrets upon targeted mutagenesis and virus passage. The critical genetic changes in airborne A/Indonesia/5/05 were not yet identified. Here, five substitutions proved to be sufficient to determine this airborne transmission phenotype. Substitutions in PB1 and PB2 collectively caused enhanced transcription and virus replication. One substitution increased HA thermostability and lowered the pH of membrane f... Abstract

Cited 28 times since 2014 (2.6 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 22, Issue 4, 1 1 2014, Pages 160-166 Left cardiac sympathetic denervation in the Netherlands for the treatment of inherited arrhythmia syndromes. Olde Nordkamp LR, Driessen AH, Odero A, Blom NA, Koolbergen DR, Schwartz PJ, Wilde AA

Introduction: Treating therapy-resistant patients with inherited arrhythmia syndromes can be difficult and left cardiac sympathetic denervation (LCSD) might be a viable alternative treatment option. We provide an overview of the indications and outcomes of LCSD in patients with inherited arrhythmia syndromes in the only tertiary referral centre in the Netherlands where LCSD is conducted in these patients. Methods: This was a retrospective study, including all patients with inherited arrhythmia s... Abstract

Cited 20 times since 2014 (1.8 per year) source: EuropePMC

Annals of oncology : official journal of the European Society for Medical Oncology, Volume 25, Issue 6, 31 5 2014, Pages 1198-1203 Screening for coronary artery disease after mediastinal irradiation in Hodgkin lymphoma survivors: phase II study of indication and acceptance†. Daniëls LA, Krol AD, de Graaf MA, Scholte AJ, Van't Veer MB, Putter H, de Roos A, Schalij MJ, Creutzberg CL

Background: Cardiovascular diseases are the most common nonmalignant cause of death in Hodgkin lymphoma (HL) survivors, especially after mediastinal irradiation. We investigated the role of computed tomographic coronary angiography (CTA) as a screening tool for coronary artery disease (CAD) in asymptomatic HL survivors, and related CTA findings to exercise testing and subsequent interventions. Patients and methods: Patients were eligible for this phase II study if at least 10 years disease-free... Abstract

Cited 157 times since 2014 (14.4 per year) source: EuropePMC

Human molecular genetics, Volume 23, Issue 16, 31 5 2014, Pages 4420-4432 Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. Deelen J, Beekman M, Uh HW, Broer L, Ayers KL, Tan Q, Kamatani Y, Bennet AM, Tamm R, Trompet S, Guðbjartsson DF, Flachsbart F, Rose G, Viktorin A, Fischer K, Nygaard M, Cordell HJ, Crocco P, van den Akker EB, Böhringer S, Helmer Q, Nelson CP, Saunders GI, Alver M, Andersen-Ranberg K, Breen ME, van der Breggen R, Caliebe A, Capri M, Cevenini E, Collerton JC, Dato S, Davies K, Ford I, Gampe J, Garagnani P, de Geus EJ, Harrow J, van Heemst D, Heijmans BT, Heinsen FA, Hottenga JJ, Hofman A, Jeune B, Jonsson PV, Lathrop M, Lechner D, Martin-Ruiz C, Mcnerlan SE, Mihailov E, Montesanto A, Mooijaart SP, Murphy A, Nohr EA, Paternoster L, Postmus I, Rivadeneira F, Ross OA, Salvioli S, Sattar N, Schreiber S, Stefánsson H, Stott DJ, Tiemeier H, Uitterlinden AG, Westendorp RG, Willemsen G, Samani NJ, Galan P, Sørensen TI, Boomsma DI, Jukema JW, Rea IM, Passarino G, de Craen AJ, Christensen K, Nebel A, Stefánsson K, Metspalu A, Magnusson P, Blanché H, Christiansen L, Kirkwood TB, van Duijn CM, Franceschi C, Houwing-Duister

The genetic contribution to the variation in human lifespan is ∼ 25%. Despite the large number of identified disease-susceptibility loci, it is not known which loci influence population mortality. We performed a genome-wide association meta-analysis of 7729 long-lived individuals of European descent (≥ 85 years) and 16 121 younger controls ( Abstract

Cited 4 times since 2014 (0.4 per year) source: EuropePMC

Journal of electrocardiology, Volume 47, Issue 4, 30 5 2014, Pages 500-504 Directionality and proportionality of the ST and ventricular gradient difference vectors during acute ischemia. ter Haar CC, Maan AC, Schalij MJ, Swenne CA

Background: The ECG is important in diagnosis and triage in the initial phase of the acute coronary syndrome (ACS). The primary goal of making an ECG at first medical contact should be the reliable detection of cardiac ischemia, thus facilitating a correct triage by corroborating the diagnosis of ACS. Ischemia detection by ST amplitude analysis is limited to situations in which there is an identifiable J point. The ventricular gradient (VG) is independent of conduction and might be an alternativ... Abstract

Cited 40 times since 2014 (3.7 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 15, Issue 9, 30 5 2014, Pages 996-1003 For what endpoint does myocardial 123I-MIBG scintigraphy have the greatest prognostic value in patients with chronic heart failure? Results of a pooled individual patient data meta-analysis. Verschure DO, Veltman CE, Manrique A, Somsen GA, Koutelou M, Katsikis A, Agostini D, Gerson MC, van Eck-Smit BL, Scholte AJ, Jacobson AF, Verberne HJ

Aims: The purpose of this study was to determine the most appropriate prognostic endpoint for myocardial (123)I-metaiodobenzylguanidine (MIBG) scintigraphy in patients with chronic heart failure (CHF) based on aggregate results from multiple studies published in the past decade. Methods and results: Original individual late (3-5 h) heart/mediastinum (H/M) ratio data of 636 CHF patients were retrieved from six studies from Europe and the USA. All-cause mortality, cardiac mortality, arrhythmic eve... Abstract

Cited 8 times since 2014 (0.7 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 25, Issue 6, 29 5 2014, Pages 631-637 Effect of induced LV dyssynchrony by right ventricular apical pacing on all-cause mortality and heart failure hospitalization rates at long-term follow-up. Auger D, Hoke U, Marsan NA, Tops LF, Leong DP, Bertini M, Schalij MJ, Bax JJ, Delgado V

Background: Right ventricular apical (RVA) pacing may induce left ventricular (LV) dyssynchrony. The long-term prognostic implications of induction of LV dyssynchrony were retrospectively evaluated in a cohort of patients who underwent RVA pacing. Methods: A total of 169 patients (62 ± 13 years, 69% male) with high RVA pacing burden were included. Echocardiographic evaluation of LV volumes, ejection fraction, and dyssynchrony were performed before and after device implantation. LV dyssynchrony w... Abstract

Cited 19 times since 2014 (1.7 per year) source: EuropePMC

Annals of hematology, Volume 93, Issue 8, 29 5 2014, Pages 1401-1412 Clinical and biological impact of TET2 mutations and expression in younger adult AML patients treated within the EORTC/GIMEMA AML-12 clinical trial. Aslanyan MG, Kroeze LI, Langemeijer SM, Koorenhof-Scheele TN, Massop M, van Hoogen P, Stevens-Linders E, van de Locht LT, Tönnissen E, van der Heijden A, da Silva-Coelho P, Cilloni D, Saglio G, Marie JP, Tang R, Labar B, Amadori S, Muus P, Willemze R, Marijt EW, de Witte T, van der Reijden BA, Suciu S, Jansen JH

We assessed the prognostic impact of TET2 mutations and mRNA expression in a prospective cohort of 357 adult AML patients < 60 years of age enrolled in the European Organization For Research and Treatment of Cancer (EORTC)/Gruppo Italiano Malattie Ematologiche dell' Adulto (GIMEMA) AML-12 06991 clinical trial. In addition the co-occurrence with other genetic defects and the functional consequences of TET2 mutations were investigated. TET2 mutations occurred in 7.6 % of the patients and w... Abstract

Cited 61 times since 2014 (5.6 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 100, Issue 9, 26 4 2014, Pages 685-690 The dialysis procedure as a trigger for atrial fibrillation: new insights in the development of atrial fibrillation in dialysis patients. Buiten MS, de Bie MK, Rotmans JI, Gabreëls BA, van Dorp W, Wolterbeek R, Trines SA, Schalij MJ, Jukema JW, Rabelink TJ, van Erven L

Aims: Atrial fibrillation (AF) is common in dialysis patients and is associated with increased morbidity and mortality. The pathophysiology may be related to common risk factors for both AF and renal disease or to dialysis-specific factors. The purpose of this study was to determine whether and how AF onset relates to the dialysis procedure itself. Methods: All dialysis patients enrolled in the implantable cardioverter defibrillator-2 (ICD-2) trial until January 2012, who were implanted with an... Abstract

Cited 255 times since 2014 (23.3 per year) source: EuropePMC

The EMBO journal, Volume 33, Issue 8, 25 4 2014, Pages 823-841 Role of receptor binding specificity in influenza A virus transmission and pathogenesis. de Graaf M, Fouchier RA

The recent emergence of a novel avian A/H7N9 influenza virus in poultry and humans in China, as well as laboratory studies on adaptation and transmission of avian A/H5N1 influenza viruses, has shed new light on influenza virus adaptation to mammals. One of the biological traits required for animal influenza viruses to cross the species barrier that received considerable attention in animal model studies, in vitro assays, and structural analyses is receptor binding specificity. Sialylated glycans... Abstract

Cited 2 times since 2014 (0.2 per year) source: EuropePMC

Acute cardiac care, Volume 16, Issue 2, 21 3 2014, Pages 41-48 Networks for improving care in patients with acute coronary syndrome: A framework. Radke PW, Halvorsen S, Jukema JW, Kolh P, Annemans L, Postma MJ, Ardissino D, Kristensen SD, Bassand JP, Collet JP, Morais J, Tuñón J, Halcox J

In recent years, it has become evident that the level of guideline adherence in patients presenting with acute coronary syndrome (ACS) is highly correlated with patient outcomes. Unfortunately, guideline adherence is low in some geographic areas and especially in those patients at high-risk. Regional networks including ambulance systems and hospitals with catheterization laboratories are able to increase guideline adherence and patient outcomes by streamlining the critical pre- and intra-hospita... Abstract

Cited 2 times since 2014 (0.2 per year) source: EuropePMC

Pediatric pulmonology, Volume 50, Issue 1, 20 3 2014, Pages 79-84 The influence of stents on microbial colonization of the airway in children after slide tracheoplasty: a 14-year single-center experience. Rijnberg FM, Butler CR, Speggiorin S, Fierens A, Wallis C, Nouraei R, McLaren CA, Roebuck DJ, Hewitt R, Elliott MJ

Objectives: This study describes the microbial colonization profile of the airway in children after slide tracheoplasty (STP) with and without stents, and compares colonization to children undergoing cardiothoracic surgical procedures without airway related disease. Methods: A 14-year retrospective single case note review was performed on patients undergoing STP and stent insertion. Nose and throat (NT) and bronchoalveolar lavage (BAL) specimens were analyzed for microbial profile and expressed... Abstract

Cited 2 times since 2014 (0.2 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 30, Issue 5, 19 3 2014, Pages 925-934 Myocardial scar identification based on analysis of Look-Locker and 3D late gadolinium enhanced MRI. Tao Q, Lamb HJ, Zeppenfeld K, van der Geest RJ

The aim of this study is to introduce and evaluate an approach for objective and reproducible scar identification from late gadolinium enhanced (LGE) MR by analysis of LGE data with post-contrast T(1) mapping from a routinely acquired T(1) scout Look-Locker (LL) sequence. In 90 post-infarction patients, a LL sequence was acquired prior to a three-dimensional LGE sequence covering the entire left ventricle. In 60/90 patients (training set), the T(1) relaxation rates of remote myocardium and dense... Abstract

Cited 9 times since 2014 (0.8 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 47, Issue 1, 18 3 2014, Pages 146-52; discussion 152 Long-term follow-up of tracheoplasty using autologous pericardial patch and strips of costal cartilage. Yazdanbakhsh AP, van Rijssen LB, Koolbergen DR, König A, de Mol BA, Hazekamp MG

Objectives: To evaluate long-term results of tracheoplasty using autologous pericardial patch and strips of costal cartilage for relieving severe long-segment tracheal stenosis. Methods: Data were collected retrospectively by clinical chart review. Between 1995 and 2013, 21 patients underwent tracheoplasty. Follow-up was performed by outpatient chart review; otherwise, referring physicians and parents were contacted and asked to fill in a questionnaire. Results: Median age at the time of operati... Abstract