Research

Publications

Below you can find a list of our published research.

6128 results

Cited 11 times since 2008 (0.7 per year) source: EuropePMC

Journal of vascular surgery, Volume 48, Issue 2, 23 4 2008, Pages 368-376 Treatment for peripheral arterial obstructive disease: An appraisal of the economic outcome of complications. Flu H, van der Hage JH, Knippenberg B, Merkus JW, Hamming JF, Lardenoye JW

Objective: This study determined the average estimated total costs after treatment for peripheral arterial occlusive disease (PAOD) and evaluated the effect of postoperative complications and their consequences for the total costs. Methods: Cost data on all admissions involving treatment for PAOD from January 2007 until July 2007 were collected. A prospective analysis was made using the patient-related risk factor and comorbidity (Society for Vascular Surgery/International Society of Cardiovascu... Abstract

Cited 280 times since 2008 (16.7 per year) source: EuropePMC

Lancet (London, England), Volume 371, Issue 9628, 22 4 2008, Pages 1927-1935 Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies. Sattar N, McConnachie A, Shaper AG, Blauw GJ, Buckley BM, de Craen AJ, Ford I, Forouhi NG, Freeman DJ, Jukema JW, Lennon L, Macfarlane PW, Murphy MB, Packard CJ, Stott DJ, Westendorp RG, Whincup PH, Shepherd J, Wannamethee SG

Background: Clinical use of criteria for metabolic syndrome to simultaneously predict risk of cardiovascular disease and diabetes remains uncertain. We investigated to what extent metabolic syndrome and its individual components were related to risk for these two diseases in elderly populations. Methods: We related metabolic syndrome (defined on the basis of criteria from the Third Report of the National Cholesterol Education Program) and its five individual components to the risk of events of i... Abstract

Cited 23 times since 2008 (1.4 per year) source: EuropePMC

European journal of endocrinology, Volume 159, Issue 2, 21 3 2008, Pages 97-103 Increased aortic root diameters in patients with acromegaly. van der Klaauw AA, Bax JJ, Smit JW, Holman ER, Delgado V, Bleeker GB, Biermasz NR, Roelfsema F, Romijn JA, Pereira AM

Objective: The clinical manifestations of acromegalic cardiomyopathy include arrhythmias, valvular regurgitation, concentric left ventricular (LV) hypertrophy, and LV systolic and diastolic dysfunction. At present, it is unknown whether acromegaly also affects the aortic root. Design: Aortic root diameters were prospectively assessed in 37 acromegalic patients (18 patients with active disease and 19 with controlled disease) by conventional two-dimensional and Doppler echocardiography before, and... Abstract

Cited 7 times since 2008 (0.4 per year) source: EuropePMC

Journal of clinical pharmacology, Volume 48, Issue 7, 19 3 2008, Pages 837-848 Population pharmacokinetic modeling of epoetin delta in pediatric patients with chronic kidney disease. Knebel W, Palmen M, Dowell JA, Gastonguay M

This analysis quantifies the population pharmacokinetics of subcutaneous and intravenous epoetin delta, an epoetin produced in a human cell line, in pediatric patients with chronic kidney disease and estimates the effects of covariate factors on epoetin delta and epoetin alfa pharmacokinetic parameters. Erythropoietin serum concentration data, taken from a phase III study conducted in 60 patients aged 1 to 17 years, were best described by a 1-compartment model with first-order absorption and eli... Abstract

Cited 77 times since 2008 (4.6 per year) source: EuropePMC

European heart journal, Volume 29, Issue 12, 19 3 2008, Pages 1516-1522 The ageing male heart: myocardial triglyceride content as independent predictor of diastolic function. van der Meer RW, Rijzewijk LJ, Diamant M, Hammer S, Schär M, Bax JJ, Smit JW, Romijn JA, de Roos A, Lamb HJ

Aims: In animal models of obesity and diabetes mellitus, myocardial TG accumulation is associated with decreased myocardial function. In the physiologically ageing heart, myocardial triglyceride (TG) accumulation may also occur due to reduced myocardial fatty acid oxidation. The role of myocardial TG in the ageing human heart is unknown. Therefore, the purpose of our study was to evaluate the effects of ageing on myocardial TG content, and to determine the association between myocardial TG conte... Abstract

European journal of clinical investigation, Volume 38, Issue 7, 16 3 2008, Pages 462-468 Increased infiltration of Chlamydophila pneumoniae in the vessel wall of human veins after perfusion. Kupreishvili K, ter Weeme M, Morré SA, van den Brule AJ, Huybregts MA, Quax PH, ten Velden J, Van Hinsbergh VW, Stooker W, Eijsman L, Niessen HW

Background: Several studies have suggested an association between Chlamydophila pneumoniae (Cp) infection and atherosclerosis. A recent study detected Cp DNA in the saphenous vein of 12% of all patients before bypass grafting and in 38% of failed grafts. We used a system in which human veins were perfused with autologous blood under arterial pressure. Materials and methods: Veins were surplus segments of saphenous veins of coronary artery bypass grafting (CABG) patients. Vein grafts were perfuse... Abstract

Cited 1 times since 2008 (0.1 per year) source: EuropePMC

Journal of cardiothoracic and vascular anesthesia, Volume 22, Issue 6, 12 2 2008, Pages 823-831 The relationship between carotid blood-flow velocity and the left ventricular area during acute regional ischemia. Broscheit JA, Weidemann F, Strotmann J, Steendijk P, Eberbach N, Karle H, Schuster F, Roewer N, Greim CA

Objective: Myocardial contractility can be described by the relationship between blood-flow velocity in the carotid artery and the left ventricular cross-sectional area. The authors investigated whether critical myocardial ischemia influences the derived contractility index, E'(es). Design: A prospective animal study. Setting: A university research laboratory. Participants: Eleven Göttinger minipigs. Interventions: Within the closed-chest model, the authors placed a U-shaped 8-MHz miniature... Abstract

Cited 1 times since 2008 (0.1 per year) source: EuropePMC

European heart journal, Volume 29, Issue 11, 8 2 2008, Pages 1344-1345 Foetal echocardiography: tool to predict the future of patients with congenital heart defects? de Groot NM, Schalij MJ

Abstract

Cited 62 times since 2008 (3.7 per year) source: EuropePMC

Circulation, Volume 117, Issue 19, 5 1 2008, Pages 2515-2522 Torcetrapib does not reduce atherosclerosis beyond atorvastatin and induces more proinflammatory lesions than atorvastatin. de Haan W, de Vries-van der Weij J, van der Hoorn JW, Gautier T, van der Hoogt CC, Westerterp M, Romijn JA, Jukema JW, Havekes LM, Princen HM, Rensen PC

Background: Although cholesteryl ester transfer protein (CETP) inhibition is regarded as a promising strategy to reduce atherosclerosis by increasing high-density lipoprotein cholesterol, the CETP inhibitor torcetrapib given in addition to atorvastatin had no effect on atherosclerosis and even increased cardiovascular death in the recent Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events trial. Therefore, we evaluated the antiatherogenic potential and adve... Abstract

Cited 1188 times since 2008 (70.6 per year) source: EuropePMC

Circulation, Volume 117, Issue 20, 5 1 2008, Pages 2608-2616 Results of the Predictors of Response to CRT (PROSPECT) trial. Chung ES, Leon AR, Tavazzi L, Sun JP, Nihoyannopoulos P, Merlino J, Abraham WT, Ghio S, Leclercq C, Bax JJ, Yu CM, Gorcsan J, St John Sutton M, De Sutter J, Murillo J

Background: Data from single-center studies suggest that echocardiographic parameters of mechanical dyssynchrony may improve patient selection for cardiac resynchronization therapy (CRT). In a prospective, multicenter setting, the Predictors of Response to CRT (PROSPECT) study tested the performance of these parameters to predict CRT response. Methods and results: Fifty-three centers in Europe, Hong Kong, and the United States enrolled 498 patients with standard CRT indications (New York Heart A... Abstract

Cited 12 times since 2008 (0.7 per year) source: EuropePMC

Vascular, Volume 16, Issue 3, 1 1 2008, Pages 140-146 Collective experience with hybrid procedures for suprarenal and thoracoabdominal aneurysms. van de Mortel RH, Vahl AC, Balm R, Buth J, Hamming JF, Schurink GW, de Vries JP

Not every patient is fit for open thoracoabdominal aortic aneurysm (TAAA) repair, nor is every TAAA or juxtarenal abdominal aortic aneurysm suitable for branched or fenestrated endovascular exclusion. The hybrid procedure consists of debranching of the renal and visceral arteries followed by endovascular exclusion of the aneurysm and might be an alternative in these patients. Between May 2004 and March 2006, 16 patients were treated with a hybrid procedure. The indications were recurrent suprare... Abstract

Cited 39 times since 2008 (2.3 per year) source: EuropePMC

Annals of surgery, Volume 247, Issue 5, 1 1 2008, Pages 877-884 Resection of carotid body tumors: results of an evolving surgical technique. van der Bogt KE, Vrancken Peeters MP, van Baalen JM, Hamming JF

Objective: To evaluate a modified technique for carotid body tumor (CBT) resection. Background: Resection of CBT can lead to substantial postoperative morbidity because of a rich vascularization and close connection to neurovascular structures. The impact of a modified surgical technique on postoperative outcome was evaluated and compared with a historical group and the literature. Methods: Medical records of patients who underwent CBT surgery at Leiden University Medical Center between 1963 and... Abstract

Cited 248 times since 2008 (14.7 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 51, Issue 20, 1 1 2008, Pages 1944-1952 Assessment of left ventricular dyssynchrony by speckle tracking strain imaging comparison between longitudinal, circumferential, and radial strain in cardiac resynchronization therapy. Delgado V, Ypenburg C, van Bommel RJ, Tops LF, Mollema SA, Marsan NA, Bleeker GB, Schalij MJ, Bax JJ

Objectives: The objective of this study was to assess the usefulness of each type of strain for left ventricular (LV) dyssynchrony assessment and its predictive value for a positive response after cardiac resynchronization therapy (CRT). Furthermore, changes in extent of LV dyssynchrony for each type of strain were evaluated during follow-up. Background: Different echocardiographic techniques have been proposed for assessment of LV dyssynchrony. The novel 2-dimensional (2D) speckle tracking stra... Abstract

Cited 10 times since 2008 (0.6 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 34, Issue 1, 1 1 2008, Pages 48-54 Long-term follow-up after repair of Ebstein's anomaly. Palmen M, de Jong PL, Klieverik LM, Venema AC, Meijboom FJ, Bogers AJ

Objective: We studied the long-term results of vertical plication repair of Ebstein's anomaly according to Carpentier. Methods: Between 1988 and 2007, 28 patients (mean age 28.8+/-15.7 years, range 4-58 years) underwent vertical plication repair of Ebstein's anomaly. At operation the anomaly was classified according to Carpentier. In three patients (11%) a cavopulmonary shunt was added at the repair on the indication of impaired right ventricular function. Results: There was no operati... Abstract

Cited 18 times since 2008 (1.1 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 94, Issue 10, 1 1 2008, Pages 1318-1322 Acute effects of alcohol septal ablation on systolic and diastolic left ventricular function in patients with hypertrophic obstructive cardiomyopathy. Steendijk P, Meliga E, Valgimigli M, Ten Cate FJ, Serruys PW

Objective: Hypertrophic obstructive cardiomyopathy (HOCM) often leads to heart failure, severe symptoms and death. Percutaneous transluminal septal myocardial ablation (PTSMA) by alcohol injection efficiently reduces left ventricular (LV) outflow tract pressure gradient and improves symptoms. We determined acute changes in haemodynamics and systolic and diastolic LV function after PTSMA. Methods: In 17 consecutive patients with symptomatic HOCM referred for PTSMA, the target vessel was determine... Abstract

Cited 229 times since 2008 (13.6 per year) source: EuropePMC

The New England journal of medicine, Volume 358, Issue 19, 1 1 2008, Pages 2024-2029 Left cardiac sympathetic denervation for catecholaminergic polymorphic ventricular tachycardia. Wilde AA, Bhuiyan ZA, Crotti L, Facchini M, De Ferrari GM, Paul T, Ferrandi C, Koolbergen DR, Odero A, Schwartz PJ

Catecholaminergic polymorphic ventricular tachycardia is a potentially lethal disease characterized by adrenergically mediated ventricular arrhythmias manifested especially in children and teenagers. Beta-blockers are the cornerstone of therapy, but some patients do not have a complete response to this therapy and receive an implantable cardioverter-defibrillator (ICD). Given the nature of catecholaminergic polymorphic ventricular tachycardia, ICD shocks may trigger new arrhythmias, leading to t... Abstract

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology, Volume 27, Issue 5, 1 1 2008, Pages 639-687 [Guidelines for cardiac pacing and cardiac resynchronization therapy]. Vardas PE, Auricchio A, Blanc JJ, Daubert JC, Drexler H, Ector H, Gasparini M, Linde C, Morgado FB, Oto A, Sutton R, Trusz-Gluza M, Grupo de Trabalho para Pacing Cardíaco e Terapia de Ressincronização Cardíaca da European Society of Cardiology, European Heart Rhythm Association, Vahanian A, Camm J, De Caterina R, Dean V, Dickstein K, Funck-Brentano C, Filippatos G, Hellemans I, Kristensen SD, McGregor K, Sechtem U, Silber S, Tendera M, Widimsky P, Zamorano JL, Priori SG, Blomström-Lundqvist C, Brignole M, Terradellas JB, Camm J, Castellano P, Cleland J, Farre J, Fromer M, Le Heuzey JY, Lip GY, Merino JL, Montenero AS, Ritter P, Schalij MJ, Stellbrink C

Abstract

Cited 15 times since 2008 (0.9 per year) source: EuropePMC

Journal of electrocardiology, Volume 41, Issue 3, 1 1 2008, Pages 211-219 Reconstruction of standard 12-lead electrocardiograms from 12-lead electrocardiograms recorded with the Mason-Likar electrode configuration. Man SC, Maan AC, Kim E, Draisma HH, Schalij MJ, van der Wall EE, Swenne CA

Electrocardiograms (ECGs) made with Mason-Likar electrode configuration (ML-ECGs) show well-known differences from standard 12-lead ECGs (Std-ECGs). We recorded, simultaneously, Std-ECGs and ML-ECGs in 180 subjects. Using these ECGs, 8 x 8 individual and general conversion matrices were created by linear regression, and standard ECGs were reconstructed from ML-ECGs using these matrices. The performance of the matrices was assessed by the root mean square differences between the original Std-ECGs... Abstract

Cited 1 times since 2008 (0.1 per year) source: EuropePMC

Nederlands tijdschrift voor geneeskunde, Volume 152, Issue 19, 1 1 2008, Pages 1088-1090 [Torcetrapib increases mortality in patients with a high risk of cardiovascular disorders]. Rensen PC, Jukema JW

Inhibition of cholesteryl ester transfer protein (CETP) is generally regarded as a promising strategy to reduce atherosclerosis by increasing HDL cholesterol. Therefore, the potent CETP inhibitor torcetrapib was given in addition to atorvastatin in half of the 15,067 patients with a high cardiovascular risk in the randomized, double-blind 'Investigation of lipid level management to understand its impact in atherosclerotic events' (ILLUMINATE) study. Torcetrapib caused a large increase... Abstract

Cited 250 times since 2008 (14.8 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 1, Issue 3, 1 1 2008, Pages 321-330 Noninvasive evaluation of the aortic root with multislice computed tomography implications for transcatheter aortic valve replacement. Tops LF, Wood DA, Delgado V, Schuijf JD, Mayo JR, Pasupati S, Lamers FP, van der Wall EE, Schalij MJ, Webb JG, Bax JJ

Objectives: In the present study, the anatomy of the aortic root was assessed noninvasively with multislice computed tomography (MSCT). Background: Transcatheter aortic valve replacement has been proposed as an alternative to surgery in high-risk patients with severe aortic stenosis. For this procedure, detailed knowledge of aortic annulus diameters and the relation between the annulus and the coronary arteries is needed. Methods: In 169 patients (111 men, age 54 +/- 11 years), a 64-slice MSCT s... Abstract