Research

Publications

Below you can find a list of our published research.

6128 results

Journal of the American College of Cardiology, Volume 48, Issue 7, 12 2 2006, Pages 1472; author reply 1472-3 Risk stratification with electrocardiographic-gated dobutamine stress imaging. Elhendy A, Schinkel AF, Bax JJ, Poldermans D

Abstract

Cited 16 times since 2006 (0.9 per year) source: EuropePMC

Heart rhythm, Volume 4, Issue 1, 9 2 2006, Pages 88-91 Incessant ventricular tachycardia in fulminant lymphocytic myocarditis: Evidence for origin in the Purkinje system and successful treatment with ablation. Zeppenfeld K, Blom NA, Bootsma M, Schalij MJ

Abstract

Cited 27 times since 2006 (1.5 per year) source: EuropePMC

Molecular and cellular biology, Volume 26, Issue 20, 5 1 2006, Pages 7731-7746 Identification of new human origins of DNA replication by an origin-trapping assay. Gerhardt J, Jafar S, Spindler MP, Ott E, Schepers A

Metazoan genomes contain thousands of replication origins, but only a limited number have been characterized so far. We developed a two-step origin-trapping assay in which human chromatin fragments associated with origin recognition complex (ORC) in vivo were first enriched by chromatin immunoprecipitation. In a second step, these fragments were screened for transient replication competence in a plasmid-based assay utilizing the Epstein-Barr virus latent origin oriP. oriP contains two elements,... Abstract

Cited 16 times since 2006 (0.9 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 13, Issue 5, 1 1 2006, Pages 635-641 Do risk factors influence the diagnostic accuracy of noninvasive coronary angiography with multislice computed tomography? Schuijf JD, Mollet NR, Cademartiri F, Jukema JW, Lamb HJ, de Roos A, van der Wall EE, de Feyter PJ, Bax JJ

Background: Multislice computed tomography (MSCT) is a relatively new noninvasive imaging modality in the evaluation of patients with suspected coronary artery disease (CAD). Whether diagnostic accuracy is influenced by gender or risk factors for CAD is currently unknown and was evaluated in this study. Methods and results: In 197 patients (171 men and 26 women; mean age, 60 +/- 11 years) 16-slice MSCT was performed and compared with invasive coronary angiography at 2 different centers (Leiden a... Abstract

Cited 52 times since 2006 (2.8 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 132, Issue 3, 1 1 2006, Pages 610-620 Surgical ventricular restoration in patients with ischemic dilated cardiomyopathy: evaluation of systolic and diastolic ventricular function, wall stress, dyssynchrony, and mechanical efficiency by pressure-volume loops. Tulner SA, Steendijk P, Klautz RJ, Bax JJ, Schalij MJ, van der Wall EE, Dion RA

Objectives: Surgical ventricular restoration aims at improving cardiac function by normalization of left ventricular shape and size. Recent studies indicate that surgical ventricular restoration is highly effective with an excellent 5-year outcome in patients with ischemic dilated cardiomyopathy. We used pressure-volume analysis to investigate acute changes in systolic and diastolic left ventricular function, mechanical dyssynchrony and efficiency, and wall stress. Methods: In 3 patient groups (... Abstract

Cited 7 times since 2006 (0.4 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 13, Issue 5, 1 1 2006, Pages 629-634 Accuracy of stress Tc-99m tetrofosmin myocardial perfusion tomography for the diagnosis and localization of coronary artery disease in women. Elhendy A, Schinkel AF, Bax JJ, van Domburg RT, Valkema R, Biagini E, Feringa HH, Poldermans D

Background: Earlier studies have suggested a modest accuracy of stress thallium 201 myocardial perfusion imaging (MPI) for the diagnosis of coronary artery disease (CAD) in women. The accuracy of stress MPI with technetium 99m tetrofosmin has not been studied in women. The aim of this study was to assess the accuracy of stress Tc-99m tetrofosmin MPI for the diagnosis and localization of CAD in women. Methods and results: We studied 88 women who underwent exercise or dobutamine stress Tc-99m tetr... Abstract

Cited 15 times since 2006 (0.8 per year) source: EuropePMC

Current opinion in cardiology, Volume 21, Issue 5, 1 1 2006, Pages 443-449 Prognostic role of dobutamine stress echocardiography in myocardial viability. Schinkel AF, Poldermans D, Elhendy A, Bax JJ

Purpose of review: The aim of this review is to provide a perspective on the role of dobutamine stress echocardiography to evaluate myocardial viability and assess prognosis in patients with ischemic left ventricular dysfunction. Recent findings: Pooled analysis of currently available data demonstrates that dobutamine stress echocardiography provides useful information on recovery of dysfunctional but viable myocardium and prognosis. In fact, improvement of long-term prognosis may be the ultimat... Abstract

Cited 2 times since 2006 (0.1 per year) source: EuropePMC

Nederlands tijdschrift voor geneeskunde, Volume 150, Issue 35, 1 1 2006, Pages 1930-1935 [Favourable results with surgical treatment in 43 children with hypoplastic left-heart syndrome or similar disorders, 1999-2005]. Hazekamp MG, Rijlaarsdam ME, Schoof PH, Wald AA, Blom NA, Ottenkamp J

Objective: To describe the results of surgical treatment of hypoplastic left-heart syndrome (HLHS) and HLHS-like disorders in the Amsterdam-Leiden Centre for Congenital Heart Disease, the Netherlands. Design: Retrospective, descriptive. Method: Data were collected on 43 neonates with HLHS or similar disorders who underwent surgical treatment between December 1999 and December 2005. HLHS was present in 37 patients and 6 had disorders similar to HLHS (unbalanced atrioventricular septal defect, tru... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 14, Issue 9, 1 1 2006, Pages 283-284 Do patients benefit from drug-eluting stents in acute myocardial infarction? Steens RF, Jukema JW, van der Wall EE

Abstract

Cited 117 times since 2006 (6.3 per year) source: EuropePMC

Stroke, Volume 37, Issue 10, 31 5 2006, Pages 2531-2534 Transesophageal echocardiography is superior to transthoracic echocardiography in management of patients of any age with transient ischemic attack or stroke. de Bruijn SF, Agema WR, Lammers GJ, van der Wall EE, Wolterbeek R, Holman ER, Bollen EL, Bax JJ

Background and purpose: The merits of transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) in the management of transient ischemic attack (TIA) and stroke patients remains matter of debate. Methods: Two hundred and thirty-one consecutive patients with a recent TIA or stroke for which no definite cause and indication for anticoagulation was assessed after standardized work-up underwent TTE and TEE. Echocardiographic findings were categorized into minor and major risk fa... Abstract

Cited 156 times since 2006 (8.4 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 26, Issue 11, 31 5 2006, Pages 2552-2559 Cholesteryl ester transfer protein decreases high-density lipoprotein and severely aggravates atherosclerosis in APOE*3-Leiden mice. Westerterp M, van der Hoogt CC, de Haan W, Offerman EH, Dallinga-Thie GM, Jukema JW, Havekes LM, Rensen PC

Objective: The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is still undergoing debate. Therefore, we evaluated the effect of human CETP expression on atherosclerosis in APOE*3-Leiden (E3L) mice with a humanized lipoprotein profile. Methods and results: E3L mice were crossbred with human CETP transgenic mice. On a chow diet, CETP expression increased plasma total cholesterol (TC) (+43%; P Abstract

Cited 10 times since 2006 (0.5 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 23, Issue 2, 29 5 2006, Pages 159-165 Plasma natriuretic peptide levels reflect changes in heart failure symptoms, left ventricular size and function after surgical mitral valve repair. Feringa HH, Poldermans D, Klein P, Braun J, Klautz RJ, van Domburg RT, van der Laarse A, van der Wall EE, Dion RA, Bax JJ

Background and aim: N-terminal pro-B-type natriuretic peptide (NT-proBNP) has diagnostic and prognostic value in patients with heart failure. The present prospective study was designed to assess whether changes in NT-proBNP levels after surgical mitral valve repair reflect changes in heart failure symptoms and changes in left atrial size, left ventricular size and left ventricular function. Methods: The study population consisted of 22 patients (mean age: 62.8 +/- 14.2 years, 68% male) undergoin... Abstract

Cited 33 times since 2006 (1.8 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 26, Issue 11, 24 4 2006, Pages 2560-2566 Dual PPARalpha/gamma agonist tesaglitazar reduces atherosclerosis in insulin-resistant and hypercholesterolemic ApoE*3Leiden mice. Zadelaar AS, Boesten LS, Jukema JW, van Vlijmen BJ, Kooistra T, Emeis JJ, Lundholm E, Camejo G, Havekes LM

Objective: We investigated whether the dual PPARalpha/gamma agonist tesaglitazar has anti-atherogenic effects in ApoE*3Leiden mice with reduced insulin sensitivity. Methods and results: ApoE*3Leiden transgenic mice were fed a high-fat (HF) insulin-resistance-inducing diet. One group received a high-cholesterol (HC) supplement (1% wt/wt; HC group). A second group received the same HC supplement along with tesaglitazar (T) 0.5 micromol/kg diet (T group). A third (control) group received a low-chol... Abstract

Cited 14 times since 2006 (0.8 per year) source: EuropePMC

Pediatric cardiology, Volume 27, Issue 5, 23 4 2006, Pages 552-556 Surgical repair of aortopulmonary window: thirty-seven years of experience. Jansen C, Hruda J, Rammeloo L, Ottenkamp J, Hazekamp MG

An aortopulmonary window (APW) is a communication between the ascending aorta and the pulmonary trunk in the presence of two separate semilunar valves. In order to increase our understanding about the surgical management of this rare lesion and its long-term results, we describe our experience over a 37-year period. Between 1968 and 2005, 18 patients were diagnosed with APW. Seventeen underwent surgical correction. Age at operation ranged from 22 days to 22 years (median, 0.20 years). Follow-up... Abstract

Cited 36 times since 2006 (1.9 per year) source: EuropePMC

Vascular pharmacology, Volume 45, Issue 5, 22 4 2006, Pages 281-301 Murine models of myocardial and limb ischemia: diagnostic end-points and relevance to clinical problems. Madeddu P, Emanueli C, Spillmann F, Meloni M, Bouby N, Richer C, Alhenc-Gelas F, Van Weel V, Eefting D, Quax PH, Hu Y, Xu Q, Hemdahl AL, van Golde J, Huijberts M, de Lussanet Q, Struijker Boudier H, Couffinhal T, Duplaa C, Chimenti S, Staszewsky L, Latini R, Baumans V, Levy BI

Ischemic disease represents the new epidemic worldwide. Animal models of ischemic disease are useful because they can help us to understand the underlying pathogenetic mechanisms and develop new therapies. The present review article summarizes the results of a consensus conference on the status and future development of experimentation in the field of cardiovascular medicine using murine models of peripheral and myocardial ischemia. The starting point was to recognize the limits of the approach,... Abstract

Cited 131 times since 2006 (7.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 48, Issue 5, 17 3 2006, Pages 964-969 Should major vascular surgery be delayed because of preoperative cardiac testing in intermediate-risk patients receiving beta-blocker therapy with tight heart rate control? Poldermans D, Bax JJ, Schouten O, Neskovic AN, Paelinck B, Rocci G, van Dortmont L, Durazzo AE, van de Ven LL, van Sambeek MR, Kertai MD, Boersma E, Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echo Study Group

Objectives: The purpose of this study was to assess the value of preoperative cardiac testing in intermediate-risk patients receiving beta-blocker therapy with tight heart rate (HR) control scheduled for major vascular surgery. Background: Treatment guidelines of the American College of Cardiology/American Heart Association recommend cardiac testing in these patients to identify subjects at increased risk. This policy delays surgery, even though test results might be redundant and beta-blockers... Abstract

Cited 44 times since 2006 (2.4 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 93, Issue 2, 16 3 2006, Pages 226-231 Plasma N-terminal pro-B-type natriuretic peptide as long-term prognostic marker after major vascular surgery. Feringa HH, Schouten O, Dunkelgrun M, Bax JJ, Boersma E, Elhendy A, de Jonge R, Karagiannis SE, Vidakovic R, Poldermans D

Objective: To assess the long-term prognostic value of plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) after major vascular surgery. Design: A single-centre prospective cohort study. Patients: 335 patients who underwent abdominal aortic aneurysm repair or lower extremity bypass surgery. Interventions: Prior to surgery, baseline NT-proBNP level was measured. Patients were also evaluated for cardiac risk factors according to the Revised Cardiac Risk Index. Dobutamine stress echocardio... Abstract

Cited 32 times since 2006 (1.7 per year) source: EuropePMC

Heart rhythm, Volume 3, Issue 12, 10 2 2006, Pages 1397-1403 Right ventricular pacing and the risk of heart failure in implantable cardioverter-defibrillator patients. Smit MD, Van Dessel PF, Nieuwland W, Wiesfeld AC, Tan ES, Anthonio RL, Van Erven L, Van Veldhuisen DJ, Van Gelder IC

Background: Right ventricular (RV) pacing in implantable cardioverter-defibrillator (ICD) patients may have detrimental effects on morbidity and mortality, in particular by inducing heart failure (HF). Objective: We investigated whether RV pacing increases the risk of HF in an asymptomatic ICD population. Methods: We evaluated all patients without symptomatic HF who received an ICD. The primary endpoint was the occurrence of HF, which was defined as new HF, hospitalization for HF, or death due t... Abstract

Cited 5 times since 2006 (0.3 per year) source: EuropePMC

Journal of pediatric gastroenterology and nutrition, Volume 43, Issue 2, 1 1 2006, Pages 265-266 Rhamnose and rhamnitol in dual sugar permeability tests. Malagon I, Onkenhout W, Klok M, van der Poel PF, Bovill JG, Hazekamp MG

Rhamnose is one of the sugars regularly used to conduct the dual sugar permeability test. For more than 30 years, it has been assumed that rhamnose is an inert sugar not metabolized by the human body and only fermented by some colonic bacteria into rhamnulose. While conducting an investigation on gut permeability in children undergoing cardiac surgery, increased concentrations of rhamnitol were found in the urine samples. The present report suggests that rhamnose is not an inert sugar and it is... Abstract

Cited 3 times since 2006 (0.2 per year) source: EuropePMC

Virus genes, Volume 33, Issue 1, 1 1 2006, Pages 59-68 The intraleader AUG nucleotide sequence context is important for equine arteritis virus replication. Archambault D, Kheyar A, de Vries AA, Rottier PJ

The 5(-terminal leader sequence of the equine arteritis virus (EAV) genome contains an open reading frame (ORF) with an AUG codon in a suboptimal context for initiation of protein synthesis. To investigate the significance of this intraleader ORF (ILO), an expression plasmid was generated carrying a DNA copy of the subgenomic mRNA7 behind a T7 promoter. Capped RNA transcribed from this construct was shown to direct, in an in vitro translation system, the synthesis of leader peptide as well as N... Abstract