Research

Publications

Below you can find a list of our published research.

9549 results

European journal of heart failure, 14 2 2025 Multimodality imaging in advanced heart failure. A clinical consensus statement of the Heart Failure Association of the ESC. Part 1: Multimodality imaging for the evaluation of patients with advanced heart failure. Aimo A, Tops LF, Adamopoulos S, Bonios M, Çelik A, Chioncel O, Cikes M, Crespo-Leiro MG, Damman K, Di Nora C, Dreyfus J, Gustafsson F, Hashmani S, Masetti M, Mordi I, Nalbantgil S, van Laake LW, von Bardeleben RS, Metra M, Gal TB, Moura B

Heart failure (HF) represents a significant global health burden, with approximately 10% of patients progressing to advanced stages characterized by severe symptoms and recurrent hospitalizations despite conventional treatments such as guideline-directed medical therapy, devices, and surgery. This clinical consensus statement from the Heart Failure Association of the European Society of Cardiology discusses the applications of imaging modalities in patients with advanced HF. Transthoracic echoca... Abstract

European journal of heart failure, 14 2 2025 Multimodality imaging in advanced heart failure. A clinical consensus statement of the Heart Failure Association of the ESC. Part 2: Mechanical circulatory support and heart transplantation. Tops LF, Aimo A, Adamopoulos S, Bonios M, Çelik A, Chioncel O, Cikes M, Crespo-Leiro MG, Damman K, Di Nora C, Dreyfus J, Gustafsson F, Hashmani S, Masetti M, Mordi I, Nalbantgil S, van Laake LW, von Bardeleben RS, Metra M, Moura B, Ben Gal T

This clinical consensus statement outlines the vital role of multimodality imaging in managing patients with advanced heart failure (HF), particularly those receiving mechanical circulatory support (MCS) and heart transplantation (HT). For both temporary and durable MCS, multimodality imaging, primarily echocardiography, is crucial for selecting candidates, ensuring proper device placement, and monitoring in the post-implantation period. Preoperatively, it helps to identify HF phenotypes, assess... Abstract

Nature communications, Volume 16, Issue 1, 14 2 2025, Pages 9122 Analysis of cfDNA fragmentomics metrics and commercial targeted sequencing panels. Helzer KT, Sharifi MN, Sperger JM, Chrostek MR, Bootsma ML, Reese SR, Taylor A, Kaufmann KR, Krause H, Schehr J, Sethakorn N, Kosoff D, Kyriakopoulos CE, Bassetti M, Blitzer G, Floberg J, Sjöström M, Armstrong AJ, Beltran H, McKay RR, Feng FY, O'Regan R, Wisinski KB, Emamekhoo H, Wyatt AW, Lang JM, Zhao SG

Fragmentomics based analysis of cell-free DNA (cfDNA) has recently emerged as a method to infer epigenetic and transcriptional data. Many of these reports analyze whole genome sequencing (WGS) which is not readily available clinically. Targeted exon panels are used for clinical cfDNA variant calling. In this report, we conduct an investigation of multiple published fragmentomics methods for WGS, but on cancer exon panels. We find that strategies utilizing normalized depth metrics, as well as all... Abstract

Irish journal of medical science, 14 2 2025 Enhancing educator preparedness for type 1 diabetes: a theory-based intervention targeting knowledge and Self-efficacy in low-resource schools. Yılmaz DA, Dege G, Atasoy M

Background: Type 1 diabetes mellitus (T1DM) is an increasing concern among school-aged children, with more than 1.2 million affected globally. In low- and middle-income countries (LMICs), teachers often act as first responders to diabetes-related emergencies despite limited preparation. Structured education programs informed by behavioral theory may help strengthen both knowledge and applied competence among school staff. Aim: This study examined the short-term effects of a Bandura-based diabete... Abstract

Environmental pollution (Barking, Essex : 1987), 13 2 2025, Pages 127266 Assessment of microplastic transport and distribution in the urban environment of Coimbra municipality. Leitão IA, van Schaik L, Ferreira AJD, Geissen V

Microplastics (MPs) largely originate from terrestrial environments, especially urban areas, where controlling their spread is difficult. This is concerning due to MPs' impacts on ecosystems and human health. To develop mitigation strategies, understanding how MPs move and spread is essential. This study examined MP transport and distribution in Coimbra municipality, Portugal, at a small watershed scale. Samples were collected from dry and wet atmospheric deposition, runoff, and streams, bo... Abstract

Trends in cardiovascular medicine, 13 2 2025, Pages S1050-1738(25)00135-5 Controversies in valvular heart disease: insights from cardiac imaging. van der Bijl P, Ajmone Marsan N, Bax JJ

Numerous controversies still exist in the diagnosis and management of valvular heart disease, for example, the benefit of treating moderate aortic stenosis (AS) or asymptomatic, severe AS and the appropriate selection criteria for transcatheter edge-to-edge mitral valve repair. While numerous imaging parameters have been linked to the risk of sudden cardiac death in mitral valve prolapse, their relative merits are unknown and this is a challenging population to risk-stratify. No large, randomize... Abstract

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 12 2 2025 Modification Procedures for Chronic Total Occlusion Percutaneous Coronary Intervention: Insights From the PROGRESS-CTO Registry. Kladou E, Strepkos D, Alexandrou M, Mutlu D, Carvalho PEP, Sara JDS, Ser OS, Alaswad K, Basir MB, Khelimskii D, Jaffer FA, Rafeh NA, Chandwaney R, Cevik C, Ahmad Y, Mastrodemos O, Rangan BV, Jalli S, Voudris K, Sandoval Y, Nicholas Burke M, Brilakis ES, PROGRESS‐CTO Investigators

Background: CTO-ARC (Chronic Total Occlusion Academic Research Consortium) defines CTO modification procedures (previously called investment procedures) as intentional balloon dilatation (diameter ≥ 2.0 mm) of the entire CTO, including the proximal and distal caps and the CTO body. Aims: The aim of this study is to compare the outcomes of repeat CTO PCI between patients who underwent lesion modification during the initial failed procedure and those who did not. Methods: We analyzed the associati... Abstract

Journal of cardiovascular development and disease, Volume 12, Issue 10, 11 2 2025, Pages 403 Trends in Conventional Heart Failure Therapy in a Real-World Multinational ATTR-CA Cohort. van der Geest EH, Ajmone Marsan N, Laenens D, Debonnaire PJMR, Claeys M, Pinto F, Brito D, Donal E, Droogmans S, Van de Veire N, Bertrand P, Nabeta T, Graziani F, Regeer MV

Background: Conventional HF treatment in transthyretin cardiac amyloidosis (ATTR-CA) resulting in restrictive cardiomyopathy is debated due to absent trial evidence in this specific sub-population of heart failure (HF) patients. Current European Society of Cardiology guidelines recommend the use of diuretics and mineralocorticoid receptor antagonists (MRAs). However, beta-blockers (BBs) and angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (ACEi/ARBs) are often discontinu... Abstract

JMIR medical informatics, Volume 13, 10 2 2025, Pages e71994 Evaluation of Machine Learning Model Performance in Diabetic Foot Ulcer: Retrospective Cohort Study. van Velze VY, Burger HL, van der Steenhoven TJ, Al-Ers H, Goncalves LN, Eefting D, de Jong WJ, Smeets HJ, Welleweerd JCS, van der Vorst JR, Uchtmann S, Rissmann R, Hamming JF, Stergioulas L, van der Bogt KE

Background: Machine learning (ML) has shown great potential in recognizing complex disease patterns and supporting clinical decision-making. Diabetic foot ulcers (DFUs) represent a significant multifactorial medical problem with high incidence and severe outcomes, providing an ideal example for a comprehensive framework that encompasses all essential steps for implementing ML in a clinically relevant fashion. Objective: This paper aims to provide a framework for the proper use of ML algorithms t... Abstract

American journal of physiology. Heart and circulatory physiology, Volume 329, Issue 5, 10 2 2025, Pages H1414-H1421 Bone morphogenetic protein 10: clinical correlates and risk of incident atrial fibrillation. Suthahar N, Yap SC, de Vries AAF, Damman K, Fabritz L, Bakker SJL, Gansevoort RT, Kirchhof P, Rienstra M, de Boer RA

Bone morphogenetic protein-10 (BMP10), a protein predominantly secreted by atrial cardiomyocytes, has emerged as a promising biomarker in patients with atrial fibrillation (AF) and as a marker of atrial stress in patients with heart failure. Its clinical correlates in community-dwelling adults and its association with incident AF remain unexplored. BMP10 was measured in 5,883 participants from the Prevention of Renal and Vascular End-stage Disease (PREVEND) community-based cohort (mean age 53.6... Abstract

Journal of clinical microbiology, Volume 63, Issue 11, 9 2 2025, Pages e0027225 In vitro activity of antibiotic monotherapy and combination therapy with bacteriophages against Staphylococcus aureus LVAD-driveline infections. Molendijk MM, Verkaik NJ, de Vogel CP, Lemmens-den Toom N, Knight GM, Caliskan K, Bode LGM, Verbon A, Koopmans MPG, de Graaf M, van Wamel WJB

Left-ventricular assist devices (LVADs) are increasingly used as a bridge to heart transplantation and destination therapy. These devices, especially the driveline, are susceptible to difficult-to-treat infections, associated with high morbidity and mortality rates. Staphylococcus aureus (S. aureus) is a major causative pathogen of LVAD infections. Antibiotic resistance and biofilm formation can complicate the treatment of these infections. A novel in vitro assay was developed to study the antib... Abstract

Journal of cardiovascular computed tomography, 8 2 2025, Pages S1934-5925(25)00442-3 Incremental value of a CCTA-derived AI-based ischemia algorithm over standard CCTA interpretation of predicting myocardial ischemia in patients with suspected coronary artery disease. Nabeta T, Bär S, Maaniitty T, Kärpijoki H, Bax JJ, Saraste A, Knuuti J

Background: A novel artificial intelligence-guided quantitative computed tomography ischemia algorithm (AI-QCTischemia) comprises a machine-learned method using atherosclerosis and vascular morphology features from coronary computed tomography angiography (CCTA) images to predict myocardial ischemia. This study evaluates the diagnostic performance of AI-QCTischemia compared to standard CCTA interpretation in detecting myocardial ischemia. Methods and results: Patients with suspected coronary art... Abstract

Biological research for nursing, 8 2 2025, Pages 10998004251385121 Effect of Infant Massage in Neonates With Hyperbilirubinemia Receiving Phototherapy: A Systematic Review and Meta-Analysis. Erçelik ZE, Yilmaz DA

Most infants are diagnosed with hyperbilirubinemia in the first day of life. Although phototherapy is the most common treatment used in hyperbilirubinemia, different alternative therapies such as massage are also used. This systematic review and meta-analysis was designed to evaluate the effect of massage on serum bilirubin levels, defecation frequency, and length of hospital stay in neonates with hyperbilirubinemia receiving phototherapy. A review of randomized controlled trials published in En... Abstract

Annals of vascular surgery, Volume 123, 7 1 2025, Pages 94-103 Prediction of Wound Healing Following Amputation Surgery Based on Near-Infrared Fluorescence with Indocyanine Green. Kruiswijk MW, Peul RC, Tange FP, Koning S, van der Aa LE, Eefting D, van der Bogt KEA, van den Hoven P, van der Vorst JR, Vascular Fluorescence group

Background: The objective of this study was to evaluate the predictive value of near-infrared (NIR) fluorescence imaging with indocyanine on wound healing complications within 6 weeks after lower extremity amputation. Methods: In this dual-center cohort study, patients undergoing minor (below ankle) or major (above ankle) amputations due to peripheral arterial disease (PAD) or diabetes mellitus, with perfusion assessment performed using indocyanine green (ICG) NIR fluorescence imaging, were incl... Abstract

Endocrine connections, Volume 14, Issue 10, 6 1 2025, Pages e250400 Validation and implementation of the Dutch PHPQoL for primary hyperparathyroidism. Zhang JLH, Schepers A, Hamming JF, Osman L, Webb SM, Welling L, Winter EM, Snel M, Appelman-Dijkstra NM

Background: Patients with primary hyperparathyroidism (PHPT) often present with nonspecific neuropsychological symptoms, which remain challenging to quantify. While parathyroidectomy (PTx) recently has been recommended for asymptomatic patients, its benefit remains unclear as existing evidence relies on generic health-related quality of life (HRQoL) tools. In contrast, the disease-specific PHPQoL questionnaire offers more sensitive and clinically relevant symptom assessment. This study aims to t... Abstract

Molecular syndromology, 4 1 2025 Personalized Treatment in Rare Genetic Syndromes: A Case-Report in Witteveen-Kolk Syndrome (SIN3A). Janssen V, van Dongen LCM, Custers MCC, Willemsen MH, Kleefstra T, Egger JIM

Introduction: Neurodevelopmental disorders (NDDs) include a broad spectrum of disorders. NDDs caused by rare gene mutations are referred to as Rare Genetic Neurodevelopmental Syndromes (RGNS). Witteveen-Kolk syndrome (WITKOS) is such a RGNS, caused by heterozygous mutations in SIN3A and characterized by developmental problems, facial dysmorphisms, short stature, brain abnormalities, intellectual disability, and behavioral problems. Care for individuals with WITKOS mainly focuses on somatic chara... Abstract

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, 2 1 2025 Development and Validation of a Prognostic Model for Persistent Hypoparathyroidism After Total or Completion Thyroidectomy. van Dijk SPJ, Maas CCHM, Alshangi A, van Driel MHE, Feitsma EA, van Kinschot CMJ, Lončar I, van Noord C, Koppert LB, Kruijff S, van Klaveren D, Verhoef C, Peeters RP, van Ginhoven TM, Hypoparathyroidism Study Group of the Thyroid Network

Background: The aim of this study was to develop and validate a clinical prediction model to predict the occurrence of persistent hypoparathyroidism after total or completion thyroidectomy. Methods: This multicentre retrospective cohort study included patients who underwent total or completion thyroidectomy between January 2010 and June 2021 in 12 Dutch hospitals. Results: Of the 366 patients included, 44 (12.0%) patients developed persistent hypoparathyroidism in the first year follow-up after... Abstract

Microbial genomics, Volume 11, Issue 10, 1 1 2025 The Kocurious case of Noodlococcus: genomic insights into Kocuria rhizophila from characterisation of a laboratory contaminant. McCallum GE, Ho SFS, Cummins EA, Wildsmith AJ, McInnes RS, Weigel C, Tong LYS, Quick J, van Schaik W, Moran RA

The laboratory contaminant strain Noodlococcus was named for its coccoid cells and unusual colony morphology, which resembled a pile of noodles. Along with laboratory characterisation and electron microscopy, we generated a complete Noodlococcus genome sequence using Illumina and Oxford Nanopore data. The genome consisted of a single, circular, 2,732,108 bp chromosome that shared 97.5% average nucleotide identity (ANI) with the Kocuria rhizophila type strain TA68. We identified genomic features... Abstract

The New England journal of medicine, Volume 393, Issue 17, 1 1 2025, Pages 1669-1680 European Study of Prostate Cancer Screening - 23-Year Follow-up. Roobol MJ, de Vos II, Månsson M, Godtman RA, Talala KM, den Hond E, Nelen V, Villers A, Poinas G, Kwiatkowski M, Wyler S, Recker F, Puliti D, Gorini G, Zappa M, Paez A, Lujan M, Bangma CH, Tammela T, Schröder FH, Remmers S, Hugosson J, Auvinen A, ERSPC Investigators

Background: The European Randomized Study of Screening for Prostate Cancer (ERSPC) was initiated in 1993 to assess the effect of prostate-specific antigen (PSA) testing on prostate cancer mortality. Because deaths from prostate cancer are expected to rise worldwide owing to increased life expectancy and population growth, a final analysis of the long-term outcomes of prostate cancer screening is essential to understanding the benefits and harms of PSA testing. Methods: We updated the findings fr... Abstract

Global change biology, Volume 31, Issue 10, 1 1 2025, Pages e70531 One Species Hibernates Shorter, the Other Longer: Rapid but Opposing Responses to Warming Climate in Two Sympatric Bat Species. Krivek G, Meier F, Grosche L, Kerth G, van Schaik J

The timing of hibernation represents a key seasonal transition in the annual cycle of hibernators, directly impacting their survival and reproductive success. Ongoing climate change affects many of the factors that influence hibernation phenology, such as weather patterns, food availability and the timing of mating and reproduction. The extent to which individuals should adjust their hibernation phenology in response is likely to vary between species, sexes and age classes. Consequently, long-te... Abstract