9549 results
Cited 71 times since 2012 (5.3 per year)
source: EuropePMC
Clinical cancer research : an official journal of the American Association for Cancer Research,
Volume 18, Issue 16, 18 3 2012, Pages 4433-4440
Influence of polymorphic OATP1B-type carriers on the disposition of docetaxel.
de Graan AJ, Lancaster CS, Obaidat A, Hagenbuch B, Elens L, Friberg LE, de Bruijn P, Hu S, Gibson AA, Bruun GH, Corydon TJ, Mikkelsen TS, Walker AL, Du G, Loos WJ, van Schaik RH, Baker SD, Mathijssen RH, Sparreboom A
Purpose: Docetaxel is extensively metabolized by CYP3A4 in the liver but mechanisms by which the drug is taken up into hepatocytes remain poorly understood. We hypothesized that (i) liver uptake of docetaxel is mediated by the polymorphic solute carriers OATP1B1 and OATP1B3 and (ii) inherited genetic defects in this process may impair systemic drug elimination. Experimental design: Transport of docetaxel was studied in vitro using various cell lines stably transfected with OATP1B1*1A (wild-type)...
Abstract
Cited 12 times since 2012 (0.9 per year)
source: EuropePMC
Breast cancer research and treatment,
Volume 135, Issue 1, 16 3 2012, Pages 125-133
Expression of the BRCA1 complex member BRE predicts disease free survival in breast cancer.
Noordermeer SM, Wennemers M, Bergevoet SM, van der Heijden A, Tönnissen E, Sweep FC, Jansen JH, Span PN, van der Reijden BA
Breast cancer is one of the leading causes of cancer mortality in women. Recent advances in gene expression profiling have indicated that breast cancer is a heterogeneous disease and the current prognostication using clinico-pathological features is not sufficient to fully predict therapy response and disease outcome. In this retrospective study, we show that expression levels of BRE, which encodes a member of the BRCA1 DNA damage repair complex, predicted disease-free survival (DFS) in non-fami...
Abstract
Cited 34 times since 2012 (2.5 per year)
source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 44, Issue 2, 15 3 2012, Pages 153-157
An association between chronic obstructive pulmonary disease and abdominal aortic aneurysm beyond smoking: results from a case-control study.
Meijer CA, Kokje VB, van Tongeren RB, Hamming JF, van Bockel JH, Möller GM, Lindeman JH
Objectives: It is currently unclear whether the parallels between abdominal aortic aneurysms (AAAs) and chronic obstructive pulmonary disease (COPD) are explained by common risk factors alone, such as cigarette smoking, or by a predetermined cause. Given the persistent controversy with regard to the association between AAA and COPD, we studied this association in depth. Methods: We conducted a case-control study comparing patients with a small AAA (maximum infrarenal diameter 35-50 mm, n = 221)...
Abstract
Cited 614 times since 2012 (45.6 per year)
source: EuropePMC
The EMBO journal,
Volume 31, Issue 14, 12 2 2012, Pages 3079-3091
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers.
Muñoz J, Stange DE, Schepers AG, van de Wetering M, Koo BK, Itzkovitz S, Volckmann R, Kung KS, Kung KS, Koster J, Radulescu S, Myant K, Versteeg R, Sansom OJ, van Es JH, Barker N, van Oudenaarden A, Mohammed S, Heck AJ, Clevers H
Two types of stem cells are currently defined in small intestinal crypts: cycling crypt base columnar (CBC) cells and quiescent '+4' cells. Here, we combine transcriptomics with proteomics to define a definitive molecular signature for Lgr5(+) CBC cells. Transcriptional profiling of FACS-sorted Lgr5(+) stem cells and their daughters using two microarray platforms revealed an mRNA stem cell signature of 384 unique genes. Quantitative mass spectrometry on the same cell populations identi...
Abstract
Cited 13 times since 2012 (1 per year)
source: EuropePMC
Journal of vision,
Volume 12, Issue 6, 12 2 2012, Pages 13
Comparing crowding in human and ideal observers.
van den Berg R, Johnson A, Martinez Anton A, Schepers AL, Cornelissen FW
A visual target is more difficult to recognize when it is surrounded by other, similar objects. This breakdown in object recognition is known as crowding. Despite a long history of experimental work, computational models of crowding are still sparse. Specifically, few studies have examined crowding using an ideal-observer approach. Here, we compare crowding in ideal observers with crowding in humans. We derived an ideal-observer model for target identification under conditions of position and id...
Abstract
Cited 18 times since 2012 (1.3 per year)
source: EuropePMC
Geriatrics & gerontology international,
Volume 13, Issue 1, 11 2 2012, Pages 190-197
Do clinical characteristics and outcome in nonagenarians with a hip fracture differ from younger patients?
Vochteloo AJ, Borger van der Burg BL, Tuinebreijer WE, de Vries MR, Niggebrugge AH, Bloem RM, Maier AB, Nelissen RG, Pilot P
Aim: To compare clinical characteristics and outcome of nonagenarian hip fracture patients with younger patients aged 65-89 years. Methods: This was a cohort follow-up study of admissions for a hip fracture between 2005-2010 (mean follow up of 3.5 years) in two teaching hospitals in The Netherlands; 230 nonagenarians and 1014 patients aged 65-89 years were included. Clinical characteristics, adverse events, mobility and mortality were compared. Results: Nonagenarians were more likely to be femal...
Abstract
Cited 11 times since 2012 (0.8 per year)
source: EuropePMC
BMC psychiatry,
Volume 12, 7 1 2012, Pages 59
Cost-effectiveness of nurse-led self-help for recurrent depression in the primary care setting: design of a pragmatic randomised controlled trial.
Biesheuvel-Leliefeld KE, Kersten SM, van der Horst HE, van Schaik A, Bockting CL, Bosmans JE, Smit F, van Marwijk HW
Background: Major Depressive Disorder is a leading cause of disability, tends to run a recurrent course and is associated with substantial economic costs due to increased healthcare utilization and productivity losses. Interventions aimed at the prevention of recurrences may reduce patients' suffering and costs. Besides antidepressants, several psychological treatments such as preventive cognitive therapy (PCT) are effective in the prevention of recurrences of depression. Yet, many patients...
Abstract
Cited 54 times since 2012 (4 per year)
source: EuropePMC
European heart journal,
Volume 33, Issue 24, 5 1 2012, Pages 3034-3045
From abstract to impact in cardiovascular research: factors predicting publication and citation.
Winnik S, Raptis DA, Walker JH, Hasun M, Speer T, Clavien PA, Komajda M, Bax JJ, Tendera M, Fox K, Van de Werf F, Mundow C, Lüscher TF, Ruschitzka F, Matter CM
Aims: Through a 4-year follow-up of the abstracts submitted to the European Society of Cardiology Congress in 2006, we aimed at identifying factors predicting high-quality research, appraising the quality of the peer review and editorial processes, and thereby revealing potential ways to improve future research, peer review, and editorial work. METHODS AND RESULTS All abstracts submitted in 2006 were assessed for acceptance, presentation format, and average reviewer rating. Accepted and rejected...
Abstract
Cited 33 times since 2012 (2.4 per year)
source: EuropePMC
Differentiation; research in biological diversity,
Volume 84, Issue 1, 3 1 2012, Pages 131-148
Normal and abnormal development of the cardiac conduction system; implications for conduction and rhythm disorders in the child and adult.
Jongbloed MR, Vicente Steijn R, Hahurij ND, Kelder TP, Schalij MJ, Gittenberger-de Groot AC, Blom NA
The cardiac conduction system is a specialized network that initiates and closely coordinates the heart beat. Cardiac conduction system development is intricately related to the development and maturation of the embryonic heart towards its four-chambered form, as is indicated by the fact that disturbed development of cardiac structures is often accompanied by a disturbed formation of the CCS. Electrophysiological studies have shown that selected conduction disturbances and cardiac arrhythmias do...
Abstract
Cited 37 times since 2012 (2.7 per year)
source: EuropePMC
Journal of human evolution,
Volume 63, Issue 1, 2 1 2012, Pages 180-190
Social organization and the evolution of cumulative technology in apes and hominins.
Pradhan GR, Tennie C, van Schaik CP
Culturally supported accumulation (or ratcheting) of technological complexity is widely seen as characterizing hominin technology relative to that of the extant great apes, and thus as representing a threshold in cultural evolution. To explain this divide, we modeled the process of cultural accumulation of technology, which we defined as adding new actions to existing ones to create new functional combinations, based on a model for great ape tool use. The model shows that intraspecific and inter...
Abstract
Cited 17 times since 2012 (1.3 per year)
source: EuropePMC
Pharmacogenetics and genomics,
Volume 22, Issue 6, 1 1 2012, Pages 399-407
Mycophenolic acid-related diarrhea is not associated with polymorphisms in SLCO1B nor with ABCB1 in renal transplant recipients.
Bouamar R, Hesselink DA, van Schaik RH, Weimar W, van der Heiden IP, de Fijter JW, Kuypers DR, van Gelder T
Objective: We investigated the association between genetic polymorphisms in ABCB1 and SLCO1B and mycophenolic acid (MPA) pharmacokinetics, and MPA-related diarrhea and leukopenia in 338 kidney transplant recipients. Methods: A total of 338 patients participating in an international, randomized-controlled clinical trial were genotyped for ABCB1 and SLCO1B. Patients were all treated with mycophenolate mofetil and either cyclosporine or tacrolimus. MPA-area under the curve (AUCs), MPA-glucuronide A...
Abstract
Cited 20 times since 2012 (1.5 per year)
source: EuropePMC
Stem cells (Dayton, Ohio),
Volume 30, Issue 6, 1 1 2012, Pages 1236-1245
Gap junctional coupling with cardiomyocytes is necessary but not sufficient for cardiomyogenic differentiation of cocultured human mesenchymal stem cells.
Ramkisoensing AA, Pijnappels DA, Swildens J, Goumans MJ, Fibbe WE, Schalij MJ, de Vries AA, Atsma DE
Gap junctional coupling is important for functional integration of transplanted cells with host myocardium. However, the role of gap junctions in cardiomyogenic differentiation of transplanted cells has not been directly investigated. The objective of this work is to study the role of connexin43 (Cx43) in cardiomyogenic differentiation of human mesenchymal stem cells (hMSCs). Knockdown of Cx43 gene expression (Cx43↓) was established in naturally Cx43-rich fetal amniotic membrane (AM) hMSCs, whil...
Abstract
Cited 353 times since 2012 (26.1 per year)
source: EuropePMC
JAMA,
Volume 307, Issue 23, 1 1 2012, Pages 2499-2506
Lipid-related markers and cardiovascular disease prediction.
Emerging Risk Factors Collaboration, Di Angelantonio E, Gao P, Pennells L, Kaptoge S, Caslake M, Thompson A, Butterworth AS, Sarwar N, Wormser D, Saleheen D, Ballantyne CM, Psaty BM, Sundström J, Ridker PM, Nagel D, Gillum RF, Ford I, Ducimetiere P, Kiechl S, Koenig W, Dullaart RP, Assmann G, D'Agostino RB, Dagenais GR, Cooper JA, Kromhout D, Onat A, Tipping RW, Gómez-de-la-Cámara A, Rosengren A, Sutherland SE, Gallacher J, Fowkes FG, Casiglia E, Hofman A, Salomaa V, Barrett-Connor E, Clarke R, Brunner E, Jukema JW, Simons LA, Sandhu M, Wareham NJ, Khaw KT, Kauhanen J, Salonen JT, Howard WJ, Nordestgaard BG, Wood AM, Thompson SG, Boekholdt SM, Sattar N, Packard C, Gudnason V, Danesh J
Context: The value of assessing various emerging lipid-related markers for prediction of first cardiovascular events is debated. Objective: To determine whether adding information on apolipoprotein B and apolipoprotein A-I, lipoprotein(a), or lipoprotein-associated phospholipase A2 to total cholesterol and high-density lipoprotein cholesterol (HDL-C) improves cardiovascular disease (CVD) risk prediction. Design, setting, and participants: Individual records were available for 165,544 participant...
Abstract
Cited 23 times since 2012 (1.7 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 20, Issue 6, 1 1 2012, Pages 254-259
Acute myocardial infarction system of care in the third world.
Dharma S, Juzar DA, Firdaus I, Soerianata S, Wardeh AJ, Jukema JW
Background: We studied the characteristics of ST-elevation myocardial infarction (STEMI) patients from a local acute coronary syndrome (ACS) registry in order to find and build an appropriate acute myocardial infarction (AMI) system of care in Jakarta, Indonesia. Methods: Data were collected from the Jakarta Acute Coronary Syndrome (JAC) registry 2008-2009, which contained 2103 ACS patients, including 654 acute STEMI patients admitted to the National Cardiovascular Center Harapan Kita, Jakarta,...
Abstract
Cited 36 times since 2012 (2.7 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 98, Issue 11, 1 1 2012, Pages 872-877
Clinical prediction model for death prior to appropriate therapy in primary prevention implantable cardioverter defibrillator patients with ischaemic heart disease: the FADES risk score.
van Rees JB, Borleffs CJ, van Welsenes GH, van der Velde ET, Bax JJ, van Erven L, Putter H, van der Bom JG, Schalij MJ
Objectives: To construct a risk score out of baseline variables to estimate the risk of death without prior implantable cardioverter defibrillator (ICD) in primary prevention ICD patients with ischaemic heart disease. Design: Retrospective cohort study. Setting: Tertiary care facility in The Netherlands. Patients: All patients with ischaemic heart disease who received an ICD for primary prevention of sudden cardiac death at the Leiden University Medical Center, Leiden, The Netherlands in the per...
Abstract
Cited 44 times since 2012 (3.3 per year)
source: EuropePMC
Vaccine,
Volume 30, Issue 29, 1 1 2012, Pages 4369-4376
A review of influenza haemagglutinin receptor binding as it relates to pandemic properties.
Wilks S, de Graaf M, Smith DJ, Burke DF
Haemagglutinin is a determinant of many viral properties, and successful adaptation to a human-like form is thought to be an important step toward pandemic influenza emergence. The availability of structurally distinct sialic acid linked receptors in the sites of human and avian influenza infection are generally held to account for the differences observed, but the relevance of other selection pressures has not been elucidated. There is evidence for genetic and structural constraints of haemaggl...
Abstract
Cited 1 times since 2012 (0.1 per year)
source: EuropePMC
Vascular,
Volume 20, Issue 4, 1 1 2012, Pages 203-209
Influence of aneurysm wall stiffness and the presence of intraluminal thrombus on the wall movement of an aneurysm - an in vitro study.
Bosman WM, Hinnen JW, Kopp WH, van der Steenhoven TJ, Kaptein BL, Koning OH, Hamming JF
The purpose of this in vitro study was to investigate the influence of aneurysm wall stiffness and of the presence of intraluminal thrombus (ILT) on aneurysm wall movement. Three latex aneurysms were used with different wall stiffness. The aneurysms, equipped with 20 tantalum markers, were attached to an in vitro circulation model. Fluoroscopic roentgenographic stereo photogrammetric analysis was used to measure marker movement during six cardiac cycles at three different systemic pressures. To...
Abstract
Cited 4 times since 2012 (0.3 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 20, Issue 6, 1 1 2012, Pages 251
Durrer prizes 2011.
van der Wall EE, Schalij MJ
Abstract
Cited 28 times since 2012 (2.1 per year)
source: EuropePMC
Molecular ecology,
Volume 21, Issue 13, 31 5 2012, Pages 3352-3362
Parentage-based pedigree reconstruction reveals female matrilineal clusters and male-biased dispersal in nongregarious Asian great apes, the Bornean orang-utans (Pongo pygmaeus).
Arora N, Van Noordwijk MA, Ackermann C, Willems EP, Nater A, Greminger M, Nietlisbach P, Dunkel LP, Utami Atmoko SS, Pamungkas J, Perwitasari-Farajallah D, Van Schaik CP, Krützen M
Philopatry and sex-biased dispersal have a strong influence on population genetic structure, so the study of species dispersal patterns and evolutionary mechanisms shaping them are of great interest. Particularly nongregarious mammalian species present an underexplored field of study: despite their lower levels of sociality compared to group-living species, interactions among individuals do occur, providing opportunities for cryptic kin selection. Among the least gregarious primates are orang-ut...
Abstract
Cited 28 times since 2012 (2.1 per year)
source: EuropePMC
PloS one,
Volume 7, Issue 5, 30 5 2012, Pages e38240
Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy.
Shiffman D, Trompet S, Louie JZ, Rowland CM, Catanese JJ, Iakoubova OA, Kirchgessner TG, Westendorp RG, de Craen AJ, Slagboom PE, Buckley BM, Stott DJ, Sattar N, Devlin JJ, Packard CJ, Ford I, Sacks FM, Jukema JW
Statin therapy reduces the risk of coronary heart disease (CHD), however, the person-to-person variability in response to statin therapy is not well understood. We have investigated the effect of genetic variation on the reduction of CHD events by pravastatin. First, we conducted a genome-wide association study of 682 CHD cases from the Cholesterol and Recurrent Events (CARE) trial and 383 CHD cases from the West of Scotland Coronary Prevention Study (WOSCOPS), two randomized, placebo-controlled...
Abstract
