Research

Publications

Below you can find a list of our published research.

9549 results

Cited 1 times since 2012 (0.1 per year) source: EuropePMC

Nederlands tijdschrift voor geneeskunde, Volume 156, Issue 17, 1 1 2012, Pages A3767 [Many adults with congenital heart disease are lost to follow up]. Vis JC, Schuuring MJ, van der Velde ET, Engelfriet-Rijk LC, Harms IM, Mantels S, Bouma BJ, Mulder BJ

Objective: Identification of adults with congenital heart disease (CHD) who were lost to cardiological follow-up. Design: Cross-sectional study. Method: Adults with CHD and not under cardiological follow-up were asked via a nationwide publicity campaign to contact the CONCOR (CONgenital CORvitia) project group. Results: A total of 593 patients with mild (85%) to moderate-severe (15%) CHD were registered via the nationwide campaign. Of these patients, 66% were examined within 1 year by a cardiolo... Abstract

Cited 3 times since 2012 (0.2 per year) source: EuropePMC

Studies in health technology and informatics, Volume 175, 1 1 2012, Pages 91-100 Provenance for distributed biomedical workflow execution. Madougou S, Santcroos M, Benabdelkader A, van Schaik BD, Shahand S, Korkhov V, van Kampen AH, Olabarriaga SD

Scientific research has become very data and compute intensive because of the progress in data acquisition and measurement devices, which is particularly true in Life Sciences. To cope with this deluge of data, scientists use distributed computing and storage infrastructures. The use of such infrastructures introduces by itself new challenges to the scientists in terms of proper and efficient use. Scientific workflow management systems play an important role in facilitating the use of the infras... Abstract

Nederlands tijdschrift voor geneeskunde, Volume 156, Issue 5, 1 1 2012, Pages A3952 [Simulation in the general hospital: differential diagnosis and policy]. van Schaik AM, van Mill JG, Appels BA, van Tilburg W

Doctors meet patients who present with non-genuine diseases. We present three patients who present with an illness with no organic cause: conversion syndrome, factitious disorder and simulation. We discuss the differential diagnosis, prevalence and diagnostics in the event of simulation. A proposal is made about how to respond in the event of simulation. The method is similar to the treatment of a factitious disorder: limitation of the potential benefits attached to the sick role; confrontation... Abstract

Cited 36 times since 2012 (2.6 per year) source: EuropePMC

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, Volume 20, Issue 1, 1 1 2012, Pages 5-17 Efficacy and safety of continuation and maintenance electroconvulsive therapy in depressed elderly patients: a systematic review. van Schaik AM, Comijs HC, Sonnenberg CM, Beekman AT, Sienaert P, Stek ML

Background: Electroconvulsive therapy (ECT) is the most efficacious treatment in severely depressed elderly patients. Relapse and recurrence of geriatric depression after recovery is an important clinical issue, which requires vigorous and safe treatment in the long term. Continuation or maintenance ECT (M-ECT) may play an important role in this respect. Methods: In this systematic search, we evaluate the efficacy and safety of M-ECT in preventing depressive relapse in patients age 55 or older.... Abstract

Cited 2 times since 2012 (0.1 per year) source: EuropePMC

Advances in experimental medicine and biology, Volume 984, 1 1 2012, Pages 13-38 Phylogenetic diversity, virulence and comparative genomics. van Schaik EJ, Samuel JE

Coxiella burnetii, the causative agent of Q fever, has remained a public health concern since the identification of this organism in 1935 by E. H. Derrick in Australia and at the Rocky Mountain Laboratory in the USA by H.R. Cox and G. Davis. Human Q fever has been described in most countries where C. burnetii is ubiquitous in the environment except in New Zealand where no cases have been described. Most human infections are acquired through inhalation of contaminated aerosols that can lead to ac... Abstract

Cited 8 times since 2012 (0.6 per year) source: EuropePMC

Turk psikiyatri dergisi = Turkish journal of psychiatry, Volume 23, Issue 4, 1 1 2012, Pages 237-246 Gray matter changes in patients with deficit schizophrenia and non-deficit schizophrenia. Özdemir Hİ, Eker MÇ, Zengin B, Yılmaz DA, İşman Haznedaroğlu D, Çınar C, Kitiş Ö, Akay A, Gönül AS

Objectives: Reduced gray matter volume is a frequently reported finding in brain imaging studies performed with schizophrenia patients. Some studies suggest a probable link between the negative symptoms of schizophrenia and gray matter loss; however, some of the negative symptoms observed in schizophrenia patients are not primarily linked to the core of schizophrenia. This study aimed to compare gray matter volumes in patients with primary negative symptoms (deficit schizophrenia [DS]), non-DS (... Abstract

Cited 6 times since 2012 (0.4 per year) source: EuropePMC

Tuberkuloz ve toraks, Volume 60, Issue 3, 1 1 2012, Pages 201-206 ACE gene I/D polymorphism and risk of sarcoidosis development in Turkish patients. Yılmaz D, Karkucak M, Coşkun F, Yakut T, Kunt Uzaslan E

Introduction: Etiology of sarcoidosis is unknown but the prevalence of disease in different ethnic groups and identical twins, family characteristics indicate that genetic predisposition is a possible factor. The angiotensin-converting enzyme (ACE) has been implicated in the pahophysiology of sarcoidosis. The aim of this study is to investigate the influence of a polymorphism in I/D (Insertion/Deletion) of the ACE gene on the susceptibility to sarcoidosis. Patients and methods: Our study include... Abstract

Cited 23 times since 2012 (1.7 per year) source: EuropePMC

Journal of hypertension, Volume 30, Issue 1, 1 1 2012, Pages 107-116 Aliskiren inhibits atherosclerosis development and improves plaque stability in APOE*3Leiden.CETP transgenic mice with or without treatment with atorvastatin. Kühnast S, van der Hoorn JW, van den Hoek AM, Havekes LM, Liau G, Jukema JW, Princen HM

Objective: Aliskiren is the first commercially available, orally active, direct renin inhibitor approved to treat hypertension. The renin-angiotensin system has been shown to be a significant contributor to the development of hypercholesterolemia-induced atherosclerosis. The aim of this study was to evaluate the antiatherosclerotic and plaque stabilization effects of aliskiren alone and in combination with atorvastatin. Methods: APOE*3Leiden.CETP mice (n = 14-17/group) were fed a western-type di... Abstract

Cited 40 times since 2012 (2.9 per year) source: EuropePMC

International journal for parasitology, Volume 42, Issue 3, 1 1 2012, Pages 269-277 Specific glycan elements determine differential binding of individual egg glycoproteins of the human parasite Schistosoma mansoni by host C-type lectin receptors. Meevissen MH, Driessen NN, Smits HH, Versteegh R, van Vliet SJ, van Kooyk Y, Schramm G, Deelder AM, Haas H, Yazdanbakhsh M, Hokke CH

During infection with the blood fluke Schistosoma mansoni, glycan motifs present on glycoproteins of the parasite’s eggs mediate immunomodulatory effects on the host. The recognition of these glycan motifs is primarily mediated by C-type lectin receptors on dendritic cells and other cells of the immune system. However, it is not yet known which individual glycoproteins interact with the different C-type lectin receptors, and which structural components are involved. Here we investigated the stru... Abstract

Cited 23 times since 2011 (1.7 per year) source: EuropePMC

Hypertension (Dallas, Tex. : 1979), Volume 59, Issue 2, 27 4 2011, Pages 241-247 Genome-wide profiling of blood pressure in adults and children. Taal HR, Verwoert GC, Demirkan A, Janssens AC, Rice K, Ehret G, Smith AV, Verhaaren BF, Witteman JC, Hofman A, Vernooij MW, Uitterlinden AG, Rivadeneira F, Ikram MA, Levy D, van der Heijden AJ, Cohort for Heart and Aging Research in Genome Epidemiology and Early Genetics and Lifecourse Epidemiology consortia, Jaddoe VW, van Duijn CM

Hypertension is an important determinant of cardiovascular morbidity and mortality and has a substantial heritability, which is likely of polygenic origin. The aim of this study was to assess to what extent multiple common genetic variants contribute to blood pressure regulation in both adults and children and to assess overlap in variants between different age groups, using genome-wide profiling. Single nucleotide polymorphism sets were defined based on a meta-analysis of genome-wide associatio... Abstract

Cited 40 times since 2011 (2.9 per year) source: EuropePMC

Cardiovascular research, Volume 93, Issue 3, 22 4 2011, Pages 434-444 Connexin43 silencing in myofibroblasts prevents arrhythmias in myocardial cultures: role of maximal diastolic potential. Askar SF, Bingen BO, Swildens J, Ypey DL, van der Laarse A, Atsma DE, Zeppenfeld K, Schalij MJ, de Vries AA, Pijnappels DA

Aims: Arrhythmogenesis in cardiac fibrosis remains incompletely understood. Therefore, this study aims to investigate how heterocellular coupling between cardiomyocytes (CMCs) and myofibroblasts (MFBs) affects arrhythmogeneity of fibrotic myocardial cultures. Potentially, this may lead to the identification of novel anti-arrhythmic strategies. Methods and results: Co-cultures of neonatal rat CMCs and MFBs in a 1:1 ratio were used as a model of cardiac fibrosis, with purified CMC cultures as cont... Abstract

Cited 146 times since 2011 (10.5 per year) source: EuropePMC

Brain : a journal of neurology, Volume 135, Issue Pt 5, 20 3 2011, Pages 1639-1649 Modifying the Medical Research Council grading system through Rasch analyses. Vanhoutte EK, Faber CG, van Nes SI, Jacobs BC, van Doorn PA, van Koningsveld R, Cornblath DR, van der Kooi AJ, Cats EA, van den Berg LH, Notermans NC, van der Pol WL, Hermans MC, van der Beek NA, Gorson KC, Eurelings M, Engelsman J, Boot H, Meijer RJ, Lauria G, Tennant A, Merkies IS, PeriNomS Study Group

The Medical Research Council grading system has served through decades for the evaluation of muscle strength and has been recognized as a cardinal feature of daily neurological, rehabilitation and general medicine examination of patients, despite being respectfully criticized due to the unequal width of its response options. No study has systematically examined, through modern psychometric approach, whether physicians are able to properly use the Medical Research Council grades. The objectives o... Abstract

Cited 29 times since 2011 (2.1 per year) source: EuropePMC

The pharmacogenomics journal, Volume 13, Issue 3, 20 3 2011, Pages 251-256 Genetic variation in the ABCC2 gene is associated with dose decreases or switches to other cholesterol-lowering drugs during simvastatin and atorvastatin therapy. Becker ML, Elens LL, Visser LE, Hofman A, Uitterlinden AG, van Schaik RH, Stricker BH

Several statins are substrates for the multidrug resistance-associated protein 2 transporter, encoded by the ABCC2 gene. We analyzed in the Rotterdam Study whether the common polymorphisms -24C>T, 1249G>A and 3972C>T in the ABCC2 gene were associated with a dose decrease or switch to another cholesterol-lowering drug in simvastatin and atorvastatin users. These events could indicate an adverse effect or a too strong reduction in cholesterol level. We identified 1014 simvastatin and ator... Abstract

Cited 14 times since 2011 (1 per year) source: EuropePMC

Nucleic acids research, Volume 40, Issue 8, 20 3 2011, Pages 3443-3455 Concerted nicking of donor and chromosomal acceptor DNA promotes homology-directed gene targeting in human cells. Gonçalves MA, van Nierop GP, Holkers M, de Vries AA

The exchange of genetic information between donor and acceptor DNA molecules by homologous recombination (HR) depends on the cleavage of phosphodiester bonds. Although double-stranded and single-stranded DNA breaks (SSBs) have both been invoked as triggers of HR, until very recently the focus has been primarily on the former type of DNA lesions mainly due to the paucity of SSB-based recombination models. Here, to investigate the role of nicked DNA molecules as HR-initiating substrates in human s... Abstract

Cited 54 times since 2011 (3.9 per year) source: EuropePMC

Differentiation; research in biological diversity, Volume 83, Issue 2, 9 2 2011, Pages S56-61 Primary cilia as biomechanical sensors in regulating endothelial function. Egorova AD, van der Heiden K, Poelmann RE, Hierck BP

Depending on the pattern of blood flow to which they are exposed and their proliferative status, vascular endothelial cells can present a primary cilium into the flow compartment of a blood vessel. The cilium modifies the response of endothelial cells to biomechanical forces. Shear stress, which is the drag force exerted by blood flow, is best studied in this respect. Here we review the structural composition of the endothelial cilia and the current status of knowledge about the relation between... Abstract

Cited 24 times since 2011 (1.7 per year) source: EuropePMC

Atherosclerosis, Volume 220, Issue 2, 7 1 2011, Pages 456-462 KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly. Akao H, Polisecki E, Kajinami K, Trompet S, Robertson M, Ford I, Jukema JW, de Craen AJ, Westendorp RG, Shepherd J, Packard C, Buckley BM, Schaefer EJ

Single nucleotide polymorphisms (SNPs) at the KIF6 (kinesin like protein 6, rs20455 or 719Arg), LPA (lipoprotein(a), rs3798220), TAS2R50 (taste receptor type 2, member 50, rs1376251) and VAMP8 (vesicle-associated membrane protein 8, rs1010) have previously been associated with low density lipoprotein cholesterol (LDL-C) lowering response to statins, coronary heart disease (CHD) at baseline, or CHD events on trial. We examined SNPs at the KIF6 (rs20455 or 719Arg), LPA (rs3798220), TAS2R50 (rs1376... Abstract

Cited 22 times since 2011 (1.6 per year) source: EuropePMC

PloS one, Volume 6, Issue 12, 6 1 2011, Pages e28638 Upregulation of the cell-cycle regulator RGC-32 in Epstein-Barr virus-immortalized cells. Schlick SN, Wood CD, Gunnell A, Webb HM, Khasnis S, Schepers A, West MJ

Epstein-Barr virus (EBV) is implicated in the pathogenesis of multiple human tumours of lymphoid and epithelial origin. The virus infects and immortalizes B cells establishing a persistent latent infection characterized by varying patterns of EBV latent gene expression (latency 0, I, II and III). The CDK1 activator, Response Gene to Complement-32 (RGC-32, C13ORF15), is overexpressed in colon, breast and ovarian cancer tissues and we have detected selective high-level RGC-32 protein expression in... Abstract

Coronary artery disease, Volume 22, Issue 8, 1 1 2011, Pages 559-564 Prognostic significance of baseline ST-T-wave abnormalities in diagnostic stress echocardiography. Pedone C, Elhendy A, van Domburg RT, Nelwan SP, Biagini E, Di Pasquale G, Bax JJ, Poldermans D

Objective: The aim of this study was to determine whether resting ST-T wave abnormalities (ST-Ta) provide incremental prognostic information in patients with no history of coronary artery disease undergoing dobutamine stress echocardiography (DSE). Methods: We evaluated 1308 consecutive patients without previous myocardial infarction (MI) or revascularization who underwent DSE. Ischemia was defined as new or worsening wall motion abnormalities. End points during follow-up were all-cause death an... Abstract

Cited 87 times since 2011 (6.2 per year) source: EuropePMC

Pharmacogenetics and genomics, Volume 21, Issue 12, 1 1 2011, Pages 861-866 Novel CYP3A4 intron 6 single nucleotide polymorphism is associated with simvastatin-mediated cholesterol reduction in the Rotterdam Study. Elens L, Becker ML, Haufroid V, Hofman A, Visser LE, Uitterlinden AG, Stricker BCh, van Schaik RH

Objectives: CYP3A4 is involved in the oxidative metabolism of many drugs and xenobiotics including the HMG-CoA reductase inhibitor simvastatin. The objective of this study was to investigate whether a new CYP3A4 functional single nucleotide polymorphism (SNP) in intron 6 (CYP3A4*22) modifies the effect of simvastatin on total cholesterol (TOTc) or LDL cholesterol (LDLc) reduction in a population-based cohort study. Methods: In a total of 80 incident simvastatin users, the association between the... Abstract

Cited 11 times since 2011 (0.8 per year) source: EuropePMC

The Journal of the Acoustical Society of America, Volume 130, Issue 6, 1 1 2011, Pages 3827-3837 Comparison of the measured and theoretical performance of a broadband circular microphone array. Parthy A, Epain N, van Schaik A, Jin CT

The design and construction of a circular microphone array (CMA) that has a wide frequency range suitable for human hearing is presented. The design of the CMA was achieved using a technique based on simulated directivity index (DI) curves. The simulated DI curves encapsulate the critical microphone array performance limitations: spatial aliasing, measurement noise, and microphone placement errors. This paper demonstrates how the non-regularized DI curves for a given beamforming order clearly de... Abstract