7702 results
Expert opinion on biological therapy,
Volume 25, Issue 11, 1 1 2025, Pages 1171-1192
Current treatment landscape of atopic dermatitis focusing on real-world evidence of dupilumab treatment.
Boesjes CM, van der Gang LF, Achten RE, Bakker DS, van der Rijst LP, Dekkers CC, van Wijk F, Haeck IM, de Bruin-Weller MS, de Graaf M
Introduction: Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disorder and has a considerable impact on patients' quality of life. Dupilumab, the first biologic approved for moderate-to-severe AD, is a human monoclonal antibody targeting the interleukin (IL)-4 receptor α, thereby blocking both IL-4 and IL-13 signaling, key drivers of type 2 inflammation in AD. Its introduction has marked a paradigm shift in the management of AD and paved the way for future therapies. As real...
Abstract
Cited 5 times since 2025 (25 per year)
source: EuropePMC
European heart journal,
Volume 46, Issue 43, 1 1 2025, Pages 4462-4568
2025 ESC Guidelines for the management of cardiovascular disease and pregnancy.
De Backer J, Haugaa KH, Hasselberg NE, de Hosson M, Brida M, Castelletti S, Cauldwell M, Cerbai E, Crotti L, de Groot NMS, Estensen ME, Goossens ES, Haring B, Kurpas D, McEniery CM, Peters SAE, Rakisheva A, Sambola A, Schlager O, Schoenhoff FS, Simoncini T, Steinbach F, Sudano I, Swan L, Valente AM, ESC Scientific Document Group
Abstract
Lancet (London, England),
Volume 406, Issue 10519, 1 1 2025, Pages 2577-2587
Contemporary, non-invasive imaging diagnosis of chronic coronary artery disease.
van der Bijl P, Gulati M, Saraste A, Marwick T, Kwong R, Blankstein R, Nieman K, Sengupta PP, van Rosendael A, Knuuti J, Bangalore S, Bax JJ
Coronary artery disease is one of the leading causes of morbidity and mortality worldwide. Although it can present with an acute coronary syndrome, it is often characterised by long periods of stability, known as chronic coronary artery disease. This Review presents a comprehensive overview of the diagnosis of the disease, with a focus on cardiac imaging. We discuss various cardiac imaging modalities, including CT coronary angiography, stress echocardiogram, stress single-photon emission CT, PET...
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 67, Issue 11, 1 1 2025, Pages ezaf387
Reply to Mukharyamov et al.
Vriesendorp MD, Sabik JF, Klautz RJM
Abstract
Cited 22 times since 2025 (109.9 per year)
source: EuropePMC
European heart journal,
Volume 46, Issue 42, 1 1 2025, Pages 4359-4378
2025 Focused Update of the 2019 ESC/EAS Guidelines for the management of dyslipidaemias.
Mach F, Koskinas KC, Roeters van Lennep JE, Tokgözoğlu L, Badimon L, Baigent C, Benn M, Binder CJ, Catapano AL, De Backer GG, Delgado V, Fabin N, Ference BA, Graham IM, Landmesser U, Laufs U, Mihaylova B, Nordestgaard BG, Richter DJ, Sabatine MS, ESC/EAS Scientific Document Group
Abstract
Cited 9 times since 2025 (44.9 per year)
source: EuropePMC
European heart journal,
Volume 46, Issue 41, 1 1 2025, Pages 4156-4225
2025 ESC Clinical Consensus Statement on mental health and cardiovascular disease: developed under the auspices of the ESC Clinical Practice Guidelines Committee.
Bueno H, Deaton C, Farrero M, Forsyth F, Braunschweig F, Buccheri S, Dragan S, Gevaert S, Held C, Kurpas D, Ladwig KH, Lionis CD, Maas AHEM, Merșa CO, Mindham R, Pedersen SS, Rojnic Kuzman M, Szmit S, Taylor RS, Uchmanowicz I, Vilchinsky N, ESC Scientific Document Group
Abstract
Annals of vascular surgery,
Volume 123, 1 1 2025, Pages 502-513
Rupture Risk of Large Abdominal Aortic Aneurysms: A Scoping Review.
Paping JHM, Bulder RMA, Lancaster E, Chang RW, Putter H, Hamming JF, Lindeman JH
Background: Abdominal aortic aneurysm (AAA) management is currently dictated by the 55 mm intervention threshold. While it has been suggested that this intervention threshold is too conservative, the rupture risk of AAAs larger than 55 mm is discussed differently. This scoping review aims to critically summarize and review the available evidence with respect to the rupture risk of larger AAA. Methods: A quantitative and qualitative evaluation of the available literature on the rupture risk of la...
Abstract
Nursing in critical care,
Volume 30, Issue 6, 1 1 2025, Pages e70191
Intensive Care and Operating Room Nurses' Knowledge Regarding Skin Tears.
Yeşilyurt M, Yılmaz D
Background: Skin tears are a prevalent but often under-recognised type of injury in clinical settings, particularly affecting vulnerable patients in intensive care and surgical environments. Aim: The aim of this study was to determine the knowledge levels of nurses working in operating rooms and intensive care units regarding skin tears. Study design: This descriptive study was conducted between December 2024 and April 2025 with 81 intensive care and 76 operating room nurses at a training and re...
Abstract
Cited 1 times since 2025 (5 per year)
source: EuropePMC
Journal of cellular and molecular medicine,
Volume 29, Issue 21, 1 1 2025, Pages e70933
Breaking (Light) Barriers: Photoacoustics in Atherosclerotic Diseases.
van Dijk K, de Vries MR
Photoacoustic imaging (PAI) is an emerging imaging modality that provides high-resolution, spatiotemporal insights into anatomical structures, functional parameters and molecular characteristics of tissues. By leveraging both endogenous absorbers, such as lipids and collagen, and exogenous contrast agents like nanoparticles and molecular dyes, PAI offers a comprehensive approach to characterising atherosclerosis. This review describes the technical principles underlying various PAI modalities an...
Abstract
Journal of cardiac failure,
Volume 31, Issue 11, 1 1 2025, Pages 1661-1671
Diagnosing HFpEF in Patients With Unexplained Dyspnea by Using Invasive Left Ventricular Pressure-Volume Loops.
Gessner R, Hübner AC, Stöbe S, Rudolph UM, Unger L, Schmeisser A, Steendijk P, Uhe T, Stegmann T, Lavall D, Hagendorff A, Laufs U, Wachter R
Background: Diagnosing heart failure with preserved ejection fraction (HFpEF) remains challenging. Noninvasive diagnostic algorithms have been proposed but not tested against the gold standard, ie, invasive measurement of left ventricular (LV) pressure-volume loops (PVL). This study's aim was to estimate the prevalence of HFpEF in euvolemic patients with unexplained exertional dyspnea by using LV PVL and to validate noninvasive diagnostic algorithms. Methods and results: We included patient...
Abstract
The British journal of surgery,
Volume 112, Issue 11, 1 1 2025, Pages znaf177
The science and art of decision-making in surgery.
Bisset CN, Baigrie R, Dames N, Corbett S, Hill S, Macdermid E, Sier VQ, van der Vorst JR, Rehman U, Sarwar MS, Brennan PA, Cleland J, Ellis R, Bryan JE, Ketley A, Morgan JL, Gogalniceanu P, Kaafarani HMA, Liang R, Moug SJ
Abstract
The British journal of surgery,
Volume 112, Issue 11, 1 1 2025, Pages znaf189
Colorectal-vaginal fistula after rectal cancer resection: international comparative cohort study of characteristics and treatment.
van Lieshout ML, Lemmens JMG, Greijdanus NG, Wienholts K, Ubels S, Talboom K, Hannink G, Wolthuis A, de Lacy FB, Lefevre JH, Solomon M, Frasson M, Rotholtz N, Denost Q, Perez RO, Konishi T, Panis Y, Rutegård M, Hompes R, van Workum F, Tanis PJ, de Wilt JHW, TENTACLE–Rectum Collaborative Group
Abstract
Journal of Crohn's & colitis,
Volume 19, Issue 10, 1 1 2025, Pages jjaf176
How long is long enough? Timing of pre-conceptional remission predicts relapse risk during pregnancy in IBD.
Bouwknegt DG, Hoekstra B, Donker HC, van Es B, Groen H, Dijkstra G, van Dop WA, Tauber T, van der Woude CJ, Visschedijk MC, Dutch Initiative on Crohn and Colitis (ICC)
Background and aims: Inflammatory bowel disease (IBD) often coincides with pregnancy, and disease activity during pregnancy increases the risk of adverse outcomes. We aimed to determine how disease course before conception influences relapse risk during pregnancy, adjusting for established risk factors. Methods: In this multicenter, retrospective cohort study, we included adult women with IBD who were pregnant during treatment at one of three university hospitals between 2017 and 2022. Using gen...
Abstract
Inflammatory bowel diseases,
Volume 31, Issue 11, 1 1 2025, Pages 3051-3059
Food Compounds Associated With Disease Activity in Inflammatory Bowel Disease.
Meima M, Westerhout J, Meijerink M, Bijlsma S, van Schaik F, Oldenburg B, Houben G
Background: Diet plays a modulatory role in inflammatory bowel disease (IBD), but specific relevant dietary factors have yet to be identified. To advance our understanding, we performed multivariate analyses of food compound intakes using dietary data from an IBD cohort. Methods: We used dietary and disease status data from IBD patients at the University Medical Center Utrecht, The Netherlands. Intake levels for 768 compounds from 135 patients were calculated. Using random forest analyses, we ex...
Abstract
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology,
Volume 80, 31 5 2025, Pages 107789
Aortic wall lamellar structure in phylogeny and in humans: insights from bicuspid and tricuspid aortic valve morphology.
Bacour N, Zafar M, Kargin N, Zinganshin B, Poelmann R, Klautz RJM, Elefteriades J, Grewal N
Objective: Despite a voluminous literature on aortopathy, comparatively little attention has been paid to the lamellar architecture of the aortic wall, including the number and distribution of these layers. This study compares the lamellar organization of the developing aorta in individuals with a bicuspid (BAV) versus tricuspid aortic valve (TAV) and includes a literature review on aortic lamellae in mammals and adult humans. Methods: Non-dilated ascending aortic wall samples (n = 83) were anal...
Abstract
American heart journal,
Volume 293, 31 5 2025, Pages 107296
Routine versus selective protamine administration to reduce bleeding after TAVI: Rationale and design of the POPular ACE TAVI trial.
Overduin DC, van Ginkel DJ, Dubois C, Lesizza P, Broeze GM, Montero-Cabezas JM, Rosseel L, van der Kley F, van Nuland PJ, Smits TP, Hemelrijk KI, Aarts HM, Rensing BJWM, Timmers L, Swaans MJ, Sonker U, Veenstra L, van 't Hof AWJ, Peper J, Tijssen JGP, Delewi R, Vriesendorp PA, Ten Berg JM
Background: Unfractionated heparin is routinely used during transcatheter aortic valve implantation (TAVI) to reduce catheter thrombosis and thromboembolism. Protamine reverses the effect of heparin and may lower bleeding risk, but it can also trigger severe allergic reactions. Robust data on the safety and efficacy of routine protamine administration after TAVI is lacking. Methods: The ``routine versus selective protamine administration to reduce bleeding complications after transcatheter aorti...
Abstract
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
31 5 2025, Pages S0894-7317(25)00608-X
Reply to "Optimizing clinical applicability of left atrial strain index in patients with heart failure with preserved ejection fraction".
Chua AP, Marsan NA
Abstract
Inflammatory bowel diseases,
31 5 2025, Pages izaf240
Implementation of a Capillary Blood Self-Sampling Technique at Home for Monitoring of Patients With IBD.
Schuurman GS, Tiel Groenestege W, Hirdes MMC, Fidder HH, Oldenburg B, de Roock S, van Schaik FDM
Background: Remote healthcare aims to improve the management of inflammatory bowel disease (IBD) patients by reducing hospital visits. This is the first study to assess capillary blood sampling at home for routine measurement of chemistry parameters and complete blood count parameters at several time points for disease monitoring in IBD patients. Methods: In this prospective, single-center proof-of-concept study, 27 patients with Crohn's disease or ulcerative colitis and an indication for f...
Abstract
Scientific reports,
Volume 15, Issue 1, 30 5 2025, Pages 38074
Safety trial assessing 1.77 cm<sup>2</sup> H<sub>2</sub>O<sub>2</sub> producing electrochemical bandages on healthy human skin.
Kies PJ, Kim WJ, Fleming D, Bozyel I, Holtegaard S, Shrivastava S, Schwartz K, Schwieder S, Beyenal H, Patel R
Mammalian skin maintains complex repair mechanisms after barrier disruption. Chronic wounds develop when these events are not efficiently completed, increasing infection risk. With ~2% of the population afflicted yearly, chronic wound care needs new technologies. Here, a Phase 0/1 study of one such therapeutic intervention is presented- H2O2 (hydrogen peroxide)-producing electrochemical bandages (e-bandages) controlled by wearable micropotentiostats. The e-bandages generate H2O2 in precise, micr...
Abstract
Journal of cardiovascular translational research,
Volume 18, Issue 6, 30 5 2025, Pages 1540-1554
RNA Therapeutics in Heart Failure.
Deiman FE, de Graaf MM, Sillje HHW, Grote Beverborg N, Bomer N, van der Meer P
RNA-based therapeutics, such as small interfering RNAs (siRNAs), antisense oligonucleotides (ASOs) and messenger RNAs (mRNAs) are promising therapeutics that offer new avenues for targeting molecular pathways underlying heart failure (HF) pathogenesis. This review provides an overview of RNA therapeutics, detailing their mechanisms and potential applications in the treatment of HF. Key pathological processes in HF, including dysregulated calcium handling, myocardial fibrosis, oxidative stress, i...
Abstract
