6128 results
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
EJNMMI physics,
Volume 8, Issue 1, 16 3 2021, Pages 48
Experimental validation of absolute SPECT/CT quantification for response monitoring in patients with coronary artery disease.
van de Burgt A, Dibbets-Schneider P, Slump CH, Scholte AJHA, Atsma DE, de Geus-Oei LF, van Velden FHP
Background: Quantitative SPECT enables absolute quantification of uptake in perfusion defects. The aim of this experimental study is to assess quantitative accuracy and precision of a novel iterative reconstruction technique (Evolution; GE Healthcare) for the potential application of response monitoring using 99mTc-tetrofosmin SPECT/CT in patients with coronary artery disease (CAD). Methods: Acquisitions of an anthropomorphic torso phantom with cardiac insert containing defects (with varying siz...
Abstract
JACC. Asia,
Volume 1, Issue 1, 15 3 2021, Pages 49-52
The Multidimensionality of Coronary Artery Disease: Combining, Conflating and Changing.
Min JK, Budoff MJ, Bax JJ
Abstract
Cited 1 times since 2021 (0.3 per year)
source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology,
Volume 17, Issue 2, 11 2 2021, Pages e156-e157
Computed tomography-derived transoesophageal echocardiographic views for preprocedural planning of direct transcatheter mitral valve annuloplasty.
Fortuni F, van der Kley F, Ajmone Marsan N, Delgado V
Abstract
Cited 1 times since 2021 (0.3 per year)
source: EuropePMC
European heart journal. Digital health,
Volume 2, Issue 3, 11 2 2021, Pages 511-520
Development of a patient-oriented Hololens application to illustrate the function of medication after myocardial infarction.
Hilt AD, Hierck BP, Eijkenduijn J, Wesselius FJ, Albayrak A, Melles M, Schalij MJ, Scherptong RWC
Aims: Statin treatment is one of the hallmarks of secondary prevention after myocardial infarction. Adherence to statins tends to be difficult and can be improved by patient education. Novel technologies such as mixed reality (MR) expand the possibilities to support this process. To assess if an MR medication-application supports patient education focused on function of statins after myocardial infarction. Methods and results: A human-centred design-approach was used to develop an MR statin tool...
Abstract
Cited 6 times since 2021 (1.6 per year)
source: EuropePMC
Journal of internal medicine,
Volume 290, Issue 3, 10 2 2021, Pages 715-727
Renal function in patients with significant tricuspid regurgitation: pathophysiological mechanisms and prognostic implications.
Butcher SC, Fortuni F, Dietz MF, Prihadi EA, van der Bijl P, Ajmone Marsan N, Bax JJ, Delgado V
Background: The pathophysiological mechanisms linking tricuspid regurgitation (TR) and chronic kidney disease (CKD) remain unknown. This study aimed to determine which pathophysiological mechanisms related to TR are independently associated with renal dysfunction and to evaluate the impact of renal impairment on long-term prognosis in patients with significant (≥ moderate) secondary TR. Methods: A total of 1234 individuals (72 [IQR 63-78] years, 50% male) with significant secondary TR were follo...
Abstract
Metabolomics : Official journal of the Metabolomic Society,
Volume 17, Issue 6, 9 2 2021, Pages 57
Differential insulin sensitivity of NMR-based metabolomic measures in a two-step hyperinsulinemic euglycemic clamp study.
Wang W, van Dijk KW, Wijsman CA, Rozing MP, Mooijaart SP, Beekman M, Slagboom PE, Jukema JW, Noordam R, van Heemst D
Background: Insulin is the key regulator of glucose metabolism, but it is difficult to dissect direct insulin from glucose-induced effects. We aimed to investigate the effects of hyperinsulemia on metabolomic measures under euglycemic conditions in nondiabetic participants. Methods: We assessed concentrations of 151 metabolomic measures throughout a two-step hyperinsulinemic euglycemic clamp procedure. We included 24 participants (50% women, mean age = 62 [s.d. = 4.2] years) and metabolomic meas...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
BMC medical education,
Volume 21, Issue 1, 8 2 2021, Pages 332
The effect of peer modelling and discussing modelled feedback principles on medical students' feedback skills: a quasi-experimental study.
van Blankenstein FM, O'Sullivan JF, Saab N, Steendijk P
Background: Teaching is an important professional skill for physicians and providing feedback is an important part of teaching. Medical students can practice their feedback skills by giving each other peer feedback. Therefore, we developed a peer feedback training in which students observed a peer that modelled the use of good feedback principles. Students then elaborated on the modelled feedback principles through peer discussion. This combination of peer modelling and discussing the modelled f...
Abstract
Cited 12 times since 2021 (3.2 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 10, Issue 12, 2 1 2021, Pages e020080
Extent of Coronary Artery Disease in Patients With Stenotic Bicuspid Versus Tricuspid Aortic Valves.
Dolmaci OB, Legué J, Lindeman JHN, Driessen AHG, Klautz RJM, Van Brakel TJ, Siebelink HJ, Mertens BJA, Poelmann RE, Gittenberger-de Groot AC, Grewal N
Background Bicuspid aortic valve (BAV) is the most common congenital cardiac malformation, which is often complicated by aortic valve stenosis (AoS). In tricuspid aortic valve (TAV), AoS strongly associates with coronary artery disease (CAD) with common pathophysiological factors. Yet, it remains unclear whether AoS in patients with BAV is also associated with CAD. This study investigated the association between the aortic valve morphological features and the extent of CAD. Methods and Results A...
Abstract
Cited 15 times since 2021 (4 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 23, Issue 6, 1 1 2021, Pages 887-897
Development and external validation of prediction models to predict implantable cardioverter-defibrillator efficacy in primary prevention of sudden cardiac death.
Verstraelen TE, van Barreveld M, van Dessel PHFM, Boersma LVA, Delnoy PPHM, Tuinenburg AE, Theuns DAMJ, van der Voort PH, Kimman GP, Buskens E, Hulleman M, Allaart CP, Strikwerda S, Scholten MF, Meine M, Abels R, Maass AH, Firouzi M, Widdershoven JWMG, Elders J, van Gent MWF, Khan M, Vernooy K, Grauss RW, Tukkie R, van Erven L, Spierenburg HAM, Brouwer MA, Bartels GL, Bijsterveld NR, Borger van der Burg AE, Vet MW, Derksen R, Knops RE, Bracke FALE, Harden M, Sticherling C, Willems R, Friede T, Zabel M, Dijkgraaf MGW, Zwinderman AH, Wilde AAM
Aims: This study was performed to develop and externally validate prediction models for appropriate implantable cardioverter-defibrillator (ICD) shock and mortality to identify subgroups with insufficient benefit from ICD implantation. Methods and results: We recruited patients scheduled for primary prevention ICD implantation and reduced left ventricular function. Bootstrapping-based Cox proportional hazards and Fine and Gray competing risk models with likely candidate predictors were developed...
Abstract
Cited 3 times since 2021 (0.8 per year)
source: EuropePMC
Open heart,
Volume 8, Issue 1, 1 1 2021, Pages e001639
Discordant severity criteria in patients with moderate aortic stenosis: prognostic implications.
Pio SM, Amanullah MR, Butcher SC, Sin KY, Ajmone Marsan N, Pibarot P, Van Mieghem NM, Ding ZP, Généreux P, Leon MB, Ewe SH, Delgado V, Bax JJ
Background: The criteria to define the grade of aortic stenosis (AS)-aortic valve area (AVA) and mean gradient (MG) or peak jet velocity-do not always coincide into one grade. Although in severe AS, this discrepancy is well characterised, in moderate AS, the phenomenon of discordant grading has not been investigated and its prognostic implications are unknown. Objectives: To investigate the occurrence of discordant grading in patients with moderate AS (defined by an AVA between 1.0 cm² and 1.5 c...
Abstract
Cited 5 times since 2021 (1.3 per year)
source: EuropePMC
The Journal of clinical endocrinology and metabolism,
Volume 106, Issue 7, 1 1 2021, Pages e2527-e2534
Bone Material Strength Index as Measured by Impact Microindentation is Low in Patients with Primary Hyperparathyroidism.
Schoeb M, Winter EM, Sleddering MA, Lips MA, Schepers A, Snel M, Appelman-Dijkstra NM
Context: In primary hyperparathyroidism (PHPT) bone mineral density (BMD) is typically decreased in cortical bone and relatively preserved in trabecular bone. An increased fracture rate is observed however not only at peripheral sites but also at the spine, and fractures occur at higher BMD values than expected. We hypothesized that components of bone quality other than BMD are affected in PHPT as well. Objective: To evaluate bone material properties using impact microindentation (IMI) in PHPT p...
Abstract
Cited 24 times since 2021 (6.4 per year)
source: EuropePMC
Journal for immunotherapy of cancer,
Volume 9, Issue 6, 1 1 2021, Pages e002916
Immune checkpoint inhibitor treatment and atherosclerotic cardiovascular disease: an emerging clinical problem.
Poels K, Neppelenbroek SIM, Kersten MJ, Antoni ML, Lutgens E, Seijkens TTP
Antibody-mediated blockade of co-inhibitory molecules such as cytotoxic T lymphocyte-associated protein 4, PD1 and PDL1 elicits potent antitumor responses and improves the prognosis of many patients with cancer. As these immune checkpoint inhibitors (ICIs) are increasingly prescribed to a diverse patient population, a broad range of adverse effects is emerging. Atherosclerosis, a lipid-driven chronic inflammatory disease of the large arteries, may be aggravated by ICI treatment. In this review,...
Abstract
Cited 36 times since 2021 (9.6 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 77, Issue 22, 1 1 2021, Pages 2796-2803
Moderate Aortic Stenosis in Patients With Heart Failure and Reduced Ejection Fraction.
Jean G, Van Mieghem NM, Gegenava T, van Gils L, Bernard J, Geleijnse ML, Vollema EM, El Azzouzi I, Spitzer E, Delgado V, Bax JJ, Pibarot P, Clavel MA
Background: The study investigators previously reported that moderate aortic stenosis (AS) is associated with a poor prognosis in patients with heart failure (HF) with reduced left ventricular ejection fraction (LVEF) (HFrEF). However, the respective contribution of moderate AS versus HFrEF to the outcomes of these patients is unknown. Objectives: This study sought to determine the impact of moderate AS on outcomes in patients with HFrEF. Methods: The study included 262 patients with moderate AS...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 22, Issue 7, 1 1 2021, Pages 751-752
Characterization of the left ventricular response to hypertension: beyond global longitudinal strain.
van der Bijl P, Delgado V, Bax JJ
Abstract
Cited 328 times since 2021 (87.5 per year)
source: EuropePMC
Nature genetics,
Volume 53, Issue 6, 31 5 2021, Pages 840-860
The trans-ancestral genomic architecture of glycemic traits.
Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems SM, Wu Y, Zhang X, Horikoshi M, Boutin TS, Mägi R, Waage J, Li-Gao R, Chan KHK, Yao J, Anasanti MD, Chu AY, Claringbould A, Heikkinen J, Hong J, Hottenga JJ, Huo S, Kaakinen MA, Louie T, März W, Moreno-Macias H, Ndungu A, Nelson SC, Nolte IM, North KE, Raulerson CK, Ray D, Rohde R, Rybin D, Schurmann C, Sim X, Southam L, Stewart ID, Wang CA, Wang Y, Wu P, Zhang W, Ahluwalia TS, Appel EVR, Bielak LF, Brody JA, Burtt NP, Cabrera CP, Cade BE, Chai JF, Chai X, Chang LC, Chen CH, Chen BH, Chitrala KN, Chiu YF, de Haan HG, Delgado GE, Demirkan A, Duan Q, Engmann J, Fatumo SA, Gayán J, Giulianini F, Gong JH, Gustafsson S, Hai Y, Hartwig FP, He J, Heianza Y, Huang T, Huerta-Chagoya A, Hwang MY, Jensen RA, Kawaguchi T, Kentistou KA, Kim YJ, Kleber ME, Kooner IK, Lai S, Lange LA, Langefeld CD, Lauzon M, Li M, Ligthart S, Liu J, Loh M, Long J, Lyssenko V, Mangino M, Marzi C, Montasser ME, Nag A, Nakatochi M, Noce D, Noordam R, Pistis G, Preuss M, Ra
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-ana...
Abstract
Cited 1 times since 2021 (0.3 per year)
source: EuropePMC
Lung cancer (Amsterdam, Netherlands),
Volume 158, 28 4 2021, Pages 18-24
Endobronchial ultrasound for T4 staging in patients with resectable NSCLC.
Kuijvenhoven JC, Livi V, Szlubowski A, Ninaber M, Stöger JL, Widya RL, Bonta PI, Crombag LC, Braun J, van Boven WJ, Trisolini R, Korevaar DA, Annema JT
Background: In lung cancer patients, accurate assessment of mediastinal and vascular tumor invasion (stage T4) is crucial for optimal treatment allocation and to prevent unnecessary thoracotomies. We assessed the diagnostic accuracy of linear endobronchial ultrasound (EBUS) for T4-status in patients with centrally located lung cancer. Methods: This is a retrospective study among consecutive patients who underwent EBUS for diagnosis and staging of lung cancer in four hospitals in The Netherlands...
Abstract
Cited 8 times since 2021 (2.1 per year)
source: EuropePMC
The American journal of cardiology,
Volume 151, 24 4 2021, Pages 1-9
Myocardial Work, an Echocardiographic Measure of Post Myocardial Infarct Scar on Contrast-Enhanced Cardiac Magnetic Resonance.
Mahdiui ME, van der Bijl P, Abou R, de Paula Lustosa R, van der Geest R, Ajmone Marsan N, Delgado V, Bax JJ
This study investigates the relation of non-invasive myocardial work and myocardial viability following ST-segment elevation myocardial infarction (STEMI) assessed on late gadolinium contrast enhanced cardiac magnetic resonance (LGE CMR) and characterizes the remote zone using non-invasive myocardial work parameters. STEMI patients who underwent primary percutaneous coronary intervention (PCI) were included. Several non-invasive myocardial work parameters were derived from speckle tracking strai...
Abstract
Cited 5 times since 2021 (1.3 per year)
source: EuropePMC
Journal of critical care,
Volume 65, 23 4 2021, Pages 36-41
Reduced quality of life in ICU survivors - the story behind the numbers: A mixed methods study.
Geense WW, de Graaf M, Vermeulen H, van der Hoeven J, Zegers M, van den Boogaard M
Purpose: To gain insight into the daily functioning of ICU survivors who reported a reduced quality of life (QoL) one year after ICU admission. Materials and methods: A two-phase mixed method study design. QoL was assessed using the SF-36 questionnaire before admission and after one year (Phase 1). Participants reporting a reduced QoL were invited for an in-depth interview (Phase 2). Interview data were coded thematically using the PROMIS framework. Results: Of the 797 participants, 173 (22%) re...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
Cardiology in the young,
Volume 31, Issue 6, 21 3 2021, Pages 915-939
Consensus document on optimal management of patients with common arterial trunk.
Hazekamp MG, Barron DJ, Dangel J, Homfray T, Jongbloed MRM, Voges I
Abstract
Cited 12 times since 2021 (3.2 per year)
source: EuropePMC
Frontiers in endocrinology,
Volume 12, 20 3 2021, Pages 674841
Levothyroxine Treatment and Cardiovascular Outcomes in Older People With Subclinical Hypothyroidism: Pooled Individual Results of Two Randomised Controlled Trials.
Zijlstra LE, Jukema JW, Westendorp RGJ, Du Puy RS, Poortvliet RKE, Kearney PM, O'Keeffe L, Dekkers OM, Blum MR, Rodondi N, Collet TH, Quinn TJ, Sattar N, Stott DJ, Trompet S, den Elzen WPJ, Gussekloo J, Mooijaart SP
Background: The cardiovascular effects of treating older adults with subclinical hypothyroidism (SCH) are uncertain. Although concerns have been raised regarding a potential increase in cardiovascular side effects from thyroid hormone replacement, undertreatment may also increase the risk of cardiovascular events, especially for patients with cardiovascular disease (CVD). Objective: To determine the effects of levothyroxine treatment on cardiovascular outcomes in older adults with SCH. Methods:...
Abstract
