7971 results
Cited 3 times since 2021 (0.7 per year)
source: EuropePMC
BMC musculoskeletal disorders,
Volume 22, Issue 1, 20 3 2021, Pages 370
The CAST study protocol: a cluster randomized trial assessing the effect of circumferential casting versus plaster splinting on fracture redisplacement in reduced distal radius fractures in adults.
Barvelink B, Reijman M, Schep NWL, Brown V, Kraan GA, Gosens T, Polinder S, Ista E, Verhaar JAN, Colaris JW, CAST study group
Background: There is no consensus concerning the optimal casting technique for displaced distal radius fractures (DRFs) following closed reduction. This study evaluates whether a splint or a circumferential cast is most optimal to prevent fracture redisplacement in adult patients with a reduced DRF. Additionally, the cost-effectiveness of both cast types will be calculated. Methods/design: This multicenter cluster randomized controlled trial will compare initial immobilization with a circumferen...
Abstract
Cited 5 times since 2021 (1.2 per year)
source: EuropePMC
Transplant infectious disease : an official journal of the Transplantation Society,
Volume 23, Issue 4, 20 3 2021, Pages e13612
Utility of methicillin-resistant Staphylococcus aureus (MRSA) nasal screening in patients with acute myeloid leukemia (AML).
Talagtag M, Patel TS, Scappaticci GB, Perissinotti AJ, Schepers AJ, Petty LA, Pettit KM, Burke PW, Bixby DL, Marini BL
Background: Current literature has demonstrated the utility of the MRSA nasal screen as a de-escalation tool to decrease unnecessary anti-MRSA antibiotic therapy. However, data on the applicability of this test in patients with hematologic malignancy is lacking. Methods: This is a single-center, retrospective cohort study of patients with acute myeloid leukemia (AML) with or without a history of hematopoietic cell transplant (HCT), with pneumonia and MRSA nasal screening with respiratory culture...
Abstract
Cited 16 times since 2021 (3.9 per year)
source: EuropePMC
Canadian journal of anaesthesia = Journal canadien d'anesthesie,
Volume 68, Issue 9, 20 3 2021, Pages 1349-1357
Hypoxemia during procedural sedation in adult patients: a retrospective observational study.
van Schaik EPC, Blankman P, Van Klei WA, Knape HJTA, Vaessen PHHB, Braithwaite SA, van Wolfswinkel L, Schellekens WM
Purpose: Since 2010, new guidelines for procedural sedation and the Helsinki Declaration on Patient Safety have increased patient safety, comfort, and acceptance considerably. Nevertheless, the administration of sedatives and opioids during sedation procedures may put the patient at risk of hypoxemia. However, data on hypoxemia during procedural sedation are scarce. Here, we studied the incidence and severity of hypoxemia during procedural sedations in our hospital. Methods: A historical, single...
Abstract
Cited 4 times since 2021 (1 per year)
source: EuropePMC
International journal of cardiology,
Volume 334, 20 3 2021, Pages 10-17
Clopidogrel in noncarriers of CYP2C19 loss-of-function alleles versus ticagrelor in elderly patients with acute coronary syndrome: A pre-specified sub analysis from the POPular Genetics and POPular Age trials CYP2C19 alleles in elderly patients.
Claassens DMF, Gimbel ME, Bergmeijer TO, Vos GJA, Hermanides RS, van der Harst P, Barbato E, Morisco C, Tjon Joe Gin RM, de Vrey EA, Heestermans TACM, Jukema JW, von Birgelen C, Waalewijn RA, Hofma SH, den Hartog FR, Voskuil M, Van't Hof AWJ, Asselbergs FW, Mosterd A, Herrman JR, Dewilde W, Mahmoodi BK, Deneer VHM, Ten Berg JM
Background: Patients with acute coronary syndrome (ACS) who are carrying CYP2C19 loss-of-function alleles derive less benefit from clopidogrel treatment. Despite this, in elderly patients, clopidogrel might be preferred over more potent P2Y12 inhibitors due to a lower bleeding risk. Whether CYP2C19 genotype-guided antiplatelet treatment in the elderly could be of benefit has not been studied specifically. Methods: Patients aged 70 years and older with known CYP2C19*2 and *3 genotype were identif...
Abstract
Cited 474 times since 2021 (115 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 77, Issue 21, 19 3 2021, Pages 2717-2746
Valve Academic Research Consortium 3: Updated Endpoint Definitions for Aortic Valve Clinical Research.
VARC-3 WRITING COMMITTEE:, Généreux P, Piazza N, Alu MC, Nazif T, Hahn RT, Pibarot P, Bax JJ, Leipsic JA, Blanke P, Blackstone EH, Finn MT, Kapadia S, Linke A, Mack MJ, Makkar R, Mehran R, Popma JJ, Reardon M, Rodes-Cabau J, Van Mieghem NM, Webb JG, Cohen DJ, Leon MB
Aims: The Valve Academic Research Consortium (VARC), founded in 2010, was intended to (i) identify appropriate clinical endpoints and (ii) standardize definitions of these endpoints for transcatheter and surgical aortic valve clinical trials. Rapid evolution of the field, including the emergence of new complications, expanding clinical indications, and novel therapy strategies have mandated further refinement and expansion of these definitions to ensure clinical relevance. This document provides...
Abstract
Cited 24 times since 2021 (5.8 per year)
source: EuropePMC
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance,
Volume 23, Issue 1, 19 3 2021, Pages 46
Normal and reference values for cardiovascular magnetic resonance-based pulse wave velocity in the middle-aged general population.
van Hout MJ, Dekkers IA, Westenberg JJ, Schalij MJ, Widya RL, de Mutsert R, Rosendaal FR, de Roos A, Jukema JW, Scholte AJ, Lamb HJ
Background: Aortic stiffness, assessed through pulse wave velocity (PWV), is an independent predictor for cardiovascular disease risk. However, the scarce availability of normal and reference values for cardiovascular magnetic resonance imaging (CMR) based PWV is limiting clinical implementation. The aim of this study was to determine normal and reference values for CMR assessed PWV in the general population. Methods: From the 2,484 participants of the Netherlands Epidemiology of Obesity (NEO) s...
Abstract
Cited 4 times since 2021 (1 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 29, Issue 9, 19 3 2021, Pages 433-440
Early career perspectives of young Dutch cardiologists.
Vorselaars VMM, van der Heijden AC, Joustra R, Berger WR, van Hout GPJ, Kapel GFL, Nuis RJ, Woudstra P, Piers SRD
Background: There are nationwide concerns about the unemployment rate among young Dutch cardiologists and the increase in temporary positions. Therefore, the aim of this study was to investigate the unemployment rate in this subgroup as well as the length of time between the end of their training and the acquisition of a permanent position. Methods: All cardiologists who completed their training between January 2015 and December 2018 were invited to fill in an online questionnaire about their de...
Abstract
Cited 5 times since 2021 (1.2 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 29, Issue Suppl 1, 16 3 2021, Pages 20-34
The effects of ACE2 expression mediating pharmacotherapy in COVID-19 patients.
van Kimmenade RRJ, Belfroid E, Hoogervorst-Schilp J, Siebelink HJ, Janssen CW, Pinto Y
Background: There has been debate on the use of angiotensin-converting enzyme‑2 (ACE2) expression mediating pharmacotherapy in COVID-19 infected patients. Although it has been suggested that these drugs might lead to a higher susceptibility and severity of COVID-19 infection, experimental data suggest these agents may reduce acute lung injury via blocking angiotensin-II-mediated pulmonary permeability, inflammation and fibrosis. Methods: A systematic literature search was performed to answer the...
Abstract
Cited 9 times since 2021 (2.2 per year)
source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 61, Issue 6, 16 3 2021, Pages 920-928
Outcomes in Octogenarians and the Effect of Comorbidities After Intact Abdominal Aortic Aneurysm Repair in the Netherlands: A Nationwide Cohort Study.
Alberga AJ, Karthaus EG, van Zwet EW, de Bruin JL, van Herwaarden JA, Wever JJ, Verhagen HJM, Dutch Society of Vascular Surgery, Steering Committee of the Dutch Surgical Aneurysm Audit, Dutch Institute for Clinical Auditing
Objective: Age is an independent risk factor for mortality after both elective open surgical repair (OSR) and endovascular aneurysm repair (EVAR). As a result of an ageing population, and the less invasive nature of EVAR, the number of patients over 80 years (octogenarians) being treated is increasing. The mortality and morbidity following aneurysm surgery are increased for octogenarians. However, the mortality for octogenarians who have either low or high peri-operative risks remains unclear. T...
Abstract
Cited 1 times since 2021 (0.2 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 29, Issue Suppl 1, 16 3 2021, Pages 13-19
Impact of cardiovascular disease and cardiovascular risk factors in hospitalised COVID-19 patients.
Jewbali LSD, Hoogervorst-Schilp J, Belfroid E, Jansen CW, Asselbergs FW, Siebelink HJ
Background: Hospitalised COVID-19 patients with underlying cardiovascular disease (CVD) and cardiovascular risk factors appear to be at risk of poor outcome. It is unknown if these patients should be considered a vulnerable group in healthcare delivery and healthcare recommendations during the COVID-19 pandemic. Methods: A systematic literature search was performed to answer the following question: In which hospitalised patients with proven COVID-19 and with underlying CVD and cardiovascular ris...
Abstract
Cited 9 times since 2021 (2.2 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 29, Issue Suppl 1, 16 3 2021, Pages 5-12
How often and to what extent do admitted COVID-19 patients have signs of cardiac injury?
Habets MAW, Sturkenboom HN, Tio RA, Belfroid E, Hoogervorst-Schilp J, Siebelink HJ, Jansen CW, Smits PC
Background: COVID-19 can cause myocardial injury in a significant proportion of patients admitted to the hospital and seems to be associated with worse prognosis. The aim of this review was to study how often and to what extent COVID-19 causes myocardial injury and whether this is an important contributor to outcome with implications for management. Methods: A literature search was performed in Medline and Embase. Myocardial injury was defined as elevated cardiac troponin (cTn) levels with at le...
Abstract
Cited 248 times since 2021 (60.1 per year)
source: EuropePMC
The Lancet. Respiratory medicine,
Volume 9, Issue 10, 16 3 2021, Pages 1141-1153
Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): a randomised, double-blind, placebo-controlled, phase 3 trial.
Han JK, Bachert C, Fokkens W, Desrosiers M, Wagenmann M, Lee SE, Smith SG, Martin N, Mayer B, Yancey SW, Sousa AR, Chan R, Hopkins C, SYNAPSE study investigators
Background: Chronic rhinosinusitis with nasal polyps affects approximately 2-4% of the general population, and long-term use of systemic corticosteroids is associated with adverse effects. The aim of this study was to assess the efficacy and safety of mepolizumab in adults with recurrent, refractory severe bilateral chronic rhinosinusitis with nasal polyps. Methods: SYNAPSE was a randomised, double-blind, placebo-controlled, parallel-group, phase 3 trial done at 93 centres, mainly hospitals, in...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 29, Issue Suppl 1, 16 3 2021, Pages 35-44
Effect of anticoagulant therapy in COVID-19 patients.
Tieleman RG, Klok FA, Belfroid E, Hoogervorst-Schilp J, Schalkers I, Jansen CW, Siebelink HJ
Background: In patients hospitalised with COVID-19, an increased incidence of thromboembolic events, such as pulmonary embolism, deep vein thrombosis and stroke, has been reported. It is unknown whether anticoagulation can prevent these complications and improve outcome. Methods: A systematic literature search was performed to answer the question: What is the effect of (prophylactic and therapeutic dose) anticoagulation therapy in COVID-19 patients on cardiovascular and thromboembolic complicati...
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 29, Issue Suppl 1, 15 3 2021, Pages 2-4
Four guidelines on cardiovascular complications and cardiovascular disease, prognosis and treatment in COVID‑19.
Siebelink HJ, Jansen CW, Belfroid E, Hoogervorst-Schilp J
Abstract
Cited 5 times since 2021 (1.2 per year)
source: EuropePMC
Thorax,
Volume 76, Issue 11, 15 3 2021, Pages 1150-1153
Genetic polymorphism in <i>ATIC</i> is associated with effectiveness and toxicity of pemetrexed in non-small-cell lung cancer.
Visser S, Koolen S, van Donk N, van Walree N, van der Leest C, Cornelissen R, van Schaik R, Mathijssen R, Aerts J, Stricker BH
Patients with advanced non-small-cell lung cancer who are treated with pemetrexed display a wide variation in clinical response and toxicity. In this prospective, multicentre cohort study, we investigated the association with treatment effectiveness and toxicity of 10 polymorphisms in nine candidate genes, covering the folate pathway (MTHFR), cell transport (SLC19A1/ABCC2/ABCC4), intracellular metabolism (FPGS/GGH) and target enzymes (TYMS/DHFR/ATIC) of pemetrexed. Adjusted for sex, ECOG perform...
Abstract
Cited 1 times since 2021 (0.2 per year)
source: EuropePMC
Journal of dairy science,
Volume 104, Issue 6, 15 3 2021, Pages 7000-7007
Possible causes of aberrations in adverse grouping behavior of dairy cows: A field study.
van Schaik G, Seinen P, Muskens J, van Erp T, Keurentjes J, Huss A, Kromhout H
In the Dutch national surveillance system, an increasing number of reports were received in the summer of 2017 from farmers about unusual behavior of their cows. The cows were grouping during the day in summer in one part of the barn and did not move for several hours, which, according to the farmers, led to reduced food and water intake and lying time and resulted in decreased milk production and increased risk of lameness. Many farmers perceived magnetic fields from, for instance, high-voltage...
Abstract
Cited 3 times since 2021 (0.7 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 14, Issue 6, 14 2 2021, Pages 1110-1112
Valve Strain: A Further Step Toward a Full Understanding of Mitral Valve Function and Dysfunction.
Marsan NA, van Wijngaarden AL
Abstract
Cited 3 times since 2021 (0.7 per year)
source: EuropePMC
European heart journal. Case reports,
Volume 5, Issue 4, 12 2 2021, Pages ytab068
Failing systemic right ventricle in a patient with dextrocardia and complex congenitally corrected transposition of the great arteries: a case report of successful transvenous cardiac resynchronization therapy.
Nederend M, van Erven L, Zeppenfeld K, Vliegen HW, Egorova AD
Background: Patients with congenitally corrected transposition of the great arteries (ccTGA) are prone to the development of advanced atrio-ventricular block requiring chronic ventricular pacing. The morphological right ventricle (RV) often develops systolic dysfunction as it is unable to withstand the chronic pressure overload it is exposed to when supporting the systemic circulation. Case summary: A 56-year-old woman with dextrocardia and complex ccTGA with a history of dual-chamber implantabl...
Abstract
Cited 113 times since 2021 (27.3 per year)
source: EuropePMC
Molecular cell,
Volume 81, Issue 10, 12 2 2021, Pages 2216-2230.e10
Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance.
Schep R, Brinkman EK, Leemans C, Vergara X, van der Weide RH, Morris B, van Schaik T, Manzo SG, Peric-Hupkes D, van den Berg J, Beijersbergen RL, Medema RH, van Steensel B
DNA double-strand break (DSB) repair is mediated by multiple pathways. It is thought that the local chromatin context affects the pathway choice, but the underlying principles are poorly understood. Using a multiplexed reporter assay in combination with Cas9 cutting, we systematically measure the relative activities of three DSB repair pathways as a function of chromatin context in >1,000 genomic locations. This reveals that non-homologous end-joining (NHEJ) is broadly biased toward euchromat...
Abstract
Cited 20 times since 2021 (4.8 per year)
source: EuropePMC
Frontiers in pharmacology,
Volume 12, 12 2 2021, Pages 640032
Policy and Practice Review: A First Guideline on the Use of Pharmacogenetics in Clinical Psychiatric Practice.
van Westrhenen R, van Schaik RHN, van Gelder T, Birkenhager TK, Bakker PR, Houwink EJF, Bet PM, Hoogendijk WJG, van Weelden-Hulshof MJM
Effective pharmacologic treatments for psychiatric disorders are available, but their effect is limited due to patients' genetic heterogeneity and low compliance-related to frequent adverse events. Only one third of patients respond to treatment and experience remission. Pharmacogenetics is a relatively young field which focusses on genetic analyses in the context of the metabolism and outcome of drug treatment. These genetic factors can, among other things, lead to differences in the activ...
Abstract
