7971 results
Cited 27 times since 2019 (5 per year)
source: EuropePMC
Scientific reports,
Volume 9, Issue 1, 24 4 2019, Pages 19788
Silicon and salicylic acid confer high-pH stress tolerance in tomato seedlings.
Khan A, Kamran M, Imran M, Al-Harrasi A, Al-Rawahi A, Al-Amri I, Lee IJ, Khan AL
Alkalinity is a known threat to crop plant growth and production, yet the role of exogenous silicon (Si) and salicylic acid (SA) application has been largely unexplored. Here, we sought to understand the beneficial impacts of Si and SA on tomato seedlings during high-pH (9.0) stress. Results showed that Si- and SA-treated plants displayed higher biomass, chlorophyll contents, relative leaf water and better root system than none-treated plants under alkaline conditions. Both Si and SA counteracte...
Abstract
Cited 71 times since 2019 (13.1 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 9, Issue 1, 24 4 2019, Pages e013841
Association Between Blood Pressure Variability and Cerebral Small-Vessel Disease: A Systematic Review and Meta-Analysis.
Tully PJ, Yano Y, Launer LJ, Kario K, Nagai M, Mooijaart SP, Claassen JAHR, Lattanzi S, Vincent AD, Tzourio C, Variability in Blood Pressure and Brain Health Consortium †, Variability in Blood Pressure and Brain Health Consortium†
Background Research links blood pressure variability (BPV) with stroke; however, the association with cerebral small-vessel disease (CSVD) remains unclear. As BPV and mean blood pressure are interrelated, it remains uncertain whether BPV adds additional information to understanding cerebrovascular morphological characteristics. Methods and Results A systematic review was performed from inception until March 3, 2019. Eligibility criteria included population, adults without stroke (
Abstract
Cited 19 times since 2019 (3.5 per year)
source: EuropePMC
European journal of heart failure,
Volume 22, Issue 2, 20 3 2019, Pages 330-337
Impact of aspirin on takotsubo syndrome: a propensity score-based analysis of the InterTAK Registry.
D'Ascenzo F, Gili S, Bertaina M, Iannaccone M, Cammann VL, Di Vece D, Kato K, Saglietto A, Szawan KA, Frangieh AH, Boffini B, Annaratone M, Sarcon A, Levinson RA, Franke J, Napp LC, Jaguszewski M, Noutsias M, Münzel T, Knorr M, Heiner S, Katus HA, Burgdorf C, Schunkert H, Thiele H, Bauersachs J, Tschöpe C, Pieske BM, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Hasenfuß G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Banning A, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Franz WM, Empen K, Felix SB, Delmas C, Lairez O, El-Battrawy I, Akin I, Borggrefe M, Horowitz JD, Kozel M, Tousek P, Widimský P, Gilyarova E, Shilova A, Gilyarov M, Biondi-Zoccai G, Winchester DE, Ukena C, Neuhaus M, Bax JJ, Prasad A, Di Mario C, Böhm M, Gasparini M, Ruschitzka F, Bossone E, Citro R, Rinaldi M, De Ferrari GM, Lüscher T, Ghadri JR, Templin C
Aims: The aim of the present study was to investigate the impact of aspirin on prognosis in takotsubo syndrome (TTS). Methods and results: Patients from the International Takotsubo (InterTAK) Registry were categorized into two groups based on aspirin prescription at discharge. A comparison of clinical outcomes between groups was performed using an adjusted analysis with propensity score (PS) stratification; results from the unadjusted analysis were also reported to note the effect of the PS adju...
Abstract
Cited 36 times since 2019 (6.6 per year)
source: EuropePMC
Medical education,
Volume 54, Issue 3, 20 3 2019, Pages 205-216
Conceptualising spaced learning in health professions education: A scoping review.
Versteeg M, Hendriks RA, Thomas A, Ommering BWC, Steendijk P
Objectives: To investigate the definitions and applications of 'spaced learning' and to propose future directions for advancing its study and practice in health professions education. Method: The authors searched five online databases for articles published on spaced learning in health professions education prior to February 2018. Two researchers independently screened articles for eligibility with set inclusion criteria. They extracted and analysed key data using both quantitative and...
Abstract
Cited 4 times since 2019 (0.7 per year)
source: EuropePMC
Forensic science international,
Volume 307, 19 3 2019, Pages 110102
Chemical attribution of the home-made explosive ETN - Part I: Liquid chromatography-mass spectrometry analysis of partially nitrated erythritol impurities.
Bezemer K, McLennan L, van Duin L, Kuijpers CJ, Koeberg M, van den Elshout J, van der Heijden A, Busby T, Yevdokimov A, Schoenmakers P, Smith J, Oxley J, van Asten A
Erythritol tetranitrate (ETN) was prepared independently by two research groups from the USA and the Netherlands. The partially nitrated impurities present in ETN were studied using liquid chromatography-mass spectrometry to address the ultimate challenge in forensic explosives investigations, i.e., providing chemical and tactical information on the production and origin of the explosive material found at a crime scene. Accurate quantification of the tri-nitrated byproduct erythritol trinitrate...
Abstract
Cited 2 times since 2019 (0.4 per year)
source: EuropePMC
Clinical case reports,
Volume 8, Issue 1, 17 3 2019, Pages 215-216
Caseous calcification of the mitral annulus assessed by multimodality imaging.
Sala ML, van Dijkman PRM, Kuijpers D
Physicians may not be familiar with caseous calcification of the mitral annulus. It can therefore easily be mistaken for other conditions including tumors. In the appropriate clinical context, by using multimodality imaging, a correct diagnosis can be made, and patient concern or even unnecessary surgery can be avoided.
Abstract
Cited 15 times since 2019 (2.8 per year)
source: EuropePMC
Travel medicine and infectious disease,
Volume 33, 17 3 2019, Pages 101547
Prevalence and risk factors for carriage of ESBL-producing Enterobacteriaceae in a population of Dutch travellers: A cross-sectional study.
Arcilla MS, Van Hattem JM, Bootsma MCJ, van Genderen PJJ, Goorhuis A, Grobusch MP, Klaassen CHW, Oude Lashof AM, Schultsz C, Stobberingh EE, de Jong MD, Penders J, Verbrugh HA, Melles DC
Background: We investigated prevalence and predictive factors for ESBL-E carriage in a population of mostly travellers prior to their travel (n = 2216). In addition, we examined ESBL genotype before travel and compared these to returning travellers. Method: A questionnaire and faecal sample were collected before travel, and a second faecal sample was collected immediately after travel. Faecal samples were analysed for ESBL-E, with genotypic characterization by PCR and sequencing. Risk factors fo...
Abstract
Cited 4 times since 2019 (0.7 per year)
source: EuropePMC
The Canadian journal of cardiology,
Volume 36, Issue 9, 17 3 2019, Pages 1525-1533
Myocardial Deformation in the Systemic Right Ventricle: Strain Imaging Improves Prediction of the Failing Heart.
Woudstra OI, van Dissel AC, van der Bom T, de Bruin-Bon RHACM, van Melle JP, van Dijk APJ, Vliegen HW, Mulder BJM, Tanck MWT, Meijboom FJ, Bouma BJ
Background: Predicting heart failure events in patients with a systemic right ventricle (sRV) due to transposition of the great arteries (TGA) is important for timely intensification of follow-up. This study assessed the value of strain compared with currently used parameters as predictor for heart failure-free survival in patients with sRV. Methods: In participants of a multicentre trial, speckle-tracking echocardiography (STE) was performed to assess global longitudinal strain (GLS), mechanica...
Abstract
Cited 39 times since 2019 (7.1 per year)
source: EuropePMC
Journal of lipid research,
Volume 61, Issue 3, 16 3 2019, Pages 365-375
Alirocumab, evinacumab, and atorvastatin triple therapy regresses plaque lesions and improves lesion composition in mice.
Pouwer MG, Pieterman EJ, Worms N, Keijzer N, Jukema JW, Gromada J, Gusarova V, Princen HMG
Atherosclerosis-related CVD causes nearly 20 million deaths annually. Most patients are treated after plaques develop, so therapies must regress existing lesions. Current therapies reduce plaque volume, but targeting all apoB-containing lipoproteins with intensive combinations that include alirocumab or evinacumab, monoclonal antibodies against cholesterol-regulating proprotein convertase subtilisin/kexin type 9 and angiopoietin-like protein 3, may provide more benefit. We investigated the effec...
Abstract
Cited 62 times since 2019 (11.3 per year)
source: EuropePMC
Arteriosclerosis, thrombosis, and vascular biology,
Volume 40, Issue 2, 12 2 2019, Pages 350-364
Shear Stress Regulation of Endothelial Glycocalyx Structure Is Determined by Glucobiosynthesis.
Wang G, Kostidis S, Tiemeier GL, Sol WMPJ, de Vries MR, Giera M, Carmeliet P, van den Berg BM, Rabelink TJ
Objective: Endothelial cells exposed to laminar shear stress express a thick glycocalyx on their surface that plays an important role in reducing vascular permeability and endothelial anti-inflammatory, antithrombotic, and antiangiogenic properties. Production and maintenance of this glycocalyx layer is dependent on cellular carbohydrate synthesis, but its regulation is still unknown. Approach and Results: Here, we show that biosynthesis of the major structural component of the endothelial glyco...
Abstract
Cited 24 times since 2019 (4.4 per year)
source: EuropePMC
Cardiovascular diabetology,
Volume 18, Issue 1, 12 2 2019, Pages 170
Visit-to-visit variability of glycemia and vascular complications: the Hoorn Diabetes Care System cohort.
Slieker RC, van der Heijden AAWH, Nijpels G, Elders PJM, 't Hart LM, Beulens JWJ
Background: Glycemic variation has been suggested to be a risk factor for diabetes-related complications. Previous studies did not address confounding of diabetes duration, number of visits and length of follow-up. Here, we characterize glycemic variability over time and whether its relation to diabetes-related complications and mortality is independent from diabetes- and follow-up duration. Materials and methods: Individuals with type 2 diabetes (n = 6770) from the Hoorn Diabetes Care System co...
Abstract
Cited 67 times since 2019 (12.3 per year)
source: EuropePMC
JACC. Heart failure,
Volume 8, Issue 2, 11 2 2019, Pages 131-140
Left Ventricular Post-Infarct Remodeling: Implications for Systolic Function Improvement and Outcomes in the Modern Era.
van der Bijl P, Abou R, Goedemans L, Gersh BJ, Holmes DR, Ajmone Marsan N, Delgado V, Bax JJ
Objectives: This study sought to investigate the impact of post-infarct left ventricular (LV) remodeling on outcomes in the contemporary era. Background: LV remodeling after ST-segment elevation myocardial infarction (STEMI) is associated with heart failure and increased mortality. Pivotal studies have mostly been performed in the era of thrombolysis, whereas the long-term prognostic impact of LV remodeling has not been reinvestigated in the current era of primary percutaneous coronary intervent...
Abstract
Cited 3 times since 2019 (0.5 per year)
source: EuropePMC
Aging,
Volume 11, Issue 23, 11 2 2019, Pages 10791-10792
PCSK9 inhibition in high-risk patients.
Zijlstra LE, Mooijaart SP, Jukema JW
Abstract
Cited 34 times since 2019 (6.2 per year)
source: EuropePMC
Neurology,
Volume 94, Issue 1, 11 2 2019, Pages e62-e74
Diagnostic accuracy of MRI and ultrasound in chronic immune-mediated neuropathies.
Oudeman J, Eftimov F, Strijkers GJ, Schneiders JJ, Roosendaal SD, Engbersen MP, Froeling M, Goedee HS, van Doorn PA, Caan MWA, van Schaik IN, Maas M, Nederveen AJ, de Visser M, Verhamme C
Objective: To assess and compare the diagnostic performance of qualitative and (semi-)quantitative MRI and ultrasound for distinguishing chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN) from segmental spinal muscular atrophy (sSMA). Methods: Patients with CIDP (n = 13), MMN (n = 10), or sSMA (n = 12) and healthy volunteers (n = 30) were included. MRI of the brachial plexus, using short tau inversion recovery (STIR), nerve-specific T2-weighted (magnet...
Abstract
Cited 5 times since 2019 (0.9 per year)
source: EuropePMC
Scientific reports,
Volume 9, Issue 1, 10 2 2019, Pages 18758
WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene.
Nersisyan L, Nikoghosyan M, Genome of the Netherlands consortium, Arakelyan A
Telomere length (TL) regulation is an important factor in ageing, reproduction and cancer development. Genetic, hereditary and environmental factors regulating TL are currently widely investigated, however, their relative contribution to TL variability is still understudied. We have used whole genome sequencing data of 250 family trios from the Genome of the Netherlands project to perform computational measurement of TL and a series of regression and genome-wide association analyses to reveal TL...
Abstract
Cited 84 times since 2019 (15.3 per year)
source: EuropePMC
Nature reviews. Cardiology,
Volume 17, Issue 5, 9 2 2019, Pages 298-312
Assessment of mitral valve regurgitation by cardiovascular magnetic resonance imaging.
Garg P, Swift AJ, Zhong L, Carlhäll CJ, Ebbers T, Westenberg J, Hope MD, Bucciarelli-Ducci C, Bax JJ, Myerson SG
Mitral regurgitation (MR) is a common valvular heart disease and is the second most frequent indication for heart valve surgery in Western countries. Echocardiography is the recommended first-line test for the assessment of valvular heart disease, but cardiovascular magnetic resonance imaging (CMR) provides complementary information, especially for assessing MR severity and to plan the timing of intervention. As new CMR techniques for the assessment of MR have arisen, standardizing CMR protocols...
Abstract
Cited 4 times since 2019 (0.7 per year)
source: EuropePMC
The pharmacogenomics journal,
Volume 20, Issue 3, 6 1 2019, Pages 482-493
Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry.
de las Fuentes L, Sung YJ, Sitlani CM, Avery CL, Bartz TM, Keyser C, Evans DS, Li X, Musani SK, Ruiter R, Smith AV, Sun F, Trompet S, Xu H, Arnett DK, Bis JC, Broeckel U, Busch EL, Chen YI, Correa A, Cummings SR, Floyd JS, Ford I, Guo X, Harris TB, Ikram MA, Lange L, Launer LJ, Reiner AP, Schwander K, Smith NL, Sotoodehnia N, Stewart JD, Stott DJ, Stürmer T, Taylor KD, Uitterlinden A, Vasan RS, Wiggins KL, Cupples LA, Gudnason V, Heckbert SR, Jukema JW, Liu Y, Psaty BM, Rao DC, Rotter JI, Stricker B, Wilson JG, Whitsel EA
Hypertension (HTN) is a significant risk factor for cardiovascular morbidity and mortality. Metabolic abnormalities, including adverse cholesterol and triglycerides (TG) profiles, are frequent comorbid findings with HTN and contribute to cardiovascular disease. Diuretics, which are used to treat HTN and heart failure, have been associated with worsening of fasting lipid concentrations. Genome-wide meta-analyses with 39,710 European-ancestry (EA) individuals and 9925 African-ancestry (AA) individ...
Abstract
Cited 14 times since 2019 (2.6 per year)
source: EuropePMC
Journal of cardiovascular computed tomography,
Volume 14, Issue 3, 5 1 2019, Pages 251-257
Coronary atherosclerosis scoring with semiquantitative CCTA risk scores for prediction of major adverse cardiac events: Propensity score-based analysis of diabetic and non-diabetic patients.
van den Hoogen IJ, van Rosendael AR, Lin FY, Lu Y, Dimitriu-Leen AC, Smit JM, Scholte AJHA, Achenbach S, Al-Mallah MH, Andreini D, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufmann PA, Kim YJ, Leipsic JA, Maffei E, Marques H, de Araújo Gonçalves P, Pontone G, Raff GL, Rubinshtein R, Villines TC, Gransar H, Jones EC, Peña JM, Shaw LJ, Min JK, Bax JJ
Aims: We aimed to compare semiquantitative coronary computed tomography angiography (CCTA) risk scores - which score presence, extent, composition, stenosis and/or location of coronary artery disease (CAD) - and their prognostic value between patients with and without diabetes mellitus (DM). Risk scores derived from general chest-pain populations are often challenging to apply in DM patients, because of numerous confounders. Methods: Out of a combined cohort from the Leiden University Medical Ce...
Abstract
Cited 16 times since 2019 (2.9 per year)
source: EuropePMC
The pharmacogenomics journal,
Volume 20, Issue 3, 5 1 2019, Pages 462-470
Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study.
Smit RAJ, Trompet S, Leong A, Goodarzi MO, Postmus I, Warren H, Theusch E, Barnes MR, Arsenault BJ, Li X, Feng Q, Chasman DI, Cupples LA, Hitman GA, Krauss RM, Psaty BM, Rotter JI, Cessie SL, Stein CM, Jukema JW, GIST consortium
It remains unclear whether the increased risk of new-onset type 2 diabetes (T2D) seen in statin users is due to low LDL-C concentrations, or due to the statin-induced proportional change in LDL-C. In addition, genetic instruments have not been proposed before to examine whether liability to T2D might cause greater proportional statin-induced LDL-C lowering. Using summary-level statistics from the Genomic Investigation of Statin Therapy (GIST, nmax = 40,914) and DIAGRAM (nmax = 159,208) consortia...
Abstract
Cited 15 times since 2019 (2.7 per year)
source: EuropePMC
Hypertension (Dallas, Tex. : 1979),
Volume 75, Issue 1, 2 1 2019, Pages 59-70
Influence of Dietary Approaches to Stop Hypertension-Type Diet, Known Genetic Variants and Their Interplay on Blood Pressure in Early Childhood: ABCD Study.
Zafarmand MH, Spanjer M, Nicolaou M, Wijnhoven HAH, van Schaik BDC, Uitterlinden AG, Snieder H, Vrijkotte TGM
There is limited evidence on association between adherence to the Dietary Approaches to Stop Hypertension (DASH diet) and a lower blood pressure (BP) in children. In a population-based cohort study, among 1068 Dutch children aged 5 to 7, we evaluated the association between a DASH-type diet, 29 known genetic variants incorporated in a genetic risk score, and their interaction on BP. We calculated DASH score based on the food intake data measured through a validated 71-item food frequency questio...
Abstract
