6125 results
Cited 2 times since 2002 (0.1 per year)
source: EuropePMC
Nederlands tijdschrift voor geneeskunde,
Volume 146, Issue 10, 1 1 2002, Pages 473-477
[Surgery and referral for subsequent 131I therapy for patients with differentiated thyroid carcinoma in the south-east of the Netherlands, 1983-1996, compared to the consensus guidelines from 1987].
Kuijpens JL, Hoekstra OS, Hamming JF, Haak HR, Ribot JG, Coebergh JW
Objective: To evaluate the treatment of patients with differentiated (papillary or follicular) thyroid cancer in general hospitals in the south-east of the Netherlands during the period 1983-1996, in relation to the 1987 national consensus recommendations. Design: Population-based, retrospective, descriptive. Method: For the period 1 January 1983-31 December 1996, data on the histology, TNM-stage and treatment (hospital, specialist, type of operation, referral for 131I therapy) of all 236 patien...
Abstract
Cited 21 times since 2002 (0.9 per year)
source: EuropePMC
British journal of cancer,
Volume 86, Issue 5, 1 1 2002, Pages 811-818
A fully human anti-Ep-CAM scFv-beta-glucuronidase fusion protein for selective chemotherapy with a glucuronide prodrug.
de Graaf M, Boven E, Oosterhoff D, van der Meulen-Muileman IH, Huls GA, Gerritsen WR, Haisma HJ, Pinedo HM
Monoclonal antibodies against tumour-associated antigens could be useful to deliver enzymes selectively to the site of a tumour for activation of a non-toxic prodrug. A completely human fusion protein may be advantageous for repeated administration, as host immune responses may be avoided. We have constructed a fusion protein consisting of a human single chain Fv antibody, C28, against the epithelial cell adhesion molecule and the human enzyme beta-glucuronidase. The sequences encoding C28 and h...
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 10, Issue 3, 1 1 2002, Pages 109-110
Vitamins C. E and β-carotene fired and statins for president?
Jukema JW, Liem AH
Abstract
Cited 6 times since 2002 (0.3 per year)
source: EuropePMC
European journal of nuclear medicine and molecular imaging,
Volume 29, Issue 4, 19 3 2002, Pages 452-457
Feasibility, safety and image quality of cardiac FDG studies during hyperinsulinaemic-euglycaemic clamping.
Bax JJ, Visser FC, Poldermans D, van Lingen A, Elhendy A, Boersma E, Visser CA
Fluorine-18 fluorodeoxyglucose (FDG) imaging for the assessment of myocardial viability has become an integral part of the diagnostic and prognostic work-up of patients with ischaemic cardiomyopathy. To ensure good image quality, in particular in patients with diabetes mellitus, hyperinsulinaemic-euglycaemic clamping has been proposed. In this study we evaluated the safety and the image quality of cardiac FDG imaging during clamping in a large group of patients, including a subgroup with diabete...
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 10, Issue 2, 1 1 2002, Pages 101-103
Einthoven meeting 2002: 9-11 June, Leiden.
Schalij MJ, Van der Wall EE
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 10, Issue 2, 1 1 2002, Pages 43-47
Rhythmic sensory stimulation improves fitness by conditioning the autonomic nervous system.
Frederiks J, Swenne CA, Ghafoerkhan A, Lalmahomed H, Maan AC, Schalij MJ, Bruschke AV, van der Wall EE
Background: Endurance training is known to alter the functioning of the autonomic nervous system, a major goal when pursuing fitness. Here, we test the hypothesis that the training-associated rhythmic sensations alone, hence without the usual accompanying physical exercise, accomplish this effect. Method: We studied sixteen resting healthy male volunteers, age (mean±SD) 25.9±3.7 years. During one hour we applied, at marching pace (2 bursts per second), bipolar transcutaneous electrical sensory n...
Abstract
Cited 15 times since 2002 (0.6 per year)
source: EuropePMC
British journal of cancer,
Volume 86, Issue 3, 1 1 2002, Pages 436-442
Prerequisites for effective adenovirus mediated gene therapy of colorectal liver metastases in the rat using an intracellular neutralizing antibody fragment to p21-Ras.
van Etten B, ten Hagen TL, de Vries MR, Ambagtsheer G, Huet T, Eggermont AM
Ras mutations are present in 40-50% of colorectal cancers. Inactivating this oncogene may therefore reduce proliferation capacity. In order to target ras we studied the transduction efficacy and anti tumour activity of an adenoviral vector expressing an intracellular, neutralizing single chain antibody to p21-ras (Y28). In in vitro studies transfection levels of the K-ras mutated rat colon carcinoma cell line CC531 were studied using the LacZ marker gene. In our in vivo liver metastases model di...
Abstract
Cited 12 times since 2002 (0.5 per year)
source: EuropePMC
Cardiovascular surgery (London, England),
Volume 10, Issue 1, 1 1 2002, Pages 62-64
Organized thrombus in the ascending aorta originating from the ostium of the right coronary artery.
Shahin GM, Bosker HA, Knaepen PJ, Morshuis WJ, Lindeboom JE
This case report describes the rare finding of a pedunculate thrombus in the ascending aorta originating from the ostium of the right coronary artery (RCA) detected after an inferior wall myocardial infarction in a young female. The thrombus was removed surgically during an emergency cardiopulmonary bypass procedure
Abstract
Cited 1 times since 2002 (0 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 73, Issue 2, 1 1 2002, Pages 699
Double-inlet left ventricle: successfully staged ventricular septation with 12.5 years follow-up.
Ottenkamp J, Hazekamp MG
Abstract
Cited 4 times since 2002 (0.2 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 123, Issue 2, 1 1 2002, Pages 348-349
Quadricuspid aortic valve in transposition of the great arteries.
Portela FA, Hazekamp MG, Bartelings MM, Gittenberger-De Groot AC
Abstract
Cited 84 times since 2002 (3.6 per year)
source: EuropePMC
Circulation,
Volume 105, Issue 6, 1 1 2002, Pages 702-706
Cardiac autonomic dysfunction in Brugada syndrome.
Wichter T, Matheja P, Eckardt L, Kies P, Schäfers K, Schulze-Bahr E, Haverkamp W, Borggrefe M, Schober O, Breithardt G, Schäfers M
Background: Patients with Brugada syndrome present with characteristic ECG abnormalities (atypical right bundle-branch block and ST-segment elevation) and life-threatening ventricular tachyarrhythmias despite structurally normal hearts. Involvement of the autonomic nervous system is suggested by the occurrence of ventricular tachyarrhythmias and sudden death at rest or during sleep and by changes of typical ECG signs under pharmacological modulation of the myocardial autonomic tone. Methods and...
Abstract
Cited 67 times since 2002 (2.9 per year)
source: EuropePMC
Clinical genetics,
Volume 61, Issue 2, 1 1 2002, Pages 115-125
ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels.
Zwarts KY, Clee SM, Zwinderman AH, Engert JC, Singaraja R, Loubser O, James E, Roomp K, Hudson TJ, Jukema JW, Kastelein JJ, Hayden MR
The authors have previously shown that individuals heterozygous for ABCA1 mutations have decreased high density lipoprotein cholesterol, increased triglycerides and an increased frequency of coronary artery disease (CAD), and that single nucleotide polymorphisms (SNPs) in the coding region of the ABCA1 gene significantly impact plasma lipid levels and the severity of CAD in the general population. They have now identified several SNPs in non-coding regions of ABCA1 which may be important for the...
Abstract
Cited 5 times since 2002 (0.2 per year)
source: EuropePMC
Cardiovascular and interventional radiology,
Volume 25, Issue 1, 17 3 2002, Pages 72-73
Successful emergency stenting of acute ruptured false iliac aneurysm.
Bierdrager E, Lohle PN, Schoemaker CM, Lampmann LE, van Berge Henegouwen DP, Hamming JF
A 75-year-old man complaining of acute abdominal pain, 1 month after elective surgical repair of an abdominal aortic aneurysm by an aortabi-iliac bypass graft, was referred and admitted to the emergency room. Imaging by sonography and computed tomography scan revealed a ruptured iliac pseudoaneurysm at the right iliac anastomotic site with associated large retroperitoneal hematoma. We inserted a self-expanding covered Z-stent graft by a transfemoral approach and the iliac anastomotic pseudoaneur...
Abstract
Cited 25 times since 2002 (1.1 per year)
source: EuropePMC
Radiology,
Volume 222, Issue 1, 1 1 2002, Pages 127-135
MR flow mapping in coronary artery bypass grafts: a validation study with Doppler flow measurements.
Langerak SE, Kunz P, Vliegen HW, Jukema JW, Zwinderman AH, Steendijk P, Lamb HJ, van der Wall EE, de Roos A
Purpose: To validate fast magnetic resonance (MR) flow mapping with intravascular Doppler flow measurements in vitro and in patients with nonstenotic and stenotic coronary artery bypass grafts. Materials and methods: MR and Doppler flow measurements were performed in a small-diameter flow phantom with physiologic flow conditions and at baseline and during adenosine stress in 27 grafts in 23 patients, who were scheduled for cardiac catheterization. At invasive analysis, the grafts were divided in...
Abstract
Cited 75 times since 2002 (3.2 per year)
source: EuropePMC
Circulation,
Volume 105, Issue 3, 1 1 2002, Pages 328-333
Detection of vein graft disease using high-resolution magnetic resonance angiography.
Langerak SE, Vliegen HW, de Roos A, Zwinderman AH, Jukema JW, Kunz P, Lamb HJ, van Der Wall EE
Background: The application of previous magnetic resonance (MR) angiography techniques has enabled noninvasive differentiation between patent and occluded coronary artery bypass grafts. However, the detection of graft stenosis remains difficult. The purpose of our study was to determine the accuracy of high-resolution navigator-gated 3-dimensional (3-D) MR angiography in detecting vein graft disease. Methods and Results- MR angiography was performed in addition to coronary angiography with quant...
Abstract
Cited 5 times since 2002 (0.2 per year)
source: EuropePMC
Methods in molecular biology (Clifton, N.J.),
Volume 178, 1 1 2002, Pages 379-387
Expression of scFvs and scFv fusion proteins in eukaryotic cells.
de Graaf M, van der Meulen-Muileman IH, Pinedo HM, Haisma HJ
Abstract
Cited 58 times since 2002 (2.5 per year)
source: EuropePMC
Current pharmaceutical design,
Volume 8, Issue 15, 1 1 2002, Pages 1391-1403
Beta-glucuronidase-mediated drug release.
de Graaf M, Boven E, Scheeren HW, Haisma HJ, Pinedo HM
The selective activation of a relatively non-toxic prodrug by an enzyme present only in the tumour should enhance the drug concentration at the tumour site and result in a better anti-tumour effect and a reduction in systemic toxicity as compared to conventional chemotherapy. beta-Glucuronidase is such an enzyme. It is normally expressed in the lysosomes of cells. In larger tumours, however, high levels of the enzyme are present in necrotic areas. Several glucuronide prodrugs have been synthesis...
Abstract
Cited 5 times since 2002 (0.2 per year)
source: EuropePMC
Journal of cardiovascular pharmacology,
Volume 39, Issue 1, 1 1 2002, Pages 61-72
Calcium sensitizer EMD 57033, but not the beta1-adrenoreceptor agonist dobutamine, increases mechanical efficiency in stunned myocardium.
Trines SA, Smits CA, van der Moer J, Slager CJ, Verdouw PD, Krams R
External work, efficiency of energy transfer (EET), and mechanical efficiency (defined as the ratio of external work over myocardial oxygen consumption (MVO2) are reduced in stunned myocardium. We therefore evaluated how inotropic stimulation by dobutamine and the calcium sensitizer EMD 57033 affected the regional stress-strain relationship as, from which contractility (E(es)), external work at the working point (EWwp), maximal external work (EWmax), EETwp (%), and EETmax are determined. Thirty...
Abstract
Cited 10 times since 2002 (0.4 per year)
source: EuropePMC
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance,
Volume 4, Issue 3, 1 1 2002, Pages 353-357
Noninvasive and invasive evaluation of noncompaction cardiomyopathy.
Bax JJ, Atsma DE, Lamb HJ, Rebergen SA, Bootsma M, Voogd PJ, Somer S, Schalij MJ, de Roos A, van der Wall EE
Noncompaction cardiomyopathy is a recently described rare congenital cardiomyopathy; patients can be asymptomatic or develop diastolic and/or systolic left ventricular dysfunction with heart failure, systemic emboli or ventricular arrhythmias. Long-term prognosis is poor. Currently, diagnosis is based on findings on 2D echocardiography; in the current case report we demonstrate the use of MRI to diagnose noncompaction cardiomyopathy.
Abstract
Cited 11 times since 2002 (0.5 per year)
source: EuropePMC
Journal of pediatric surgery,
Volume 37, Issue 1, 1 1 2002, Pages 80-82
Evaluation of the location of the anus by a modified technique in the neonate.
Genç A, Taneli C, Tansuğ N, Kasirga E, Yilmaz D, Küçükoğlu T, Onağ A
Purpose: The aim of the current study was to bring to notice the anterior displacement of the anus and to recommend the measurement of anal position index in the neonate by a modified method. Methods: Sixty newborns (34 girls and 26 boys) were taken into study, and the anal position index (API), which is the ratio of anus-fourchette (scrotum) distance to coccyx fourchette (scrotum) distance, was measured. To obtain the measurement, a transparent adhesive tape was placed along the midline on the...
Abstract
