9374 results
Cited 155 times since 2012 (11.7 per year)
source: EuropePMC
PLoS genetics,
Volume 8, Issue 3, 29 5 2012, Pages e1002584
Genome-wide association and functional follow-up reveals new loci for kidney function.
Pattaro C, Köttgen A, Teumer A, Garnaas M, Böger CA, Fuchsberger C, Olden M, Chen MH, Tin A, Taliun D, Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster MC, O'Seaghdha CM, Glazer N, Isaacs A, Liu CT, Smith AV, O'Connell JR, Struchalin M, Tanaka T, Li G, Johnson AD, Gierman HJ, Feitosa M, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Johansson Å, Tönjes A, Dehghan A, Chouraki V, Holliday EG, Sorice R, Kutalik Z, Lehtimäki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Kollerits B, Pistis G, CARDIoGRAM Consortium, ICBP Consortium, CARe Consortium, Wellcome Trust Case Control Consortium 2 (WTCCC2), Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Cavalieri M, Rao M, Hu FB, Demirkan A, Oostra BA, de Andrade M, Turner ST, Ding J, Andrews JS, Freedman BI, Koenig W, Illig T, Döring A, Wichmann HE, Kolcic I, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nöthlings U, Jacobs G, Biffar R, Endlic
Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80. Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte...
Abstract
Cited 28 times since 2012 (2.1 per year)
source: EuropePMC
The Journal of infectious diseases,
Volume 205, Issue 10, 28 4 2012, Pages 1539-1543
Latent acyclovir-resistant herpes simplex virus type 1 in trigeminal ganglia of immunocompetent individuals.
van Velzen M, van Loenen FB, Meesters RJ, de Graaf M, Remeijer L, Luider TM, Osterhaus AD, Verjans GM
Specific mutations within the hypervariable herpes simplex virus (HSV) gene thymidine kinase (TK) gene lead to acyclovir (ACV) resistance. To uncover the existence of latent ACV-resistant (ACV(R)) HSV-1, we determined the genetic and functional variability of the HSV-1 TK gene pool in paired trigeminal ganglia (TG) of 5 immunocompetent individuals. The latent virus pool consisted of a donor-specific HSV-1 quasispecies, including one major ACV-sensitive (ACV(S)) and multiple phylogenetic-related...
Abstract
Cited 11 times since 2012 (0.8 per year)
source: EuropePMC
Journal of internal medicine,
Volume 271, Issue 6, 26 4 2012, Pages 521-536
Management of acute coronary syndrome: achievements and goals still to pursue. Novel developments in diagnosis and treatment.
Boden H, van der Hoeven BL, Karalis I, Schalij MJ, Jukema JW
Acute coronary syndromes contribute a substantial part of the global disease burden. To realize a reduction in mortality and morbidity, the management of patients with these conditions involves the integration of several different approaches. Timely delivery of appropriate care is a key factor, as the beneficial effect of reperfusion is greatest when performed as soon as possible. Innovations in antithrombotic therapy have also contributed significantly to improvements in the prevention of ischa...
Abstract
Cited 62 times since 2012 (4.7 per year)
source: EuropePMC
Molecular genetics and metabolism,
Volume 106, Issue 2, 24 4 2012, Pages 135-141
Small fiber neuropathy in Fabry disease.
Biegstraaten M, Hollak CE, Bakkers M, Faber CG, Aerts JM, van Schaik IN
Previous studies have explicitly shown that small nerve fibers are affected in Fabry disease which is assumed to cause the severe neuropathic pain that patients may have from childhood on. Neuropathic pain and small fiber neuropathy characteristics have therefore been considered as appropriate study endpoints in studies on the efficacy of enzyme replacement therapy. However, the relationship between small fiber neuropathy characteristics and pain, as well as the course of small fiber neuropathy...
Abstract
Cited 83 times since 2012 (6.3 per year)
source: EuropePMC
The American journal of cardiology,
Volume 109, Issue 11, 23 4 2012, Pages 1657-1663
Social burden and lifestyle in adults with congenital heart disease.
Zomer AC, Vaartjes I, Uiterwaal CS, van der Velde ET, Sieswerda GJ, Wajon EM, Plomp K, van Bergen PF, Verheugt CL, Krivka E, de Vries CJ, Lok DJ, Grobbee DE, Mulder BJ
We aimed to evaluate how the presence and severity of congenital heart disease (CHD) influence social life and lifestyle in adult patients. A random sample (n = 1,496) from the CONgenital CORvitia (n = 11,047), the Dutch national registry of adult patients with CHD, completed a questionnaire on educational attainment, employment and marital statuses, and lifestyle (response 76%). The Utrecht Health Project provided a large reference group (n = 6,810) of unaffected subjects. Logistic regression m...
Abstract
Cited 1 times since 2012 (0.1 per year)
source: EuropePMC
Early human development,
Volume 88, Issue 9, 22 4 2012, Pages 711-716
Genetic variants associated with adult blood pressure and kidney function do not affect fetal kidney volume. The Generation R Study.
Taal HR, van den Hil LC, Hofman A, van der Heijden AJ, Jaddoe VW
Background: Smaller kidneys with reduced number of nephrons in early life lead to impaired kidney function and risk for hypertension and chronic kidney disease. These associations might be partly explained by common genetic variation. Aims: To assess the associations between common genetic variants, which have recently shown to be associated with blood pressure or kidney function, with fetal kidney volume. Study design: A prospective population based cohort study in Rotterdam, The Netherlands. S...
Abstract
Cited 9 times since 2012 (0.7 per year)
source: EuropePMC
The American journal of cardiology,
Volume 109, Issue 12, 22 4 2012, Pages 1792-1796
Relation of prolonged tissue Doppler imaging-derived atrial conduction time to atrial arrhythmia in adult patients with congenital heart disease.
van der Hulst AE, Roest AA, Holman ER, Vliegen HW, Hazekamp MG, Bax JJ, Blom NA, Delgado V
Atrial arrhythmia (AA) is common in adult patients with congenital heart disease (CHD). To enable the prevention of AA or its complications, timely identification of adult patients with CHD at risk of AA is crucial. Long total atrial activation times have been related to AA. Tissue Doppler imaging (TDI) permits noninvasive evaluation of the total atrial conduction time (PA-TDI duration). The present study evaluated the association between the PA-TDI duration and the development of AA in adult pa...
Abstract
Cited 28 times since 2012 (2.1 per year)
source: EuropePMC
International psychogeriatrics,
Volume 24, Issue 8, 22 4 2012, Pages 1242-1251
Contradictory effects for prevention of depression and anxiety in residents in homes for the elderly: a pragmatic randomized controlled trial.
Dozeman E, van Marwijk HW, van Schaik DJ, Smit F, Stek ML, van der Horst HE, Bohlmeijer ET, Beekman AT
Background: The aim of this study was to evaluate the effectiveness of a stepped-care program to prevent the onset of depression and anxiety disorders in elderly people living in residential homes. Methods: A pragmatic randomized controlled trial was conducted to compare the intervention with usual care in 14 residential homes in the Netherlands. A total of 185 residents with a minimum score of 8 on the Centre for Epidemiologic Studies Depression Scale, who did not meet the diagnostic criteria f...
Abstract
Cited 64 times since 2012 (4.8 per year)
source: EuropePMC
Neurology,
Volume 78, Issue 14, 21 3 2012, Pages 1079-1084
Long-term remission of CIDP after pulsed dexamethasone or short-term prednisolone treatment.
Eftimov F, Vermeulen M, van Doorn PA, Brusse E, van Schaik IN, PREDICT
Objective: Achieving long-term remission after a limited more intense treatment period would prevent prolonged use of corticosteroids or IV immunoglobulin (IVIg) in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). In this prospective cohort study we present long-term follow-up data on patients included in a multicenter randomized controlled trial comparing 6 monthly pulses of dexamethasone with 8 months of daily prednisolone. Methods: Treatment effect was assessed with the Infla...
Abstract
Cited 3 times since 2012 (0.2 per year)
source: EuropePMC
The American journal of cardiology,
Volume 109, Issue 12, 20 3 2012, Pages 1738-1742
Comparison of lipid profiles and attainment of lipid goals in patients <65 years versus patients ≥65 years (from the Lipid Treatment Assessment Project [L-TAP] 2).
Rodriguez F, Santos RD, Messig M, Tarasenko L, Ferrières J, Jukema JW, Chiang CW, Waters DD, Foody JM, L-TAP 2 Investigators
There is a well-established link between dyslipidemia and cardiovascular events, although this risk is modified by age. Little is known about how treatment of dyslipidemia and low-density lipoprotein (LDL) cholesterol goal attainment differ between older and younger patients. We obtained clinical data from 9,926 dyslipidemic patients across 9 countries in North and Latin America, Europe, and Asia from 2006 through 2007. Multivariate regressions were performed to determine predictors of lipid lev...
Abstract
Cited 9 times since 2012 (0.7 per year)
source: EuropePMC
Advances in health sciences education : theory and practice,
Volume 18, Issue 2, 15 3 2012, Pages 181-192
Understanding self-assessment as an informed process: residents' use of external information for self-assessment of performance in simulated resuscitations.
Plant JL, Corden M, Mourad M, O'Brien BC, van Schaik SM
Self-directed learning requires self-assessment of learning needs and performance, a complex process that requires collecting and interpreting data from various sources. Learners' approaches to self-assessment likely vary depending on the learner and the context. The aim of this study was to gain insight into how learners process external information and apply their interpretation of this information to their self-assessment and learning during a structured educational activity. The study c...
Abstract
Cited 741 times since 2012 (55.7 per year)
source: EuropePMC
Lancet (London, England),
Volume 379, Issue 9822, 14 2 2012, Pages 1214-1224
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.
Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium, Swerdlow DI, Holmes MV, Kuchenbaecker KB, Engmann JE, Shah T, Sofat R, Sofat R, Guo Y, Chung C, Peasey A, Pfister R, Mooijaart SP, Ireland HA, Leusink M, Langenberg C, Li KW, Palmen J, Howard P, Cooper JA, Drenos F, Hardy J, Nalls MA, Li YR, Lowe G, Stewart M, Bielinski SJ, Peto J, Timpson NJ, Gallacher J, Dunlop M, Houlston R, Tomlinson I, Tzoulaki I, Luan J, Boer JM, Forouhi NG, Onland-Moret NC, van der Schouw YT, Schnabel RB, Hubacek JA, Kubinova R, Baceviciene M, Tamosiunas A, Pajak A, Topor-Madry R, Malyutina S, Baldassarre D, Sennblad B, Tremoli E, de Faire U, Ferrucci L, Bandenelli S, Tanaka T, Meschia JF, Singleton A, Navis G, Mateo Leach I, Bakker SJ, Gansevoort RT, Ford I, Epstein SE, Burnett MS, Devaney JM, Jukema JW, Westendorp RG, Jan de Borst G, van der Graaf Y, de Jong PA, Mailand-van der Zee AH, Klungel OH, de Boer A, Doevendans PA, Stephens JW, Eaton CB, Robinson JG, Manson JE, Fowkes FG, Frayling TM, Price JF, Whin
Background: A high circulating concentration of interleukin 6 is associated with increased risk of coronary heart disease. Blockade of the interleukin-6 receptor (IL6R) with a monoclonal antibody (tocilizumab) licensed for treatment of rheumatoid arthritis reduces systemic and articular inflammation. However, whether IL6R blockade also reduces risk of coronary heart disease is unknown. Methods: Applying the mendelian randomisation principle, we used single nucleotide polymorphisms (SNPs) in the...
Abstract
Cited 17 times since 2012 (1.3 per year)
source: EuropePMC
European journal of cardiovascular nursing,
Volume 11, Issue 3, 13 2 2012, Pages 349-355
Patients with a congenital heart defect and type D personality feel functionally more impaired, report a poorer health status and quality of life, but use less healthcare.
Schoormans D, Mulder BJ, van Melle JP, Pieper EG, van Dijk AP, Sieswerda GJ, Hulsbergen-Zwarts MS, Plokker TH, Brunninkhuis LG, Vliegen HW, Sprangers MA
Background: Type D personality, characterized by high levels of negative affectivity and social inhibition, is related to mortality, morbidity, poor health status, quality of life (QoL) and less healthcare utilization in various cardiovascular patient groups. To date, studies in patients with congenital heart disease (CHD) are lacking. Aims: (1) To examine the prevalence of type D personality in CHD patients; (2) to compare type D to non-type D patients with regard to disease severity, functiona...
Abstract
Cited 99 times since 2012 (7.4 per year)
source: EuropePMC
Circulation. Cardiovascular imaging,
Volume 5, Issue 3, 12 2 2012, Pages 383-391
Global longitudinal strain predicts long-term survival in patients with chronic ischemic cardiomyopathy.
Bertini M, Ng AC, Antoni ML, Nucifora G, Ewe SH, Auger D, Marsan NA, Schalij MJ, Bax JJ, Delgado V
Background: Left ventricular (LV) global longitudinal strain (GLS) is a measure of the active shortening of the LV in the longitudinal direction, which can be assessed with speckle-tracking echocardiography. The aims of this evaluation were to validate the prognostic value of GLS as a new index of LV systolic function in a large cohort of patients with chronic ischemic cardiomyopathy and to determine the incremental value of GLS to predict long-term outcome over other strong and well-established...
Abstract
Cited 11 times since 2012 (0.8 per year)
source: Scopus
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 41, Issue 5, 9 2 2012, Pages e117-25
No prominent role for terminal complement activation in the early myocardial reperfusion phase following cardiac surgery.
Kortekaas KA, van der Pol P, Lindeman JH, Baan CC, van Kooten C, Klautz RJ
Objectives: Complement activation is considered an important mediator of myocardial ischaemia/reperfusion (I/R) injury. Although complement inhibitors are highly effective in animals, clinical trials fail to show a substantial benefit in humans. This raises questions on the role of complement activation in human myocardial I/R injury. Methods: Soluble C5b-9, i.e. terminal complement complex, and C5a were assessed in patients with non-ischaemic (n = 10) and ischaemic heart failure (n = 10), and p...
Abstract
Cited 17 times since 2012 (1.3 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 144, Issue 6, 8 2 2012, Pages 1315-1322
Disturbed myocardial connexin 43 and N-cadherin expressions in hypoplastic left heart syndrome and borderline left ventricle.
Mahtab EA, Gittenberger-de Groot AC, Vicente-Steijn R, Lie-Venema H, Rijlaarsdam ME, Hazekamp MG, Bartelings MM
Objectives: Borderline left ventricle is the left ventricular morphology at the favorable end of the hypoplastic left heart syndrome. In contrast to the severe end, it is suitable for biventricular repair. Wondering whether it is possible to identify cases suitable for biventricular repair from a developmental viewpoint, we investigated the myocardial histology of borderline and severely hypoplastic left ventricles. Methods: Postmortem specimens of neonatal, unoperated human hearts with severe h...
Abstract
Cited 11 times since 2012 (0.8 per year)
source: EuropePMC
Bone,
Volume 50, Issue 6, 8 2 2012, Pages 1260-1265
5-HIAA excretion is not associated with bone metabolism in carcinoid syndrome patients.
van Dijk SC, de Herder WW, Kwekkeboom DJ, Zillikens MC, Feelders RA, van Schaik RH, van Driel M, van Leeuwen JP
In patients with a carcinoid syndrome and neuroendocrine tumors of the digestive tract (carcinoids), elevated circulating serotonin (5-hydroxytryptamine, 5-HT) levels can be demonstrated. It can be hypothesized that bone metabolism will be affected in these patients, since serotonin receptors are expressed on bone cells and serotonin effects on bone have been demonstrated. However, to date, no data are available on bone metabolism parameters in patients with neuroendocrine tumors of the digestiv...
Abstract
Cited 29 times since 2012 (2.2 per year)
source: EuropePMC
Journal of proteome research,
Volume 11, Issue 4, 8 2 2012, Pages 2331-2346
Metabolic adaptation to a disruption in oxygen supply during myocardial ischemia and reperfusion is underpinned by temporal and quantitative changes in the cardiac proteome.
Li X, Arslan F, Ren Y, Adav SS, Poh KK, Sorokin V, Lee CN, de Kleijn D, Lim SK, Sze SK
Despite decades of intensive research, there is still no effective treatment for ischemia/reperfusion (I/R) injury, an important corollary in the treatment of ischemic disease. I/R injury is initiated when the altered biochemistry of cells after ischemia is no longer compatible with oxygenated microenvironment (or reperfusion). To better understand the molecular basis of this alteration and subsequent incompatibility, we assessed the temporal and quantitative alterations in the cardiac proteome...
Abstract
Cited 8 times since 2012 (0.6 per year)
source: EuropePMC
Nurse education today,
Volume 33, Issue 2, 8 2 2012, Pages 110-115
Turkish nursing students' knowledge and perceptions regarding virginity.
Zeyneloğlu S, Kısa S, Yılmaz D
The aim of this study was to describe the level of knowledge and perceptions of the Turkish nursing students regarding virginity, the virginity examination and the hymen repair. A convenience sample was used for the study purpose. An investigator designed questionnaire was administered to a total sample of 781 undergraduate nursing students originating from two universities in Mersin and Gaziantep, Turkey, respectively. The results showed that the participating nursing students agreed that a man...
Abstract
Cited 28 times since 2012 (2.1 per year)
source: EuropePMC
PloS one,
Volume 7, Issue 3, 7 1 2012, Pages e32494
Impartial third-party interventions in captive chimpanzees: a reflection of community concern.
von Rohr CR, Koski SE, Burkart JM, Caws C, Fraser ON, Ziltener A, van Schaik CP
Because conflicts among social group members are inevitable, their management is crucial for group stability. The rarest and most interesting form of conflict management is policing, i.e., impartial interventions by bystanders, which is of considerable interest due to its potentially moral nature. Here, we provide descriptive and quantitative data on policing in captive chimpanzees. First, we report on a high rate of policing in one captive group characterized by recently introduced females and...
Abstract
