Research

Publications

Below you can find a list of our published research.

6382 results

European journal of heart failure, 14 2 2025 Multimodality imaging in advanced heart failure. A clinical consensus statement of the Heart Failure Association of the ESC. Part 2: Mechanical circulatory support and heart transplantation. Tops LF, Aimo A, Adamopoulos S, Bonios M, Çelik A, Chioncel O, Cikes M, Crespo-Leiro MG, Damman K, Di Nora C, Dreyfus J, Gustafsson F, Hashmani S, Masetti M, Mordi I, Nalbantgil S, van Laake LW, von Bardeleben RS, Metra M, Moura B, Ben Gal T

This clinical consensus statement outlines the vital role of multimodality imaging in managing patients with advanced heart failure (HF), particularly those receiving mechanical circulatory support (MCS) and heart transplantation (HT). For both temporary and durable MCS, multimodality imaging, primarily echocardiography, is crucial for selecting candidates, ensuring proper device placement, and monitoring in the post-implantation period. Preoperatively, it helps to identify HF phenotypes, assess... Abstract

Trends in cardiovascular medicine, 13 2 2025, Pages S1050-1738(25)00135-5 Controversies in valvular heart disease: insights from cardiac imaging. van der Bijl P, Ajmone Marsan N, Bax JJ

Numerous controversies still exist in the diagnosis and management of valvular heart disease, for example, the benefit of treating moderate aortic stenosis (AS) or asymptomatic, severe AS and the appropriate selection criteria for transcatheter edge-to-edge mitral valve repair. While numerous imaging parameters have been linked to the risk of sudden cardiac death in mitral valve prolapse, their relative merits are unknown and this is a challenging population to risk-stratify. No large, randomize... Abstract

Journal of cardiovascular development and disease, Volume 12, Issue 10, 11 2 2025, Pages 403 Trends in Conventional Heart Failure Therapy in a Real-World Multinational ATTR-CA Cohort. van der Geest EH, Ajmone Marsan N, Laenens D, Debonnaire PJMR, Claeys M, Pinto F, Brito D, Donal E, Droogmans S, Van de Veire N, Bertrand P, Nabeta T, Graziani F, Regeer MV

Background: Conventional HF treatment in transthyretin cardiac amyloidosis (ATTR-CA) resulting in restrictive cardiomyopathy is debated due to absent trial evidence in this specific sub-population of heart failure (HF) patients. Current European Society of Cardiology guidelines recommend the use of diuretics and mineralocorticoid receptor antagonists (MRAs). However, beta-blockers (BBs) and angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (ACEi/ARBs) are often discontinu... Abstract

JMIR medical informatics, Volume 13, 10 2 2025, Pages e71994 Evaluation of Machine Learning Model Performance in Diabetic Foot Ulcer: Retrospective Cohort Study. van Velze VY, Burger HL, van der Steenhoven TJ, Al-Ers H, Goncalves LN, Eefting D, de Jong WJ, Smeets HJ, Welleweerd JCS, van der Vorst JR, Uchtmann S, Rissmann R, Hamming JF, Stergioulas L, van der Bogt KE

Background: Machine learning (ML) has shown great potential in recognizing complex disease patterns and supporting clinical decision-making. Diabetic foot ulcers (DFUs) represent a significant multifactorial medical problem with high incidence and severe outcomes, providing an ideal example for a comprehensive framework that encompasses all essential steps for implementing ML in a clinically relevant fashion. Objective: This paper aims to provide a framework for the proper use of ML algorithms t... Abstract

Journal of clinical microbiology, Volume 63, Issue 11, 9 2 2025, Pages e0027225 In vitro activity of antibiotic monotherapy and combination therapy with bacteriophages against Staphylococcus aureus LVAD-driveline infections. Molendijk MM, Verkaik NJ, de Vogel CP, Lemmens-den Toom N, Knight GM, Caliskan K, Bode LGM, Verbon A, Koopmans MPG, de Graaf M, van Wamel WJB

Left-ventricular assist devices (LVADs) are increasingly used as a bridge to heart transplantation and destination therapy. These devices, especially the driveline, are susceptible to difficult-to-treat infections, associated with high morbidity and mortality rates. Staphylococcus aureus (S. aureus) is a major causative pathogen of LVAD infections. Antibiotic resistance and biofilm formation can complicate the treatment of these infections. A novel in vitro assay was developed to study the antib... Abstract

Journal of cardiovascular computed tomography, 8 2 2025, Pages S1934-5925(25)00442-3 Incremental value of a CCTA-derived AI-based ischemia algorithm over standard CCTA interpretation of predicting myocardial ischemia in patients with suspected coronary artery disease. Nabeta T, Bär S, Maaniitty T, Kärpijoki H, Bax JJ, Saraste A, Knuuti J

Background: A novel artificial intelligence-guided quantitative computed tomography ischemia algorithm (AI-QCTischemia) comprises a machine-learned method using atherosclerosis and vascular morphology features from coronary computed tomography angiography (CCTA) images to predict myocardial ischemia. This study evaluates the diagnostic performance of AI-QCTischemia compared to standard CCTA interpretation in detecting myocardial ischemia. Methods and results: Patients with suspected coronary art... Abstract

Annals of vascular surgery, Volume 123, 7 1 2025, Pages 94-103 Prediction of Wound Healing Following Amputation Surgery Based on Near-Infrared Fluorescence with Indocyanine Green. Kruiswijk MW, Peul RC, Tange FP, Koning S, van der Aa LE, Eefting D, van der Bogt KEA, van den Hoven P, van der Vorst JR, Vascular Fluorescence group

Background: The objective of this study was to evaluate the predictive value of near-infrared (NIR) fluorescence imaging with indocyanine on wound healing complications within 6 weeks after lower extremity amputation. Methods: In this dual-center cohort study, patients undergoing minor (below ankle) or major (above ankle) amputations due to peripheral arterial disease (PAD) or diabetes mellitus, with perfusion assessment performed using indocyanine green (ICG) NIR fluorescence imaging, were incl... Abstract

Endocrine connections, Volume 14, Issue 10, 6 1 2025, Pages e250400 Validation and implementation of the Dutch PHPQoL for primary hyperparathyroidism. Zhang JLH, Schepers A, Hamming JF, Osman L, Webb SM, Welling L, Winter EM, Snel M, Appelman-Dijkstra NM

Background: Patients with primary hyperparathyroidism (PHPT) often present with nonspecific neuropsychological symptoms, which remain challenging to quantify. While parathyroidectomy (PTx) recently has been recommended for asymptomatic patients, its benefit remains unclear as existing evidence relies on generic health-related quality of life (HRQoL) tools. In contrast, the disease-specific PHPQoL questionnaire offers more sensitive and clinically relevant symptom assessment. This study aims to t... Abstract

Molecular syndromology, 4 1 2025 Personalized Treatment in Rare Genetic Syndromes: A Case-Report in Witteveen-Kolk Syndrome (SIN3A). Janssen V, van Dongen LCM, Custers MCC, Willemsen MH, Kleefstra T, Egger JIM

Introduction: Neurodevelopmental disorders (NDDs) include a broad spectrum of disorders. NDDs caused by rare gene mutations are referred to as Rare Genetic Neurodevelopmental Syndromes (RGNS). Witteveen-Kolk syndrome (WITKOS) is such a RGNS, caused by heterozygous mutations in SIN3A and characterized by developmental problems, facial dysmorphisms, short stature, brain abnormalities, intellectual disability, and behavioral problems. Care for individuals with WITKOS mainly focuses on somatic chara... Abstract

Frontiers in digital health, Volume 7, 1 1 2025, Pages 1528860 Content evaluation of the inclusive eHealth guide: how to develop interventions for people with a lower socioeconomic position? Al-Dhahir I, Breeman LD, Faber JS, Wentzel J, van den Berg-Emons RJG, Kraal JJ, Janssen VR, Kraaijenhagen RA, Visch VT, Chavannes NH, Evers AWM

Objectives: eHealth interventions favor those with higher socio-economic positions (SEPs). This can widen disparities, as people with lower SEPs may lack resources and face digital or financial barriers, making tailored solutions necessary. This study evaluates professionals' perceptions of the Inclusive eHealth Guide (IeG) regarding its content. The aim was to ensure it meets the needs of professionals and the targeted lower SEP demographic, thereby enhancing the effectiveness of eHealth i... Abstract

Therapeutic advances in medical oncology, Volume 17, 1 1 2025, Pages 17588359251379665 Predicting response and survival to first-line treatment with baseline [18F]FDG-PET-CT in patients with small-cell lung cancer: an integrated diagnostic approach. Ventura D, Schindler P, Kies P, Bleckmann A, Mohr M, Lenz G, Schäfers M, Roll W, Evers G

Background: Small-cell lung cancer (SCLC) is a highly malignant disease with a propensity for early progression and high mortality. The prognostic value of treatment response and survival has been verified for solely established imaging, clinical, and biochemical markers. There is a lack of evidence for the combination of those parameters with machine learning and integrated models, particularly in the context of molecular imaging. Objectives: The aim of this study was to predict early disease p... Abstract

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 27, Issue 11, 1 1 2025, Pages euaf276 The SIDECAR 2.0 (S-ICD registry in European paediatric and young adult patients with congenital heart defects 2.0): an analysis of European S-ICD clinical practice and its evolution in paediatric patients. Silvetti MS, Bruyndonckx L, Waldmann V, Gebauer R, Környei L, Ksiazczyk T, Illikova V, Tavacova T, Roses-Noguer F, Kwiatkowska J, Pazzano V, Wilkin M, Paech C, Fésüs G, Egorova AD, Wieniawski P, Rivas-Gandara N, Kempa M, Battipaglia I, Klehs S, Chalupka M, Maltret A, Knops RE, Janousek J, Blom NA, Lovecchio M, Valsecchi S, Drago F

Aims: Subcutaneous implantable cardioverter-defibrillators (S-ICDs) are effective in patients who require protection from sudden cardiac death while avoiding the long-term risks associated with transvenous leads. However, data on their real-world performance in paediatric and young patients remain limited. This study aims to evaluate the safety and efficacy of S-ICDs in a large, multicentre cohort of paediatric and young patients across Europe, with a focus on contemporary implantation practices... Abstract

Family practice, Volume 42, Issue 6, 1 1 2025, Pages cmaf081 Cost-effectiveness of a corticosteroid injection versus exercise therapy for shoulder pain in general practice (SIX-Shoulder Study): a randomized controlled trial. Versloot AHC, Toy M, Schiphof D, Bindels P, Ottenheijm RPG, de Graaf M, van der Windt DA, van Ochten JM, Koes BW, Runhaar J

Background: Shoulder pain often results in functional limitations leading to substantial societal and healthcare costs. Guidelines recommend a corticosteroid injection or exercise therapy, but long-term comparative cost-effectiveness remains unclear. This study examined the cost-effectiveness of these two treatments over 12 months in patients with shoulder pain presenting in Dutch primary care. Methods: A randomized controlled trial was conducted with patients consulting for a new episode of sho... Abstract

Aims: In non-ischaemic cardiomyopathy (NICM), late gadolinium enhancement (LGE) detected by cardiovascular magnetic resonance is related to ventricular arrhythmia (VA) and sudden cardiac death (SCD) risk. The incremental prognostic value of quantifying LGE volume or mass beyond its mere presence, however, remains unresolved. The aim was to evaluate whether LGE quantification improves the prediction of SCD. Methods and results: PubMed, Embase, and Web of Science were searched on 20 November 2024... Abstract

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 27, Issue 10, 1 1 2025, Pages euaf240 Evolution of implantable cardioverter-defibrillator shock therapy in children in the era of optimized ICD programming and remote monitoring. Bertels RA, Boersma E, Zeggelaar MD, van Dongen SAF, Ten Harkel ADJ, van Erven L, Smeding C, Bartelds B, van den Berg G, Boesaard EP, Bhagwandien RE, Yap SC, Knops RE, Blom NA, Kammeraad JAE

Aims: Implantable cardioverter defibrillator (ICD) therapy is effective in preventing sudden cardiac death in children. Unnecessary shocks should be avoided. ICD programming strategies and remote monitoring have been proven to be effective in preventing ICD shock therapy in adults; the present study evaluates the effectiveness in children. Methods and results: Retrospective multi-centre study, including children with transvenous or epicardial ICD implantation. During follow-up data on ICD shocks... Abstract

Interdisciplinary cardiovascular and thoracic surgery, 30 5 2025, Pages ivaf231 A European survey on non-technical skills in robotic thoracic surgery for lung resections. Shahin GMM, Verhagen MJ, Hutteman M, Wink J, Stamenkovic SA, Durand M, Baste JM, Melfi F, Braun J

Objectives: In robotic surgery, interaction between team-members differs from that in open surgery, which impacts the team-members' tasks and responsibilities. Training for robot-assisted thoracic surgery (RATS) is primarily focused on technical skills. However, non-technical skills (NOTECHS) are equally important for safe and high-quality surgery. There is debate whether NOTECHS require adjustments to meet specific needs of RATS. The aim of this study is to evaluate how NOTECHS-domains are... Abstract

Arteriosclerosis, thrombosis, and vascular biology, Volume 45, Issue 11, 25 4 2025, Pages 2111-2123 Multiplex Apolipoprotein Panel Improves Cardiovascular Event Prediction and Cardiovascular Outcome by Identifying Patients Who Benefit From Targeted PCSK9 Inhibitor Therapy. Reijnders E, Bossuyt PM, Jukema JW, Ruhaak LR, Romijn FPHTM, Szarek M, Trompet S, Bhatt DL, Bittner VA, Diaz R, Fazio S, Stevanovic I, Goodman SG, Harrington RA, White HD, Steg PG, Schwartz GG, Cobbaert CM

Background: Residual cardiovascular risk remains, despite achieving low-density lipoprotein cholesterol targets with high-intensity statins. Traditional risk scores are suboptimal. This study evaluated the prognostic utility of a 9-plex apolipoprotein panel in recent patients with acute coronary syndrome on statins and its role in predicting treatment benefit by alirocumab, a PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor, enabling precision medicine. Methods: Baseline serum sam... Abstract

Allergy, 24 4 2025 Biologics to Treat Atopic Dermatitis: Effectiveness, Safety, and Future Directions. de Bruin-Weller MS, Boesjes CM, Achten RA, Beck LA, Irvine AD, Vestergaard C, de Graaf M, van Wijk F, Bakker DS, Weidinger S

Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases worldwide. The clinical presentation of AD is heterogeneous and is characterized by a relapsing and remitting course. Most patients suffer from mild AD while approximately 5% to 20% experience severe disease activity, which often requires systemic treatment. Before 2017, systemic treatment options were limited to broad immunosuppressants, which often had significant toxicity and limited effectiveness. Advances in... Abstract

The Canadian journal of cardiology, 23 4 2025, Pages S0828-282X(25)01178-X New Cardiovascular Damage Staging Classification for Chronic Significant Aortic Regurgitation. Bergeron A, Lopez Santi P, Bernard J, Hecht S, Fleury MA, Jacob S, Marchand C, Clavel MA, Côté N, Bax JJ, Marsan NA, Pibarot P

Background: Current recommendations for management of chronic aortic regurgitation (AR) are based on AR severity, symptoms and repercussions on the left ventricle (LV), only providing modest risk stratification value in patients with AR. The objective was to assess the prognostic value of a new staging classification characterizing the extent of cardiovascular damage for risk stratification in patients with chronic AR. Methods: According to cardiovascular damages at echocardiography, 619 patient... Abstract

BMJ open, Volume 15, Issue 9, 23 4 2025, Pages e097306 Comparison of cardiovascular risk profiles of patients with type A aortic dissection and thoracic aortic aneurysm: a retrospective multicentre study. Tirpan AU, Dolmaci OB, Jansen EK, Twisk JWR, Klautz RJM, Grewal N

Objective: A thoracic aortic aneurysm (TAA) is often considered a precursor to an acute type A aortic dissection (ATAAD), a life-threatening condition requiring immediate surgical intervention. While both conditions share histopathological similarities, less is known about their overlap in clinical cardiovascular risk factors. This study aimed to map the cardiovascular disease burden in patients with ATAAD and compare it with patients with TAA. Design: A multicentre retrospective study. Setting:... Abstract