7993 results
Cited 137 times since 2017 (17.7 per year)
source: EuropePMC
Neuroscience letters,
Volume 710, 28 4 2017, Pages 132931
Inflammation and mitochondrial dysfunction: A vicious circle in neurodegenerative disorders?
van Horssen J, van Schaik P, Witte M
Experimental evidence supports an intricate association between inflammation and mitochondrial dysfunction as main contributors of neurological diseases. Inflammatory mediators produced by activated microglia and infiltrated immune cells trigger intracellular signalling cascades that can alter cellular mitochondrial metabolism. Cytokines, particularly tumor necrosis factor-alpha, impede mitochondrial oxidative phosphorylation and associated ATP production and instigate mitochondrial reactive oxy...
Abstract
Cited 10 times since 2017 (1.3 per year)
source: EuropePMC
International journal of cardiology,
Volume 244, 27 4 2017, Pages 298-302
Chronic use of low-dose aspirin is not associated with lower bone mineral density in the general population.
Bonten TN, de Mutsert R, Rosendaal FR, Jukema JW, van der Bom JG, de Jongh RT, den Heijer M
Background: Low-dose aspirin is the cornerstone of secondary prevention of cardiovascular disease. Previous studies suggested that the use of aspirin is associated with an increased fracture risk. However, there is uncertainty whether this is due to an effect of aspirin on bone mineral density (BMD). Methods: Between 2008 and 2012, information on medication use and dual X-ray absorptiometry measured vertebral and femoral BMD of 916 participants was collected in the Netherland Epidemiology of Obe...
Abstract
Cited 11 times since 2017 (1.4 per year)
source: EuropePMC
Psychotherapy and psychosomatics,
Volume 86, Issue 4, 24 4 2017, Pages 220-230
Effectiveness of Supported Self-Help in Recurrent Depression: A Randomized Controlled Trial in Primary Care.
Biesheuvel-Leliefeld KEM, Dijkstra-Kersten SMA, van Schaik DJF, van Marwijk HWJ, Smit F, van der Horst HE, Bockting CLH
Background: The burden and economic consequences of depression are high, mostly due to its recurrent nature. Due to current budget and time restraints, a preventive, low- cost, accessible minimal intervention is much needed. In this study, we evaluated the effectiveness of a supported self-help preventive cognitive therapy (S-PCT) added to treatment as usual (TAU) in primary care, compared to TAU alone. Methods: We conducted a randomized controlled trial among 248 patients with a history of depr...
Abstract
Cited 12 times since 2017 (1.6 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 33, Issue 11, 24 4 2017, Pages 1809-1819
Automatic identification of coronary tree anatomy in coronary computed tomography angiography.
Cao Q, Broersen A, de Graaf MA, Kitslaar PH, Yang G, Scholte AJ, Lelieveldt BPF, Reiber JHC, Dijkstra J
An automatic coronary artery tree labeling algorithm is described to identify the anatomical segments of the extracted centerlines from coronary computed tomography angiography (CCTA) images. This method will facilitate the automatic lesion reporting and risk stratification of cardiovascular disease. Three-dimensional (3D) models for both right dominant (RD) and left dominant (LD) coronary circulations were built. All labels in the model were matched with their possible candidates in the extract...
Abstract
Cited 30 times since 2017 (3.9 per year)
source: EuropePMC
Journal of cardiovascular computed tomography,
Volume 11, Issue 5, 23 4 2017, Pages 383-388
Interpreting results of coronary computed tomography angiography-derived fractional flow reserve in clinical practice.
Rabbat MG, Berman DS, Kern M, Raff G, Chinnaiyan K, Koweek L, Shaw LJ, Blanke P, Scherer M, Jensen JM, Lesser J, Nørgaard BL, Pontone G, De Bruyne B, Bax JJ, Leipsic J
The application of computational fluid dynamics to coronary computed tomography angiography allows Fractional Flow Reserve (FFR) to be calculated non-invasively (FFRCT), enabling computation of FFR from coronary computed tomography angiography acquired at rest both for individual lesions as well as along the entire course of a coronary artery. FFRCT, validated in a number of accuracy studies and a large clinical utility trial, is beginning to penetrate clinical practice. Importantly, while accur...
Abstract
Cited 21 times since 2017 (2.7 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 33, Issue 9, 22 4 2017, Pages 1305-1312
Accuracy and reproducibility of fast fractional flow reserve computation from invasive coronary angiography.
van Rosendael AR, Koning G, Dimitriu-Leen AC, Smit JM, Montero-Cabezas JM, van der Kley F, Jukema JW, Reiber JHC, Bax JJ, Scholte AJHA
Fractional flow reserve (FFR) guided percutaneous coronary intervention (PCI) is associated with favourable outcome compared with revascularization based on angiographic stenosis severity alone. The feasibility of the new image-based quantitative flow ratio (QFR) assessed from 3D quantitative coronary angiography (QCA) and thrombolysis in myocardial infarction (TIMI) frame count using three different flow models has been reported recently. The aim of the current study was to assess the accuracy,...
Abstract
Cited 35 times since 2017 (4.5 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 34, Issue 1, 22 4 2017, Pages 97-112
Cardiovascular magnetic resonance imaging to assess myocardial fibrosis in valvular heart disease.
Podlesnikar T, Delgado V, Bax JJ
The left ventricular (LV) remodeling process associated with significant valvular heart disease (VHD) is characterized by an increase of myocardial interstitial space with deposition of collagen and loss of myofibers. These changes occur before LV systolic function deteriorates or the patient develops symptoms. Cardiovascular magnetic resonance (CMR) permits assessment of reactive fibrosis, with the use of T1 mapping techniques, and replacement fibrosis, with the use of late gadolinium contrast...
Abstract
Cited 4 times since 2017 (0.5 per year)
source: EuropePMC
The Cochrane database of systematic reviews,
Volume 6, 20 3 2017, Pages CD003456
Drug therapy for chronic idiopathic axonal polyneuropathy.
Warendorf J, Vrancken AF, van Schaik IN, Hughes RA, Notermans NC
Background: Chronic idiopathic axonal polyneuropathy (CIAP) is an insidiously progressive sensory or sensorimotor polyneuropathy that affects elderly people. Although severe disability or handicap does not occur, CIAP reduces quality of life. CIAP is diagnosed in 10% to 25% of people referred for evaluation of polyneuropathy. There is a need to gather and review emerging evidence on treatments, as the number of people affected is likely to increase in ageing populations. This is an update of a r...
Abstract
Cited 104 times since 2017 (13.4 per year)
source: EuropePMC
Journal of biological rhythms,
Volume 32, Issue 4, 20 3 2017, Pages 359-368
The Association between Social Jetlag, the Metabolic Syndrome, and Type 2 Diabetes Mellitus in the General Population: The New Hoorn Study.
Koopman ADM, Rauh SP, van 't Riet E, Groeneveld L, van der Heijden AA, Elders PJ, Dekker JM, Nijpels G, Beulens JW, Rutters F
Only a few studies have investigated the metabolic consequences of social jetlag. Therefore, we examined the association of social jetlag with the metabolic syndrome and type 2 diabetes mellitus in a population-based cohort. We used cross-sectional data from the New Hoorn Study cohort ( n = 1585, 47% men, age 60.8 ± 6 years). Social jetlag was calculated as the difference in midpoint sleep (in hours) between weekdays and weekend days. Poisson and linear regression models were used to study the a...
Abstract
Cited 4 times since 2017 (0.5 per year)
source: EuropePMC
The American journal of cardiology,
Volume 120, Issue 5, 15 3 2017, Pages 734-739
Comparison of Left Ventricular Function and Myocardial Infarct Size Determined by 2-Dimensional Speckle Tracking Echocardiography in Patients With and Without Chronic Obstructive Pulmonary Disease After ST-Segment Elevation Myocardial Infarction.
Goedemans L, Abou R, Hoogslag GE, Ajmone Marsan N, Taube C, Delgado V, Bax JJ
Patients with chronic obstructive pulmonary disease (COPD) have a high risk of mortality after acute ST-segment elevation myocardial infarction (STEMI). We compared STEMI patients with versus without COPD in terms of infarct size and left ventricular (LV) systolic function using advanced 2-dimensional speckle tracking echocardiography. Of 1,750 patients with STEMI (mean age 61 ± 12 years, 76% male), 133 (7.6%) had COPD. With transthoracic echocardiography, left ventricular ejection fraction (LVE...
Abstract
Cited 14 times since 2017 (1.8 per year)
source: EuropePMC
Frontiers in zoology,
Volume 14, 12 2 2017, Pages 29
Getting fat or getting help? How female mammals cope with energetic constraints on reproduction.
Heldstab SA, van Schaik CP, Isler K
Background: Fat deposits enable a female mammal to bear the energy costs of offspring production and thus greatly influence her reproductive success. However, increasing locomotor costs and reduced agility counterbalance the fitness benefits of storing body fat. In species where costs of reproduction are distributed over other individuals such as fathers or non-breeding group members, reproductive females might therefore benefit from storing less energy in the form of body fat. Results: Using a...
Abstract
Cited 24 times since 2017 (3.1 per year)
source: EuropePMC
Frontiers in pharmacology,
Volume 8, 8 2 2017, Pages 358
Tacrolimus Updated Guidelines through popPK Modeling: How to Benefit More from CYP3A Pre-emptive Genotyping Prior to Kidney Transplantation.
Woillard JB, Mourad M, Neely M, Capron A, van Schaik RH, van Gelder T, Lloberas N, Hesselink DA, Marquet P, Haufroid V, Elens L
Tacrolimus (Tac) is a profoundly effective immunosuppressant that reduces the risk of rejection after solid organ transplantation. However, its use is hampered by its narrow therapeutic window along with its highly variable pharmacological (pharmacokinetic [PK] and pharmacodynamic [PD]) profile. Part of this variability is explained by genetic polymorphisms affecting the metabolic pathway. The integration of CYP3A4 and CY3A5 genotype in tacrolimus population-based PK (PopPK) modeling approaches...
Abstract
Cited 128 times since 2017 (16.4 per year)
source: EuropePMC
European journal of heart failure,
Volume 19, Issue 12, 8 2 2017, Pages 1664-1671
Right ventricular dysfunction in left-sided heart failure with preserved versus reduced ejection fraction.
Bosch L, Lam CSP, Gong L, Chan SP, Sim D, Yeo D, Jaufeerally F, Leong KTG, Ong HY, Ng TP, Richards AM, Arslan F, Ling LH
Background: Right ventricular (RV) dysfunction is recognized as a major prognostic factor in left-sided heart failure (HF). However, the relative contribution of RV dysfunction in HF with preserved (HFpEF) vs. reduced ejection fraction (HFrEF) is unclear. Methods and results: Right ventricular longitudinal strain (RVLS), tricuspid annular plane systolic excursion (TAPSE) and pulmonary artery systolic pressure (PASP) were determined by echocardiography in 657 age- and gender-matched groups of pat...
Abstract
Cited 11 times since 2017 (1.4 per year)
source: EuropePMC
Journal of human evolution,
Volume 109, 7 1 2017, Pages 11-21
The social organization of Homo ergaster: Inferences from anti-predator responses in extant primates.
Willems EP, van Schaik CP
Patterns of primate socioecology have been used to suggest that the first truly savanna-dwelling hominin, Homo ergaster, lived in sizeable groups. Here, we revisit these estimates and infer additional features of the social organization of these early hominins based on anti-predator responses observed across the primate taxon. We first show that the effect of habitat on primate group size, composition, and sexual dimorphism is negligible after controlling for substrate use and phylogeny: terrest...
Abstract
Cited 3 times since 2017 (0.4 per year)
source: EuropePMC
Pain management nursing : official journal of the American Society of Pain Management Nurses,
Volume 18, Issue 4, 7 1 2017, Pages 260-267
Effect of the Use of Buzzy<sup>®</sup> during Phlebotomy on Pain and Individual Satisfaction in Blood Donors.
Yılmaz D, Heper Y, Gözler L
Phlebotomy causes pain and discomfort to adults. The objective of this study was to investigate the effect of the use of Buzzy® on phlebotomy satisfaction and pain relating to the phlebotomy process in healthy adult blood donors voluntarily donating blood. This was a prospective, randomized, controlled experimental study. The research sample was made up of 90 healthy adult men. These individuals were randomly assigned to an experimental group (Buzzy group), a placebo control group, and a noninte...
Abstract
Cited 10 times since 2017 (1.3 per year)
source: EuropePMC
Journal of clinical research in pediatric endocrinology,
Volume 9, Issue 4, 7 1 2017, Pages 366-370
Successful Growth Hormone Therapy in Cornelia de Lange Syndrome.
de Graaf M, Kant SG, Wit JM, Willem Redeker EJ, Eduard Santen GW, Henriëtta Verkerk AJM, Uitterlinden AG, Losekoot M, Oostdijk W
Cornelia de Lange syndrome (CdLS) is a both clinically and genetically heterogeneous syndrome. In its classical form, it is characterised by distinctive facial features, intra-uterine growth retardation, short stature, developmental delay, and anomalies in multiple organ systems. NIPBL, SMC1A, SMC3, RAD21 and HDAC8, all involved in the cohesin pathway, have been identified to cause CdLS. Growth hormone (GH) secretion has been reported as normal, and to our knowledge, there are no reports on the...
Abstract
Cited 2 times since 2017 (0.3 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 24, Issue 5, 7 1 2017, Pages 1583-1587
Neuro-cardiac imaging has a proven value in patient management: Con.
Liga R, Scholte AJHA
Abstract
Cited 44 times since 2017 (5.6 per year)
source: EuropePMC
BMJ open,
Volume 7, Issue 5, 6 1 2017, Pages e015599
The Hoorn Diabetes Care System (DCS) cohort. A prospective cohort of persons with type 2 diabetes treated in primary care in the Netherlands.
van der Heijden AA, Rauh SP, Dekker JM, Beulens JW, Elders P, 't Hart LM, Rutters F, van Leeuwen N, Nijpels G
Purpose: People with type 2 diabetes (T2D) have a doubled morbidity and mortality risk compared with persons with normal glucose tolerance. Despite treatment, clinical targets for cardiovascular risk factors are not achieved. The Hoorn Diabetes Care System cohort (DCS) is a prospective cohort representing a comprehensive dataset on the natural course of T2D, with repeated clinical measures and outcomes. In this paper, we describe the design of the DCS cohort. Participants: The DCS consists of pe...
Abstract
Cited 3 times since 2017 (0.4 per year)
source: EuropePMC
International journal of cardiology,
Volume 243, 2 1 2017, Pages 191-193
Clinical course of tricuspid regurgitation in repaired tetralogy of Fallot.
Woudstra OI, Bokma JP, Winter MM, Kiès P, Jongbloed MRM, Vliegen HW, Groenink M, Meijboom FJ, Mulder BJM, Bouma BJ
Background: Little is known on the clinical course of tricuspid regurgitation (TR) in patients with repaired tetralogy of Fallot (rTOF) and which patients are at particular risk. This study aims to determine TR course, characteristics associated with TR progression, and the prognostic relevance of TR in rTOF patients. Methods: In this dualcenter cohort study, rTOF patients from a prospective national registry with ≥1 cardiac magnetic resonance imaging study and ≥2 echocardiograms available were...
Abstract
Cited 31 times since 2017 (4 per year)
source: EuropePMC
Critical care medicine,
Volume 45, Issue 6, 1 1 2017, Pages 972-979
Increased Early Systemic Inflammation in ICU-Acquired Weakness; A Prospective Observational Cohort Study.
Witteveen E, Wieske L, van der Poll T, van der Schaaf M, van Schaik IN, Schultz MJ, Verhamme C, Horn J, Molecular Diagnosis and Risk Stratification of Sepsis (MARS) Consortium
Objectives: To investigate whether patients who develop ICU-acquired weakness have a different pattern of systemic inflammatory markers compared with critically ill patients who do not develop ICU-acquired weakness. Design: Prospective observational cohort study. Setting: Mixed medical-surgical ICU of a tertiary care hospital in the Netherlands. Patients: Newly admitted critically ill patients, greater than or equal to 48 hours on mechanical ventilation with a nonneurologic ICU admission diagnos...
Abstract
