Research

Publications

Below you can find a list of our published research.

6161 results

Cited 34 times since 2007 (1.9 per year) source: EuropePMC

Journal of virological methods, Volume 143, Issue 2, 8 2 2007, Pages 169-174 An improved plaque reduction virus neutralization assay for human metapneumovirus. de Graaf M, Herfst S, Schrauwen EJ, van den Hoogen BG, Osterhaus AD, Fouchier RA

Virus-neutralizing antibodies against human metapneumovirus (hMPV) have been shown to be important indicators for protection in experimental animal models. An improved plaque reduction virus neutralization assay to detect hMPV-specific neutralizing antibodies was designed using two prototype recombinant hMPV strains expressing green fluorescent protein (GFP). These prototypes represented each of the main antigenic variants of hMPV, because antigenic variability could have implications for vaccin... Abstract

Cited 141 times since 2007 (7.8 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 49, Issue 16, 5 1 2007, Pages 1708-1714 Phase analysis of gated myocardial perfusion single-photon emission computed tomography compared with tissue Doppler imaging for the assessment of left ventricular dyssynchrony. Henneman MM, Chen J, Ypenburg C, Dibbets P, Bleeker GB, Boersma E, Stokkel MP, van der Wall EE, Garcia EV, Bax JJ

Objectives: The purpose of this study was to compare left ventricular (LV) dyssynchrony assessment by gated myocardial perfusion single-photon emission computed tomography (SPECT) (GMPS) and tissue Doppler imaging (TDI). Background: Recently, it has been suggested that LV dyssynchrony is an important predictor of response to cardiac resynchronization therapy (CRT); dyssynchrony is predominantly assessed by TDI with echocardiography. Information on LV dyssynchrony can also be provided by GMPS wit... Abstract

European heart journal, Volume 28, Issue 8, 4 1 2007, Pages 922-923 Monitoring of therapeutic effect in heart failure patients: a clinical application of 123I MIBG imaging? Henneman MM, Bax JJ, van der Wall EE

Abstract

Cited 5 times since 2007 (0.3 per year) source: EuropePMC

International journal of cardiology, Volume 124, Issue 2, 3 1 2007, Pages 166-171 Dexamethasone-eluting stents for the prevention of in-stent restenosis: evidence for a differential effect in insulin-dependent and non-insulin-dependent diabetic patients. van der Hoeven BL, Pires NM, Warda HM, Putter H, Quax PH, Schalij MJ, Jukema JW

Unlabelled: Diabetes mellitus (DM) is a strong predictor of in-stent restenosis. This may be due to a higher level of vascular inflammation. We hypothesized that diabetic patients will benefit from dexamethasone-eluting stents, since local inflammation and consequently neointimal growth are suppressed and no systemic side effects will occur. Methods: 21 consecutive patients with DM with 32 lesions were treated with dexamethasone-eluting stents. Excluded were patients with triple vessel disease,... Abstract

Cited 84 times since 2007 (4.7 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 49, Issue 15, 2 1 2007, Pages 1660-1665 Reduced aortic elasticity and dilatation are associated with aortic regurgitation and left ventricular hypertrophy in nonstenotic bicuspid aortic valve patients. Grotenhuis HB, Ottenkamp J, Westenberg JJM, Bax JJ, Kroft LJM, de Roos A

Objectives: This study sought to assess elasticity and dimensions of the aorta and their impact on aortic valve competence and left ventricular (LV) function in patients with a nonstenotic bicuspid aortic valve (BAV). Background: Intrinsic pathology of the aortic wall is a possible explanation for reduced aortic elasticity and aortic dilatation in patients with BAVs, even in the absence of a stenotic aortic valve. The relationship between aortic wall elasticity, aortic dimensions, aortic valve c... Abstract

Cited 9 times since 2007 (0.5 per year) source: EuropePMC

Journal of cardiac failure, Volume 13, Issue 3, 1 1 2007, Pages 178-183 Clinical efficacy of surgical heart failure therapy by ventricular restoration and restrictive mitral annuloplasty. Tulner SA, Steendijk P, Klautz RJ, Tops L, Bax JJ, Versteegh MI, Verwey HF, Schalij MJ, van der Wall EE, Dion RA

Background: Treatment of heart failure by advanced surgical procedures such as ventricular restoration (SVR) and restrictive mitral annuloplasty (RMA) is increasingly applied. We studied clinical efficacy of heart failure surgery in patients with severe heart failure. Methods and results: Thirty-three patients (New York Heart Association (NYHA) class III/IV, left ventricular ejection fraction < or =35%) were included. Patients with moderate to severe mitral regurgitation underwent RMA (85%) a... Abstract

Cited 35 times since 2007 (1.9 per year) source: EuropePMC

The Journal of general virology, Volume 88, Issue Pt 4, 1 1 2007, Pages 1251-1259 Experimental infection of macaques with human metapneumovirus induces transient protective immunity. van den Hoogen BG, Herfst S, de Graaf M, Sprong L, van Lavieren R, van Amerongen G, Yüksel S, Fouchier RAM, Osterhaus ADME, de Swart RL

Human metapneumovirus (hMPV), a member of the family Paramyxoviridae, is a causative agent of acute respiratory-tract illness. Two main hMPV lineages circulate worldwide and reinfections occur frequently. It is unclear what level of protection is induced by natural hMPV infection, what the durability of this protection is and whether it differs for reinfection with homologous or heterologous viruses. Here, protective immunity in cynomolgus macaques at different time points after inoculation with... Abstract

Cited 32 times since 2007 (1.8 per year) source: EuropePMC

Annals of the New York Academy of Sciences, Volume 1100, 1 1 2007, Pages 189-198 Genetic variation in the interleukin-10 gene promoter and risk of coronary and cerebrovascular events: the PROSPER study. Trompet S, Pons D, DE Craen AJ, Slagboom P, Shepherd J, Blauw GJ, Murphy MB, Cobbe SM, Bollen EL, Buckley BM, Ford I, Hyland M, Gaw A, Macfarlane PW, Packard CJ, Norrie J, Perry IJ, Stott DJ, Sweeney BJ, Twomey C, Westendorp RG, Jukema JW

Proinflammatory cytokines, like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), are implicated in the development of atherosclerosis. The role of anti-inflammatory cytokines, like IL-10, is largely unknown. We investigated the association of four single nucleotide polymorphisms (SNPs) in the promoter region of the IL-10 gene (4259AG, -1082GA, -592CA, and -2849GA), with coronary and cerebrovascular disease in participants of the PROspective Study of Pravastatin in the Elderly at... Abstract

Cited 3 times since 2007 (0.2 per year) source: EuropePMC

International journal of pediatric otorhinolaryngology, Volume 71, Issue 6, 26 4 2007, Pages 857-861 Immunohistochemical assesment of heat shock protein 70 in adenoid tissue. Aktepe F, Sahin O, Dilek H, Yilmaz D, Kahveci O, Derekoy S

Objectives: To evaluate the expression of heat shock protein 70 (HSP70) and its relation to histopathologic parameters in adenoid hypertrophy and hyperplasia. In addition, HSP70 expression in adenoid tissue was compared with in adult and childhood. Methods: Paraffin-embedded adenoid tissue sections were obtained from 19 childhood and 15 adult patients. Expression of HSP70 was evaluated by immunohistochemical staining using anti-HSP70 monoclonal antibody and correlated with histopathologic parame... Abstract

Cited 68 times since 2007 (3.8 per year) source: EuropePMC

American journal of respiratory and critical care medicine, Volume 176, Issue 2, 22 4 2007, Pages 121-128 Bronchial inflammation and airway responses to deep inspiration in asthma and chronic obstructive pulmonary disease. Slats AM, Janssen K, van Schadewijk A, van der Plas DT, Schot R, van den Aardweg JG, de Jongste JC, Hiemstra PS, Mauad T, Rabe KF, Sterk PJ

Rationale: Deep inspirations provide physiologic protection against airway narrowing in healthy subjects, which is impaired in asthma and chronic obstructive pulmonary disease (COPD). Airway inflammation has been suggested to alter airway mechanics during deep inspiration. Objectives: We tested the hypothesis that the number of bronchial inflammatory cells is related to deep inspiration-induced bronchodilation in asthma and COPD. Methods: In a cross-sectional study, three modified methacholine c... Abstract

Cited 11 times since 2007 (0.6 per year) source: EuropePMC

The American journal of cardiology, Volume 99, Issue 9, 15 3 2007, Pages 1193-1195 Prognostic significance of myocardial ischemia during dobutamine stress echocardiography in asymptomatic patients with diabetes mellitus and no prior history of coronary events. Sozzi FB, Elhendy A, Rizzello V, Biagini E, van Domburg RT, Schinkel AF, Bax JJ, Vourvouri E, Danzi GB, Poldermans D

The prognostic significance of myocardial ischemia assessed by dobutamine stress echocardiography in asymptomatic patients with diabetes mellitus who have no previous coronary artery disease remains unclear. We assessed the value of dobutamine stress echocardiography for risk stratification in 161 asymptomatic patients with type 2 diabetes (mean 62 +/- 12 years of age; 96 men) who had no previous myocardial infarction or revascularization. End point during follow-up was hard cardiac events (card... Abstract

Cited 63 times since 2007 (3.5 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 27, Issue 6, 15 3 2007, Pages 1426-1432 Expression of vascular endothelial growth factor, stromal cell-derived factor-1, and CXCR4 in human limb muscle with acute and chronic ischemia. van Weel V, Seghers L, de Vries MR, Kuiper EJ, Schlingemann RO, Bajema IM, Lindeman JH, Delis-van Diemen PM, van Hinsbergh VW, van Bockel JH, Quax PH

Objective: Vascular endothelial growth factor (VEGF)-induced stromal cell-derived factor-1 (SDF-1) has been implicated in angiogenesis in ischemic tissues by recruitment of CXCR4-positive bone marrow-derived circulating cells with paracrine functions in preclinical models. Here, evidence for this is provided in patients with peripheral artery disease. Methods and results: Expression patterns of VEGF, SDF-1, and CXCR4 were studied in amputated limbs of 16 patients. VEGF-A was expressed in vascula... Abstract

Cited 57 times since 2007 (3.2 per year) source: EuropePMC

Journal of vascular surgery, Volume 45, Issue 5, 13 2 2007, Pages 936-943 The effect of intensified lipid-lowering therapy on long-term prognosis in patients with peripheral arterial disease. Feringa HH, Karagiannis SE, van Waning VH, Boersma E, Schouten O, Bax JJ, Poldermans D

Background: The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are associated with improved outcome in patients with peripheral arterial disease. Statins may also have beneficial properties beyond their lipid-lowering effect. Methods: A prospective, observational cohort study was conducted at a university hospital from 1990 to 2005 to examine whether higher doses of statins and lower low-density lipoprotein (LDL) cholesterol levels are both independently associated with imp... Abstract

Cited 105 times since 2007 (5.8 per year) source: EuropePMC

Circulation, Volume 115, Issue 11, 12 2 2007, Pages 1426-1432 Noninvasive evaluation of coronary sinus anatomy and its relation to the mitral valve annulus: implications for percutaneous mitral annuloplasty. Tops LF, Van de Veire NR, Schuijf JD, de Roos A, van der Wall EE, Schalij MJ, Bax JJ

Background: Percutaneous mitral annuloplasty has been proposed as an alternative to surgical annuloplasty. In this respect, evaluation of the coronary sinus (CS) and its relation with the mitral valve annulus (MVA) and the coronary arteries is relevant. The feasibility of evaluating these issues noninvasively with multislice computed tomography was determined. Methods and results: In 105 patients (72 men, age 59+/-11 years), 64-slice multislice computed tomography was performed for noninvasive e... Abstract

Cited 174 times since 2007 (9.6 per year) source: EuropePMC

The American journal of cardiology, Volume 99, Issue 8, 6 1 2007, Pages 1072-1081 Cyphering the complexity of coronary artery disease using the syntax score to predict clinical outcome in patients with three-vessel lumen obstruction undergoing percutaneous coronary intervention. Valgimigli M, Serruys PW, Tsuchida K, Vaina S, Morel MA, van den Brand MJ, Colombo A, Morice MC, Dawkins K, de Bruyne B, Kornowski R, de Servi S, Guagliumi G, Jukema JW, Mohr FW, Kappetein AP, Wittebols K, Stoll HP, Boersma E, Parrinello G, ARTS II

The Syntax score (SXscore) was recently developed as a comprehensive angiographic scoring system aiming to assist in patient selection and risk stratification of patients with extensive coronary artery disease undergoing contemporary revascularization. A validation of this angiographic classification scheme is lacking. We assessed its predictive value in patients who underwent percutaneous intervention (PCI) for 3-vessel disease and explored its performance in comparison with the modified lesion... Abstract

Cited 87 times since 2007 (4.8 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 49, Issue 11, 6 1 2007, Pages 1137-1148 Role of imaging in cardiac stem cell therapy. Beeres SL, Bengel FM, Bartunek J, Atsma DE, Hill JM, Vanderheyden M, Penicka M, Schalij MJ, Wijns W, Bax JJ

Stem cell therapy has emerged as a potential therapeutic option for cell death-related heart diseases. Preclinical and a number of early phase human studies suggested that cell therapy may augment perfusion and increase myocardial contractility. The rapid translation into clinical trials has left many issues unresolved, and emphasizes the need for specific techniques to visualize the mechanisms involved. Furthermore, the clinical efficacy of cell therapy remains to be proven. Imaging allows for... Abstract

Cited 17 times since 2007 (0.9 per year) source: EuropePMC

Stroke, Volume 38, Issue 4, 1 1 2007, Pages 1374-1376 Pravastatin decreases wall shear stress and blood velocity in the internal carotid artery without affecting flow volume: results from the PROSPER MRI study. Box FM, van der Grond J, de Craen AJ, Palm-Meinders IH, van der Geest RJ, Jukema JW, Reiber JH, van Buchem MA, Blauw GJ, PROSPER Study Group

Background and purpose: Despite speculations, it is unknown whether statins affect wall shear stress (WSS). Therefore, the effect of pravastatin on WSS was investigated. Methods: In 355 elderly individuals participating in the PROSPER study (follow up after 3 years), the effect of 40 mg pravastatin on WSS was assessed in the internal carotid artery using magnetic resonance imaging. Results: WSS and blood velocity decreased both in the pravastatin group and in the placebo group but decreased fast... Abstract

Cited 57 times since 2007 (3.1 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 83, Issue 3, 1 1 2007, Pages 907-911 Predicting outcome of pulmonary valve replacement in adult tetralogy of Fallot patients. Henkens IR, van Straten A, Schalij MJ, Hazekamp MG, de Roos A, van der Wall EE, Vliegen HW

Background: Predicting changes in right ventricular (RV) size and function after pulmonary valve replacement (PVR) is important for timely reintervention in adult tetralogy of Fallot patients. Methods: We analyzed the influence of pulmonary regurgitation severity and RV size and function before PVR on the outcome of RV size and function after PVR in 27 adult Fallot patients who had cardiac magnetic resonance imaging before and after PVR. RV dimensions were indexed for body surface area. Results:... Abstract

Cited 1 times since 2007 (0.1 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 20, Issue 3, 1 1 2007, Pages 257-261 Prognostic significance of akinesis becoming dyskinesis during dobutamine stress echocardiography. Sozzi FB, Elhendy A, Rizzello V, Biagini E, van Domburg RT, Vourvouri EC, Schinkel AF, Danzi GB, Bax JJ, Poldermans D

Background: Akinesis becoming dyskinesis (AKBD) at high-dose dobutamine stress echocardiography (DSE) has been disregarded as a marker of myocardial ischemia. However, its prognostic significance is unknown. Objectives: We sought to assess the long-term outcome of patients with AKBD during DSE. Methods: A total of 731 patients (age 62 +/- 15 years, 628 men) with two or more akinetic left ventricular segments at rest underwent DSE and were followed up for a mean period of 5 +/- 2.7 years. The end... Abstract

Cited 13 times since 2007 (0.7 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 93, Issue 3, 1 1 2007, Pages 375-376 Scar tissue on contrast-enhanced MRI predicts left ventricular remodelling after acute infarction. Kaandorp TA, Lamb HJ, Viergever EP, Poldermans D, Boersma E, van der Wall EE, de Roos A, Bax JJ

Abstract