6173 results
Cited 38 times since 2001 (1.6 per year)
source: EuropePMC
European journal of immunology,
Volume 31, Issue 1, 1 1 2001, Pages 146-155
Long lasting p53-specific T cell memory responses in the absence of anti-p53 antibodies in patients with resected primary colorectal cancer.
van der Burg SH, de Cock K, Menon AG, Franken KL, Palmen M, Redeker A, Drijfhout J, Kuppen PJ, van de Velde C, Erdile L, Tollenaar RA, Melief CJ, Offringa R
Colorectal carcinoma is commonly associated with mutation and overexpression of p53, making this antigen a potential target for immune intervention. We analyzed humoral and proliferative immunity against p53 in the blood of patients with resected primary colorectal cancer. The majority of these patients displayed anti-p53 T helper (Th) immunity in the absence of measurable p53 specific antibody levels. The Th responses were long-lasting since they could be detected up to several years after rese...
Abstract
Cited 34 times since 2001 (1.4 per year)
source: EuropePMC
Circulation,
Volume 103, Issue 4, 1 1 2001, Pages 562-569
Adenoviral expression of a urokinase receptor-targeted protease inhibitor inhibits neointima formation in murine and human blood vessels.
Quax PH, Lamfers ML, Lardenoye JH, Grimbergen JM, de Vries MR, Slomp J, de Ruiter MC, Kockx MM, Verheijen JH, van Hinsbergh VW
Background: Smooth muscle cell migration, in addition to proliferation, contributes to a large extent to the neointima formed in humans after balloon angioplasty or bypass surgery. Plasminogen activator/plasmin-mediated proteolysis is an important mediator of this smooth muscle cell migration. Here, we report the construction of a novel hybrid protein designed to inhibit the activity of cell surface-bound plasmin, which cannot be inhibited by its natural inhibitors, such as alpha(2)-antiplasmin....
Abstract
Cited 6 times since 2001 (0.2 per year)
source: EuropePMC
Early human development,
Volume 60, Issue 3, 1 1 2001, Pages 159-170
Inhibition of nitric oxide synthesis following severe hypoxia-ischemia restores autoregulation of cerebral blood flow in newborn lambs.
Dorrepaal CA, Steendijk P, Baan J, van Bel F
Birth asphyxia impairs the autoregulatory ability of the cerebral blood flow. Inappropriate synthesis of vasodilatory nitric oxide may be important in this respect. We investigated if nitric oxide synthesis inhibition by N(omega)-nitro-L-arginine (NLA) could restore cerebral autoregulation after severe hypoxia-ischemia (HI). HI was induced in 15 newborn lambs. Cerebral blood flow (carotid artery blood flow [ml/min]: Qcar) and mean aortic blood pressure [mmHg]: MABP) were measured over a 30 min p...
Abstract
Cited 25 times since 2001 (1 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 8, Issue 1, 1 1 2001, Pages 10-18
Comparison of left ventricular function at rest and post-stress in patients with myocardial infarction: Evaluation with gated SPECT.
Bavelaar-Croon CD, America YG, Atsma DE, Dibbets-Schneider P, Zwinderman AH, Stokkel MP, Pauwels EK, van der Wall EE
Background: Quantitative electrocardiogram-gated single photon emission computed tomography (SPECT) myocardial imaging (QGS) is a means of providing functional information about the left ventricle and myocardial perfusion. However, the functional information derived 30 minutes post-stress may be different from the left ventricular (LV) function determined at rest. This study determined whether LV function post-stress would be different from LV function at rest in patients with an earlier myocard...
Abstract
Cited 9 times since 2001 (0.4 per year)
source: EuropePMC
Nuclear medicine communications,
Volume 22, Issue 1, 1 1 2001, Pages 45-55
The additive value of gated SPET myocardial perfusion imaging in patients with known and suspected coronary artery disease.
Bavelaar-Croon CD, Atsma DE, van der Wall EE, Dibbets-Schneider P, Zwinderman AH, Pauwels EK
In myocardial perfusion scintigraphy, the clinical significance of fixed defects presents some difficulty. In this study, we evaluated whether additional information on left ventricular function assessed by quantitative gated single-photon emission computed tomography (gated SPET) would increase the diagnostic yield of the study in such patients. We studied 55 patients with a previous myocardial infarction and 20 patients without a previous myocardial infarction using gated SPET 99Tc(m)-tetrofos...
Abstract
Cited 19 times since 2001 (0.8 per year)
source: EuropePMC
Journal of biomechanics,
Volume 34, Issue 1, 1 1 2001, Pages 41-50
Predicting systolic and diastolic aortic blood pressure and stroke volume in the intact sheep.
Segers P, Steendijk P, Stergiopulos N, Westerhof N
We developed a mathematical model describing the interaction between the heart and the arterial system. The model was constructed and tested on basis of invasive hemodynamic data in six sheep. Data from a first group of three animals (49 cardiac cycles) were used to assess a template time-varying elastance curve for the left ventricle, while the baseline steady-state data of a second group of three animals were used to assess reference cardiac and arterial parameters in sheep. The model is fully...
Abstract
Cited 15 times since 2001 (0.6 per year)
source: EuropePMC
American journal of physiology. Heart and circulatory physiology,
Volume 280, Issue 1, 1 1 2001, Pages H392-400
Enhanced systolic function of the right ventricle during respiratory distress syndrome in newborn lambs.
De Vroomen M, Steendijk P, Lopes Cardozo RH, Brouwers HH, Van Bel F, Baan J
Respiratory distress syndrome (RDS) causes pulmonary hypertension. It is often suggested that this increased afterload for the right ventricle (RV) might lead to cardiac dysfunction. To examine this, we studied biventricular function in an experimental model. RDS was induced by lung lavages in seven newborn lambs. Five additional lambs served as controls. Cardiac function was quantified by indexes derived from end-systolic pressure-volume relations obtained by pressure-conductance catheters. Aft...
Abstract
Cited 8 times since 2000 (0.3 per year)
source: EuropePMC
Cardiovascular research,
Volume 48, Issue 3, 1 1 2000, Pages 455-463
A new approach to determine parallel conductance for left ventricular volume measurements.
Kornet L, Schreuder JJ, van der Velde ET, Baan J, Jansen JR
Objectives: To determine absolute ventricular volume with the conductance catheter technique, the electrical conductance of tissues and fluids (parallel conductance) around the ventricle should be determined precisely. Methods: A new objective method to estimate parallel conductance based on analysis of the dilution curve of hypertonic saline was investigated. The parallel conductances obtained with the new method (G(a)(p)) were compared to those obtained with the conventional method (G(l)(p))....
Abstract
Cited 19 times since 2000 (0.8 per year)
source: EuropePMC
International journal of cardiac imaging,
Volume 16, Issue 6, 1 1 2000, Pages 447-453
Good correlation between gated single photon emission computed myocardial tomography and contrast ventriculography in the assessment of global and regional left ventricular function.
Atsma DE, Bavelaar-Croon CD, Germano G, Dibbets-Schneider P, van Eck-Smit BL, Pauwels EK, van der Wall EE
Purpose: The purpose of this study was to determine the reliability of the measured left ventricular ejection fraction (LVEF) and wall motion analysis by the recently introduced quantitative electrocardiographically (ECG)-gated myocardial perfusion single-photon emission computed myocardial tomography technique (gated SPECT) (QGS). Materials and methods: We compared technetium-99 m tetrofosmin gated SPECT imaging and contrast ventriculography in the assessment of global and regional left ventric...
Abstract
Cited 105 times since 2000 (4.3 per year)
source: EuropePMC
The American journal of cardiology,
Volume 86, Issue 12, 1 1 2000, Pages 1299-1305
Comparison of gated single-photon emission computed tomography with magnetic resonance imaging for evaluation of left ventricular function in ischemic cardiomyopathy.
Bax JJ, Lamb H, Dibbets P, Pelikan H, Boersma E, Viergever EP, Germano G, Vliegen HW, de Roos A, Pauwels EK, Van der Wall EE
To perform a head-to-head comparison between magnetic resonance imaging (MRI) and gated single-photon emission computed tomography (SPECT) for the evaluation of left ventricular (LV) function (LV ejection fraction [LVEF], LV volumes, and regional wall motion) in patients with ischemic cardiomyopathy, we studied 22 patients with chronic coronary artery disease and LV dysfunction. Multislice, multiphase echoplanar MRI was performed with Philips Gyroscan ACS-NT15. Image analysis was performed using...
Abstract
Cited 39 times since 2000 (1.6 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 36, Issue 7, 1 1 2000, Pages 2104-2114
Acute and short-term effects of partial left ventriculectomy in dilated cardiomyopathy: assessment by pressure-volume loops.
Schreuder JJ, Steendijk P, van der Veen FH, Alfieri O, van der Nagel T, Lorusso R, van Dantzig JM, Prenger KB, Baan J, Wellens HJ, Batista RJ
Objectives: The aim of this study was to evaluate the short-term effects of partial left ventriculectomy (PLV) on left ventricular (LV) pressure-volume (P-V) loops, wall stress, and the synchrony of LV segmental volume motions in patients with dilated cardiomyopathy. Background: Surgical LV volume reduction is under investigation as an alternative for, or bridge to, heart transplantation for patients with end-stage dilated cardiomyopathy. Methods: We measured P-V loops in eight patients with dil...
Abstract
Cited 41 times since 2000 (1.7 per year)
source: EuropePMC
Journal of cardiovascular electrophysiology,
Volume 11, Issue 11, 1 1 2000, Pages 1183-1192
Three-dimensional catheter positioning during radiofrequency ablation in patients: first application of a real-time position management system.
de Groot NM, Bootsma M, van der Velde ET, Schalij MJ
Introduction: Precise localization of target sites for radiofrequency catheter ablation (RFCA) of arrhythmias is hampered by the relative inaccuracy of X-ray localization procedures. This study evaluated the efficacy of a three-dimensional (3D) real-time position management system in guiding RFCA procedures in patients. Methods and results: Patients (n = 30, age 59+/-20 years) referred for ablation of either atrial flutter (n = 10), ventricular tachycardia (n = 15), or accessory pathways (n = 5)...
Abstract
Cited 2 times since 2000 (0.1 per year)
source: EuropePMC
Health & social work,
Volume 25, Issue 4, 1 1 2000, Pages 276-279
Suggestions to social workers for surviving in managed care.
Schneider AW, Hyer K, Luptak M
Abstract
Cited 103 times since 2000 (4.2 per year)
source: EuropePMC
Radiology,
Volume 217, Issue 2, 1 1 2000, Pages 572-575
Left ventricular function: correlation of quantitative gated SPECT and MR imaging over a wide range of values.
Bavelaar-Croon CD, Kayser HW, van der Wall EE, de Roos A, Dibbets-Schneider P, Pauwels EK, Germano G, Atsma DE
In 21 patients, the authors compared results with quantitative gated single photon emission computed tomography (SPECT) to results with magnetic resonance imaging in the assessment of left ventricular (LV) end-diastolic volume (LVEDV), end-systolic volume (LVESV), and ejection fraction (LVEF). Between the two methods, correlations were good for LVEF (r = 0.85), LVEDV (r = 0.94), and LVESV (r = 0.95). Quantitative gated SPECT can help determine LVEF, LVEDV, and LVESV.
Abstract
Cited 29 times since 2000 (1.2 per year)
source: EuropePMC
Circulation,
Volume 102, Issue 21, 1 1 2000, Pages 2650-2658
Anisotropic reentry in a perfused 2-dimensional layer of rabbit ventricular myocardium.
Schalij MJ, Boersma L, Huijberts M, Allessie MA
Background: Anisotropy creates nonuniformity in electrical propagation and may contribute to the occurrence of unidirectional conduction block and reentry. We describe the characteristics of reentrant tachycardia in a 2D layer of anisotropic ventricular myocardium. Methods and results: A Langendorff-perfused epicardial sheet (1.0+/-0.4 mm, n=35) was created by freezing the intramural layers of the rabbit left ventricle. Epicardial activation maps were constructed by use of different high-resolut...
Abstract
Cited 31 times since 2000 (1.3 per year)
source: EuropePMC
Pacing and clinical electrophysiology : PACE,
Volume 23, Issue 11 Pt 1, 1 1 2000, Pages 1638-1644
Reduction of radiation exposure in the cardiac electrophysiology laboratory.
Wittkampf FH, Wever EF, Vos K, Geleijns J, Schalij MJ, van der Tol J, Robles de Medina EO
The purpose of this study was to determine the effects of various protective measures on patient and operator radiation dose levels in catheter ablation procedures. Catheter ablation procedures are associated with significant radiation levels. The patient's skin and operator radiation levels were measured (1) at baseline, (2) after primary beam filtration by 0.3-mm copper sheet and 2-mm aluminium plate and implementation of the LocaLisa system, and (3) after reduction of the left anterior o...
Abstract
Cited 42 times since 2000 (1.7 per year)
source: EuropePMC
Journal of hypertension,
Volume 18, Issue 11, 1 1 2000, Pages 1635-1644
The importance of high-frequency paced breathing in spectral baroreflex sensitivity assessment.
Frederiks J, Swenne CA, TenVoorde BJ, Honzíková N, Levert JV, Maan AC, Schalij MJ, Bruschke AV
Objective: Computation of the low-frequency (LF) blood pressure variability (BPV) to heart rate variability (HRV) transfer-index is a common method to assess baroreflex sensitivity (BRS), tacitly assuming that all LF-HRV is caused by baroreflex feedback of LF-BPV. However, respiration may also cause HRV by mechanisms not involving the baroreflex. Application of narrow-band (controlled) high-frequency breathing would keep such non-baroreflex-mediated HRV best out of the LF band. Spontaneous breat...
Abstract
Cited 2 times since 2000 (0.1 per year)
source: EuropePMC
International journal of cardiac imaging,
Volume 16, Issue 5, 1 1 2000, Pages 359-364
Stentless bioprostheses have ideal haemodynamics, even in the small aortic root.
Baur LH, Houdas Y, Peels KH, Braun J, van Straten B, Prat A, Kappetein AP, Wolters-Geldoff M, van der Wall EE, Bruschke AV, Huysmans HA
Objective: To determine normal Doppler and 2D gradients and flow characteristics of the Freestyle stentless aortic bioprosthesis related to valve size. Background: The Freestyle stentless aortic bioprosthesis is one of the newer aortic xenografts. Only limited data are available of the echocardiographic flow characteristics during a mid-term follow-up period of this valve. Therefore valve performance related to valve size was measured during a follow-up period of two years. Methods: 175 consecut...
Abstract
Echocardiography (Mount Kisco, N.Y.),
Volume 17, Issue 7, 1 1 2000, Pages 625-629
Echocardiographic imaging of stentless aortic valve prostheses.
Baur LH, Peels K, Braun J, Kappetein AP, Bootsma M, Van Der Ploeg A, Sieders A, Hazekamp M, Van Der Wall EE, Huysmans HA
Unlabelled: Homografts and stentless xenografts are increasingly used in aortic valve surgery. Echocardiography technicians and cardiologists have to know what they will find when performing an echo-Doppler examination in patients who received a stentless valve. We therefore evaluated echocardiographic images of 74 patients who received a Freestyle stentless bioprosthesis with three techniques and a follow-up of 2 years in two high-volume hospitals. Of the patients studied, 81% were operated usi...
Abstract
Cited 6 times since 2000 (0.2 per year)
source: EuropePMC
The American journal of cardiology,
Volume 86, Issue 7, 1 1 2000, Pages 774-6, A6
Effect of simvastatin on restenosis after percutaneous transluminal angioplasty of femoropopliteal arterial obstruction.
Hagenaars T, Gussenhoven EJ, van Sambeek MR, Jukema JW, Kranendonk SE, Bom N
This retrospective observational intravascular ultrasound study evaluated whether simvastatin therapy limits lumen area reduction 1-year after percutaneous transluminal angioplasty (PTA) by reducing reactive plaque growth, reducing reactive vasoconstriction, or both. This study showed that plaque growth is a general response 1 year after PTA regardless of the use of simvastatin; simvastatin has the potential to induce positive vascular remodeling, thereby reducing the occurrence of restenosis.
Abstract
