9618 results
The Journal of dermatological treatment,
Volume 36, Issue 1, 27 4 2025, Pages 2503273
Treatment goals and preferences of pediatric atopic dermatitis patients, young adults, and caregivers.
van der Rijst LP, de Bruin-Weller MS, Zuithoff NPA, Spillekom-van Koulil S, Seyger MMB, de Graaf M
Purpose: Understanding the treatment goals and preferences of young atopic dermatitis (AD) patients and their caregivers is crucial for enhancing patient-centered care. This study aims to identify these goals and preferences and explore heterogeneity among subgroups. Materials and methods: A web-based survey was conducted among children (6-11 years), adolescents (12-17 years), and young adults (18-30 years) with AD and caregivers of AD patients. Survey questions included multiple-choice, four-po...
Abstract
Open heart,
Volume 12, Issue 1, 27 4 2025, Pages e003355
Clinical course and outcomes of supravalvular aortic stenosis in adults.
de Keijzer AR, Keuning ZA, Meccanici F, van Kimmenade RRL, van Melle JP, Bouma BJ, Kluin J, Jongbloed MRM, Voskuil M, Roos-Hesselink JW, van den Bosch AE
Background: Supravalvular aortic stenosis (SVAS) is a rare condition with limited data on patients beyond childhood. This study aims to investigate the clinical course and outcomes of SVAS in adults. Methods: All adult (≥18 years) patients with SVAS, prospectively registered in the Dutch Congenital Cor Vitia database between 2001 and 2019, were included. Survival and event-free survival were assessed. Evolution of peak velocity was analysed using linear mixed models. Differences in previous oper...
Abstract
Chemistry & biodiversity,
27 4 2025, Pages e00911
Formation of Colchicine-incorporated Hybrid Nanoflower With an Intrinsic Peroxidase-Mimic and Enhanced Antimicrobial Activities.
Yilmaz E, Koca FD, Saticioglu IB, Ozen B, Yilmaz DD, Nisari M, Ocsoy I
We report the formation of colchicine-Cu3(PO4)2 hybrid nanoflowers (Colc-NFs) with intrinsic catalytic and antimicrobial activities with and without hydrogen peroxide (H2O2). While the colchicine molecule, known as a secondary metabolite with anti-inflammatory properties, was used as an organic part of Colc-NFs, the Cu2+ ion acted as an inorganic part of Colc-NFs. The acetamide group in the colchicine structure may react with Cu2+ ions in phosphate-buffered saline to form Colc-NFs. The Colc-NFs...
Abstract
Journal of cardiac failure,
23 4 2025, Pages S1071-9164(25)00236-2
The Association Between Serially Measured Circulating Biomarker Patterns and Pulmonary Artery Pressures Measured by Invasive Hemodynamic Monitoring.
Barry-Loncq DE Jong M, Allach Y, Abou Kamar S, Clephas PRD, Brunner-LA Rocca HP, Handoko ML, VAN Halm VP, Kok WEM, Asselbergs FW, VAN Kimmenade RRJ, Beeres SLMA, Rienstra M, Szymanski MK, DE Boer RA, Kardys I, Brugts JJ
Background: Invasive hemodynamic monitoring devices provide relevant insights into the hemodynamic status of heart failure (HF) patients. Additionally, circulating biomarkers have been advocated as additives in HF management by offering prognostic information and therapeutic targets. However, limited data exist correlating serially measured biomarkers to hemodynamic pressures provided by invasive sensors. This study aims to investigate the association between serial biomarker patterns and pulmon...
Abstract
Bone research,
Volume 13, Issue 1, 23 4 2025, Pages 55
Age- and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature aging.
Yılmaz D, Marques FC, Gregorio L, Schlatter J, Gehre C, Pararajasingam T, Qiu W, Mathavan N, Qin XH, Wehrle E, Kuhn GA, Müller R
Age-related osteoporosis poses a significant challenge in musculoskeletal health; a condition characterized by reduced bone density and increased fracture susceptibility in older individuals necessitates a better understanding of underlying molecular and cellular mechanisms. Emerging evidence suggests that osteocytes are the pivotal orchestrators of bone remodeling and represent novel therapeutic targets for age-related bone loss. Our study uses the prematurely aged PolgD257A/D257A (PolgA) mouse...
Abstract
The international journal of cardiovascular imaging,
Volume 41, Issue 7, 22 4 2025, Pages 1371-1379
Evolution and prognostic implications of cardiac damage in women after transcatheter aortic valve implantation.
Myagmardorj R, Fortuni F, Galloo X, Nabeta T, Meucci MC, Butcher SC, van der Kley F, Ajmone Marsan N, Bax JJ
Recently, a cardiac damage staging system has been proposed in patients with severe AS to improve risk stratification, but there is still paucity of data in women. Accordingly, we aimed to characterize the change in cardiac damage after transcatheter aortic valve implantation (TAVI), and to assess the prognostic value of cardiac damage staging in women. A total of 334 women (mean age 81 ± 7 years) with severe AS undergoing TAVI were included and retrospectively analyzed. Echocardiography was per...
Abstract
BMC medical education,
Volume 25, Issue 1, 22 4 2025, Pages 757
The effect of three different techniques used to improve vein prominence on the first peripheral venous catheterization experience in nursing students: a randomized controlled study.
Yılmaz H, Yılmaz D, Çinar HG
Background: Peripheral venous catheterization (PVC) insertion is a complex sensory-motor skill that can be difficult for nursing students to acquire. Objectives: The authors aimed to examine the effect of three techniques used to improve vein prominence on achievement, knowledge, and psychomotor skills in the first PVC experience in nursing students. Methods: A single-center, parallel-group, randomized control study. Near-infrared light visualization (n = 49) and isometric exercise (n = 50) tech...
Abstract
Healthcare (Basel, Switzerland),
Volume 13, Issue 11, 22 4 2025, Pages 1217
Bridging Barriers: Engaging Ethnic Minorities in Cardiovascular Research.
Bacour N, Grewal S, Ploem MC, Suurmond J, Klautz RJM, Grewal N
Background/Objectives: We address the ongoing under-representation of ethnic minority groups in cardiovascular research in this opinion paper-a challenge that limits both scientific validity and equitable healthcare outcomes. We aim to outline the underlying causes of this issue and propose concrete strategies to address it. Methods: To engage ethnic minorities in cardiovascular research, we thoroughly studied the existing literature and gathered expert opinions to identify barriers and formulat...
Abstract
American journal of preventive cardiology,
Volume 22, 22 4 2025, Pages 101008
The interactions of Lipoprotein(a) with common cardiovascular risk factors in cardiovascular disease risk: evidence based on the UK Biobank.
Ao L, Noordam R, Jukema JW, van Heemst D, Willems van Dijk K
Background: : Although Lipoprotein(a) (Lp(a)) is associated with cardiovascular disease, it is unclear whether the associated risk is similar in the presence of other concomitant risk factors. Here, we aimed to investigate the interactions between Lp(a) and common cardiovascular risk factors on coronary artery disease (CAD), calcific aortic valve stenosis (CAVS) and ischemic stroke (IS). Methods: : We included 127,958 unrelated European-ancestry participants from UK Biobank (54.7 % women) with d...
Abstract
European urology oncology,
20 3 2025, Pages S2588-9311(25)00104-X
Towards Defining Follow-up Strategies for Patients with Primary Intermediate-risk Non-muscle-invasive Bladder Cancer.
Contieri R, Martini A, Beijert IJ, Mertens LS, Hentschel AE, Bründl J, Compérat EM, Plass K, Rodríguez O, Subiela Henríquez JD, Hernández V, de la Peña E, Alemany I, Turturica D, Pisano F, Soria F, Čapoun O, Bauerová L, Pešl M, Maxim Bruins H, Runneboom W, Herdegen S, Breyer J, Brisuda A, Calatrava A, Rubio-Briones J, Seles M, Mannweiler S, Bosschieter J, Kusuma VRM, Ashabere D, Huebner N, Seisen T, Claps F, Masson-Lecomte A, Liedberg F, Cohen D, Lunelli L, Cussenot O, Sheikh SE, Volanis D, Côté JF, Rouprêt M, Haitel A, Shariat SF, Mostafid AH, Nieuwenhuijzen JA, Zigeuner R, Dominguez-Escrig JL, Hacek J, Zlotta AR, Burger M, Evert M, de Kaa CAH, van der Heijden AG, Kiemeney LALM, Soukup V, Molinaro L, Hurle R, Paciotti M, Moschini M, Pradere B, Perdonà S, Gontero P, Llorente C, Algaba F, Palou J, N'Dow J, Ribal MJ, van der Kwast TH, Babjuk M, Sylvester RJ, van Rhijn BWG
Background and objective: The current European Association of Urology (EAU) guidelines on non-muscle-invasive bladder cancer (NMIBC) categorize patients into four risk groups. In 2024, a specific follow-up schedule was introduced for intermediate-risk (IR) disease. However, recommendations are based on expert opinion and restricted to patients with IR-NMIBC who have primary low-grade or high-grade/grade 2 disease. Our aim was to identify a subgroup of patients with IR-NMIBC who may require more...
Abstract
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
Volume 106, Issue 1, 19 3 2025, Pages 711-719
Efficacy and Safety of Intravascular Lithotripsy in the Management of Underexpanded Stents: A Systematic Review and Meta-Analysis.
Sagris M, Soulaidopoulos S, Papanikolaou A, Ktenopoulos N, van Oort MJH, Montero-Cabezas JM, Patsourakos N, Honton B, Tousoulis D, Tsioufis K
Background: Stent underexpansion significantly heightens the risk of major adverse cardiac events (MACE), and available treatment options for this condition remain limited. Intravascular Lithotripsy (IVL) technology disrupts superficial and deep calcium by using localized pulsative sonic pressure waves, emerges as a promising tool for underexpanded stents. Aims: This study examines the overall efficacy and safety of IVL, an until-now off-label modality, in the management of underexpanded stents....
Abstract
Cited 1 times since 2025 (3.9 per year)
source: EuropePMC
BMJ open,
Volume 15, Issue 5, 16 3 2025, Pages e095504
Study protocol of the multicentre, randomised, triple-blind, placebo-controlled MERCURI-2 trial: promoting effective renoprotection in cardiac surgery patients by inhibition of sodium glucose cotransporter (SGLT)-2.
Oosterom-Eijmael M, Monteiro de Oliveira NP, Niesten ED, Tolsma M, Snellen FT, Gerritse BM, Scohy TV, Rettig T, Godfried MB, Voogd MF, Wink J, van der Werff LM, Eberl S, Preckel B, Hermanides J, van Raalte DH, Hulst AH, MERCURI-2 study group
Introduction: Acute kidney injury (AKI) is a major complication after cardiac surgery and is associated with postoperative morbidity and mortality. Currently, no effective therapy exists to reduce the incidence of postoperative AKI. Sodium-glucose cotransporter-2 (SGLT2) inhibitors are effective in reducing AKI in outpatient settings for patients with chronic kidney disease. We hypothesised that perioperative SGLT2 inhibition will also reduce AKI incidence after cardiac surgery according to Kidn...
Abstract
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
Volume 55, Issue 7, 15 3 2025, Pages 552-563
Complementary Analysis of Local and Systemic Effects of Dupilumab in Paediatric AD Using Tape Strips and Serum.
van der Rijst LP, Knol EF, Zuithoff NPA, den Hartog Jager CF, van Wijk F, de Bruin-Weller MS, de Graaf M
Objective: This study investigates local and systemic immune-related proteins in tape strips and serum of paediatric atopic dermatitis (AD) patients treated with dupilumab, and explores their correlation with clinical severity. Methods: Twenty paediatric AD patients (
Abstract
Journal of clinical medicine,
Volume 14, Issue 10, 13 2 2025, Pages 3393
Pseudoaneurysmectomy After Left Ventricular Free Wall Rupture Repair: A Case Report.
Baldan BU, Klein P, Stöger JL, Klautz RJM, Palmen M
Background/Objectives: Left ventricular (LV) pseudoaneurysm is a rare but life-threatening complication after acute myocardial infarction, often resulting from inadequate excision of damaged myocardium and use of only a xenopericardial patch during primary LV free wall rupture repair. Methods: A 62-year-old female developed a giant LV pseudoaneurysm one year after initial surgical repair of a free wall rupture with a xenopericardial patch. Imaging confirmed a large pseudoaneurysm with a broad ne...
Abstract
CJC open,
Volume 7, Issue 7, 13 2 2025, Pages 887-896
Concomitant Atrial Fibrillation Ablation in Surgical Aortic Valve Replacement: A Systematic Review and Meta-Analysis.
Polat E, Kharbanda RK, Ghafar M, Schoones JW, Klautz RJM, de Riva M, Palmen M, Girdauskas E, Tomšič A
Background: Atrial fibrillation (AF) is common in patients undergoing surgical aortic valve replacement; however, surgical ablation remains underused due to limited data on its efficacy. Methods: We conducted a systematic review of the literature by searching PubMed, Embase, Web of Science, Emcare, and the Cochrane Library for studies reporting outcomes of concomitant surgical AF ablation in patients undergoing surgical aortic valve replacement. The primary outcomes included freedom from AF recu...
Abstract
Heart & lung : the journal of critical care,
Volume 73, 12 2 2025, Pages 108-113
Intravascular lithotripsy and temporary mechanical circulatory support for the treatment of heavily calcified coronary artery disease: insights from the BENELUX-IVL registry.
Oliveri F, Merino I, van Oort MJH, Al Amri I, Bingen BO, Arslan F, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, van der Kley F, Jukema JW, Montero-Cabezas J
Background: Intravascular lithotripsy (IVL) is increasingly utilized for the treatment of heavily calcified coronary lesions. However its use in conjunction with temporary mechanical circulatory support (tMCS) remains underexplored. Objective: This study aims to evaluate the current use of tMCS and IVL for the treatment of heavily calcified coronary lesions. Method: From the BENELUX-IVL prospective registry, patients who underwent IVL during PCI and required tMCS during the procedure were select...
Abstract
Arthritis & rheumatology (Hoboken, N.J.),
12 2 2025
Differences in Dynamics of Specific Antinuclear Antibodies and Their Susceptibility to B Cell-Targeting Treatment in Patients With Systemic Lupus Erythematosus.
van Dooren HJ, van Schaik M, Dorjée AL, Arends EJ, Mackay M, Cooney L, Fox DA, Wofsy D, Smilek D, Aranow C, Dall'Era M, Huizinga TWJ, van Kooten C, Toes REM, Diamond B, Teng YKO, Suurmond J
Objective: The presence of antinuclear antibodies (ANAs) is characteristic for systemic lupus erythematosus (SLE). Antibody dynamics over time are thought to reflect the cellular source of ANAs and their therapeutic targetability. Anti-double-stranded DNA (anti-dsDNA) is the most prevalent and well-studied of all ANAs, and fluctuations in anti-dsDNA serum levels are associated with disease activity. Antibody dynamics of other ANAs, such as antibodies targeting RNA-binding proteins (RBPs), are of...
Abstract
Psychological research,
Volume 89, Issue 3, 8 2 2025, Pages 98
Moral decision-making 'on the fly'.
Kusev P, Martin R, van Schaik P, Teal J
Over a century of research has focused on the consistency and inconsistency of human moral decision preferences. We proposed and found that moral decision preferences are flexible and shift towards newly learned moral rules when their application leads to utilitarian choices. Hence, decision-makers' psychological concept of morality is continually under construction (on the fly); based on learning, informed by changes in moral rules and specific moral contexts. Accordingly, in two experimen...
Abstract
Annals of surgery,
8 2 2025
Combined Clinical and Histopathological Risk Stratification for Prediction of (severe) Endoscopic Postoperative Recurrence in Patients with Crohn's Disease after Ileocolic Resection: Results from A Prospective Multicenter Cohort Study.
Bak MTJ, Bak MTJ, Oudijk L, Ooms AHAG, Beelen EMJ, van der Bilt JDW, Romberg-Camps M, Dijkstra G, Duijvestein M, van der Marel S, Stassen LPS, Maljaars PWJ, Buskens CJ, Lange JFM, Kats-Ugurlu G, Jansen SV, Jharap BJH, Horjus CS, van Schaik FDM, West RL, de Boer NKH, Janneke van der Woude C, Parikh K, van Ruler O, Doukas M, de Vries AC, RAP-CD study group; on behalf of the Dutch Initiative on Crohn and Colitis (ICC) & Dutch Initiative on Crohn and Colitis – Surgery (ICC-S)
Objective: This study assessed the association of histopathological features in the resection specimen of CD patients with (severe) endoscopic postoperative recurrence (ePOR) in a large prospective, multicenter cohort study. Summary background data: The predictive value of histopathologic features of the intestinal resection specimen for the risk of Crohn's disease (CD) recurrence after ileocolic (re-)resection (ICR) remains a matter of debate. Methods: CD patients (≥16 y) scheduled for ICR...
Abstract
Molecular therapy. Nucleic acids,
Volume 36, Issue 2, 5 1 2025, Pages 102553
Validation of tRNA-derived fragments as diagnostic biomarkers in suspected acute stroke; limitations in analysis and quantification methods.
Woudenberg T, van der Bent ML, van den Homberg DAL, Nguyen TTM, Wermer MJH, van den Wijngaard IR, Quax PHA, Nossent AY, Kruyt ND
In acute stroke, timely diagnosis is essential to prevent extensive neuronal damage and improve patient outcomes. However, differentiating between ischemic stroke, intracerebral hemorrhage, and stroke mimics remains challenging. Transfer RNA-derived fragments (tRFs) have emerged as potential biomarkers for distinguishing between these stroke subtypes. Here we used reverse transcription-quantitative PCR (RT-qPCR) to investigate the expression of specific tRFs that we previously identified in smal...
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