9618 results
Developmental psychology,
5 1 2025
Psychological needs and well-being through the eyes of vocational students in Aruba, Dutch Caribbean.
Proveyer Llopiz MR, van Schaik SDM, Harkness S, Super CM, Denessen EJPG
Well-being has been thoroughly studied worldwide mostly using questionnaires. Still, it is unclear what well-being means in specific contexts, as studies found that both well-being and underlying psychological needs may vary across cultures. In Aruba, concerns were raised regarding youth well-being. Therefore, this project used a mixed-method approach to explore the development of young people's well-being in Aruba. By taking a culture and human development approach, this project aims to co...
Abstract
Cancers,
Volume 17, Issue 9, 3 1 2025, Pages 1557
Patterns of Recurrence After Postoperative Stereotactic Radiotherapy for Brain Metastases.
Crouzen JA, Petoukhova AL, Hakstege M, van Schaik EEMW, Nandoe Tewarie RDS, Nabuurs RJA, Vos MJ, Kerkhof M, van der Vaart T, Koekkoek JAF, Hagenbeek RE, Yildirim FM, Wiltink LM, van der Voort van Zyp NCMG, Kiderlen M, Broekman MLD, Mast ME, Zindler JD
Background/objectives: Neurosurgical resection is the standard treatment for large brain metastases (BMs). Postoperative stereotactic radiotherapy (SRT) is used to reduce local recurrence (LR) but does not always prevent leptomeningeal disease (LMD). This study aims to analyze patterns of tumor recurrence and to identify opportunities for the further improvement of treatment efficacy. Methods: We included 147 patients who underwent resection and SRT for BMs. The distance between the resection ca...
Abstract
The Science of the total environment,
Volume 980, 3 1 2025, Pages 179386
Towards a European sustainable beneficiation of rare earth elements bearing minerals: a review.
Gajendra N, Yilmaz D, Vila MC, de Lurdes Dinis M, Levei EA, Török AI, Avsar D, Kladis A, Preveniou A, Hansen AM, Aaen SB, Ferrando-Climent L
This review explores the multifaceted aspects of sustainable extraction of rare earth elements (REEs) bearing minerals within Europe, stressing the exploitation of local deposits, that together with the integration of cleaner and greener approaches (including circular economy approaches) might help to reduce dependency on imports and contribute to a greener economy. The mineralogical characteristics and distribution of REEs in European deposits are examined, alongside current and emerging benefi...
Abstract
Cited 1 times since 2025 (3.4 per year)
source: EuropePMC
Journal of the Society for Cardiovascular Angiography & Interventions,
Volume 4, Issue 5, 1 1 2025, Pages 102635
Coronary Compliance Modification by Intravascular Lithotripsy: New Predictor of Stent Expansion in Calcified Coronary Lesions.
Oliveri F, Van Oort MJH, Al Amri I, Bingen BO, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, Van der Kley F, Jukema JW, Montero-Cabezas JM
Background: Intravascular lithotripsy (IVL) has been demonstrated to be effective in treating balloon-crossable calcified coronary lesions by inducing calcium fractures and facilitating stent expansion (SE), theoretically by improving coronary artery compliance (CACom). Direct evidence of this theory has not yet been provided. Methods: From the BENELUX-IVL prospective registry (NCT06577038) enrolling patients with calcified coronary artery lesions treated with IVL, intravascular ultrasound-guide...
Abstract
Journal of the American College of Cardiology,
Volume 85, Issue 17, 1 1 2025, Pages 1695-1705
Proactive Mapping and Preventive Ablation Reduce Defibrillator Implantation Rates in Tetralogy of Fallot.
Kimura Y, Wallet J, Brouwer C, Bokma JP, Bertels RA, Jongbloed MRM, Hazekamp MG, Blom NA, Zeppenfeld K
Background: In patients with repaired tetralogy of Fallot (rTOF) and spontaneous ventricular tachycardia (VT), transection of slow-conducting anatomical isthmus (SCAI) by ablation results in excellent long-term VT-free survival. In patients without prior VT, proactive electroanatomical mapping and preventive SCAI ablation may impact patient selection for primary prevention implantable cardioverter-defibrillator (ICD) implantation. Objectives: The purpose of this study was to evaluate long-term o...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 26, Issue 6, 1 1 2025, Pages 1082
Mitral valve stretched to its limit: a case of an aborted sudden cardiac death with extensive fibrotic ventricular remodelling.
van Rosendael PJ, Biesbroek PS, Meijs TA, Gotte MJW, Hopman LHGA
Abstract
European heart journal. Cardiovascular Imaging,
Volume 26, Issue 6, 1 1 2025, Pages 945-954
CCTA-Derived coronary plaque burden offers enhanced prognostic value over CAC scoring in suspected CAD patients.
Dahdal J, Jukema RA, Maaniitty T, Nurmohamed NS, Raijmakers PG, Hoek R, Driessen RS, Twisk JWR, Bär S, Planken RN, van Royen N, Nijveldt R, Bax JJ, Saraste A, van Rosendael AR, Knaapen P, Knuuti J, Danad I
Aims: To assess the prognostic utility of coronary artery calcium (CAC) scoring and coronary computed tomography angiography (CCTA)-derived quantitative plaque metrics for predicting adverse cardiovascular outcomes. Methods and results: The study enrolled 2404 patients with suspected coronary artery disease (CAD) but without a prior history of CAD. All participants underwent CAC scoring and CCTA, with plaque metrics quantified using an artificial intelligence (AI)-based tool (Cleerly, Inc). Perc...
Abstract
Cited 1 times since 2025 (3.4 per year)
source: EuropePMC
Brain : a journal of neurology,
Volume 148, Issue 5, 1 1 2025, Pages 1531-1539
N-methyl-d-aspartate receptor hypofunction causes recurrent and transient failures of perceptual inference.
Weilnhammer V, Rothkirch M, Yilmaz D, Fritsch M, Ptasczynski LE, Reichenbach K, Roediger L, Corlett P, Sterzer P
Perception integrates external sensory signals with internal predictions that reflect prior knowledge about the world. Previous research suggests that this integration is governed by slow alternations between an external mode, driven by sensory signals, and an internal mode, shaped by prior knowledge. Using a double-blind, placebo-controlled, cross-over experiment in healthy human participants, we investigated the effects of the N-methyl-D-aspartate receptor (NMDAR) antagonist S-ketamine on the...
Abstract
Cited 1 times since 2025 (3.4 per year)
source: EuropePMC
European heart journal. Cardiovascular pharmacotherapy,
Volume 11, Issue 3, 1 1 2025, Pages 230-240
Cost-effectiveness of implementing a genotype-guided de-escalation strategy in patients with acute coronary syndrome.
van den Broek WWA, van den Broek WWA, Azzahhafi J, Chan Pin Yin DRPP, van der Sangen NMR, Sivanesan S, Dijksman LM, Walhout RJ, Tjon Joe Gin M, Breet NJ, Langerveld J, Vlachojannis GJ, van Bommel RJ, Appelman Y, van Schaik RHN, Henriques JPS, Kikkert WJ, Ten Berg JM
Aims: A genotype-guided P2Y12-inhibitor de-escalation strategy, switching acute coronary syndrome (ACS) patients without a CYP2C19 loss-of-function allele from ticagrelor or prasugrel to clopidogrel, has shown to reduce bleeding risk without affecting the effectivity of therapy by increasing ischaemic risk. We estimated the cost-effectiveness of this personalized approach compared to standard dual antiplatelet therapy (DAPT; aspirin plus ticagrelor/prasugrel) in the Netherlands. Methods and resu...
Abstract
Cited 1 times since 2025 (3.4 per year)
source: EuropePMC
Rheumatology (Oxford, England),
Volume 64, Issue 5, 1 1 2025, Pages 2979-2986
Type I interferon biomarker in idiopathic inflammatory myopathies: associations of Siglec-1 with disease activity and treatment response.
Kamperman RG, Veldkamp SR, Evers SW, Lim J, van Schaik I, van Royen-Kerkhof A, van Wijk F, van der Kooi AJ, Jansen M, Raaphorst J
Objectives: Novel biomarkers are needed to guide therapy in idiopathic inflammatory myopathies (IIM). Expression of Siglec-1, a type I interferon biomarker, was examined in adult patients with IIM in relation to disease activity and treatment response. Methods: We analyzed PBMC samples from 19 newly diagnosed adult IIM patients who participated in a phase-2 pilot study on efficacy of intravenous immunoglobulin (IVIG) monotherapy, and from 9 healthy controls. Siglec-1 expression on monocytes was...
Abstract
Cancer communications (London, England),
1 1 2025
Semaglutide impairs bioavailability of alectinib: a note of warning based on a cross-over pharmacokinetic drug-drug interaction study.
Heersche N, Lanser DAC, Oomen-de Hoop E, Içli A, de Bruijn P, Paats MS, van Rossum EFC, Koolen SLW, van Schaik RHN, Dingemans AC, Veerman GDM, Mathijssen RHJ
Abstract
Environmental microbiology,
Volume 27, Issue 5, 1 1 2025, Pages e70113
Patchy Distribution of Potato Cyst Nematodes Within Single Arable Fields Reveals Local Disease Suppressiveness Mediated by Disparate Microbial Communities.
van Himbeeck R, Geisen S, van Schaik C, van den Elsen S, Berendsen R, Bertran A, Schepel E, Helder J
Disease suppressiveness is a complex phenomenon that is assumed to be the resultant of the actions of local microbial antagonists. Exploitation of disease suppressiveness as a tool to manage pathogens is hindered by our poor understanding of this phenomenon. Here we investigated soil microbiome-based suppression of potato cyst nematodes (PCN), and to this end, four apparently homogeneous potato fields with an unexplained non-homogeneous PCN distribution were selected. We hypothesised that this p...
Abstract
Frontiers in microbiology,
Volume 16, 30 5 2025, Pages 1582703
Rapid extended-spectrum beta-lactamase-confirmation by using a machine learning model directly on routine automated susceptibility testing results.
Ghouch YE, Schut MC, Sigaloff KCE, Altorf-Van Der Kuil W, Prins JM, Schade RP, ISIS-AR study group
Objectives: Phenotypical Extended Spectrum β-Lactamase (ESBL)-production is commonly determined using the combination disk diffusion test or gradient test. This requires overnight incubation, prolonging time-to-detection and increasing duration of empirical treatment for patients with infections caused by gram-negative bacteria. To achieve instant confirmation without incubation, we developed a machine learning (ML)-model that predicts phenotypic ESBL-confirmation using Minimum Inhibitory Concen...
Abstract
European journal of cancer (Oxford, England : 1990),
Volume 224, 30 5 2025, Pages 115483
Dose-individualisation of fluoropyrimidines based on pre-treatment serum uracil levels: the Alpe2U study.
Knikman JE, de With M, Heersche N, Lopez-Yurda M, Baars A, Creemers GJ, Droogendijk HJ, Fiets E, Imholz ALT, Iersel LV, Mandigers CMPW, van de Vendel AJ, Jeurissen FJF, Nieboer P, Deenen MJ, van de Poel MHW, Wymenga MNM, van Schaik RHN, van den Bosch BJC, Hoop EO, Rosing H, Swen JJ, Gelderblom H, Schellens JHM, Beijnen JH, Mathijssen RHJ, Guchelaar HJ, Cats A
Background: DPYD-guided dosing enhances safety of fluoropyrimidine-based chemotherapy. However, approximately 23 % of patients still experience severe toxicity unexplained by the four commonly tested DPYD-variant alleles. Elevated pre-treatment uracil levels have been proposed as a surrogate marker for reduced DPD activity and an independent predictor of toxicity. This prospective study evaluated whether uracil-guided dose individualisation can reduce severe fluoropyrimidine-induced toxicity in...
Abstract
ASAIO journal (American Society for Artificial Internal Organs : 1992),
29 5 2025
Bridging Therapy and Risk of Bleeding and Thrombosis in Continuous-Flow Left Ventricular Assist Device Patients: A Quasi-Experimental Study.
Camilleri E, Roovers RPW, Janssen E, Krommenhoek JF, Klok FA, Palmen M, Jukema JW, van Rein N, Tops LF
Bridging with low-molecular-weight heparin (LMWH) is recommended in continuous-flow left ventricular assist device (CF-LVAD) patients during subtherapeutic international normalized ratios (INRs). We aimed to assess the risk of adverse events during bridging in patients implanted at Leiden University Medical Center between 2010 and 2024. Incidence rates and hazard ratios of major bleeding, thromboembolic events, neurologic complications, and death with 95% confidence intervals (95% CI) were estim...
Abstract
Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society,
Volume 114, Issue 2, 29 5 2025, Pages 172
Sex differences as a catalyst for the next step in surgeon personality research.
Sier JA, van der Vorst JR, Sier VQ
Abstract
Portuguese journal of cardiac thoracic and vascular surgery,
Volume 32, Issue 1, 29 5 2025, Pages 25-33
Surgical Aortic Valve Replacement For Bicuspid And Tricuspid Valve Disease: 7-Year Outcomes In >1100 Patients.
Labrousse L, Moront MG, Dagenais F, Reardon MJ, Deeb GM, Günzinger R, Ruel M, Wu T, Klautz RJM, Sabik JF
Introduction: Bicuspid aortic valve affects 0.5-2% of the population in developed countries. Given uncertainties about the best aortic valve replacement (AVR) option in this often younger, low-risk, population, it is important to understand how newer bioprostheses perform in these patients. The primary objective of this analysis was to compare 7-year outcomes of surgical AVR (SAVR) with the Avalus bioprosthesis between patients with a congenital bicuspid or tricuspid valve. Methods: This prospec...
Abstract
The Pediatric infectious disease journal,
28 4 2025
Listeria Meningitis in Pediatric Patient with Associated Pneumonia Presenting with Refractory Status Epilepticus: Expanding the Clinical Spectrum of an Underrecognized Entity.
Kuş S, Alataş ŞÖ, Tüz AE, Dündar NO, Durak F, Yilmaz D
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 169, 28 4 2025, Pages D8365
[Bilateral femoral fractures due to bisphosphonate use].
Reijmer JFH, van Schaik TJA, Vermeulen MAR, van der Stappen WJM, Strang S
The risk of an atypical femoral fracture increases with the use of bisphosphonates for longer than 5 years. The typical presentation of an atypical femoral fracture consists of a transverse subtrochanteric femoral fracture originating from the lateral cortex with a medial spike, occurring after minimal or no trauma. For patients presenting with a spontaneous femoral fracture who are using bisphosphonates, it is recommended to discontinue bisphosphonate use and to determine the future fracture ri...
Abstract
CJC open,
Volume 7, Issue 7, 27 4 2025, Pages 967-968
Dual Sinus Origins of the Left Coronary Artery From the Right and Left Coronary Sinus.
Oliveri F, Van Oort M, Van der Kley F, Jukema JW, Montero-Cabezas J
Abstract
