Research

Publications

Below you can find a list of our published research.

9618 results

Cited 1 times since 2024 (1 per year) source: EuropePMC

Microbiology spectrum, Volume 12, Issue 10, 20 3 2024, Pages e0420823 An interlaboratory proficiency test using metagenomic sequencing as a diagnostic tool for the detection of RNA viruses in swine fecal material. Liu L, Hakhverdyan M, Wallgren P, Vanneste K, Fu Q, Lucas P, Blanchard Y, de Graaf M, Oude Munnink BB, van Boheemen S, Bossers A, Hulst M, Van Borm S

Metagenomic shotgun sequencing (mNGS) can serve as a generic molecular diagnostic tool. An mNGS proficiency test (PT) was performed in six European veterinary and public health laboratories to detect porcine astroviruses in fecal material and the extracted RNA. While different mNGS workflows for the generation of mNGS data were used in the different laboratories, the bioinformatic analysis was standardized using a metagenomic read classifier as well as read mapping to selected astroviral referen... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 32, Issue 10, 19 3 2024, Pages 356-362 Trends in adoption of extravascular cardiac implantable electronic devices: the Dutch cohort. Breeman KTN, Knops RE, van der Stoel MD, Boersma LVA, Yap SC, van Erven L, van Dijk VF, Maass AH, Wilde AAM, Tjong FVY, Device Registration Committee of the Netherlands Heart Registration

Introduction: Conventional implantable cardioverter-defibrillators (ICDs) and pacemakers carry a risk of pocket- and lead-related complications in particular. To avoid these complications, extravascular devices (EVDs) have been developed, such as the subcutaneous ICD (S-ICD) and leadless pacemaker (LP). However, data on patient or centre characteristics related to the actual adoption of EVDs are lacking. Objective: To assess real-world nationwide trends in EVD adoption in the Netherlands. Method... Abstract

Cited 4 times since 2024 (4 per year) source: EuropePMC

EBioMedicine, Volume 107, 17 3 2024, Pages 105279 NMR metabolomics-guided DNA methylation mortality predictors. Bizzarri D, Reinders MJT, Kuiper L, Beekman M, Deelen J, van Meurs JBJ, van Dongen J, Pool R, Boomsma DI, Ghanbari M, Franke L, BBMRI Consortium, Slagboom PE, van den Akker EB

Background: 1H-NMR metabolomics and DNA methylation in blood are widely known biomarkers predicting age-related physiological decline and mortality yet exert mutually independent mortality and frailty signals. Methods: Leveraging multi-omics data in four Dutch population studies (N = 5238, ∼40% of which male) we investigated whether the mortality signal captured by 1H-NMR metabolomics could guide the construction of DNA methylation-based mortality predictors. Findings: We trained DNA methylation... Abstract

Cited 1 times since 2024 (1 per year) source: EuropePMC

BMC public health, Volume 24, Issue 1, 16 3 2024, Pages 2235 Assessing the knowledge, attitude, and practice of frontline physicians in Egyptian university hospitals regarding pharyngitis and acute rheumatic fever: a cross-sectional study that calls for action. Abdelsayed K, Ali HT, Helal MB, Assar A, Madany M, Gabra MD, Abdelrahman A, Goudy Y, Dandrawy A, Soliman ZA, Qubaisy HM, Shahin GMM, ARF –RHD Prevention Group, Azimullah PC

Background: Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) remain major public health issues. Although the primary and secondary prevention of RHD through appropriate management of bacterial pharyngitis and ARF are well-described in the literature, few studies address the knowledge, attitude, and practice (KAP) of developing countries. We aimed to evaluate the KAP of the frontline physicians in Egyptian university hospitals regarding pharyngitis and ARF. Methods: We employed a cro... Abstract

Cited 3 times since 2024 (3 per year) source: EuropePMC

Genome medicine, Volume 16, Issue 1, 15 3 2024, Pages 101 Discovering novel germline genetic variants linked to severe fluoropyrimidine-related toxicity in- and outside DPYD. Knikman JE, Zhai Q, Lunenburg CATC, Henricks LM, Böhringer S, van der Lee M, de Man FM, Offer SM, Shrestha S, Creemers GJ, Baars A, Dezentjé VO, Imholz ALT, Jeurissen FJF, Portielje JEA, Jansen RLH, Hamberg P, Droogendijk HJ, Koopman M, Nieboer P, van de Poel MHW, Mandigers CMPW, van Schaik RHN, Gelderblom H, Mathijssen RHJ, Schellens JHM, Cats A, Guchelaar HJ, Swen JJ

Background: The Alpe-DPD study (NCT02324452) demonstrated that prospective genotyping and dose-individualization using four alleles in DPYD (DPYD*2A/rs3918290, c.1236G > A/rs75017182, c.2846A > T/rs67376798 and c.1679 T > G/rs56038477) can mitigate the risk of severe fluoropyrimidine toxicity. However, this could not prevent all toxicities. The goal of this study was to identify additional genetic variants, both inside and outside DPYD, that may contribute to fluoropyrimidine toxicity.... Abstract

Cited 2 times since 2024 (2 per year) source: EuropePMC

Preventive veterinary medicine, Volume 232, 13 2 2024, Pages 106313 Risk factors for the introduction of Salmonella spp. serogroups B and D into Dutch dairy herds. Fabri ND, Santman-Berends IMGA, Weber MF, van Schaik G

Salmonella spp. infections in animals are a concern due to their zoonotic nature, welfare effects and economic impact on the livestock industry. To enable targeted surveillance, it is important to identify risk factors for the introduction of Salmonella spp. in a herd. Since 2009, Dutch dairy processors require herds delivering milk to their plants to participate in a Salmonella programme. In this programme, bulk milk is tested three times a year (i.e. test rounds) by ELISA on presence of antibo... Abstract

Cited 15 times since 2024 (14.8 per year) source: EuropePMC

The lancet. Gastroenterology & hepatology, Volume 9, Issue 10, 13 2 2024, Pages 924-934 Indocyanine green near-infrared fluorescence bowel perfusion assessment to prevent anastomotic leakage in minimally invasive colorectal surgery (AVOID): a multicentre, randomised, controlled, phase 3 trial. Faber RA, Meijer RPJ, Droogh DHM, Jongbloed JJ, Bijlstra OD, Boersma F, Braak JPBM, Meershoek-Klein Kranenbarg E, Putter H, Holman FA, Mieog JSD, Neijenhuis PA, van Staveren E, Bloemen JG, Burger JWA, Aukema TS, Brouwers MAM, Marinelli AWKS, Westerterp M, Doornebosch PG, van der Weijde A, Bosscha K, Handgraaf HJM, Consten ECJ, Sikkenk DJ, Burggraaf J, Keereweer S, van der Vorst JR, Hutteman M, Peeters KCMJ, Vahrmeijer AL, Hilling DE

Background: Anastomotic leakage is a severe postoperative complication in colorectal surgery and compromised bowel perfusion is considered a major contributing factor. Conventional methods to assess bowel perfusion have a low predictive value for anastomotic leakage. We therefore aimed to evaluate the efficacy of real-time assessment with near-infrared (NIR) fluorescence imaging with indocyanine green (ICG) in the prevention of anastomotic leakage. Methods: This multicentre, randomised, controll... Abstract

Cited 4 times since 2024 (3.9 per year) source: EuropePMC

Antimicrobial agents and chemotherapy, Volume 68, Issue 9, 13 2 2024, Pages e0065024 Bacteriophage therapy reduces Staphylococcus aureus in a porcine and human ex vivo burn wound infection model. Molendijk MM, Boekema BKHL, Lattwein KR, Vlig M, Bode LGM, Koopmans MPG, Verbon A, de Graaf M, van Wamel WJB

Burn wounds are a major burden, with high mortality rates due to infections. Staphylococcus aureus is a major causative agent of burn wound infections, which can be difficult to treat because of antibiotic resistance and biofilm formation. An alternative to antibiotics is the use of bacteriophages, viruses that infect and kill bacteria. We investigated the efficacy of bacteriophage therapy for burn wound infections, in both a porcine and a newly developed human ex vivo skin model. In both models... Abstract

Journal of thoracic disease, Volume 16, Issue 8, 13 2 2024, Pages 4914-4923 Deep learning to predict long-term mortality from plain chest X-ray in patients referred for suspected coronary artery disease. D'Ancona G, Savardi M, Massussi M, Van Der Valk V, Scherptong RWC, Signoroni A, Farina D, Murero M, Ince H, Benussi S, Curello S, Arslan F

Background: The hypothesis that a deep learning (DL) model can produce long-term prognostic information from chest X-ray (CXR) has already been confirmed within cancer screening programs. We summarize our experience with DL prediction of long-term mortality, from plain CXR, in patients referred for angina and coronary angiography. Methods: Data of patients referred to an Italian academic hospital were analyzed retrospectively. We designed a deep convolutional neural network (DCNN) that, from CXR... Abstract

Holistic nursing practice, Volume 38, Issue 6, 9 2 2024, Pages 371-384 Effect of Acupressure on Menopausal Symptoms and Quality of Life in Postmenopausal Women: A Randomized Controlled Trial. Can AA, Yilmaz DV

This study was conducted as a randomized controlled experimental trial with the aim of determining the effect of acupressure on menopausal symptoms and quality of life in postmenopausal women, as well as the correlation between the two. This randomized controlled experimental study was conducted between May and November 2021 with women coming to a Menopause School in Turkey. A Descriptive Characteristics Form, the Menopause Rating Scale, and the World Health Organization Quality of Life Scale Sh... Abstract

Cited 1 times since 2024 (1 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 35, Issue 10, 8 2 2024, Pages 1972-1980 Characterization of atrial arrhythmias following mitral valve repair: Incidence and risk factors. El Mathari S, Tomšič A, Kharbanda RK, Zappala P, Wijnmaalen AP, Klautz RJM, Silva MR, Palmen M

Objectives: This study aims to investigate the occurrence, type and correlation of early and late atrial arrhythmias following mitral valve repair in patients with no preoperative history of atrial arrhythmias. Methods: Patients undergoing mitral valve (MV) repair for degenerative disease were included. Early and late postoperative electrocardiograms were evaluated for the incidence and type of atrial arrhythmia (atrial fibrillation [AF] or atrial tachycardia [AT]). Results: The 192 patients wer... Abstract

Cited 6 times since 2024 (5.8 per year) source: EuropePMC

Current biology : CB, Volume 34, Issue 16, 7 1 2024, Pages 3735-3746.e5 Targeted memory reactivation to augment treatment in post-traumatic stress disorder. van der Heijden AC, van der Werf YD, van den Heuvel OA, Talamini LM, van Marle HJF

Post-traumatic stress disorder (PTSD) is a psychiatric disorder with traumatic memories at its core. Post-treatment sleep may offer a unique time window to increase therapeutic efficacy through consolidation of therapeutically modified traumatic memories. Targeted memory reactivation (TMR) enhances memory consolidation by presenting reminder cues (e.g., sounds associated with a memory) during sleep. Here, we applied TMR in PTSD patients to strengthen therapeutic memories during sleep after one t... Abstract

Cited 6 times since 2024 (5.8 per year) source: EuropePMC

Annals of surgery, Volume 280, Issue 5, 5 1 2024, Pages 763-771 Milestones in Surgical Complication Reporting: Clavien-Dindo Classification 20 Years and Comprehensive Complication Index 10 Years. Abbassi F, Pfister M, Lucas KL, Domenghino A, Puhan MA, Clavien PA, Outcome Reporting Group

Objective: To provide improved guidance for the consistent application of the Clavien-Dindo classification (CDC) and Comprehensive Complication Index (CCI ® ) in challenging clinical scenarios. Background: Standardized outcome reporting is key for the proper assessment of surgical procedures. A recent consensus conference recommended the CDC and the CCI ® for assessing postoperative morbidity. Several challenging scenarios for grading complications still require evidence-based guidance, and the... Abstract

Cited 2 times since 2024 (1.9 per year) source: EuropePMC

Turkish journal of medical sciences, Volume 54, Issue 5, 5 1 2024, Pages 938-948 Relationship between microbiota awareness, nutrition literacy, and health literacy among adolescents. Ülker İ, Aydin MA, Yildiz M, Gökçay G, Elkoca A, Yildirim MS, Tanimowo A, Yilmaz DA

Background/aim: Microbiota awareness, nutritional literacy, and health literacy levels in adolescents have a significant impact on their health and well-being. This research was conducted to examine the relationship between microbiota awareness, nutrition literacy, and health literacy in adolescents. Material and methods: This research was structured with a descriptive-correlational design. The study population comprised adolescents aged 10-19 years, living in Türkiye (n = 739), between June 202... Abstract

Frontiers in immunology, Volume 15, 5 1 2024, Pages 1466387 Corrigendum: Establishment and immune phenotyping of patient-derived glioblastoma models in humanized mice. Liu L, van Schaik TA, Chen KS, Rossignoli F, Borges P, Vrbanac V, Wakimoto H, Shah K

[This corrects the article DOI: 10.3389/fimmu.2023.1324618.]. Abstract

Future oncology (London, England), Volume 20, Issue 27, 5 1 2024, Pages 2015-2022 Expression of integrin αvβ3 in medullary thyroid carcinoma. de Vries LH, Lodewijk L, Pijnappel EW, van Diest PJ, Schepers A, Bonenkamp HJ, van Engen-van Grunsven IA, Kruijff S, van Hemel BM, Links TP, Nieveen van Dijkum EJ, van Eeden S, van Leeuwaarde RS, Valk GD, de Keizer B, Borel Rinkes IH, Vriens MR

Aim: Tumor markers often remain elevated after intended curative resection of medullary thyroid carcinoma (MTC). The aim of this study was to determine the expression of αvβ3, a promising theranostics target, in MTC and its metastases.Materials & methods: Avβ3 expression was analyzed in 104 patients using a tissue microarray and correlated with clinicopathological variables and survival.Results: Cytoplasmic αvβ3 positivity was seen in 70 patients and was associated with lymph node metastases... Abstract

Journal of electrocardiology, Volume 86, 5 1 2024, Pages 153768 Rationale and design of the artificial intelligence scalable solution for acute myocardial infarction (ASSIST) study. Domingo-Gardeta T, Montero-Cabezas JM, Jurado-Román A, Sabaté M, Aboal J, Baranchuk A, Carrillo X, García-Zamora S, Dores H, van der Valk V, Scherptong RWC, Andrés-Cordón JF, Vidal P, Moreno-Martínez D, Toribio-Fernández R, Lillo-Castellano JM, Cruz R, De Guio F, Marina-Breysse M, Martínez-Sellés M

Background: Acute coronary syndrome (ACS), specifically ST-segment elevation myocardial infarction is a major cause of morbidity and mortality throughout Europe. Diagnosis in the acute setting is mainly based on clinical symptoms and physician's interpretation of an electrocardiogram (ECG), which may be subject to errors. ST-segment elevation is the leading criteria to activate urgent reperfusion therapy, but a clear ST-elevation pattern might not be present in patients with coronary occlus... Abstract

Cited 8 times since 2024 (7.7 per year) source: EuropePMC

Physics of life reviews, Volume 50, 3 1 2024, Pages 211-225 Language follows a distinct mode of extra-genomic evolution. Bickel B, Giraud AL, Zuberbühler K, van Schaik CP

As one of the most specific, yet most diverse of human behaviors, language is shaped by both genomic and extra-genomic evolution. Sharing methods and models between these modes of evolution has significantly advanced our understanding of language and inspired generalized theories of its evolution. Progress is hampered, however, by the fact that the extra-genomic evolution of languages, i.e. linguistic evolution, maps only partially to other forms of evolution. Contrasting it with the biological... Abstract

Cited 1 times since 2024 (1 per year) source: EuropePMC

International journal of cardiology, Volume 415, 3 1 2024, Pages 132421 CIED-based remote monitoring in heart failure using the HeartLogic™ algorithm: Which patients benefit most? van der Lande ACMH, Feijen M, Egorova AD, Beles M, van Bockstal K, Phagu AAS, Schalij MJ, Heggermont WA, Beeres SLMA

Background & aims: Early identification of worsening HF enables timely adjustments to prevent hospitalization. Recent studies show the HeartLogic™ algorithm detects congestion and reduces HF events. However, it is unclear which patients benefit most. Therefore, this study aims to identify and characterize HF patients who benefit most from CIED-based remote monitoring with HeartLogic™. Methods: In this multicenter retrospective study, patients with a CIED and HeartLogic™ algorithm under struc... Abstract

Cited 1 times since 2024 (1 per year) source: EuropePMC

International journal of cardiology, Volume 414, 3 1 2024, Pages 132414 The prognostic value of changes in pulmonary vein flow patterns after surgical repair for primary mitral regurgitation. Yedidya I, Stassen J, Butcher S, van Wijngaarden AL, Wu Y, van der Bijl P, Marsan NA, Delgado V, Bax J

Background: The pulmonary vein (PV) flow pattern is influenced by the presence of mitral regurgitation (MR). After a successful reduction in MR severity, the pattern is expected to be changed. We aimed to evaluate the prognostic value of a change in the PV flow pattern in patients with primary MR undergoing mitral valve repair (MVR). Methods: The PV flow pattern was assessed with transthoracic echocardiography in 216 patients (age 65 [IQR 56-72] years, 70% male) with primary MR before and after... Abstract