7971 results
Cited 7 times since 2020 (1.4 per year)
source: EuropePMC
Journal of clinical medicine,
Volume 9, Issue 4, 26 4 2020, Pages E911
Ventricular Repolarization is Associated with Cognitive Function, but Not with Cognitive Decline and Brain Magnetic Resonance Imaging (MRI) Measurements in Older Adults.
Zonneveld MH, Noordam R, Grond JV, Sabayan B, Mooijaart SP, Mcfarlane PW, Jukema JW, Trompet S
We aimed to investigate the cross-sectional and longitudinal associations of electrocardiogram (ECG)-based QT, QTc, JT, JTc, and QRS intervals with cognitive function and brain magnetic resonance imaging (MRI) measurements in a cohort of older individuals at increased risk for cardiovascular disease, but free of known arrhythmias. We studied 4627 participants (54% female, mean age 75 years) enrolled in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Ten-second ECGs were co...
Abstract
Cited 21 times since 2020 (4.1 per year)
source: EuropePMC
Current opinion in cell biology,
Volume 64, 26 4 2020, Pages 58-66
How to maintain the genome in nuclear space.
Mitrentsi I, Yilmaz D, Soutoglou E
Genomic instability can be life-threatening. The fine balance between error-free and mutagenic DNA repair pathways is essential for maintaining genome integrity. Recent advances in DNA double-strand break induction and detection techniques have allowed the investigation of DNA damage and repair in the context of the highly complex nuclear structure. These studies have revealed that the 3D genome folding, nuclear compartmentalization and cytoskeletal components control the spatial distribution of...
Abstract
Cited 14 times since 2020 (2.7 per year)
source: EuropePMC
Journal of clinical medicine,
Volume 9, Issue 4, 26 4 2020, Pages E908
The Development of the Ascending Aortic Wall in Tricuspid and Bicuspid Aortic Valve: A Process from Maturation to Degeneration.
Grewal N, Gittenberger-de Groot AC, Thusen JV, Wisse LJ, Bartelings MM, DeRuiter MC, Klautz RJM, Poelmann RE
Background: Patients with a bicuspid aortic valve (BAV) have an increased risk for aortic dilation and dissection. In this study, we provide a histological stratification of the developing aorta in the tricuspid aortic valve (TAV) and the BAV populations as a reference for future studies on aortopathy and related syndromes. Methods: Non-dilated TAV and BAV ascending aortic wall samples were collected, including 60 TAV (embryonic-70 years) and 32 BAV specimens (fetal-72 years, categorized in eigh...
Abstract
Cited 8 times since 2020 (1.5 per year)
source: EuropePMC
JACC. Basic to translational science,
Volume 5, Issue 4, 25 4 2020, Pages 360-373
Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular <sup>18</sup>F-FDG Uptake in Atherosclerotic Mice.
Ståhle M, Silvola JMU, Hellberg S, de Vries M, Quax PHA, Kroon J, Rinne P, de Jong A, Liljenbäck H, Savisto N, Wickman A, Stroes ESG, Ylä-Herttuala S, Saukko P, Abrahamsson T, Pettersson K, Knuuti J, Roivainen A, Saraste A
This study showed that treatment with a therapeutic monoclonal immunoglobulin-G1 antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow reserve and attenuates atherosclerotic inflammation as determined by the uptake of 18F-fluorodeoxyglucose in atherosclerotic mice. The noninvasive imaging techniques represent translational tools to assess the efficacy of phosphorylcholine-targeted therapy on coronary artery function and atherosclerosis in clinical studies.
Abstract
Cited 85 times since 2020 (16.4 per year)
source: EuropePMC
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc,
Volume 33, Issue 8, 20 3 2020, Pages 1595-1605
Major p53 immunohistochemical patterns in in situ and invasive squamous cell carcinomas of the vulva and correlation with TP53 mutation status.
Tessier-Cloutier B, Kortekaas KE, Thompson E, Pors J, Chen J, Ho J, Prentice LM, McConechy MK, Chow C, Proctor L, McAlpine JN, Huntsman DG, Gilks CB, Bosse T, Hoang LN
The recent literature has shown that vulvar squamous cell carcinoma (VSCC) can be stratified into two prognostically relevant groups based on human papillomavirus (HPV) status. The prognostic value of p53 for further sub-stratification, particularly in the HPV-independent group, has not been agreed upon. This disagreement is likely due to tremendous variations in p53 immunohistochemical (IHC) interpretation. To address this problem, we sought to compare p53 IHC patterns with TP53 mutation status...
Abstract
Cited 13 times since 2020 (2.5 per year)
source: EuropePMC
Oral surgery, oral medicine, oral pathology and oral radiology,
Volume 130, Issue 2, 18 3 2020, Pages 209-216
Evaluation of a metal artifact reduction algorithm and an optimization filter in the estimation of peri-implant dehiscence defects by using cone beam computed tomography: an in-vitro study.
Bayrak S, Orhan K, Kursun Çakmak ES, Görürgöz C, Odabaşı O, Yilmaz D, Atakan C
Objectives: The aim of this study was to assess the effect of a metal artifact reduction (MAR) algorithm and the adaptive image noise optimizer (AINO) optimization filter in the detection of peri-implant dehiscences with cone beam computed tomography (CBCT). Study design: Nine implants (3 zirconium, 3 titanium, and 3 zirconium-titanium) were placed in 3 sheep heads. Dehiscences were created on the buccal and lingual/palatal surfaces. A total of 9 defects and 9 controls with no defects were evalu...
Abstract
Cited 3 times since 2020 (0.6 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 13, Issue 5, 18 3 2020, Pages 1133-1134
Individualized Patient Risk Stratification Using Machine Learning and Topological Data Analysis.
Ng ACT, Delgado V, Bax JJ
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
The AAPS journal,
Volume 22, Issue 3, 17 3 2020, Pages 59
Optimal Sampling Strategies for Irinotecan (CPT-11) and its Active Metabolite (SN-38) in Cancer Patients.
Karas S, Etheridge AS, Tsakalozou E, Ramírez J, Cecchin E, van Schaik RHN, Toffoli G, Ratain MJ, Mathijssen RHJ, Forrest A, Bies RR, Innocenti F
Irinotecan (CPT-11) is an anticancer agent widely used in the treatment of a variety of adult solid tumors. The objective of this study was to develop an optimal sampling strategy model that accurately estimates pharmacokinetic parameters of CPT-11 and its active metabolite, SN-38. This study included 221 patients with advanced solid tumors or lymphoma receiving CPT-11 single or combination therapy with 5-fluorouracil (5-FU)/leucovorin (LV) (FOLFIRI) plus bevacizumab from 4 separate clinical tri...
Abstract
Cited 5 times since 2020 (1 per year)
source: EuropePMC
International journal of cardiology. Heart & vasculature,
Volume 27, 17 3 2020, Pages 100499
Multifocal cardiovascular calcification in patients with established cardiovascular disease; prevalence, risk factors, and relation with recurrent cardiovascular disease.
van 't Klooster CC, Nathoe HM, Hjortnaes J, Bots ML, Isgum I, Lessmann N, van der Graaf Y, Leiner T, Visseren FLJ, UCC-SMART-study group
Aims: The aim is to investigate (multifocal) cardiovascular calcification in patients with established cardiovascular disease (CVD), regarding prevalence, risk factors, and relation with recurrent CVD or vascular interventions. Coronary artery calcification (CAC), thoracic aortic calcification (TAC) (including ascending aorta, aortic arch, descending aorta), mitral annular calcification (MAC), and aortic valve calcification (AVC) are studied. Methods: The study concerned 568 patients with establ...
Abstract
Cited 8 times since 2020 (1.5 per year)
source: EuropePMC
Wiley interdisciplinary reviews. Cognitive science,
Volume 11, Issue 4, 16 3 2020, Pages e1527
Must all signals be evolved? A proposal for a new classification of communicative acts.
Fröhlich M, van Schaik CP
While signals in evolutionary biology are usually defined as "acts or traits that have evolved because of their effect on others", work on gestures and vocalizations in various animal taxa have revealed population- or even individual-specific meanings of social signals. These results strongly suggest that communicative acts that are like signals with regard to both form and function (meaning) can also be acquired ontogenetically, and we discuss direct evidence for such plasticity in ca...
Abstract
Cited 25 times since 2020 (4.8 per year)
source: EuropePMC
Journal of diabetes science and technology,
Volume 15, Issue 3, 16 3 2020, Pages 655-663
Validation of Automated Screening for Referable Diabetic Retinopathy With an Autonomous Diagnostic Artificial Intelligence System in a Spanish Population.
Shah A, Clarida W, Amelon R, Hernaez-Ortega MC, Navea A, Morales-Olivas J, Dolz-Marco R, Verbraak F, Jorda PP, van der Heijden AA, Peris Martinez C
Purpose: The purpose of this study is to compare the diagnostic performance of an autonomous artificial intelligence (AI) system for the diagnosis of referable diabetic retinopathy (RDR) to manual grading by Spanish ophthalmologists. Methods: Subjects with type 1 and 2 diabetes participated in a diabetic retinopathy (DR) screening program in 2011 to 2012 in Valencia (Spain), and two images per eye were collected according to their standard protocol. Mydriatic drops were used in all patients. Ret...
Abstract
Cited 10 times since 2020 (1.9 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 162, Issue 6, 12 2 2020, Pages 1684-1695
Comparison of microstructural alterations in the proximal aorta between aortic stenosis and regurgitation.
Sequeira Gross TM, Lindner D, Ojeda FM, Neumann J, Grewal N, Kuntze T, Blankenberg S, Reichenspurner H, Westermann D, Girdauskas E
Objective: We aimed to analyze the association among flow patterns, gene expression, and histologic alterations of the proximal aorta in patients with aortic valve disease. Methods: A total of 131 patients referred for aortic valve replacement were grouped by valve dysfunction (aortic stenosis vs aortic regurgitation) and valve morphology (bicuspid vs tricuspid). On the basis of magnetic resonance imaging, aortic tissue from outer and inner curvature was collected for gene expression and histolo...
Abstract
Cited 41 times since 2020 (7.9 per year)
source: EuropePMC
Circulation. Cardiovascular imaging,
Volume 13, Issue 3, 12 2 2020, Pages e009750
Impact of Clinical Characteristics and Statins on Coronary Plaque Progression by Serial Computed Tomography Angiography.
Smit JM, van Rosendael AR, El Mahdiui M, Neglia D, Knuuti J, Saraste A, Buechel RR, Teresinska A, Pizzi MN, Roque A, Poddighe R, Mertens BJ, Caselli C, Rocchiccioli S, Parodi O, Pelosi G, Scholte AJ
Background Progression of coronary artery disease using serial coronary computed tomography angiography (CTA) is of clinical interest. Our primary aim was to prospectively assess the impact of clinical characteristics and statin use on quantitatively assessed coronary plaque progression in a low-risk study population during long-term follow-up. Methods Patients who previously underwent coronary CTA for suspected coronary artery disease were prospectively included to undergo follow-up coronary CT...
Abstract
Cited 17 times since 2020 (3.3 per year)
source: EuropePMC
Cells,
Volume 9, Issue 3, 12 2 2020, Pages E701
Local Mast Cell Activation Promotes Neovascularization.
Bot I, Velden DV, Bouwman M, Kröner MJ, Kuiper J, Quax PHA, de Vries MR
Mast cells have been associated with arteriogenesis and collateral formation. In advanced human atherosclerotic plaques, mast cells have been shown to colocalize with plaque neovessels, and mast cells have also been associated with tumor vascularization. Based on these associations, we hypothesize that mast cells promote angiogenesis during ischemia. In human ischemic muscle tissue from patients with end-stage peripheral artery disease, we observed activated mast cells, predominantly located aro...
Abstract
Cited 18 times since 2020 (3.4 per year)
source: EuropePMC
mSphere,
Volume 5, Issue 2, 11 2 2020, Pages e00143-20
Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates.
Janssen AB, Bartholomew TL, Marciszewska NP, Bonten MJM, Willems RJL, Bengoechea JA, van Schaik W
Infections by multidrug-resistant Gram-negative bacteria are increasingly common, prompting the renewed interest in the use of colistin. Colistin specifically targets Gram-negative bacteria by interacting with the anionic lipid A moieties of lipopolysaccharides, leading to membrane destabilization and cell death. Here, we aimed to uncover the mechanisms of colistin resistance in nine colistin-resistant Escherichia coli strains and one Escherichia albertii strain. These were the only colistin-res...
Abstract
Cited 10 times since 2020 (1.9 per year)
source: EuropePMC
mSystems,
Volume 5, Issue 2, 10 2 2020, Pages e00607-19
Carbon Assimilation Strategies in Ultrabasic Groundwater: Clues from the Integrated Study of a Serpentinization-Influenced Aquifer.
Seyler LM, Brazelton WJ, McLean C, Putman LI, Hyer A, Kubo MDY, Hoehler T, Cardace D, Schrenk MO
Serpentinization is a low-temperature metamorphic process by which ultramafic rock chemically reacts with water. Such reactions provide energy and materials that may be harnessed by chemosynthetic microbial communities at hydrothermal springs and in the subsurface. However, the biogeochemistry mediated by microbial populations that inhabit these environments is understudied and complicated by overlapping biotic and abiotic processes. We applied metagenomics, metatranscriptomics, and untargeted m...
Abstract
Cited 9 times since 2020 (1.7 per year)
source: EuropePMC
European journal of nuclear medicine and molecular imaging,
Volume 47, Issue 6, 9 2 2020, Pages 1518-1526
Prevalence of hyperfunctioning thyroid nodules among those in need of fine needle aspiration cytology according to ATA 2015, EU-TIRADS, and ACR-TIRADS.
Noto B, Eveslage M, Pixberg M, Gonzalez Carvalho JM, Schäfers M, Riemann B, Kies P
Purpose: Given the large number of patients with thyroid nodules, improvement of the specificity of current ultrasound-based thyroid nodule classification systems (ATA, EU-TIRADS, and ACR-TIRADS) is warranted to reduce the number of diagnostic thyroidectomies. Thyroid scintigraphy has been shown to demonstrate hyperfunctional nodules, associated with a low malignancy risk, in euthyroid patients. However, it is not known if thyroid scintigraphy could improve specificity of current classification...
Abstract
Cited 5 times since 2020 (1 per year)
source: EuropePMC
European journal of obstetrics, gynecology, and reproductive biology,
Volume 248, 6 1 2020, Pages 150-155
Evaluation of mode of birth in pregnant women with heart disease.
Petrus AHJ, Jongert BL, Kiès P, Sueters M, Jongbloed MRM, Vliegen HW, Schalij MJ, van Lith J, van den Akker T
Objective: Maternal heart disease (HD) complicates 1-4 % of pregnancies and is associated with adverse maternal and fetal outcomes. Although vaginal birth is generally recommended in the guidelines, cesarean section (CS) rates in women with HD are often high. Aim of the present study was to evaluate mode of birth and pregnancy outcomes in women with HD in a tertiary care hospital in the Netherlands. Study design: The study population consisted of 128 consecutive pregnancies in 99 women with HD,...
Abstract
Frontiers in veterinary science,
Volume 7, 6 1 2020, Pages 67
The Comparison of Three Statistical Models for Syndromic Surveillance in Cattle Using Milk Production Data.
Veldhuis AMB, Swart WAJM, Brouwer-Middelesch H, Stegeman JA, Mars MH, van Schaik G
Two vector-borne infections have emerged and spread throughout the north-western part of Europe in the last decade: Bluetongue virus serotype-8 (BTV-8) and the Schmallenberg virus (SBV). The objective of the current study was to compare three statistical methods when applied in a syndromic surveillance context for the early detection of emerging diseases in cattle in the Netherlands. Since BTV-8 and SBV both have a negative effect on milk production in dairy cattle, routinely collected bulk milk...
Abstract
Cited 13 times since 2020 (2.5 per year)
source: EuropePMC
BMC nephrology,
Volume 21, Issue 1, 5 1 2020, Pages 81
The association of kidney function and cognitive decline in older patients at risk of cardiovascular disease: a longitudinal data analysis.
Zijlstra LE, Trompet S, Mooijaart SP, van Buren M, Sattar N, Stott DJ, Jukema JW
Background: Chronic kidney disease (CKD) has been identified as a significant direct marker for cognitive decline, but controversy exists regarding the magnitude of the association of kidney function with cognitive decline across the different CKD stages. Therefore, the aim of this study was to investigate the association of kidney function with cognitive decline in older patients at high risk of cardiovascular disease, using data from the PROspective Study of Pravastatin in the Elderly at Risk...
Abstract
