8313 results
Cited 3 times since 2018 (0.5 per year)
source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 57, Issue 2, 11 2 2018, Pages 229-237
The Value of Sigmoidoscopy to Detect Colonic Ischaemia After Ruptured Abdominal Aortic Aneurysm Repair.
Jalalzadeh H, van Schaik TG, Duin JJ, Indrakusuma R, van Beek SC, Vahl AC, Wisselink W, Balm R, Koelemay MJW
Objectives: Diagnosing colonic ischaemia (CI) after ruptured abdominal aortic aneurysm (RAAA) repair is challenging. This study determined the diagnostic value of sigmoidoscopy in patients suspected of CI after RAAA repair. Methods: This was a retrospective multicentre cohort study. Patients who underwent RAAA repair in three hospitals in Amsterdam, the Netherlands, between 2004 and 2011 (AJAX cohort) were included. Sigmoidoscopies were carried out based on clinical judgment. Endoscopy results w...
Abstract
Cited 34 times since 2018 (5.3 per year)
source: EuropePMC
Clinical research in cardiology : official journal of the German Cardiac Society,
Volume 108, Issue 5, 8 2 2018, Pages 520-538
Apolipoproteins A1, B, and apoB/apoA1 ratio are associated with first ST-segment elevation myocardial infarction but not with recurrent events during long-term follow-up.
Bodde MC, Hermans MPJ, Jukema JW, Schalij MJ, Lijfering WM, Rosendaal FR, Romijn FPHTM, Ruhaak LR, van der Laarse A, Cobbaert CM
Introduction: The current way to assess the risk of cardiovascular disease (CVD) is to measure conventional lipid and lipoprotein cholesterol fractions. Despite the success of statin treatment, residual cardiovascular risk remains high. Therefore, the value of extensive serum apolipoprotein (apo) profiling to assess the risk of ST-segment elevation myocardial infarction (STEMI) and of major adverse cardiac events (MACE) in patients with STEMI was investigated in a case-control design. Methods an...
Abstract
Cited 6 times since 2018 (0.9 per year)
source: EuropePMC
Philosophical transactions of the Royal Society of London. Series B, Biological sciences,
Volume 373, Issue 1760, 8 2 2018, Pages 20170408
Widespread reduction in sun-induced fluorescence from the Amazon during the 2015/2016 El Niño.
Koren G, van Schaik E, Araújo AC, Boersma KF, Gärtner A, Killaars L, Kooreman ML, Kruijt B, van der Laan-Luijkx IT, von Randow C, Smith NE, Peters W
The tropical carbon balance dominates year-to-year variations in the CO2 exchange with the atmosphere through photosynthesis, respiration and fires. Because of its high correlation with gross primary productivity (GPP), observations of sun-induced fluorescence (SIF) are of great interest. We developed a new remotely sensed SIF product with improved signal-to-noise in the tropics, and use it here to quantify the impact of the 2015/2016 El Niño Amazon drought. We find that SIF was strongly suppres...
Abstract
Cited 6 times since 2018 (0.9 per year)
source: EuropePMC
Philosophical transactions of the Royal Society of London. Series B, Biological sciences,
Volume 373, Issue 1760, 8 2 2018, Pages 20180084
Changes in surface hydrology, soil moisture and gross primary production in the Amazon during the 2015/2016 El Niño.
van Schaik E, Killaars L, Smith NE, Koren G, van Beek LPH, Peters W, van der Laan-Luijkx IT
The 2015/2016 El Niño event caused severe changes in precipitation across the tropics. This impacted surface hydrology, such as river run-off and soil moisture availability, thereby triggering reductions in gross primary production (GPP). Many biosphere models lack the detailed hydrological component required to accurately quantify anomalies in surface hydrology and GPP during droughts in tropical regions. Here, we take the novel approach of coupling the biosphere model SiBCASA with the advanced...
Abstract
Cited 950 times since 2018 (147.9 per year)
source: EuropePMC
Nature genetics,
Volume 50, Issue 11, 8 2 2018, Pages 1505-1513
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.
Mahajan A, Taliun D, Thurner M, Robertson NR, Torres JM, Rayner NW, Payne AJ, Steinthorsdottir V, Scott RA, Grarup N, Cook JP, Schmidt EM, Wuttke M, Sarnowski C, Mägi R, Nano J, Gieger C, Trompet S, Lecoeur C, Preuss MH, Prins BP, Guo X, Bielak LF, Below JE, Bowden DW, Chambers JC, Kim YJ, Ng MCY, Petty LE, Sim X, Zhang W, Bennett AJ, Bork-Jensen J, Brummett CM, Canouil M, Ec Kardt KU, Fischer K, Kardia SLR, Kronenberg F, Läll K, Liu CT, Locke AE, Luan J, Ntalla I, Nylander V, Schönherr S, Schurmann C, Yengo L, Bottinger EP, Brandslund I, Christensen C, Dedoussis G, Florez JC, Ford I, Franco OH, Frayling TM, Giedraitis V, Hackinger S, Hattersley AT, Herder C, Ikram MA, Ingelsson M, Jørgensen ME, Jørgensen T, Kriebel J, Kuusisto J, Ligthart S, Lindgren CM, Linneberg A, Lyssenko V, Mamakou V, Meitinger T, Mohlke KL, Morris AD, Nadkarni G, Pankow JS, Peters A, Sattar N, Stančáková A, Strauch K, Taylor KD, Thorand B, Thorleifsson G, Thorsteinsdottir U, Tuomilehto J, Witte DR, Dupuis J, Peyser PA, Zeggini E, Loos
We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent individuals (9% cases), after imputation to high-density reference panels. With these data, we (i) extend the inventory of T2D-risk variants (243 loci, 135 newly implicated in T2D predisposition, comprising 403 distinct association signals); (ii) enrich discovery of lower-frequency risk alleles (80 index variants with minor allele frequency 2); (iii) substantially improve fine-mapping of causal v...
Abstract
Cited 8 times since 2018 (1.2 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 107, Issue 4, 6 1 2018, Pages 1195-1201
Outcomes of Valve Repair for Degenerative Disease in Patients With Mitral Annular Calcification.
Tomšič A, Hiemstra YL, van Brakel TJ, Versteegh MIM, Marsan NA, Klautz RJM, Palmen M
Background: The risk factors for the development of mitral annular calcification (MAC) in degenerative mitral valve disease and the effect it may have on patient-and valve-related outcomes require further evaluation. Methods: Between January 2002 and December 2015, 627 patients underwent mitral valve operations for degenerative disease. MAC was seen in 75 patients (12%); 73 (97%) underwent valve repair (6 without annuloplasty ring implantation) and 2 (3%) underwent valve replacement after an uns...
Abstract
Cited 12 times since 2018 (1.9 per year)
source: EuropePMC
Genetics in medicine : official journal of the American College of Medical Genetics,
Volume 21, Issue 5, 5 1 2018, Pages 1199-1208
Variants affecting diverse domains of MEPE are associated with two distinct bone disorders, a craniofacial bone defect and otosclerosis.
Schrauwen I, Valgaeren H, Tomas-Roca L, Sommen M, Altunoglu U, Wesdorp M, Beyens M, Fransen E, Nasir A, Vandeweyer G, Schepers A, Rahmoun M, van Beusekom E, Huentelman MJ, Offeciers E, Dhooghe I, Huber A, Van de Heyning P, Zanetti D, De Leenheer EMR, Gilissen C, Hoischen A, Cremers CW, Verbist B, de Brouwer APM, Padberg GW, Pennings R, Kayserili H, Kremer H, Van Camp G, van Bokhoven H
Purpose: To characterize new molecular factors implicated in a hereditary congenital facial paresis (HCFP) family and otosclerosis. Methods: We performed exome sequencing in a four-generation family presenting nonprogressive HCFP and mixed hearing loss (HL). MEPE was analyzed using either Sanger sequencing or molecular inversion probes combined with massive parallel sequencing in 89 otosclerosis families, 1604 unrelated affected subjects, and 1538 unscreened controls. Results: Exome sequencing i...
Abstract
Cited 5 times since 2018 (0.8 per year)
source: EuropePMC
Frontiers in physiology,
Volume 9, 4 1 2018, Pages 1381
Myocyte Remodeling Due to Fibro-Fatty Infiltrations Influences Arrhythmogenicity.
De Coster T, Claus P, Seemann G, Willems R, Sipido KR, Panfilov AV
The onset of cardiac arrhythmias depends on the electrophysiological and structural properties of cardiac tissue. Electrophysiological remodeling of myocytes due to the presence of adipocytes constitutes a possibly important pathway in the pathogenesis of atrial fibrillation. In this paper we perform an in-silico study of the effect of such myocyte remodeling on the onset of atrial arrhythmias and study the dynamics of arrhythmia sources-spiral waves. We use the Courtemanche model for atrial myo...
Abstract
Cited 4 times since 2018 (0.6 per year)
source: EuropePMC
International journal of cardiology,
Volume 280, 1 1 2018, Pages 19-28
Chest pain in the absence of obstructive coronary artery disease: A critical review of current concepts focusing on sex specificity, microcirculatory function, and clinical implications.
Zijlstra LE, Bootsma M, Jukema JW, Schalij MJ, Vliegen HW, Bruschke AVG
Patients presenting with chest pain suggestive of coronary artery disease (CAD) who at coronary arteriography appear to be free of obstructive disease have presented a diagnostic and therapeutic challenge since the 1970's. Studies in female patient populations have suggested that this is predominantly a women's syndrome usually caused by microvascular endothelial dependent and independent dysfunction. A critical review of the literature focusing on studies including both women and men...
Abstract
Cited 11 times since 2018 (1.7 per year)
source: EuropePMC
European heart journal. Quality of care & clinical outcomes,
Volume 4, Issue 4, 1 1 2018, Pages 239-245
Privacy of patient data in quality-of-care registries in cardiology and cardiothoracic surgery: the impact of the new general data protection regulation EU-law.
Wierda E, Eindhoven DC, Schalij MJ, Borleffs CJW, Amoroso G, van Veghel D, Mitchell CR, de Mol BAJM, Hirsch A, Ploem MC
Quality-of-care registries have been shown to improve quality of healthcare and should be facilitated and encouraged. The data of these registries are also very valuable for medical data research. While fully acknowledging the importance of re-using already available data for research purposes, there are concerns about how the applicable privacy legislation is dealt with. These concerns are also articulated in the new European law on privacy, the 'General Data Protection Regulation' (G...
Abstract
Cited 23 times since 2018 (3.6 per year)
source: EuropePMC
Therapeutic drug monitoring,
Volume 40, Issue 5, 1 1 2018, Pages 515-525
Liquid Biopsies to Monitor Solid Organ Transplant Function: A Review of New Biomarkers.
Verhoeven JGHP, Boer K, Van Schaik RHN, Manintveld OC, Huibers MMH, Baan CC, Hesselink DA
Despite modern immunosuppressive therapy, allograft rejection remains a major cause of solid organ transplant dysfunction. For clinical care, organ transplant function is routinely monitored by measuring biomarkers that, depending on the organ transplanted, include serum creatinine, N-terminal pro-hormone of brain natriuretic peptide (NT-proBNP), and aspartate aminotransferase. All can be measured easily in clinical chemistry laboratories. The main problem with these biomarkers is that they have...
Abstract
Cited 154 times since 2018 (23.9 per year)
source: EuropePMC
Clinical pharmacokinetics,
Volume 57, Issue 10, 1 1 2018, Pages 1229-1254
Individualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics.
de Man FM, Goey AKL, van Schaik RHN, Mathijssen RHJ, Bins S
Since its clinical introduction in 1998, the topoisomerase I inhibitor irinotecan has been widely used in the treatment of solid tumors, including colorectal, pancreatic, and lung cancer. Irinotecan therapy is characterized by several dose-limiting toxicities and large interindividual pharmacokinetic variability. Irinotecan has a highly complex metabolism, including hydrolyzation by carboxylesterases to its active metabolite SN-38, which is 100- to 1000-fold more active compared with irinotecan...
Abstract
Cited 3 times since 2018 (0.5 per year)
source: EuropePMC
Journal of graduate medical education,
Volume 10, Issue 5, 1 1 2018, Pages 573-582
Leadership Observation and Feedback Tool: A Novel Instrument for Assessment of Clinical Leadership Skills.
Oza SK, van Schaik S, Boscardin CK, Pierce R, Miao E, Lockspeiser T, Tad-Y D, Aagaard E, Kuo AK
Background: While leadership training is increasingly incorporated into residency education, existing assessment tools to provide feedback on leadership skills are only applicable in limited contexts. Objective: We developed an instrument, the Leadership Observation and Feedback Tool (LOFT), for assessing clinical leadership. Methods: We used an iterative process to develop the tool, beginning with adapting the Leadership Practices Inventory to create an open-ended survey for identification of c...
Abstract
Cited 2 times since 2018 (0.3 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 26, Issue 10, 1 1 2018, Pages 473-483
Appropriate use criteria for optical coherence tomography guidance in percutaneous coronary interventions : Recommendations of the working group of interventional cardiology of the Netherlands Society of Cardiology.
IJsselmuiden AJJ, Zwaan EM, Oemrawsingh RM, Bom MJ, Dankers FJWM, de Boer MJ, Camaro C, van Geuns RJM, Daemen J, van der Heijden DJ, Jukema JW, Kraaijeveld AO, Meuwissen M, Schölzel BE, Pundziute G, van der Harst P, van Ramshorst J, Dirksen MT, Zivelonghi C, Agostoni P, van der Heyden JAS, Wykrzykowska JJ, Scholte MJ, Nef HM, Kofflard MJM, van Royen N, Alings M, Kedhi E
Introduction: Optical coherence tomography (OCT) enables detailed imaging of the coronary wall, lumen and intracoronary implanted devices. Responding to the lack of specific appropriate use criteria (AUC) for this technique, we conducted a literature review and a procedure for appropriate use criteria. Methods: Twenty-one of all 184 members of the Dutch Working Group on Interventional Cardiology agreed to evaluate 49 pre-specified cases. During a meeting, factual indications were established whe...
Abstract
Cited 26 times since 2018 (4 per year)
source: EuropePMC
The Journal of clinical endocrinology and metabolism,
Volume 103, Issue 10, 1 1 2018, Pages 3658-3667
The Relation Between Thyroid Function and Anemia: A Pooled Analysis of Individual Participant Data.
Wopereis DM, Du Puy RS, van Heemst D, Walsh JP, Bremner A, Bakker SJL, Bauer DC, Cappola AR, Ceresini G, Degryse J, Dullaart RPF, Feller M, Ferrucci L, Floriani C, Franco OH, Iacoviello M, Iervasi G, Imaizumi M, Jukema JW, Khaw KT, Luben RN, Molinaro S, Nauck M, Patel KV, Peeters RP, Psaty BM, Razvi S, Schindhelm RK, van Schoor NM, Stott DJ, Vaes B, Vanderpump MPJ, Völzke H, Westendorp RGJ, Rodondi N, Cobbaert CM, Gussekloo J, den Elzen WPJ, Thyroid Studies Collaboration
Context: Anemia and thyroid dysfunction often co-occur, and both increase with age. Human data on relationships between thyroid disease and anemia are scarce. Objective: To investigate the cross-sectional and longitudinal associations between clinical thyroid status and anemia. Design: Individual participant data meta-analysis. Setting: Sixteen cohorts participating in the Thyroid Studies Collaboration (n = 42,162). Main outcome measures: Primary outcome measure was anemia (hemoglobin
Abstract
Cited 53 times since 2018 (8.2 per year)
source: EuropePMC
European heart journal,
Volume 39, Issue 39, 1 1 2018, Pages 3574-3581
Development of significant tricuspid regurgitation over time and prognostic implications: new insights into natural history.
Prihadi EA, van der Bijl P, Gursoy E, Abou R, Mara Vollema E, Hahn RT, Stone GW, Leon MB, Ajmone Marsan N, Delgado V, Bax JJ
Aims: To evaluate the risk factors influencing the development of significant (moderate and severe) tricuspid regurgitation (TR), and its impact on all-cause mortality in large registry of referral centre. Methods and results: In 1000 patients (mean age 68 ± 13 years; 50.9% male) with documented significant TR, clinical, and echocardiographic data were retrospectively analysed when the echocardiogram showed none/mild TR. Patients with congenital heart disease were excluded. The study population...
Abstract
Cited 11 times since 2018 (1.7 per year)
source: EuropePMC
Environmental science & technology,
Volume 52, Issue 20, 27 4 2018, Pages 11500-11509
Patterns of Host-Associated Fecal Indicators Driven by Hydrology, Precipitation, and Land Use Attributes in Great Lakes Watersheds.
Dila DK, Corsi SR, Lenaker PL, Baldwin AK, Bootsma MJ, McLellan SL
Fecal contamination from sewage and agricultural runoff is a pervasive problem in Great Lakes watersheds. Most work examining fecal pollution loads relies on discrete samples of fecal indicators and modeling land use. In this study, we made empirical measurements of human and ruminant-associated fecal indicator bacteria and combined these with hydrological measurements in eight watersheds ranging from predominantly forested to highly urbanized. Flow composited river samples were collected over l...
Abstract
Cited 28 times since 2018 (4.3 per year)
source: EuropePMC
eLife,
Volume 7, 27 4 2018, Pages e41076
Optogenetics enables real-time spatiotemporal control over spiral wave dynamics in an excitable cardiac system.
Majumder R, Feola I, Teplenin AS, de Vries AA, Panfilov AV, Pijnappels DA
Propagation of non-linear waves is key to the functioning of diverse biological systems. Such waves can organize into spirals, rotating around a core, whose properties determine the overall wave dynamics. Theoretically, manipulation of a spiral wave core should lead to full spatiotemporal control over its dynamics. However, this theory lacks supportive evidence (even at a conceptual level), making it thus a long-standing hypothesis. Here, we propose a new phenomenological concept that involves a...
Abstract
Cited 28 times since 2018 (4.3 per year)
source: EuropePMC
Nature communications,
Volume 9, Issue 1, 26 4 2018, Pages 3945
Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.
Vojinovic D, Adams HH, Jian X, Yang Q, Smith AV, Bis JC, Teumer A, Scholz M, Armstrong NJ, Hofer E, Saba Y, Luciano M, Bernard M, Trompet S, Yang J, Gillespie NA, van der Lee SJ, Neumann A, Ahmad S, Andreassen OA, Ames D, Amin N, Arfanakis K, Bastin ME, Becker DM, Beiser AS, Beyer F, Brodaty H, Bryan RN, Bülow R, Dale AM, De Jager PL, Deary IJ, DeCarli C, Fleischman DA, Gottesman RF, van der Grond J, Gudnason V, Harris TB, Homuth G, Knopman DS, Kwok JB, Lewis CE, Li S, Loeffler M, Lopez OL, Maillard P, El Marroun H, Mather KA, Mosley TH, Muetzel RL, Nauck M, Nyquist PA, Panizzon MS, Pausova Z, Psaty BM, Rice K, Rotter JI, Royle N, Satizabal CL, Schmidt R, Schofield PR, Schreiner PJ, Sidney S, Stott DJ, Thalamuthu A, Uitterlinden AG, Valdés Hernández MC, Vernooij MW, Wen W, White T, Witte AV, Wittfeld K, Wright MJ, Yanek LR, Tiemeier H, Kremen WS, Bennett DA, Jukema JW, Paus T, Wardlaw JM, Schmidt H, Sachdev PS, Villringer A, Grabe HJ, Longstreth WT, van Duijn CM, Launer LJ, Seshadri S, Ikram MA, Fornage M
The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic determinants is lacking. In this meta-analysis of genome-wide association studies of 23,533 healthy middle-aged to elderly individuals from 26 population-based cohorts, we identify 7 genetic loci associated with LV volume. These loci map to chrom...
Abstract
Cited 13 times since 2018 (2 per year)
source: EuropePMC
The American journal of cardiology,
Volume 123, Issue 1, 26 4 2018, Pages 75-83
Effect of Functional Mitral Regurgitation on Outcome in Patients Receiving Cardiac Resynchronization Therapy for Heart Failure.
van der Bijl P, Khidir M, Ajmone Marsan N, Delgado V, Leon MB, Stone GW, Bax JJ
Functional mitral regurgitation (FMR) is common in heart failure (HF), and negatively impacts prognosis. Cardiac resynchronization therapy (CRT) can improve FMR, but the long-term changes in and impact of FMR after CRT are still unclear. The present study investigated the prevalence, evolution and impact on mortality of FMR before and after CRT in patients with HF. A total of 1,313 patients (66 ± 11 years, 77% male, 59% ischemic heart disease) treated with CRT were evaluated. Patients were divid...
Abstract
