Research

Publications

Below you can find a list of our published research.

6128 results

Cited 124 times since 2009 (8 per year) source: EuropePMC

Journal of neurology, Volume 257, Issue 1, 4 1 2009, Pages 85-90 Pravastatin and cognitive function in the elderly. Results of the PROSPER study. Trompet S, van Vliet P, de Craen AJ, Jolles J, Buckley BM, Murphy MB, Ford I, Macfarlane PW, Sattar N, Packard CJ, Stott DJ, Shepherd J, Bollen EL, Blauw GJ, Jukema JW, Westendorp RG

Observational studies have given conflicting results about the effect of statins in preventing dementia and cognitive decline. Moreover, observational studies are subject to prescription bias, making it hard to draw definite conclusions from them. Randomized controlled trials are therefore the preferred study design to investigate the association between statins and cognition. Here we present detailed cognitive outcomes from the randomized placebo-controlled PROspective Study of Pravastatin in t... Abstract

Cited 29 times since 2009 (1.9 per year) source: EuropePMC

Nucleic acids research, Volume 37, Issue 17, 3 1 2009, Pages 5725-5736 Stimulation of homology-directed gene targeting at an endogenous human locus by a nicking endonuclease. van Nierop GP, de Vries AA, Holkers M, Vrijsen KR, Gonçalves MA

Homologous recombination (HR) is a highly accurate mechanism of DNA repair that can be exploited for homology-directed gene targeting. Since in most cell types HR occurs very infrequently (approximately 10(-6) to 10(-8)), its practical application has been largely restricted to specific experimental systems that allow selection of the few cells that become genetically modified. HR-mediated gene targeting has nonetheless revolutionized genetics by greatly facilitating the analysis of mammalian ge... Abstract

Cited 17 times since 2009 (1.1 per year) source: EuropePMC

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Volume 24, Issue 3-4, 3 1 2009, Pages 201-210 Pressure overload-induced right ventricular failure is associated with re-expression of myocardial tenascin-C and elevated plasma tenascin-C levels. Hessel M, Steendijk P, den Adel B, Schutte C, van der Laarse A

Background: We investigated whether (1) monocrotaline(MCT)-induced right ventricular (RV) dilatation is associated with re-expression of myocardial tenascin-C (TNC), (2) elevated plasma TNC levels can be used as a marker of ventricular dilatation, and (3) MCT-induced RV dilatation is associated with alterations of other remodeling-related proteins. Methods: Rats were treated with MCT in low dose (30 mg/kg, MCT30, n=10) to induce compensated RV hypertrophy, in high dose (80 mg/kg, MCT80, n=11) to... Abstract

Cited 11 times since 2009 (0.7 per year) source: EuropePMC

American heart journal, Volume 158, Issue 2, 1 1 2009, Pages 202-208 Intima media thickness of the common carotid artery in vascular surgery patients: a predictor of postoperative cardiovascular events. Flu WJ, van Kuijk JP, Hoeks SE, Kuiper R, Schouten O, Goei D, Winkel T, van Gestel YR, Verhagen HJ, Bax JJ, Poldermans D

Background: Cardiovascular (CV) complications are the leading cause of morbidity and mortality in vascular surgery patients. The Revised Cardiac Risk (RCR) index, identifying cardiac risk factors, is commonly used for preoperative risk stratification. However, a more direct marker of the underlying atherosclerotic disease, such as the common carotid artery intimamedia thickness (CCA-IMT) may be of predictive value as well. The current study evaluated the prognostic value of the CCA-IMT for posto... Abstract

Cited 168 times since 2009 (10.8 per year) source: EuropePMC

Journal of cellular and molecular medicine, Volume 13, Issue 8A, 1 1 2009, Pages 1577-1585 Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis. van Solingen C, Seghers L, Bijkerk R, Duijs JM, Roeten MK, van Oeveren-Rietdijk AM, Baelde HJ, Monge M, Vos JB, de Boer HC, Quax PH, Rabelink TJ, van Zonneveld AJ

MicroRNAs are negative regulators of gene expression that play a key role in cell-type specific differentiation and modulation of cell function and have been proposed to be involved in neovascularization. Previously, using an extensive cloning and sequencing approach, we identified miR-126 to be specifically and highly expressed in human endothelial cells (EC). Here, we demonstrate EC-specific expression of miR-126 in capillaries and the larger vessels in vivo. We therefore explored the potentia... Abstract

Cited 196 times since 2009 (12.6 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 54, Issue 9, 1 1 2009, Pages 764-776 The effects of right ventricular apical pacing on ventricular function and dyssynchrony implications for therapy. Tops LF, Schalij MJ, Bax JJ

Cardiac pacing is the only effective treatment for patients with sick sinus syndrome and atrioventricular conduction disorders. In cardiac pacing, the endocardial pacing lead is typically positioned at the right ventricular (RV) apex. At the same time, there is increasing indirect evidence, derived from large pacing mode selection trials and observational studies, that conventional RV apical pacing may have detrimental effects on cardiac structure and left ventricular function, which are associa... Abstract

Cited 3 times since 2009 (0.2 per year) source: EuropePMC

Minerva cardioangiologica, Volume 57, Issue 4, 1 1 2009, Pages 415-441 Advanced applications of 3-dimensional echocardiography. Ng AC, Delgado V, Bertini M, Nucifora G, Shanks M, Ajmone Marsan N, Holman E, Van De Veire NR, Leung DY, Bax JJ

Over the last few decades, advancements in ultrasound, electronic and computing technologies have permitted current second generation 3-dimensional (3D) echocardiography to display on-line 3D rendered images of the heart. Since various studies demonstrated its superiority over 2-dimensional echocardiography, there is growing enthusiasm to embrace this new 3D echocardiographic technology. With its increasing widespread clinical availability, 3D echocardiography is getting closer to routine clinic... Abstract

Cited 37 times since 2009 (2.4 per year) source: EuropePMC

Pacing and clinical electrophysiology : PACE, Volume 32, Issue 8, 1 1 2009, Pages 1040-1049 Relevance of echocardiographic evaluation of right ventricular function in patients undergoing cardiac resynchronization therapy. Scuteri L, Rordorf R, Marsan NA, Landolina M, Magrini G, Klersy C, Frattini F, Petracci B, Vicentini A, Campana C, Tavazzi L, Ghio S

Aims: Right ventricular (RV) dysfunction is a marker of poor prognosis in heart failure (HF) patients. It is still unclear whether RV function might influence response to cardiac resynchronization therapy (CRT). Methods: Forty-four consecutive patients with HF, large QRS, and either intraventricular or interventricular dyssynchrony underwent echocardiographic evaluation before, 1 month after, and 6 months after CRT. Response to CRT was considered in case of significant LV reverse remodeling, def... Abstract

Journal of vascular surgery, Volume 50, Issue 2, 1 1 2009, Pages 407-412 Fluoroscopic Roentgen stereophotogrammetric analysis (FRSA) to study three-dimensional stent graft dynamics. Koning OH, Kaptein BL, van der Vijver R, Dias NV, Malina M, Schalij MJ, Valstar ER, van Bockel JH

We report the clinical feasibility of fluoroscopic Roentgen stereophotogrammetric analysis (FRSA), a validated method to quantify real time three-dimensional (3D) dynamic motion of stent grafts and the first clinical results after abdominal and thoracic endovascular repair (EVAR). Stent graft motion was measured at 30 (stereo) frames per second, during the cardiac cycle and in the patient after abdominal EVAR, due to respiratory action. Translational motions of the center of mass, diameter chang... Abstract

Cited 26 times since 2009 (1.7 per year) source: EuropePMC

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Volume 74, Issue 2, 1 1 2009, Pages 335-343 In-ambulance abciximab administration in STEMI patients prior to primary PCI is associated with smaller infarct size, improved LV function and lower incidence of heart failure: results from the Leiden MISSION! acute myocardial infarction treatment optimization program. Hassan AK, Liem SS, van der Kley F, Bergheanu SC, Wolterbeek R, Bosch J, Bootsma M, Zeppenfeld K, van der Laarse A, Atsma DE, Jukema JW, Schalij MJ

Objectives: Our aim was to evaluate the effects of early abciximab administration in the ambulance on immediate, short, and long term outcomes. Background: Early abciximab administration before primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) is recommended in practice guidelines. However, optimal timing of administration remains indistinct. Methods: Within a fixed protocol for PPCI, December 2006 was the cut-off point for this prospective... Abstract

Cited 24 times since 2009 (1.5 per year) source: EuropePMC

Archives of surgery (Chicago, Ill. : 1960), Volume 144, Issue 8, 1 1 2009, Pages 728-733 Type D personality and mortality in peripheral arterial disease: a pilot study. Aquarius AE, Smolderen KG, Hamming JF, De Vries J, Vriens PW, Denollet J

Background: Type D personality refers to the tendency to experience negative emotions and to inhibit self-expression in social interaction and has been shown to be an independent predictor of mortality in cardiac disease. Information about the effects of psychological traits on prognosis is lacking in cases of peripheral arterial disease (PAD). Objective: To examine whether type D personality predicts all-cause mortality in PAD. Design: Pilot follow-up study. Setting: Vascular surgery department... Abstract

Critical care medicine, Volume 37, Issue 8, 1 1 2009, Pages 2482-2483 Optimizing the shape of defibrillation shocks. Steendijk P

Abstract

Cited 55 times since 2009 (3.5 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 25, Issue 7, 30 5 2009, Pages 669-676 Right ventricular peak systolic longitudinal strain is a sensitive marker for right ventricular deterioration in adult patients with tetralogy of Fallot. Scherptong RW, Mollema SA, Blom NA, Kroft LJ, de Roos A, Vliegen HW, van der Wall EE, Bax JJ, Holman ER

The aim of this study was to evaluate the feasibility of right ventricular (RV) longitudinal peak systolic strain (LPSS) assessment for the follow-up of adult patients with corrected tetralogy of Fallot (TOF). Adult patients (n = 18) with corrected TOF underwent echocardiography and CMR twice with a time interval of 4.2 +/- 1.7 years. RV performance was derived from CMR, and included RV volumes and ejection fraction (EF). LPSS was calculated globally (GLPSS) and in the RV free wall (LPSS FW), wi... Abstract

Cited 5 times since 2009 (0.3 per year) source: EuropePMC

The American journal of cardiology, Volume 104, Issue 6, 21 3 2009, Pages 758-763 Relation between Framingham risk categories and the presence of functionally relevant coronary lesions as determined on multislice computed tomography and stress testing. Nucifora G, Schuijf JD, van Werkhoven JM, Djaberi R, van der Wall EE, de Roos A, Scholte AJ, Schalij MJ, Jukema JW, Bax JJ

Noninvasive assessment of subclinical atherosclerosis by multislice computed tomographic (MSCT) coronary angiography and demonstration of significant, flow-limiting coronary artery disease (CAD) by stress testing may improve patients' risk stratification. However, data relating the complementary information provided by these noninvasive techniques to traditional risk assessment are scarce. In 255 subjects (45% women, mean age 54 +/- 12 years) without known CAD, 64-slice MSCT coronary angiog... Abstract

Cited 18 times since 2009 (1.1 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 2, Issue 5, 7 1 2009, Pages 524-530 New ECG criteria in arrhythmogenic right ventricular dysplasia/cardiomyopathy. Cox MG, van der Smagt JJ, Wilde AA, Wiesfeld AC, Atsma DE, Nelen MR, Rodriguez LM, Loh P, Cramer MJ, Doevendans PA, van Tintelen JP, de Bakker JM, Hauer RN

Background: Desmosomal changes, electric uncoupling, and surviving myocardial bundles in fibrofatty tissue characterize arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). Resultant activation delay is pivotal for reentry and thereby ventricular tachycardia (VT). Current task force criteria (TFC) for diagnosis have limited sensitivity. The aim of this study was to assess the diagnostic value of additional criteria on activation delay and VT to improve identification of affected i... Abstract

Cited 31 times since 2009 (2 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 95, Issue 19, 5 1 2009, Pages 1607-1611 Multislice computed tomography coronary angiography for risk stratification in patients with an intermediate pretest likelihood. van Werkhoven JM, Gaemperli O, Schuijf JD, Jukema JW, Kroft LJ, Leschka S, Alkadhi H, Valenta I, Pundziute G, de Roos A, van der Wall EE, Kaufmann PA, Bax JJ

Objectives: To assess whether multislice computed tomography coronary angiography (MSCTA) may be useful for risk stratification of patients with suspected coronary artery disease (CAD) at intermediate pretest likelihood according to Diamond and Forrester. Design and patients: MSCTA images were evaluated for the presence of significant CAD in 316 patients with suspected CAD (60% male, average (SD) age 57 (11) years) and an intermediate pretest likelihood according to Diamond and Forrester. Patien... Abstract

Cited 72 times since 2009 (4.6 per year) source: EuropePMC

European heart journal, Volume 30, Issue 19, 4 1 2009, Pages 2360-2367 Magnetic resonance imaging and response to cardiac resynchronization therapy: relative merits of left ventricular dyssynchrony and scar tissue. Marsan NA, Westenberg JJ, Ypenburg C, van Bommel RJ, Roes S, Delgado V, Tops LF, van der Geest RJ, Boersma E, de Roos A, Schalij MJ, Bax JJ

Aim: To assess the relative value of a novel measure of left ventricular (LV) dyssynchrony derived from magnetic resonance imaging (MRI) and the extent of scar tissue for prediction of response to cardiac resynchronization therapy (CRT). Methods and results: Thirty-five heart failure patients scheduled for CRT were included. Left ventricular dyssynchrony was defined as the standard deviation of 16 segment time-to-maximum radial wall thickness (SDt-16) obtained from a cine-set of short-axis slice... Abstract

Cited 187 times since 2009 (11.9 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 54, Issue 5, 1 1 2009, Pages 402-409 Heart failure with preserved ejection fraction is characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency. Phan TT, Abozguia K, Nallur Shivu G, Mahadevan G, Ahmed I, Williams L, Dwivedi G, Patel K, Steendijk P, Ashrafian H, Henning A, Frenneaux M

Objectives: We sought to evaluate the role of exercise-related changes in left ventricular (LV) relaxation and of LV contractile function and vasculoventricular coupling (VVC) in the pathophysiology of heart failure with preserved ejection fraction (HFpEF) and to assess myocardial energetic status in these patients. Background: To date, no studies have investigated exercise-related changes in LV relaxation and VVC as well as in vivo myocardial energetic status in patients with HFpEF. Methods: We... Abstract

Cited 23 times since 2009 (1.5 per year) source: EuropePMC

Pediatric research, Volume 66, Issue 1, 1 1 2009, Pages 74-79 Histopathological changes of the heart after neonatal dexamethasone treatment: studies in 4-, 8-, and 50-week-old rats. Bal MP, de Vries WB, Steendijk P, Homoet-van der Kraak P, van der Leij FR, Baan J, van Oosterhout MF, van Bel F

Dexamethasone (Dex), for prevention of chronic lung disease in preterm infants, showed potential negative long-term effects. Studies regarding long-term cardiovascular effects are lacking. We investigated possible histopathological myocardial changes after neonatal Dex in the young and adult rat heart. Rats were treated with Dex on d 1, 2, and 3 (0.5, 0.3, and 0.1 mg/kg) of life. Control-pups received saline. At 4, 8, and 50 wk after birth rats were killed and anatomic data collected. Heart tiss... Abstract

Cited 26 times since 2009 (1.7 per year) source: EuropePMC

American heart journal, Volume 158, Issue 1, 1 1 2009, Pages 40-46 Delayed improvement of right ventricular diastolic function and regression of right ventricular mass after percutaneous pulmonary valve implantation in patients with congenital heart disease. Romeih S, Kroft LJ, Bokenkamp R, Schalij MJ, Grotenhuis H, Hazekamp MG, Groenink M, de Roos A, Blom NA

Background: Percutaneous pulmonary valve implantation (PPVI) has been introduced as therapy for right ventricular (RV) to pulmonary artery conduit dysfunction in patients with congenital heart disease. It has been shown that RV systolic function improved early after PPVI. The effects of PPVI on RV diastolic function and RV hypertrophy have not yet been studied. Purpose: The objective of this study is to assess early and late changes in systolic and diastolic RV function and RV mass after PPVI. M... Abstract