Research

Publications

Below you can find a list of our published research.

9543 results

Cited 53 times since 2009 (3.3 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 54, Issue 14, 1 1 2009, Pages 1238-1245 Paraoxonase variants relate to 10-year risk in coronary artery disease: impact of a high-density lipoprotein-bound antioxidant in secondary prevention. Regieli JJ, Jukema JW, Doevendans PA, Zwinderman AH, Kastelein JJ, Grobbee DE, van der Graaf Y

Objectives: We investigated the effects of paraoxonase (PON)-1 variants on long-term clinical outcome in patients with coronary artery disease (CAD). Background: PON-1 is a potential therapeutic target to further reduce cardiovascular risk because it is a detoxifying esterase with antioxidant properties. The PON-1 knockout models result in higher susceptibility to atherosclerosis, and PON activity contributes to cardiovascular risk in humans. Human gene variants determine PON activity; however,... Abstract

Cited 21 times since 2009 (1.3 per year) source: EuropePMC

Tissue engineering. Part B, Reviews, Volume 15, Issue 3, 1 1 2009, Pages 307-317 Translating autologous heart valve tissue engineering from bench to bed. Hjortnaes J, Bouten CV, Van Herwerden LA, Gründeman PF, Kluin J

Tissue engineering is currently being actively investigated to ascertain if it can offer an alternative to prosthetic aortic heart valves that may overcome the current limitations of prosthetic aortic heart valves while at the same time conferring the advantages of a living autologous structure, such as biocompatibility, the capacity to grow, repair, and remodel. In vitro studies have shown tissue-engineered heart valves to have adequate structural and functional properties, indicating a promisi... Abstract

Cited 2 times since 2009 (0.1 per year) source: EuropePMC

Pediatric neurology, Volume 41, Issue 3, 1 1 2009, Pages 179-182 Cerebrospinal fluid nitric oxide levels in subacute sclerosing panencephalitis. Yilmaz D, Yüksel D, Senbil N, Eminzade S, Kilinç K, Anlar B, Gürer Y

Oxidative damage plays a role in neurodegenerative diseases. Levels of cerebrospinal fluid nitrite and nitrate levels (oxidation products that provide an indirect estimation of nitric oxide) were investigated in relation to clinical and laboratory features in subacute sclerosing panencephalitis (n = 47) and age-matched control (n = 43) groups. Significantly decreased levels of nitrite (median, 4.91 micromol/L) and nitrate (median, 6.14 micromol/L) were found in the patients. Nitrite and nitrate... Abstract

Cited 8 times since 2009 (0.5 per year) source: EuropePMC

Expert review of cardiovascular therapy, Volume 7, Issue 9, 1 1 2009, Pages 1117-1122 Opportunities in pulmonary valve replacement. Oosterhof T, Hazekamp MG, Mulder BJ

Pulmonary regurgitation is the most important residual lesion after initial surgical correction for pulmonary (sub)valvular stenosis in the early life of patients with tetralogy of Fallot or isolated pulmonary stenosis. Symptomatic or asymptomatic patients with severe right ventricular dilatation due to pulmonary regurgitation may benefit from pulmonary valve replacement. Surgery is ideally performed before the right ventricle becomes irreversibly damaged as a result of longstanding volume overl... Abstract

Cited 86 times since 2009 (5.3 per year) source: EuropePMC

American heart journal, Volume 158, Issue 3, 1 1 2009, Pages 327-334.e4 The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA*CER) trial: study design and rationale. TRA*CER Executive and Steering Committees

Background: The protease-activated receptor 1 (PAR-1), the main platelet receptor for thrombin, represents a novel target for treatment of arterial thrombosis, and SCH 530348 is an orally active, selective, competitive PAR-1 antagonist. We designed TRA*CER to evaluate the efficacy and safety of SCH 530348 compared with placebo in addition to standard of care in patients with non-ST-segment elevation (NSTE) acute coronary syndromes (ACS) and high-risk features. Trial design: TRA*CER is a prospect... Abstract

Cited 17 times since 2009 (1 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 95, Issue 18, 1 1 2009, Pages 1538-1546 Percutaneous aortic valve therapy: clinical experience and the role of multi-modality imaging. Tops LF, Delgado V, van der Kley F, Bax JJ

Abstract

Cited 161 times since 2009 (9.9 per year) source: EuropePMC

Journal of magnetic resonance imaging : JMRI, Volume 30, Issue 3, 1 1 2009, Pages 521-526 Validation and reproducibility of aortic pulse wave velocity as assessed with velocity-encoded MRI. Grotenhuis HB, Westenberg JJ, Steendijk P, van der Geest RJ, Ottenkamp J, Bax JJ, Jukema JW, de Roos A

Purpose: To validate magnetic resonance imaging (MRI) assessment of aortic pulse wave velocity (PWV(MRI)) with PWV determined from invasive intra-aortic pressure measurements (PWV(INV)) and to test the reproducibility of the measurement by MRI. Materials and methods: PWV(MRI) was compared with PWV(INV) in 18 nonconsecutive patients scheduled for catheterization for suspected coronary artery disease. Reproducibility of PWV(MRI) was tested in 10 healthy volunteers who underwent repeated measuremen... Abstract

Cited 10 times since 2009 (0.6 per year) source: EuropePMC

Annals of vascular surgery, Volume 23, Issue 5, 1 1 2009, Pages 583-597 Morbidity and mortality caused by cardiac adverse events after revascularization for critical limb ischemia. Flu HC, Lardenoye JH, Veen EJ, Aquarius AE, Van Berge Henegouwen DP, Hamming JF

Background: We assessed cardiac adverse events (AEs) after primary lower extremity arterial revascularization (LEAR) for critical lower limb ischemia (CLI) in order to evaluate the impact of cardiac AEs on the clinical outcome. We created an optimized care protocol concerning CLI patients' preoperative work-up as well as intra- and postoperative surveillance according to recent important literature and guidelines. Methods: We conducted a prospective analysis of clinical outcome after LEAR u... Abstract

Cited 199 times since 2009 (12.3 per year) source: EuropePMC

The New England journal of medicine, Volume 361, Issue 10, 1 1 2009, Pages 980-989 Fluvastatin and perioperative events in patients undergoing vascular surgery. Schouten O, Boersma E, Hoeks SE, Benner R, van Urk H, van Sambeek MR, Verhagen HJ, Khan NA, Dunkelgrun M, Bax JJ, Poldermans D, Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group

Background: Adverse cardiac events are common after vascular surgery. We hypothesized that perioperative statin therapy would improve postoperative outcomes. Methods: In this double-blind, placebo-controlled trial, we randomly assigned patients who had not previously been treated with a statin to receive, in addition to a beta-blocker, either 80 mg of extended-release fluvastatin or placebo once daily before undergoing vascular surgery. Lipid, interleukin-6, and C-reactive protein levels were me... Abstract

Cited 89 times since 2009 (5.5 per year) source: EuropePMC

Trends in microbiology, Volume 17, Issue 9, 31 5 2009, Pages 423-430 LPxTG surface proteins of enterococci. Hendrickx AP, Willems RJ, Bonten MJ, van Schaik W

Enterococci have become an important cause of nosocomial infections since the late 1980s. Several surface proteins have been implicated in contributing to infections caused by Enterococcus faecalis and Enterococcus faecium. Understanding the in vivo function of enterococcal surface proteins, particularly their role in directing interactions with the host during infection, is essential to explain the success of enterococci as nosocomial pathogens. Here we review current knowledge of enterococcal... Abstract

Cited 144 times since 2009 (8.9 per year) source: EuropePMC

European heart journal, Volume 30, Issue 20, 30 5 2009, Pages 2470-2477 Characteristics of heart failure patients associated with good and poor response to cardiac resynchronization therapy: a PROSPECT (Predictors of Response to CRT) sub-analysis. van Bommel RJ, Bax JJ, Abraham WT, Chung ES, Pires LA, Tavazzi L, Zimetbaum PJ, Gerritse B, Kristiansen N, Ghio S

Aims: Predictors of Response to Cardiac Resynchronization Therapy (CRT) (PROSPECT) was the first large-scale, multicentre clinical trial that evaluated the ability of several echocardiographic measures of mechanical dyssynchrony to predict response to CRT. Since response to CRT may be defined as a spectrum and likely influenced by many factors, this sub-analysis aimed to investigate the relationship between baseline characteristics and measures of response to CRT. Methods and results: A total of... Abstract

Cited 21 times since 2009 (1.3 per year) source: EuropePMC

International journal of cardiology, Volume 147, Issue 1, 28 4 2009, Pages 52-57 Can we use the end systolic volume index to monitor intrinsic right ventricular function after repair of tetralogy of Fallot? Uebing A, Fischer G, Schlangen J, Apitz C, Steendijk P, Kramer HH

Background: After tetralogy of Fallot (ToF) repair the right ventricle (RV) is commonly exposed to abnormal volume load resulting from pulmonary regurgitation (PR) leading to progressive RV dilatation. The objective of this study was to assess the relationship between RV volumes, especially the end systolic volume index (ESVi), and RV contractility in patients after ToF repair and significant PR and to determine whether RV dilatation reflects intrinsic RV dysfunction in these patients. Methods:... Abstract

Cited 156 times since 2009 (9.6 per year) source: EuropePMC

The Biochemical journal, Volume 422, Issue 3, 27 4 2009, Pages 443-453 Human Ccr4-Not complexes contain variable deadenylase subunits. Lau NC, Kolkman A, van Schaik FM, Mulder KW, Pijnappel WW, Heck AJ, Timmers HT

The Ccr4-Not complex is evolutionarily conserved and important for regulation of mRNA synthesis and decay. The composition of the yeast complex has been well described. Orthologues of the yeast Ccr4-Not components have been identified in human cells including multiple subunits with mRNA deadenylase activity. In the present study, we examine the composition of the human Ccr4-Not complex in an in-depth proteomic approach using stable cell lines expressing tagged CNOT proteins. We find at least fou... Abstract

Cited 39 times since 2009 (2.4 per year) source: EuropePMC

PloS one, Volume 4, Issue 8, 27 4 2009, Pages e6809 Both paraoxonase-1 genotype and activity do not predict the risk of future coronary artery disease; the EPIC-Norfolk Prospective Population Study. Birjmohun RS, Vergeer M, Stroes ES, Sandhu MS, Ricketts SL, Tanck MW, Wareham NJ, Jukema JW, Kastelein JJ, Khaw KT, Boekholdt SM

Background: Paraoxonase-1 (PON1) is an antioxidant enzyme, that resides on high-density lipoprotein (HDL). PON1-activity, is heavily influenced by the PON1-Q192R polymorphism. PON1 is considered to protect against atherosclerosis, but it is unclear whether this relation is independent of its carrier, HDL. In order to evaluate the atheroprotective potential of PON1, we assessed the relationships among PON1-genotype, PON1-activity and risk of future coronary artery disease (CAD), in a large prospe... Abstract

Cited 13 times since 2009 (0.8 per year) source: EuropePMC

European heart journal, Volume 30, Issue 19, 27 4 2009, Pages 2304-2307 Three-dimensional speckle tracking echocardiography: a novel approach in the assessment of left ventricular volume and function? Flu WJ, van Kuijk JP, Bax JJ, Gorcsan J, Poldermans D

Abstract

Cited 389 times since 2009 (23.9 per year) source: EuropePMC

European heart journal, Volume 30, Issue 22, 27 4 2009, Pages 2769-2812 Guidelines for pre-operative cardiac risk assessment and perioperative cardiac management in non-cardiac surgery. Task Force for Preoperative Cardiac Risk Assessment and Perioperative Cardiac Management in Non-cardiac Surgery, European Society of Cardiology (ESC), Poldermans D, Bax JJ, Boersma E, De Hert S, Eeckhout E, Fowkes G, Gorenek B, Hennerici MG, Iung B, Kelm M, Kjeldsen KP, Kristensen SD, Lopez-Sendon J, Pelosi P, Philippe F, Pierard L, Ponikowski P, Schmid JP, Sellevold OF, Sicari R, Van den Berghe G, Vermassen F

Abstract

Cited 25 times since 2009 (1.5 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 95, Issue 23, 25 4 2009, Pages 1931-1936 Aortic elasticity and size are associated with aortic regurgitation and left ventricular dysfunction in tetralogy of Fallot after pulmonary valve replacement. Grotenhuis HB, Ottenkamp J, de Bruijn L, Westenberg JJ, Vliegen HW, Kroft LJ, de Roos A

Background: Aortic wall pathology and concomitant aortic dilatation have been described in tetralogy of Fallot (TOF) patients, which may negatively affect aortic valve and left ventricular systolic function. Objective: To assess aortic dimensions, aortic elasticity, aortic valve competence and biventricular function in repaired TOF patients after pulmonary valve replacement (PVR) using magnetic resonance imaging (MRI). Methods: MRI was performed in 16 patients with TOF after PVR (10 male; mean a... Abstract

Cited 54 times since 2009 (3.3 per year) source: EuropePMC

BJOG : an international journal of obstetrics and gynaecology, Volume 116, Issue 12, 13 2 2009, Pages 1593-1601 Comparison of pregnancy outcomes in women with repaired versus unrepaired atrial septal defect. Yap SC, Drenthen W, Meijboom FJ, Moons P, Mulder BJ, Vliegen HW, van Dijk AP, Jaddoe VW, Steegers EA, Roos-Hesselink JW, Pieper PG, ZAHARA investigators

Objective: To compare the risks of complications during pregnancy in women with repaired and unrepaired atrial septal defects (ASDs) without associated complex cardiac lesions. Design: A retrospective multicentre study. Setting: Tertiary centres in the Netherlands and Belgium. Population: Women with ASD without associated complex cardiac lesions. Methods: Women were identified using two congenital heart disease registries. One hundred women were identified who had 243 pregnancies, including 49 m... Abstract

Cited 21 times since 2009 (1.3 per year) source: EuropePMC

Circulation, Volume 120, Issue 8, 10 2 2009, Pages 669-676 p27kip1-838C>A single nucleotide polymorphism is associated with restenosis risk after coronary stenting and modulates p27kip1 promoter activity. van Tiel CM, Bonta PI, Rittersma SZ, Beijk MA, Bradley EJ, Klous AM, Koch KT, Baas F, Jukema JW, Pons D, Sampietro ML, Pannekoek H, de Winter RJ, de Vries CJ

Background: The cyclin-dependent kinase inhibitor p27(kip1) is a key regulator of smooth muscle cell and leukocyte proliferation in vascular disease, including in-stent restenosis. We therefore hypothesized that common genetic variations or single nucleotide polymorphisms in p27(kip1) may serve as a useful tool in risk stratification for in-stent restenosis. Methods and results: Three single nucleotide polymorphisms concerning the p27(kip1) gene (-838C>A, rs36228499; -79C>T, rs34330; +326G... Abstract

Cited 71 times since 2009 (4.4 per year) source: EuropePMC

Circulation. Heart failure, Volume 2, Issue 6, 6 1 2009, Pages 643-653 A new direction for cardiac regeneration therapy: application of synergistically acting epicardium-derived cells and cardiomyocyte progenitor cells. Winter EM, van Oorschot AA, Hogers B, van der Graaf LM, Doevendans PA, Poelmann RE, Atsma DE, Gittenberger-de Groot AC, Goumans MJ

Background: Adult human epicardium-derived cells (EPDCs), transplanted into the infarcted heart, are known to improve cardiac function, mainly through paracrine protection of the surrounding tissue. We hypothesized that this effect might be further improved if these supportive EPDCs were combined with cells that could possibly supply the ischemic heart with new cardiomyocytes. Therefore, we transplanted EPDCs together with cardiomyocyte progenitor cells that can generate mature cardiomyocytes in... Abstract