9543 results
Cited 18 times since 2008 (1 per year)
source: EuropePMC
Journal of virology,
Volume 82, Issue 12, 2 1 2008, Pages 5693-5702
The affinity of EBNA1 for its origin of DNA synthesis is a determinant of the origin's replicative efficiency.
Lindner SE, Zeller K, Schepers A, Sugden B
Epstein-Barr virus (EBV) replicates its genome as a licensed plasmid in latently infected cells. Although replication of this plasmid is essential for EBV latent infection, its synthesis still fails for 16% of the templates in S phase. In order to understand these failures, we sought to determine whether the affinity of the initiator protein (EBNA1) for its binding sites in the origin affects the efficiency of plasmid replication. We have answered this question by using several engineered origin...
Abstract
Cited 7 times since 2008 (0.4 per year)
source: EuropePMC
Circulation research,
Volume 102, Issue 7, 1 1 2008, Pages 749-751
Pitx2: a challenging teenager.
Poelmann RE, Jongbloed MR, Gittenberger-de Groot AC
Abstract
Cited 55 times since 2008 (3.1 per year)
source: EuropePMC
JACC. Cardiovascular interventions,
Volume 1, Issue 2, 1 1 2008, Pages 192-201
Stent malapposition after sirolimus-eluting and bare-metal stent implantation in patients with ST-segment elevation myocardial infarction: acute and 9-month intravascular ultrasound results of the MISSION! intervention study.
van der Hoeven BL, Liem SS, Dijkstra J, Bergheanu SC, Putter H, Antoni ML, Atsma DE, Bootsma M, Zeppenfeld K, Jukema JW, Schalij MJ
Objectives: Acute and late stent malapposition (SM) after bare-metal stents (BMS) and sirolimus-eluting stents (SES) in ST-segment elevation myocardial infarction patients were studied. Background: Stent thrombosis may be caused by SM after primary percutaneous coronary intervention in ST-segment elevation myocardial infarction patients. Methods: Post-procedure and follow-up intravascular ultrasound data were available in 184 out of 310 patients (60%; 104 SES, 80 BMS) included in the MISSION! In...
Abstract
Cited 33 times since 2008 (1.9 per year)
source: EuropePMC
The Netherlands journal of medicine,
Volume 66, Issue 4, 1 1 2008, Pages 169-174
Clinical practice guideline for cardiovascular risk management in the Netherlands.
Smulders YM, Burgers JS, Scheltens T, van Hout BA, Wiersma T, Simoons ML, Guideline development group for the Dutch guideline for multidisciplinary cardiovascular risk management
Abstract
Cited 96 times since 2008 (5.4 per year)
source: EuropePMC
JACC. Cardiovascular interventions,
Volume 1, Issue 2, 1 1 2008, Pages 176-182
Head-to-head comparison of coronary plaque evaluation between multislice computed tomography and intravascular ultrasound radiofrequency data analysis.
Pundziute G, Schuijf JD, Jukema JW, Decramer I, Sarno G, Vanhoenacker PK, Reiber JH, Schalij MJ, Wijns W, Bax JJ
Objectives: The purpose of this study was to perform a head-to-head comparison of plaque observations with multislice computed tomography (MSCT) to virtual histology intravascular ultrasound (VH IVUS). Background: The VH IVUS allows in vivo coronary plaque characterization with high spatial resolution. Noninvasively, plaques may be evaluated with MSCT, but limited data are available. Methods: A total of 50 patients underwent 64-slice MSCT followed by VH IVUS. The Agatston score was evaluated on...
Abstract
Cited 33 times since 2008 (1.9 per year)
source: EuropePMC
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology,
Volume 15, Issue 2, 1 1 2008, Pages 140-144
Exercise training increases oxygen uptake efficiency slope in chronic heart failure.
Gademan MG, Swenne CA, Verwey HF, van de Vooren H, Haest JC, van Exel HJ, Lucas CM, Cleuren GV, Schalij MJ, van der Wall EE
Background and aim: The oxygen uptake efficiency slope (OUES) is a novel measure of cardiopulmonary reserve. OUES is measured during an exercise test, but it is independent of the maximally achieved exercise intensity. It has a higher prognostic value in chronic heart failure (CHF) than other exercise test-derived variables such as(Equation is included in full-text article.)or(Equation is included in full-text article.)slope. Exercise training improves(Equation is included in full-text article.)...
Abstract
Cited 4 times since 2008 (0.2 per year)
source: EuropePMC
Minerva cardioangiologica,
Volume 56, Issue 2, 1 1 2008, Pages 227-235
Measuring left ventricular mechanical dyssynchrony from ECG-gated SPECT myocardial perfusion imaging.
Chen J, Garcia EV, Henneman MM, Bax JJ, Boogers MJ, Trimble MA, Borges-Neto S, Velazquez EJ, Iskandrian AE
Cardiac resynchronization therapy (CRT) has shown benefits in patients with severe heart failure. The traditional criteria to select patients for CRT (New York Heart Association [NYHA] class III or IV, depressed left ventricular [LV] ejection fraction, and prolonged QRS duration) result in at least 30% of the selected patients with no response to CRT. Recent studies with echocardiography have shown that the presence of LV dyssynchrony is an important predictor for response to CRT. However, the r...
Abstract
Cited 97 times since 2008 (5.5 per year)
source: EuropePMC
Pharmacogenetics and genomics,
Volume 18, Issue 4, 1 1 2008, Pages 339-348
CYP3A5 genotype is not associated with a higher risk of acute rejection in tacrolimus-treated renal transplant recipients.
Hesselink DA, van Schaik RH, van Agteren M, de Fijter JW, Hartmann A, Zeier M, Budde K, Kuypers DR, Pisarski P, Le Meur Y, Mamelok RD, van Gelder T
Objective: Patients expressing the tacrolimus-metabolizing enzyme, cytochrome P450 (CYP) 3A5, require more tacrolimus to reach target concentrations. We studied the influence of the CYP3A5(*)3 allele, which results in the absence of CYP3A5 protein, on tacrolimus dose and exposure, as well as the incidence of biopsy-proven acute rejection (BPAR) after renal transplantation. Methods: A total of 136 patients participating in a prospective, randomized-controlled clinical trial with the primary aim o...
Abstract
Cited 26 times since 2008 (1.5 per year)
source: EuropePMC
Environmental science & technology,
Volume 42, Issue 7, 1 1 2008, Pages 2367-2373
EXAFS study on the reactions between iron and fulvic acid in acid aqueous solutions.
van Schaik JW, Persson I, Kleja DB, Gustafsson JP
Iron(III) competes with trace metals for binding sites on organic ligands. We used X-ray absorption fine structure (EXAFS) spectroscopy to determine the binding mode and oxidation state of iron in solutions initially containing only iron(III) and fulvic acid at pHs 2 and 4. EXAFS spectra were recorded at different times after sample preparation. Iron was octahedrally configured with inner-sphere Fe-O interactions at 1.98-2.10 A, depending on the oxidation state of iron. Iron(III) formed complexe...
Abstract
Cited 12 times since 2008 (0.7 per year)
source: EuropePMC
The Veterinary record,
Volume 162, Issue 15, 1 1 2008, Pages 475-479
Subclinical hypocalcaemia in captive Asian elephants (Elephas maximus).
van der Kolk JH, van Leeuwen JP, van den Belt AJ, van Schaik RH, Schaftenaar W
The hypothesis that hypocalcaemia may play a role in dystocia in captive Asian elephants (Elephas maximus) was investigated. The objectives of the study were to measure the total calcium concentration in elephant plasma; assess the changes in parameters of calcium metabolism during a feeding trial; investigate a possible relationship between calcium metabolism and dystocia; and assess bone mineralisation in captive Asian elephants in vivo. The following parameters were measured: total and ionise...
Abstract
Cited 58 times since 2008 (3.3 per year)
source: EuropePMC
Pharmacogenetics and genomics,
Volume 18, Issue 4, 1 1 2008, Pages 299-305
Common ATP-binding cassette B1 variants are associated with increased digoxin serum concentration.
Aarnoudse AJ, Dieleman JP, Visser LE, Arp PP, van der Heiden IP, van Schaik RH, Molokhia M, Hofman A, Uitterlinden AG, Stricker BH
Background and objective: Digoxin is a known substrate of ATP-binding cassette B1 (ABCB1/MDR1). The results of studies on the association between ABCB1 polymorphisms and digoxin kinetics, however, remain contradictory. Almost all studies were small and involved only single dose kinetics. The goal of this study was to establish ABCB1 genotype effect on digoxin blood concentrations in a large cohort of chronic digoxin users in a general Dutch European population. Methods: Digoxin users were identi...
Abstract
Cited 13 times since 2008 (0.7 per year)
source: EuropePMC
The Journal of general virology,
Volume 89, Issue Pt 4, 1 1 2008, Pages 975-983
Specificity and functional interaction of the polymerase complex proteins of human and avian metapneumoviruses.
de Graaf M, Herfst S, Schrauwen EJA, Choi Y, van den Hoogen BG, Osterhaus ADME, Fouchier RAM
Human metapneumovirus (HMPV) and avian metapneumovirus (AMPV) have a similar genome organization and protein composition, but a different host range. AMPV subgroup C (AMPV-C) is more closely related to HMPV than other AMPVs. To investigate the specificity and functional interaction of the polymerase complex proteins of human and avian metapneumoviruses, a minireplicon system was generated for AMPV-C and used in combination with minireplicon systems for HMPV lineages A1 and B1. Viral RNA-like mol...
Abstract
Cited 151 times since 2008 (8.6 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 51, Issue 16, 1 1 2008, Pages 1588-1596
Long-term prognosis of patients with peripheral arterial disease: a comparison in patients with coronary artery disease.
Welten GM, Schouten O, Hoeks SE, Chonchol M, Vidakovic R, van Domburg RT, Bax JJ, van Sambeek MR, Poldermans D
Objectives: This study was designed to compare the long-term outcomes of patients with peripheral arterial disease (PAD) with a risk factor matched population of coronary artery disease (CAD) patients, but without PAD. Background: The PAD is considered to be a risk factor for adverse late outcome. Methods: A total of 2,730 PAD patients undergoing vascular surgery were categorized into groups: 1) carotid endarterectomy (n = 560); 2) elective abdominal aortic surgery (AAA) (n = 923); 3) acute AAA...
Abstract
Cited 3 times since 2008 (0.2 per year)
source: EuropePMC
Minerva cardioangiologica,
Volume 56, Issue 2, 1 1 2008, Pages 215-226
Multi-slice computed tomography coronary angiography: anatomic vs functional assessment in clinical practice.
Van Werkhoven JM, Schuijf JD, Jukema JW, Van Der Wall EE, Bax JJ
Non-invasive imaging plays an increasingly important role in the diagnosis and risk stratification of coronary artery disease (CAD). Several techniques such as stress echocardiography and myocardial perfusion imaging have become available to assess cardiac function and myocardial perfusion. With the arrival of multi-slice computed tomography coronary angiography (CTA), non-invasive imaging of coronary anatomy has also become possible. Studies concerning the diagnostic accuracy have demonstrated...
Abstract
Cited 4 times since 2008 (0.2 per year)
source: EuropePMC
Interactive cardiovascular and thoracic surgery,
Volume 7, Issue 3, 28 4 2008, Pages 517-518
Early atrial septal defect surgery due to a bronchogenic cyst causing congestive heart failure by left atrium compression.
Mosquera VX, Rijlaarsdam M, Filippini L, Hazekamp MG
We report on an uncommon case of a 10-month-old patient who required early surgical closure of an ostium secumdum atrial septal defect due to the concomitant presence of a big subcarinal bronchogenic cyst compressing the left atrium and, therefore, increasing the left-to-right shunt. It led to refractory congestive heart failure symptoms, establishing thereby an earlier indication of surgical treatment.
Abstract
Cited 7 times since 2008 (0.4 per year)
source: EuropePMC
BMC psychiatry,
Volume 8, 25 4 2008, Pages 18
Treatment of chronically depressed patients: a multisite randomized controlled trial testing the effectiveness of 'Cognitive Behavioral Analysis System of Psychotherapy' (CBASP) for chronic depressions versus usual secondary care.
Wiersma JE, van Schaik DJ, van Oppen P, McCullough JP, Schoevers RA, Dekker JJ, Blom MB, Maas K, Smit JH, Penninx BW, Beekman AT
Background: 'Cognitive Behavioral Analysis System of Psychotherapy' (CBASP) is a form of psychotherapy specifically developed for patients with chronic depression. In a study in the U.S., remarkable favorable effects of CBASP have been demonstrated. However, no other studies have as yet replicated these findings and CBASP has not been tested outside the United States. This protocol describes a randomized controlled trial on the effectiveness of CBASP in the Netherlands. Methods/design:...
Abstract
Cited 22 times since 2008 (1.2 per year)
source: EuropePMC
Journal of neuroimmunology,
Volume 195, Issue 1-2, 20 3 2008, Pages 164-170
B and T cell imbalances in CSF of patients with Hu-antibody associated PNS.
de Graaf M, de Beukelaar J, Bergsma J, Kraan J, van den Bent M, Klimek M, van Norden Y, Kusuma A, Smitt PS, Gratama JW
In paraneoplastic neurological syndromes associated with Hu-antibodies (Hu-PNS) an important role for cellular immunity is hypothesized. We characterized the cerebrospinal fluid (CSF) pleocytosis in Hu-PNS patients by assessing the major lymphocyte subsets by flow cytometry. The B cell subset in the CSF of Hu-PNS patients showed a significant absolute (approximately 20x) and relative (approximately 3x) expansion, while the numbers of CD4+ T cells, CD8+ T cells and NK cells only showed an absolut...
Abstract
Cited 54 times since 2008 (3 per year)
source: EuropePMC
Circulation,
Volume 117, Issue 12, 10 2 2008, Pages 1508-1517
Epicardium-derived cells in development of annulus fibrosis and persistence of accessory pathways.
Kolditz DP, Wijffels MC, Blom NA, van der Laarse A, Hahurij ND, Lie-Venema H, Markwald RR, Poelmann RE, Schalij MJ, Gittenberger-de Groot AC
Background: The developmental mechanisms underlying the persistence of myocardial accessory atrioventricular pathways (APs) that bypass the annulus fibrosis are mainly unknown. In the present study, we investigated the role of epicardium-derived cells (EPDCs) in annulus fibrosis formation and the occurrence of APs. Methods and results: EPDC migration was mechanically inhibited by in ovo microsurgery in quail embryos. In ovo ECGs were recorded in wild-type (n=12) and EPDC-inhibited (n=12) hearts...
Abstract
Cited 12 times since 2008 (0.7 per year)
source: EuropePMC
The American journal of cardiology,
Volume 101, Issue 8, 4 1 2008, Pages 1179-1184
Effects of percutaneous transluminal septal myocardial ablation for obstructive hypertrophic cardiomyopathy on systolic and diastolic left ventricular function assessed by pressure-volume loops.
Meliga E, Steendijk P, Valgimigli M, Ten Cate FJ, Serruys PW
The aim of the present study was to determine the long-term effects of percutaneous transluminal septal myocardial ablation (PTSMA) on systolic and diastolic left ventricular (LV) functions in patients with obstructive hypertrophic cardiomyopathy (HC). Ten consecutive patients with symptomatic HC despite optimal medical treatment were referred for PTSMA at our center. LV systolic and diastolic functions were assessed by online LV pressure-volume loops obtained by conductance catheter at baseline...
Abstract
Cited 20 times since 2008 (1.1 per year)
source: EuropePMC
Atherosclerosis,
Volume 200, Issue 2, 4 1 2008, Pages 417-423
Elevated CRP levels are associated with increased carotid atherosclerosis independent of visceral obesity.
Alizadeh Dehnavi R, de Roos A, Rabelink TJ, van Pelt J, Wensink MJ, Romijn JA, Tamsma JT
Background: Visceral obesity (VO) is associated with an increased risk of cardiovascular disease. Elevated C-reactive protein (CRP) levels are associated with VO and cardiovascular disease. After exploring the relation between CRP and VO, we aimed to evaluate the VO independent relation between CRP and carotid atherosclerosis. Methods and results: The prevalence of inflammation was evaluated in 439 male subjects with VO without type 2 diabetes and manifest cardiovascular disease. Waist circumfer...
Abstract
