Research

Publications

Below you can find a list of our published research.

9543 results

Cited 5 times since 2006 (0.3 per year) source: EuropePMC

The American journal of cardiology, Volume 98, Issue 11, 16 3 2006, Pages 1515-1518 Impact of glomerular filtration rate on minor troponin T elevations for risk assessment in patients undergoing operation for abdominal aortic aneurysm or lower extremity arterial obstruction. Feringa HH, Bax JJ, de Jonge R, Elhendy A, van Domburg RT, Dunkelgrun M, Schouten O, Karagiannis SE, Vidakovic R, Poldermans D

Debate surrounds the impact of renal function on the prognostic value of minor troponin T release in vascular surgery patients. The objective of this study was to assess the long-term prognostic value of minor degrees of troponin T release in patients who undergo major vascular surgery, especially those with concomitant renal dysfunction. Survivors of major noncardiac vascular surgery (n = 558) were preoperatively screened for cardiac risk factors and renal function. Serial troponin T was measur... Abstract

Cited 233 times since 2006 (12.2 per year) source: EuropePMC

Gastroenterology, Volume 132, Issue 1, 12 2 2006, Pages 66-75; quiz 432-3 Once-daily, high-concentration MMX mesalamine in active ulcerative colitis. Kamm MA, Sandborn WJ, Gassull M, Schreiber S, Jackowski L, Butler T, Lyne A, Stephenson D, Palmen M, Joseph RE

Background & aims: SPD476 (LIALDA in the US; MEZAVANT in the EU; otherwise known as MMX mesalamine; Shire Pharmaceuticals Inc., Wayne, PA, under license from Giuliani SpA, Milan, Italy) is a novel, once-daily, high-strength (1.2 g/tablet) formulation of mesalamine, utilizing MMX Multi Matrix System (MMX) technology designed to deliver the active drug throughout the colon. We performed a double-blind, multicenter study, comparing MMX mesalamine vs placebo for the treatment of active ulcerativ... Abstract

Cited 11 times since 2006 (0.6 per year) source: EuropePMC

Environmental pollution (Barking, Essex : 1987), Volume 147, Issue 1, 12 2 2006, Pages 32-40 Distribution and movement of nutrients and metals in a Pinus radiata forest soil following applications of biosolids. McLaren RG, Clucas LM, Speir TW, van Schaik AP

Samples of biosolids, spiked with increasing amounts of Cu, Ni or Zn were applied to field plots in a Pinus radiata forest, and the nutrient and metal status of the forest litter and underlying mineral soil was monitored over a period of six years following application. The macronutrient status of the forest litter was changed markedly by the biosolids application, with substantial increases in N, P and Ca concentrations, and decreases in Mg and K. The C/N ratio of the litter was also decreased... Abstract

Cited 45 times since 2006 (2.4 per year) source: EuropePMC

The British journal of ophthalmology, Volume 91, Issue 3, 11 2 2006, Pages 313-318 Accuracy of GDx VCC, HRT I, and clinical assessment of stereoscopic optic nerve head photographs for diagnosing glaucoma. Reus NJ, de Graaf M, Lemij HG

Aims: To determine and compare the accuracy and reproducibility of GDx variable cornea compensation (VCC) scanning laser polarimetry (SLP) with VCC, Heidelberg retina tomograph (HRT) I confocal scanning laser ophthalmoscopy (CSLO), and clinical assessment of stereoscopic optic nerve head (ONH) photographs for diagnosing glaucoma. Methods: One eye each of 40 healthy subjects, 48 glaucoma patients, and six patients with ocular hypertension were measured with SLP-VCC and CSLO. Simultaneous stereosc... Abstract

Cited 11 times since 2006 (0.6 per year) source: EuropePMC

Drug metabolism and disposition: the biological fate of chemicals, Volume 35, Issue 1, 11 2 2006, Pages 67-71 A new CYP3A5 variant, CYP3A5*11, is shown to be defective in nifedipine metabolism in a recombinant cDNA expression system. Lee SJ, van der Heiden IP, Goldstein JA, van Schaik RH

A new CYP3A5 variant, CYP3A5*11, was found in a white European subject by DNA sequencing. The CYP3A5*11 allele contains a single nucleotide polymorphism (SNP) (g.3775A>G) in exon 2, which results in a Tyr53Cys substitution, and a g.6986A>G splice change, the latter SNP previously reported in the defective CYP3A5*3 allele. However, the CYP3A5*3 is not a null allele because this variant is associated with leaky splicing, resulting in small amounts of functional protein still being produced.... Abstract

Cited 75 times since 2006 (3.9 per year) source: EuropePMC

European heart journal, Volume 28, Issue 15, 9 2 2006, Pages 1854-1861 Outcome of implantable cardioverter defibrillators in adults with congenital heart disease: a multi-centre study. Yap SC, Roos-Hesselink JW, Hoendermis ES, Budts W, Vliegen HW, Mulder BJ, van Dijk AP, Schalij MJ, Drenthen W

Aims: To investigate outcome and complications of implantable cardioverter defibrillators (ICDs) in adults with congenital heart disease (CHD) and to identify predictors of (in-) appropriate shocks. Methods and results: Sixty-four CHD patients >/= 18 years at first ICD implantation [63% tetralogy of Fallot (TOF) and age at implantation 37 +/- 13 years] were identified using the Dutch adult CHD registry and a Belgian tertiary care centre database. Median follow-up duration was 3.7 years. Early... Abstract

Cited 48 times since 2006 (2.5 per year) source: EuropePMC

The Journal of urology, Volume 176, Issue 4 Pt 1, 1 1 2006, Pages 1349-53; discussion 1353 Phase II marker lesion study with intravesical instillation of apaziquone for superficial bladder cancer: toxicity and marker response. van der Heijden AG, Moonen PM, Cornel EB, Vergunst H, de Reijke TM, van Boven E, Barten EJ, Puri R, van Kalken CK, Witjes JA

Purpose: We studied the ablative activity of intravesical apaziquone (EOquin) on a papillary marker tumor and determined the incidence of side effects. Materials and methods: A total of 46 patients with multiple pTa or pT1 bladder tumors underwent visible lesion resection except for 1 marker tumor. Patients were then treated with 6 instillations of apaziquone at weekly intervals. The response was determined 2 to 4 weeks after the last instillation. Results: One patient withdrew informed consent... Abstract

Circulation, Volume 114, Issue 14, 1 1 2006, Pages e526; author reply e527 Letter by Schinkel et al regarding article, "Projected valve area at normal flow rate improves the assessment of stenosis severity in patients with low-flow, low-gradient aortic stenosis: the multicenter TOPAS (Truly or Pseudo-Severe Aortic Stenosis) study". Schinkel AF, Bountioukos M, Poldermans D, Bax JJ

Abstract

Cited 58 times since 2006 (3 per year) source: EuropePMC

Alimentary pharmacology & therapeutics, Volume 24, Issue 7, 1 1 2006, Pages 1087-1097 Once daily MMX mesalazine for the treatment of mild-to-moderate ulcerative colitis: a phase II, dose-ranging study. D'Haens G, Hommes D, Engels L, Baert F, van der Waaij L, Connor P, Ramage J, Dewit O, Palmen M, Stephenson D, Joseph R

Background: SPD476 (MMX mesalazine), is a novel, once daily, high-strength mesalazine formulation (1.2 g/tablet) that utilizes Multi Matrix System (MMX) technology to delay and extend delivery of the active drug throughout the colon. Aim: To assess the safety and efficacy of MMX mesalazine in patients with mild-to-moderately active ulcerative colitis, in a pilot, phase II, randomized, multicentre, double-blind, parallel-group, dose-ranging study (SPD476-202). Methods: Thirty-eight patients with... Abstract

Cited 70 times since 2006 (3.7 per year) source: EuropePMC

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 47, Issue 10, 1 1 2006, Pages 1565-1570 Extent of viability to predict response to cardiac resynchronization therapy in ischemic heart failure patients. Ypenburg C, Schalij MJ, Bleeker GB, Steendijk P, Boersma E, Dibbets-Schneider P, Stokkel MP, van der Wall EE, Bax JJ

Unlabelled: The response to cardiac resynchronization therapy (CRT) varies significantly among individuals. Preliminary data suggest that the presence of myocardial viability may be important for response to CRT. The aim of this study was to evaluate whether the extent of viability could predict response to CRT after 6 mo. Methods: Sixty-one consecutive patients with advanced heart failure, left ventricular ejection fraction < 35%, QRS duration > 120 ms, and chronic coronary artery disease... Abstract

Cited 39 times since 2006 (2 per year) source: EuropePMC

American heart journal, Volume 152, Issue 4, 1 1 2006, Pages 684.e11-6 Sustained effect of autologous bone marrow mononuclear cell injection in patients with refractory angina pectoris and chronic myocardial ischemia: twelve-month follow-up results. Beeres SL, Bax JJ, Dibbets-Schneider P, Stokkel MP, Fibbe WE, van der Wall EE, Schalij MJ, Atsma DE

Background: Cell therapy has recently been introduced to treat patients with refractory angina. Because most studies have only included short-term follow-up, the effects of cell therapy over a longer period are unknown. Methods: In 25 patients (mean age 64 +/- 10 years, 21 men) with refractory angina, a total of 84 +/- 29 x 10(6) bone marrow-derived mononuclear cells was injected intramyocardially in regions with ischemia on technetium-99m tetrofosmin single-photon emission computed tomography.... Abstract

Cited 51 times since 2006 (2.7 per year) source: EuropePMC

Clinical pharmacology and therapeutics, Volume 80, Issue 4, 1 1 2006, Pages 367-374 MDR1 gene polymorphisms are associated with neuropsychiatric adverse effects of mefloquine. Aarnoudse AL, van Schaik RH, Dieleman J, Molokhia M, van Riemsdijk MM, Ligthelm RJ, Overbosch D, van der Heiden IP, Stricker BH

Background: Mefloquine, a drug used for treatment and prophylaxis of malaria, is known for its neuropsychiatric adverse effects. We hypothesized that neuropsychiatric adverse effects of mefloquine are associated with polymorphisms in the MDR1/ABCB1 gene that encodes for the efflux pump P-glycoprotein. Methods: The association between MDR1 C1236T, G2677T, and C3435T single-nucleotide polymorphisms and the occurrence of neuropsychiatric adverse effects was examined in a prospective cohort study of... Abstract

Cited 6 times since 2006 (0.3 per year) source: EuropePMC

American heart journal, Volume 152, Issue 4, 1 1 2006, Pages 636-640 Implantable defibrillator early after primary percutaneous intervention for ST-elevation myocardial infarction: rationale and design of the Defibrillator After Primary Angioplasty (DAPA) trial. Ottervanger JP, Ramdat Misier AR, Zijlstra F, Schalij MJ, Wever E, Jordaens LJ, Henriques JP, de Boer MJ, Robbe HW, Wellens HJ, DAPA Investigators

Background: It has been shown that an implantable cardioverter defibrillator (ICD) may be beneficial when added to optimal drug treatment in patients with reduced left ventricular function who survive a myocardial infarction (MI). However, it is not known whether patients with increased risk of death after primary percutaneous coronary intervention (PCI) for ST-elevation MI also have benefit of prophylactic ICD therapy to reduce sudden cardiac death. Methods and study design: The DAPA trial is d... Abstract

Cited 26 times since 2006 (1.4 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 17, Issue 10, 1 1 2006, Pages 1086-1092 Fragmented, long-duration, low-amplitude electrograms characterize the origin of focal atrial tachycardia. De Groot NM, Schalij MJ

Background: Focal atrial tachycardias (FAT) originate from areas with poor cell-to-cell coupling. Due to cellular uncoupling extracellular potentials become fractionated. The degree of fragmentation may be used to identify the site of origin of FAT prior to catheter ablation. We studied electrical fragmentation in relation to the distance to the site of earliest activity during FAT. Methods: Three-dimensional (3-D) electroanatomical activation/voltage maps obtained from patients (n = 15: 6 male,... Abstract

Cited 1 times since 2006 (0.1 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 14, Issue 10, 1 1 2006, Pages 323-324 Genetic factors in arrhythmogenic right ventricular cardiomyopathy: need for a DNA bank! van der Wall EE, Schalij MJ, van der Laarse A

Abstract

Cited 181 times since 2006 (9.4 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 48, Issue 8, 27 4 2006, Pages 1642-1648 Right ventricular pacing can induce ventricular dyssynchrony in patients with atrial fibrillation after atrioventricular node ablation. Tops LF, Schalij MJ, Holman ER, van Erven L, van der Wall EE, Bax JJ

Objectives: This study was designed to assess the effects of long-term right ventricular (RV) pacing on left ventricular (LV) dyssynchrony, LV function, and heart failure symptoms. Background: Atrioventricular (AV) node ablation and subsequent long-term RV pacing is a well-established treatment option in patients with atrial fibrillation (AF). Methods: In 55 patients with drug-refractory AF, AV node ablation and implantation of a pacemaker was performed. At baseline and after a mean of 3.8 +/- 1... Abstract

Cited 3 times since 2006 (0.2 per year) source: EuropePMC

European heart journal, Volume 27, Issue 20, 26 4 2006, Pages 2378-2379 Selecting optimal non-invasive cardiac imaging stress test in intermediate-risk patients using cost effectiveness analysis. Poldermans D, Bax JJ

Abstract

Cited 26 times since 2006 (1.4 per year) source: EuropePMC

Journal of cell science, Volume 119, Issue Pt 20, 26 4 2006, Pages 4247-4256 Changes in lamina structure are followed by spatial reorganization of heterochromatic regions in caspase-8-activated human mesenchymal stem cells. Raz V, Carlotti F, Vermolen BJ, van der Poel E, Sloos WC, Knaän-Shanzer S, de Vries AA, Hoeben RC, Young IT, Tanke HJ, Garini Y, Dirks RW

Apoptosis is fundamental to the regulation of homeostasis of stem cells in vivo. Whereas the pathways underlying the molecular and biochemical details of nuclear breakdown that accompanies apoptosis have been elucidated, the precise nature of nuclear reorganization that precedes the demolition phase is not fully understood. Here, we expressed an inducible caspase-8 in human mesenchymal stem cells, and quantitatively followed the early changes in nuclear organization during apoptosis. We found th... Abstract

Cited 125 times since 2006 (6.5 per year) source: EuropePMC

Stem cells (Dayton, Ohio), Volume 25, Issue 2, 21 3 2006, Pages 271-278 Epicardial cells of human adults can undergo an epithelial-to-mesenchymal transition and obtain characteristics of smooth muscle cells in vitro. van Tuyn J, Atsma DE, Winter EM, van der Velde-van Dijke I, Pijnappels DA, Bax NA, Knaän-Shanzer S, Gittenberger-de Groot AC, Poelmann RE, van der Laarse A, van der Wall EE, Schalij MJ, de Vries AA

Myocardial and coronary development are both critically dependent on epicardial cells. During cardiomorphogenesis, a subset of epicardial cells undergoes an epithelial-to-mesenchymal transition (EMT) and invades the myocardium to differentiate into various cell types, including coronary smooth muscle cells and perivascular and cardiac interstitial fibroblasts. Our current knowledge of epicardial EMT and the ensuing epicardium-derived cells (EPDCs) comes primarily from studies of chick and mouse... Abstract

Journal of the American College of Cardiology, Volume 48, Issue 7, 12 2 2006, Pages 1472; author reply 1472-3 Risk stratification with electrocardiographic-gated dobutamine stress imaging. Elhendy A, Schinkel AF, Bax JJ, Poldermans D

Abstract