Research

Publications

Below you can find a list of our published research.

8804 results

Cited 12 times since 2022 (3.4 per year) source: EuropePMC

The Journal of clinical endocrinology and metabolism, Volume 107, Issue 2, 1 1 2022, Pages 512-524 The Cortisol Response of Male and Female Choroidal Endothelial Cells: Implications for Central Serous Chorioretinopathy. Brinks J, van Dijk EHC, Kiełbasa SM, Mei H, van der Veen I, Peters HAB, Sips HCM, Notenboom RGE, Quax PHA, Boon CJF, Meijer OC

Context: Central serous chorioretinopathy (CSC) is a severe ocular disease characterized by fluid accumulation under the retina and abnormalities in the underlying vascular layer, the choroid. CSC has a striking prevalence in males of 80% to 90% of total patients. Corticosteroids are the most pronounced extrinsic risk factor for CSC. Choroidal endothelial cells (CECs) are important for the vascular integrity of the choroid, but the effects of corticosteroid effects in these cells are unknown. Ob... Abstract

Cited 84 times since 2022 (24.1 per year) source: EuropePMC

Proceedings of the National Academy of Sciences of the United States of America, Volume 119, Issue 1, 1 1 2022, Pages e2110877119 Coxiella burnetii inhibits host immunity by a protein phosphatase adapted from glycolysis. Zhang Y, Fu J, Liu S, Wang L, Qiu J, van Schaik EJ, Samuel JE, Song L, Luo ZQ

Coxiella burnetii is a bacterial pathogen that replicates within host cells by establishing a membrane-bound niche called the Coxiella-containing vacuole. Biogenesis of this compartment requires effectors of its Dot/Icm type IV secretion system. A large cohort of such effectors has been identified, but the function of most of them remain elusive. Here, by a cell-based functional screening, we identified the effector Cbu0513 (designated as CinF) as an inhibitor of NF-κB signaling. CinF is highly... Abstract

Tijdschrift voor psychiatrie, Volume 64, Issue 9, 1 1 2022, Pages 574-579 [Guided discontinuation of antidepressants: approach and first results of a Dutch multidisciplinary outpatient clinic]. Dozeman E, van der Lande HJ, Bet PM, Fransen K, Jager I, Jonker J, Philippo E, Reisman-Dolman J, van Schaik DJF, Scholten W, van de Velde I, Verheijen V, van der Wart M, van Zon M, Batelaan N, Vinkers CH

Background: Discontinuation of antidepressant medication can be difficult due to withdrawal symptoms and relapse risk. Scientific evidence on the questions of who, when, and how to stop antidepressants is limited. In Amsterdam a multidisciplinary outpatient clinic was started to provide advice and guidance. Aim: To substantiate the design of the clinic. Central questions relate to knowing which patients are referred, the background of their request, and their experiences with the outpatient clin... Abstract

Tijdschrift voor psychiatrie, Volume 64, Issue 2, 1 1 2022, Pages 108-111 [Plea for a work policy aiming autonomy and recovery in child and adolescent psychiatry]. van Schaik HJ, Pelzer ACM

When a child or adolescent is admitted to a High & Intensive Care (HIC) unit for adolescents, this implies that they find themselves in a severe psychiatric crisis. The work policy aiming autonomy and recovery is a vision that has been implemented in the treatment method at the HIC unit for adolescents. This policy focuses on the recovery of young people, in which learning to understand their own story and learning taking responsibility, are essential components. Sharing these experience... Abstract

Cited 11 times since 2022 (3.2 per year) source: EuropePMC

Gut microbes, Volume 14, Issue 1, 1 1 2022, Pages 2060676 Enterobacteriaceae and Bacteroidaceae provide resistance to travel-associated intestinal colonization by multi-drug resistant Escherichia coli. Davies M, Galazzo G, van Hattem JM, Arcilla MS, Melles DC, de Jong MD, Schultsz C, Wolffs P, McNally A, Schaik WV, Penders J

Previous studies have shown high acquisition risks of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) among international travelers visiting antimicrobial resistance (AMR) hotspots. Although antibiotic use and travelers' diarrhea have shown to influence the ESBL-E acquisition risk, it remains largely unknown whether successful colonization of ESBL-E during travel is associated with the composition, functional capacity and resilience of the traveler's microbiome.... Abstract

Cited 12 times since 2022 (3.4 per year) source: EuropePMC

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, Volume 23, Issue 1, 1 1 2022, Pages 54-59 Establishing Entrustable Professional Activities in Pediatric Cardiac Critical Care. Werho DK, DeWitt AG, Owens ST, McBride ME, van Schaik S, Roth SJ

Objectives: Define a set of entrustable professional activities for pediatric cardiac critical care that are recognized as the core activities of the subspecialty by a diverse group of pediatric cardiac critical care physicians and that can be broadly and consistently applied irrespective of training pathway. Design: Mixed methods study with sequential integration of qualitative and quantitative data. Setting: Structured telephone interviews of pediatric cardiac critical care medical directors a... Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

The Journal of the Acoustical Society of America, Volume 151, Issue 1, 1 1 2022, Pages 500 Noise-robust text-dependent speaker identification using cochlear models. Islam MA, Xu Y, Monk T, Afshar S, van Schaik A

One challenging issue in speaker identification (SID) is to achieve noise-robust performance. Humans can accurately identify speakers, even in noisy environments. We can leverage our knowledge of the function and anatomy of the human auditory pathway to design SID systems that achieve better noise-robust performance than conventional approaches. We propose a text-dependent SID system based on a real-time cochlear model called cascade of asymmetric resonators with fast-acting compression (CARFAC)... Abstract

Cited 2 times since 2022 (0.6 per year) source: EuropePMC

Methods in molecular biology (Clifton, N.J.), Volume 2458, 1 1 2022, Pages 215-229 Genome-Wide Mapping and Microscopy Visualization of Protein-DNA Interactions by pA-DamID. van Schaik T, Manzo SG, van Steensel B

Several methods have been developed to map protein-DNA interactions genome-wide in the last decades. Protein A-DamID (pA-DamID) is a recent addition to this list with distinct advantages. pA-DamID relies on antibody-based targeting of the bacterial Dam enzyme, resulting in adenine methylation of DNA in contact with the protein of interest. This m6A can then be visualized by microscopy, or mapped genome-wide. The main advantages of pA-DamID are an easy and direct visualization of DNA that is in c... Abstract

Cited 6 times since 2022 (1.7 per year) source: EuropePMC

European heart journal. Cardiovascular pharmacotherapy, Volume 8, Issue 1, 1 1 2022, Pages 77-84 Medication in adults after atrial switch for transposition of the great arteries: clinical practice and recommendations. Woudstra OI, Kuijpers JM, Jongbloed MRM, van Dijk APJ, Sieswerda GT, Vliegen HW, Egorova AD, Kiès P, Duijnhouwer AL, Robbers-Visser D, Konings TC, Zwinderman AH, Meijboom FJ, Mulder BJM, Bouma BJ

Aims: Heart failure is the main threat to long-term health in adults with transposition of the great arteries (TGA) corrected by an atrial switch operation (AtrSO). Current guidelines refrain from recommending heart failure medication in TGA-AtrSO, as there is insufficient data to support the hypothesis that it is beneficial. Medication is therefore prescribed based on personal judgements. We aimed to evaluate medication use in TGA-AtrSO patients and examine the association of use of renin-angio... Abstract

Cited 2 times since 2022 (0.6 per year) source: EuropePMC

BJS open, Volume 6, Issue 1, 1 1 2022, Pages zrab150 Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery. STARSurg Collaborative and EuroSurg Collaborative

Background: Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and long-term survival. No validated system for risk stratification exists for this patient group. This study aimed to validate externally a prognostic model for AKI after major gastrointestinal surgery in two multicentre cohort studies. Methods: The Outcomes After Kidney injury in Surgery (OAKS) prognostic model was developed to predict risk of AKI in the 7 day... Abstract

Cited 2 times since 2022 (0.6 per year) source: EuropePMC

Pediatrics international : official journal of the Japan Pediatric Society, Volume 64, Issue 1, 1 1 2022, Pages e14858 Early application of non-invasive ventilation for children with pulmonary edema after drowning. Şık N, Şenol HB, Çağlar A, Yılmaz D, Duman M

Background: The present study aimed to assess the efficacy of non-invasive ventilation (NIV) on the clinical course, oxygenation, need for invasive mechanical ventilation (IMV), and outcomes for children with pulmonary edema after drowning. Methods: We conducted a retrospective chart review. Children who were referred to the pediatric emergency department due to drowning-related pulmonary edema and underwent NIV between May 2014 and October 2020 were included. Demographics, vital signs, clinical... Abstract

Journal of chromatographic science, Volume 60, Issue 1, 1 1 2022, Pages 96-103 Application of Tandem Dispersive Liquid-Liquid Microextraction as an Efficient Method for Preconcentration of Two Antidepressant Drugs in Real Samples Combined with High Performance Liquid Chromatography. Arabkhani B, Goudarzi N, Bagherian G, Chamjangali MA

In the present work, tandem dispersive liquid-liquid microextraction (TDLLME) coupled with liquid chromatography was used for the determination of the two antidepressant drugs citalopram (CIT) and sertraline (SER) in complicated matrices. Indeed, the present approach was used to improve the suitability and appropriateness of the dispersive liquid-liquid microextraction (DLLME) method in complicated matrices. Firstly, 10 mL of the sample solution containing the two understudied drugs was extracte... Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

Methods in molecular biology (Clifton, N.J.), Volume 2478, 1 1 2022, Pages 677-700 Mechanics of Single Vimentin Intermediate Filaments Under Load. Schepers AV, Kraxner J, Lorenz C, Köster S

The eukaryotic cytoskeleton consists of three different types of biopolymers - microtubules, actin filaments, and intermediate filaments - and provides cells with versatile mechanical properties, combining stability and flexibility. The unique molecular structure of intermediate filaments leads to high extensibility and stability under load. With high laser power dual optical tweezers, the mechanical properties of intermediate filaments may be investigated, while monitoring the extension with fl... Abstract

Cited 4 times since 2022 (1.1 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 23, Issue 2, 1 1 2022, Pages 266-274 Associations between dyspnoea, coronary atherosclerosis, and cardiovascular outcomes: results from the long-term follow-up CONFIRM registry. van Rosendael AR, Bax AM, van den Hoogen IJ, Smit JM, Al'Aref SJ, Achenbach S, Al-Mallah MH, Andreini D, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufmann PA, Kim YJ, Leipsic JA, Maffei E, Marques H, de Araújo Gonçalves P, Pontone G, Raff GL, Rubinshtein R, Villines TC, Gransar H, Lu Y, Peña JM, Lin FY, Shaw LJ, Narula J, Min JK, Bax JJ

Aims: The relationship between dyspnoea, coronary artery disease (CAD), and major cardiovascular events (MACE) is poorly understood. This study evaluated (i) the association of dyspnoea with the severity of anatomical CAD by coronary computed tomography angiography (CCTA) and (ii) to which extent CAD explains MACE in patients with dyspnoea. Methods and results: From the international COronary CT Angiography EvaluatioN for Clinical Outcomes: An InteRnational Multicenter (CONFIRM) registry, 4425 p... Abstract

Cited 4 times since 2021 (1.1 per year) source: EuropePMC

Pediatric nephrology (Berlin, Germany), Volume 37, Issue 8, 31 5 2022, Pages 1867-1875 Impact of coronavirus disease-2019 on pediatric nephrology practice and education: an ESPN survey. Yazıcıoğlu B, Bakkaloğlu SA, European Society for Pediatric Nephrology

Background: Coronavirus disease-2019 (COVID-19) has been challenging for patients and medical staff. Radical changes have been needed to prevent disruptions in patient care and medical education. Methods: A web-based survey was sent to European Society for Pediatric Nephrology (ESPN) members via the ESPN mailing list to evaluate the effects of the COVID-19 pandemic on delivery of pediatric nephrology (PN) care and educational activities. There were ten questions with subheadings. Results: Sevent... Abstract

Cited 9 times since 2021 (2.6 per year) source: EuropePMC

Micromachines, Volume 13, Issue 1, 29 5 2022, Pages 49 Rapid Prototyping of Organ-on-a-Chip Devices Using Maskless Photolithography. Kasi DG, de Graaf MNS, Motreuil-Ragot PA, Frimat JMS, Ferrari MD, Sarro PM, Mastrangeli M, van den Maagdenberg AMJM, Mummery CL, Orlova VV

Organ-on-a-chip (OoC) and microfluidic devices are conventionally produced using microfabrication procedures that require cleanrooms, silicon wafers, and photomasks. The prototyping stage often requires multiple iterations of design steps. A simplified prototyping process could therefore offer major advantages. Here, we describe a rapid and cleanroom-free microfabrication method using maskless photolithography. The approach utilizes a commercial digital micromirror device (DMD)-based setup using... Abstract

Cited 10 times since 2021 (2.9 per year) source: EuropePMC

Annals of surgery, Volume 276, Issue 1, 28 4 2022, Pages 38-45 Pelvic Floor Rehabilitation After Rectal Cancer Surgery: A Multicenter Randomized Clinical Trial (FORCE Trial). van der Heijden JAG, Kalkdijk-Dijkstra AJ, Pierie JPEN, van Westreenen HL, Broens PMA, Klarenbeek BR, FORCE trial group

Objective: To investigate the effects of PFR after LAR compared to usual care without PFR. Summary of background data: Functional complaints, including fecal incontinence, often occur after LAR for rectal cancer. Controversy exists about the effectiveness of PFR in improving such postoperative functional outcomes. Methods: This was a multicenter, randomized controlled trial involving 17 Dutch centers. Patients after LAR for rectal cancer were randomly assigned (1:1) to usual care or PFR and stra... Abstract

Cited 2 times since 2021 (0.6 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 15, Issue 1, 23 4 2021, Pages e009886 Ultrasound-Guided Optogenetic Gene Delivery for Shock-Free Ventricular Rhythm Restoration. Nyns ECA, Jin T, Bart CI, Bax WH, Zhang G, Poelma RH, de Vries AAF, Pijnappels DA

Abstract

Cited 12 times since 2021 (3.4 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 35, Issue 5, 23 4 2021, Pages 486-494.e2 Left Atrial Deformation Imaging and Atrial Fibrillation in Patients with Rheumatic Mitral Stenosis. Stassen J, Butcher SC, Namazi F, Ajmone Marsan N, Bax JJ, Delgado V

Background: Atrial fibrillation (AF) is a frequent complication of rheumatic mitral stenosis (MS) and is associated with worse outcomes. Prediction of new-onset AF by assessing left atrial (LA) mechanics with speckle-tracking echocardiography might be useful for risk stratification and guiding therapeutic strategies. Therefore, the aim of this study was to assess the association of LA reservoir strain (LASr) and strain rate (LASRr) with AF at follow-up in patients with rheumatic MS. Methods: Lef... Abstract

Cited 47 times since 2021 (13.4 per year) source: EuropePMC

Journal of advanced research, Volume 40, 22 4 2021, Pages 1-15 The microbiota of the grapevine holobiont: A key component of plant health. Bettenfeld P, Cadena I Canals J, Jacquens L, Fernandez O, Fontaine F, van Schaik E, Courty PE, Trouvelot S

Background: Grapevine is a woody, perennial plant of high economic importance worldwide. Like other plants, it lives in close association with large numbers of microorganisms. Bacteria, fungi and viruses are structured in communities, and each individual can be beneficial, neutral or harmful to the plant. In this sense, microorganisms can interact with each other and regulate plant functions (including immunity) and even provide new ones. Thus, the grapevine associated with its microbial communi... Abstract