Research

Publications

Below you can find a list of our published research.

6131 results

Cited 32 times since 2017 (4 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 10, Issue 3, 1 1 2017, Pages e005155 Sex Differences in Phenotypes of Bicuspid Aortic Valve and Aortopathy: Insights From a Large Multicenter, International Registry. Kong WK, Regeer MV, Ng AC, McCormack L, Poh KK, Yeo TC, Shanks M, Parent S, Enache R, Popescu BA, Yip JW, Ma L, Kamperidis V, van der Velde ET, Mertens B, Ajmone Marsan N, Delgado V, Bax JJ

Background: This large multicenter, international bicuspid aortic valve (BAV) registry aimed to define the sex differences in prevalence, valve morphology, dysfunction (aortic stenosis/regurgitation), aortopathy, and complications (endocarditis and aortic dissection). Methods and results: Demographic, clinical, and echocardiographic data at first presentation of 1992 patients with BAV (71.5% men) were retrospectively analyzed. BAV morphology and valve function were assessed; aortopathy configura... Abstract

Cited 20 times since 2017 (2.5 per year) source: EuropePMC

Cardiovascular research, Volume 113, Issue 3, 1 1 2017, Pages 354-366 Optogenetic manipulation of anatomical re-entry by light-guided generation of a reversible local conduction block. Watanabe M, Feola I, Majumder R, Jangsangthong W, Teplenin AS, Ypey DL, Schalij MJ, Zeppenfeld K, de Vries AA, Pijnappels DA

Aims: Anatomical re-entry is an important mechanism of ventricular tachycardia, characterized by circular electrical propagation in a fixed pathway. It's current investigative and therapeutic approaches are non-biological, rather unspecific (drugs), traumatizing (electrical shocks), or irreversible (ablation). Optogenetics is a new biological technique that allows reversible modulation of electrical function with unmatched spatiotemporal precision using light-gated ion channels. We therefor... Abstract

Cited 17 times since 2017 (2.1 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 51, Issue 3, 1 1 2017, Pages 532-538 Incidence and predictors of vasoplegia after heart failure surgery. van Vessem ME, Palmen M, Couperus LE, Mertens B, Berendsen RR, Tops LF, Verwey HF, de Jonge E, Klautz RJ, Schalij MJ, Beeres SL

Objectives: Vasoplegia has been described as a complication after cardiac surgery, particularly in patients with a poor left ventricular ejection fraction. The aim of this study was to assess the incidence, survival and predictors of vasoplegia in patients undergoing heart failure surgery and to propose a risk model. Methods: A retrospective study including heart failure patients who underwent surgical left ventricular restoration, CorCap implantation or left ventricular assist device implantati... Abstract

Cited 37 times since 2017 (4.6 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 25, Issue 3, 1 1 2017, Pages 181-185 2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: comments from the Dutch ACS working group. Damman P, van 't Hof AW, Ten Berg JM, Jukema JW, Appelman Y, Liem AH, de Winter RJ

On behalf of the Dutch ACS working group, we discuss multiple recommendations which have been implemented in the 2015 ESC guidelines for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation. Abstract

Cited 47 times since 2017 (5.9 per year) source: EuropePMC

JAMA cardiology, Volume 2, Issue 3, 1 1 2017, Pages 285-292 Prognostic Implications of Raphe in Bicuspid Aortic Valve Anatomy. Kong WK, Delgado V, Poh KK, Regeer MV, Ng AC, McCormack L, Yeo TC, Shanks M, Parent S, Enache R, Popescu BA, Liang M, Yip JW, Ma LC, Kamperidis V, van Rosendael PJ, van der Velde ET, Ajmone Marsan N, Bax JJ

Importance: Little is known about the association between bicuspid aortic valve (BAV) morphologic findings and the degree of valvular dysfunction, presence of aortopathy, and complications, including aortic valve surgery, aortic dissection, and all-cause mortality. Objective: To investigate the association between BAV morphologic findings (raphe vs nonraphe) and the degree of valve dysfunction, presence of aortopathy, and prognosis (including need for aortic valve surgery, aortic dissection, and... Abstract

Cited 4 times since 2017 (0.5 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 25, Issue 3, 1 1 2017, Pages 170-172 The management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: early invasive strategy for all? Arslan F, Voskuil M

Abstract

Cited 7 times since 2017 (0.9 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 53, Issue 4, 28 4 2017, Pages 520-532 Adjusted Hospital Outcomes of Abdominal Aortic Aneurysm Surgery Reported in the Dutch Surgical Aneurysm Audit. Lijftogt N, Vahl AC, Wilschut ED, Elsman BHP, Amodio S, van Zwet EW, Leijdekkers VJ, Wouters MWJM, Hamming JF, Dutch Society of Vascular Surgery, the Steering Committee of the Dutch Surgical Aneurysm Audit, and the Dutch Institute for Clinical Auditing

Objective/background: The Dutch Surgical Aneurysm Audit (DSAA) is mandatory for all patients with primary abdominal aortic aneurysms (AAAs) in the Netherlands. The aims are to present the observed outcomes of AAA surgery against the predicted outcomes by means of V-POSSUM (Vascular-Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity). Adjusted mortality was calculated by the original and re-estimated V(physiology)-POSSUM for hospital comparisons. Methods: Al... Abstract

Cited 8 times since 2017 (1 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 103, Issue 6, 24 4 2017, Pages 1976-1983 Long-Term Follow-Up After the Ross Procedure: A Single Center 22-Year Experience. Schneider AW, Putter H, Klautz RJM, Bruggemans EF, Holman ER, Bökenkamp R, Hazekamp MG

Background: The aim of this study was to analyze long-term outcomes after the Ross procedure, focusing on autograft function and risk of reoperation in time. Methods: Between February 1994 and February 2016, 154 patients underwent the Ross (n = 105) and Ross-Konno (n = 49) procedure at our institution and were included in this study. Data were collected retrospectively from patients' medical records or through telephone contact. Competing risks analyses were performed to determine incidence... Abstract

Cited 19 times since 2017 (2.4 per year) source: EuropePMC

RNA biology, Volume 14, Issue 9, 23 4 2017, Pages 1089-1098 Antibodies specific for nucleic acid modifications. Feederle R, Schepers A

Nucleotide modifications constitute marks in RNA and DNA that contribute to gene regulation, development and other cellular processes. The understanding of their intricate molecular roles has been hampered by the high number of different modifications, the lack of effective methods and tools for their detection and quantification as well as by their complex structure-function relationship. The recent development of RNA and DNA immunoprecipitation followed by high-throughput sequencing (RIP- and... Abstract

Cited 9 times since 2017 (1.1 per year) source: EuropePMC

Annals of intensive care, Volume 7, Issue 1, 23 4 2017, Pages 20 Hemodynamic effects of short-term hyperoxia after coronary artery bypass grafting. Helmerhorst HJF, de Wilde RBP, Lee DH, Palmen M, Jansen JRC, van Westerloo DJ, de Jonge E

Background: Although oxygen is generally administered in a liberal manner in the perioperative setting, the effects of oxygen administration on dynamic cardiovascular parameters, filling status and cerebral perfusion have not been fully unraveled. Our aim was to study the acute hemodynamic and microcirculatory changes before, during and after arterial hyperoxia in mechanically ventilated patients after coronary artery bypass grafting (CABG) surgery. Methods: This was a single-center physiologica... Abstract

Cited 34 times since 2017 (4.2 per year) source: EuropePMC

Circulation. Cardiovascular quality and outcomes, Volume 10, Issue 2, 22 4 2017, Pages e003178 Does the Use of a Decision Aid Improve Decision Making in Prosthetic Heart Valve Selection? A Multicenter Randomized Trial. Korteland NM, Ahmed Y, Koolbergen DR, Brouwer M, de Heer F, Kluin J, Bruggemans EF, Klautz RJ, Stiggelbout AM, Bucx JJ, Roos-Hesselink JW, Polak P, Markou T, van den Broek I, Ligthart R, Bogers AJ, Takkenberg JJ

Background: A Dutch online patient decision aid to support prosthetic heart valve selection was recently developed. A multicenter randomized controlled trial was conducted to assess whether use of the patient decision aid results in optimization of shared decision making in prosthetic heart valve selection. Methods and results: In a 5-center randomized controlled trial, patients were allocated to receive either standard preoperative care (control group) or additional access to the patient decisi... Abstract

Cardiovascular revascularization medicine : including molecular interventions, Volume 18, Issue 6 Suppl 1, 20 3 2017, Pages 48-51 Microcatheters: A valuable tool in the presence of a challenging coronary anatomy in the setting of acute coronary interventions. Case report and mini review. Karalis I, Andreou C, Montero Cabezas JM, Schalij MJ

Popularity of microcatheters (MCs) is growing among interventional cardiologists, especially when complex coronary anatomy is involved. However, MCs are still considered by many as a niche tool and their value in common clinical practice and in the setting of acute coronary interventions has not been fully appreciated. This case report highlights the decisive role of MC use in the successful completion of a primary percutaneous coronary intervention. Characteristics and indications of the most c... Abstract

Cited 11 times since 2017 (1.4 per year) source: EuropePMC

Archives of cardiovascular diseases, Volume 110, Issue 5, 17 3 2017, Pages 354-362 Ventricular arrhythmias and sudden death in tetralogy of Fallot. Maury P, Sacher F, Rollin A, Mondoly P, Duparc A, Zeppenfeld K, Hascoet S, Réseau francophone de rythmologie pédiatrique et congénitale

Malignant ventricular arrhythmias and sudden cardiac death may late happen in repaired tetralogy of Fallot, although probably less frequently than previously thought, especially with the advent of new surgical techniques/management. Ventricular tachycardias are caused by reentry around the surgical scars/patches and valves. Many predictive factors have been proposed, which suffer from poor accuracy. There is currently no recommended indication for prophylactic implantable cardioverter defibrilla... Abstract

Cited 9 times since 2017 (1.1 per year) source: EuropePMC

The American journal of cardiology, Volume 119, Issue 9, 9 2 2017, Pages 1456-1462 Relation of Myocardial Contrast-Enhanced T<sub>1</sub> Mapping by Cardiac Magnetic Resonance to Left Ventricular Reverse Remodeling After Cardiac Resynchronization Therapy in Patients With Nonischemic Cardiomyopathy. Höke U, Khidir MJ, van der Geest RJ, Schalij MJ, Bax JJ, Delgado V, Ajmone Marsan N

Myocardial scar is known to be associated with limited left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT). However, the impact of diffuse myocardial interstitial fibrosis, as assessed with myocardial T1 mapping cardiac magnetic resonance (CMR), has not been studied in patients with CRT. Therefore, we aimed at evaluating the association between diffuse myocardial interstitial fibrosis, in nonischemic cardiomyopathy patients, and LV reverse remodeling after CRT.... Abstract

Cited 11 times since 2017 (1.4 per year) source: EuropePMC

European journal of heart failure, Volume 19, Issue 9, 8 2 2017, Pages 1145-1151 Impact of QRS complex duration and morphology on left ventricular reverse remodelling and left ventricular function improvement after cardiac resynchronization therapy. van der Bijl P, Khidir M, Leung M, Mertens B, Ajmone Marsan N, Delgado V, Bax JJ

Aims: To evaluate the impact of the interaction of QRS duration and morphology on left ventricular (LV) reverse remodelling and LV functional improvement in heart failure (HF) patients treated with cardiac resynchronization therapy (CRT). Methods and results: From an ongoing registry of HF patients treated with CRT according to contemporary guidelines, demographic, clinical, electrocardiographic (ECG) and echocardiographic characteristics were analysed. Patients were divided according to QRS dur... Abstract

Cited 23 times since 2017 (2.8 per year) source: EuropePMC

BMC endocrine disorders, Volume 17, Issue 1, 3 1 2017, Pages 6 Study protocol; Thyroid hormone Replacement for Untreated older adults with Subclinical hypothyroidism - a randomised placebo controlled Trial (TRUST). Stott DJ, Gussekloo J, Kearney PM, Rodondi N, Westendorp RG, Mooijaart S, Kean S, Quinn TJ, Sattar N, Hendry K, Du Puy R, Den Elzen WP, Poortvliet RK, Smit JW, Jukema JW, Dekkers OM, Blum M, Collet TH, McCarthy V, Hurley C, Byrne S, Browne J, Watt T, Bauer D, Ford I

Background: Subclinical hypothyroidism (SCH) is a common condition in elderly people, defined as elevated serum thyroid-stimulating hormone (TSH) with normal circulating free thyroxine (fT4). Evidence is lacking about the effect of thyroid hormone treatment. We describe the protocol of a large randomised controlled trial (RCT) of Levothyroxine treatment for SCH. Methods: Participants are community-dwelling subjects aged ≥65 years with SCH, diagnosed by elevated TSH levels (≥4.6 and ≤19.9 mU/L) o... Abstract

Cited 30 times since 2017 (3.7 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 69, Issue 5, 1 1 2017, Pages 497-507 Isolated Subepicardial Right Ventricular Outflow Tract Scar in Athletes With Ventricular Tachycardia. Venlet J, Piers SR, Jongbloed JD, Androulakis AF, Naruse Y, den Uijl DW, Kapel GF, de Riva M, van Tintelen JP, Barge-Schaapveld DQ, Schalij MJ, Zeppenfeld K

Background: High-level endurance training has been associated with right ventricular pathological remodeling and ventricular tachycardia (VT). Although overlap with arrhythmogenic right ventricular cardiomyopathy (ARVC) has been suggested, the arrhythmogenic substrate for VTs in athletes is unknown. Objectives: The goal of this study was to evaluate whether electroanatomic scar patterns related to sustained VT can distinguish exercise-induced arrhythmogenic remodeling from ARVC and post-inflamma... Abstract

Cited 15 times since 2017 (1.9 per year) source: EuropePMC

JACC. Cardiovascular interventions, Volume 10, Issue 4, 1 1 2017, Pages 388-390 Bioprosthetic Heart Valves, Thrombosis, Anticoagulation, and Imaging Surveillance. Bax JJ, Delgado V

Abstract

Cited 24 times since 2017 (3 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 10, Issue 2, 1 1 2017, Pages e004614 Association Between Posterior Left Atrial Adipose Tissue Mass and Atrial Fibrillation. van Rosendael AR, Dimitriu-Leen AC, van Rosendael PJ, Leung M, Smit JM, Saraste A, Knuuti J, van der Geest RJ, van der Arend BW, van Zwet EW, Scholte AJ, Delgado V, Bax JJ

Background: Epicardial adipose tissue located close to the atrial wall can change the electric conduction of the left atrium, potentially leading to atrial fibrillation (AF). The aim of this study was to assess whether an increased atrial adipose tissue mass posterior to the left atrium is related to AF independent of demographical and cardiovascular risk factors. Methods and results: Two hundred patients with AF and 200 patients without AF who underwent computed tomographic angiography were inc... Abstract

Cited 2 times since 2017 (0.2 per year) source: EuropePMC

European heart journal, Volume 38, Issue 6, 1 1 2017, Pages 390-399 The year in cardiology 2016: imaging. Delgado V, Gaemperli O, Lombardi M, Kaufmann PA, Bax JJ

Abstract