6883 results
Cited 1470 times since 2015 (154.6 per year)
source: EuropePMC
Nature genetics,
Volume 47, Issue 10, 7 1 2015, Pages 1121-1130
A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.
Nikpay M, Goel A, Won HH, Hall LM, Willenborg C, Kanoni S, Saleheen D, Kyriakou T, Nelson CP, Hopewell JC, Webb TR, Zeng L, Dehghan A, Alver M, Armasu SM, Auro K, Bjonnes A, Chasman DI, Chen S, Ford I, Franceschini N, Gieger C, Grace C, Gustafsson S, Huang J, Hwang SJ, Kim YK, Kleber ME, Lau KW, Lu X, Lu Y, Lyytikäinen LP, Mihailov E, Morrison AC, Pervjakova N, Qu L, Rose LM, Salfati E, Saxena R, Scholz M, Smith AV, Tikkanen E, Uitterlinden A, Yang X, Zhang W, Zhao W, de Andrade M, de Vries PS, van Zuydam NR, Anand SS, Bertram L, Beutner F, Dedoussis G, Frossard P, Gauguier D, Goodall AH, Gottesman O, Haber M, Han BG, Huang J, Jalilzadeh S, Kessler T, König IR, Lannfelt L, Lieb W, Lind L, Lindgren CM, Lokki ML, Magnusson PK, Mallick NH, Mehra N, Meitinger T, Memon FU, Morris AP, Nieminen MS, Pedersen NL, Peters A, Rallidis LS, Rasheed A, Samuel M, Shah SH, Sinisalo J, Stirrups KE, Trompet S, Wang L, Zaman KS, Ardissino D, Boerwinkle E, Borecki IB, Bottinger EP, Buring JE, Chambers JC, Collins R, Cupples LA, D
Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of ∼185,000 CAD cases and controls, interrogating 6.7 million common (minor allele frequency (MAF) > 0.05) and 2.7 million low-frequency (0.005 < MAF < 0.05) variants. In addition to confirming most known CAD-associated loci, we id...
Abstract
Cited 58 times since 2015 (6.1 per year)
source: EuropePMC
American journal of physiology. Heart and circulatory physiology,
Volume 309, Issue 9, 4 1 2015, Pages H1407-18
A porcine model of hypertensive cardiomyopathy: implications for heart failure with preserved ejection fraction.
Schwarzl M, Hamdani N, Seiler S, Alogna A, Manninger M, Reilly S, Zirngast B, Kirsch A, Steendijk P, Verderber J, Zweiker D, Eller P, Höfler G, Schauer S, Eller K, Maechler H, Pieske BM, Linke WA, Casadei B, Post H
Heart failure with preserved ejection fraction (HFPEF) evolves with the accumulation of risk factors. Relevant animal models to identify potential therapeutic targets and to test novel therapies for HFPEF are missing. We induced hypertension and hyperlipidemia in landrace pigs (n = 8) by deoxycorticosteroneacetate (DOCA, 100 mg/kg, 90-day-release subcutaneous depot) and a Western diet (WD) containing high amounts of salt, fat, cholesterol, and sugar for 12 wk. Compared with weight-matched contro...
Abstract
Cited 19 times since 2015 (2 per year)
source: EuropePMC
Journal of lipid research,
Volume 56, Issue 11, 4 1 2015, Pages 2085-2093
Anacetrapib reduces (V)LDL cholesterol by inhibition of CETP activity and reduction of plasma PCSK9.
van der Tuin SJ, Kühnast S, Berbée JF, Verschuren L, Pieterman EJ, Havekes LM, van der Hoorn JW, Rensen PC, Jukema JW, Princen HM, Willems van Dijk K, Wang Y
Recently, we showed in APOE*3-Leiden cholesteryl ester transfer protein (E3L.CETP) mice that anacetrapib attenuated atherosclerosis development by reducing (V)LDL cholesterol [(V)LDL-C] rather than by raising HDL cholesterol. Here, we investigated the mechanism by which anacetrapib reduces (V)LDL-C and whether this effect was dependent on the inhibition of CETP. E3L.CETP mice were fed a Western-type diet alone or supplemented with anacetrapib (30 mg/kg body weight per day). Microarray analyses o...
Abstract
Cited 14 times since 2015 (1.5 per year)
source: EuropePMC
PloS one,
Volume 10, Issue 9, 2 1 2015, Pages e0137035
Circulating MicroRNAs Characterizing Patients with Insufficient Coronary Collateral Artery Function.
Hakimzadeh N, Nossent AY, van der Laan AM, Schirmer SH, de Ronde MW, Pinto-Sietsma SJ, van Royen N, Quax PH, Hoefer IE, Piek JJ
Background: Coronary collateral arteries function as natural bypasses in the event of coronary obstruction. The degree of collateral network development significantly impacts the outcome of patients after an acute myocardial infarction (AMI). MicroRNAs (miRNAs, miRs) have arisen as biomarkers to identify heterogeneous patients, as well as new therapeutic targets in cardiovascular disease. We sought to identify miRNAs that are differentially expressed in chronic total occlusion (CTO) patients wit...
Abstract
Cited 6 times since 2015 (0.6 per year)
source: EuropePMC
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis,
Volume 26, Issue 6, 1 1 2015, Pages 613-620
Fibrinogen reduction and coagulation in cardiac surgery: an investigational study.
Gielen CL, Grimbergen J, Klautz RJ, Koopman J, Quax PH
Fibrinogen as precursor of fibrin plays an essential role in clot formation. There are three main mechanisms associated with a reduction in fibrinogen concentration during cardiac surgery: hemodilution, consumption, and degradation. Moreover, early fibrinogen degradation products (FgDPs) can interfere with normal fibrin formation of intact fibrinogen. The aim of this study was to determine the relative contributions of hemodilution, consumption, and degradation to fibrinogen loss in cardiac surg...
Abstract
Cited 8 times since 2015 (0.8 per year)
source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology,
Volume 11 Suppl W, 1 1 2015, Pages W123-7
The tricuspid valve and the right heart: anatomical, pathological and imaging specifications.
van Rosendael PJ, Delgado V, Bax JJ
Transcatheter tricuspid valve repair/replacement is an emerging therapy for patients with symptomatic severe tricuspid regurgitation who are deemed inoperable. Accurate knowledge of the anatomy of the tricuspid valve and right ventricle is key to developing transcatheter techniques. In addition, it is important to understand the mechanistic concept of transcatheter tricuspid valve repair/replacement in order to select the patients who may benefit from it. The severity and mechanism of tricuspid...
Abstract
Circulation. Cardiovascular imaging,
Volume 8, Issue 9, 1 1 2015, Pages e003985
Cardiac Simulation to Personalize Cardiac Resynchronization Therapy.
Delgado V, Bax JJ
Abstract
European heart journal. Cardiovascular Imaging,
Volume 16, Issue 9, 1 1 2015, Pages 959-965
Highlights of the 12th International Conference on Nuclear Cardiology and Cardiac CT.
Kitsiou A, Dorbala S, Scholte AJ
The 12th International Conference on Nuclear Cardiology and Cardiac CT was held from 3 to 5 May 2015 in Madrid, Spain. In this article, the three Congress Program Committee Chairs summarize selected highlights of the presented abstracts.
Abstract
Cited 1119 times since 2015 (117.5 per year)
source: EuropePMC
The New England journal of medicine,
Volume 373, Issue 10, 1 1 2015, Pages 929-938
Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy.
Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M, Cammann VL, Sarcon A, Geyer V, Neumann CA, Seifert B, Hellermann J, Schwyzer M, Eisenhardt K, Jenewein J, Franke J, Katus HA, Burgdorf C, Schunkert H, Moeller C, Thiele H, Bauersachs J, Tschöpe C, Schultheiss HP, Laney CA, Rajan L, Michels G, Pfister R, Ukena C, Böhm M, Erbel R, Cuneo A, Kuck KH, Jacobshagen C, Hasenfuss G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Cuculi F, Banning A, Fischer TA, Vasankari T, Airaksinen KE, Fijalkowski M, Rynkiewicz A, Pawlak M, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Franz WM, Empen K, Felix SB, Delmas C, Lairez O, Erne P, Bax JJ, Ford I, Ruschitzka F, Prasad A, Lüscher TF
Background: The natural history, management, and outcome of takotsubo (stress) cardiomyopathy are incompletely understood. Methods: The International Takotsubo Registry, a consortium of 26 centers in Europe and the United States, was established to investigate clinical features, prognostic predictors, and outcome of takotsubo cardiomyopathy. Patients were compared with age- and sex-matched patients who had an acute coronary syndrome. Results: Of 1750 patients with takotsubo cardiomyopathy, 89.8%...
Abstract
Cited 4 times since 2015 (0.4 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 23, Issue 10, 1 1 2015, Pages 457-465
The year of transparency: measuring quality of cardiac care.
Eindhoven DC, Wierda E, de Bruijne MC, Amoroso G, de Mol BAJM, Umans VAWM, Schalij MJ, Borleffs CJW
The assessment of quality of care is becoming increasingly important in healthcare, both globally and in the Netherlands. The Dutch Minister of Health declared 2015 to be the year of transparency, thereby aiming to improve quality of care by transparent reporting of outcome data. With the increasing importance of transparency, knowledge on quality measurement will be essential for a cardiologist in daily clinical care. To that end, this paper provides a comprehensive overview of the Dutch health...
Abstract
Cited 40 times since 2015 (4.2 per year)
source: EuropePMC
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne,
Volume 187, Issue 15, 31 5 2015, Pages E442-E449
Resting heart rate, heart rate variability and functional decline in old age.
Ogliari G, Mahinrad S, Stott DJ, Jukema JW, Mooijaart SP, Macfarlane PW, Clark EN, Kearney PM, Westendorp RGJ, de Craen AJM, Sabayan B
Background: Heart rate and heart rate variability, markers of cardiac autonomic function, have been linked with cardiovascular disease. We investigated whether heart rate and heart rate variability are associated with functional status in older adults, independent of cardiovascular disease. Methods: We obtained data from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). A total of 5042 participants were included in the present study, and mean follow-up was 3.2 years. Heart r...
Abstract
Cited 2 times since 2015 (0.2 per year)
source: EuropePMC
International journal of surgery case reports,
Volume 15, 30 5 2015, Pages 133-136
Case report of nail bed injury after blunt trauma; what lies beneath the nail?
Nanninga GL, de Leur K, van den Boom AL, de Vries MR, van Ginhoven TM
Introduction: A stable, mobile and sensate fingertip is of paramount importance to perform daily tasks and sense dangerous situations. Unfortunately, fingertips are easily injured with various extents of soft tissue damage. Delayed and inadequate treatment of nail bed injuries may cause substantial clinical problems. The aim is to increase awareness about nail bed injuries among physicians who often treat these patients. Presentation of case: We present a 26-year-old male with blunt trauma to a...
Abstract
Cited 30 times since 2015 (3.1 per year)
source: EuropePMC
European heart journal,
Volume 37, Issue 1, 30 5 2015, Pages 49-59
Association of persistent or worsened echocardiographic dyssynchrony with unfavourable clinical outcomes in heart failure patients with narrow QRS width: a subgroup analysis of the EchoCRT trial.
Gorcsan J, Sogaard P, Bax JJ, Singh JP, Abraham WT, Borer JS, Dickstein K, Gras D, Krum H, Brugada J, Robertson M, Ford I, Holzmeister J, Ruschitzka F
Aims: EchoCRT was a randomized trial of cardiac resynchronization therapy (CRT) in severely symptomatic heart failure (HF) patients with narrow QRS width
Abstract
Cited 7 times since 2015 (0.7 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 31, Issue 8, 29 5 2015, Pages 1583-1590
Effect of statins on aortic root growth rate in patients with bicuspid aortic valve anatomy.
Regeer MV, van Rosendael PJ, Kamperidis V, Schalij MJ, Bax JJ, Marsan NA, Delgado V
Bicuspid aortic valve (BAV) anatomy is associated with increased growth rate of the aortic root compared to tricuspid aortic valves. Statins decrease the growth rate of abdominal aneurysms; however their effect on the aortic root growth rate has not been elucidated. The present study evaluated the association between use of statins and aortic root growth in patients with BAV. A total of 199 patients (43 ± 15 years, 69% male) with BAV who underwent ≥ 2 echocardiographic measurements of the aortic...
Abstract
Cited 1728 times since 2015 (181.2 per year)
source: EuropePMC
European heart journal,
Volume 37, Issue 3, 29 5 2015, Pages 267-315
2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC).
Roffi M, Patrono C, Collet JP, Mueller C, Valgimigli M, Andreotti F, Bax JJ, Borger MA, Brotons C, Chew DP, Gencer B, Hasenfuss G, Kjeldsen K, Lancellotti P, Landmesser U, Mehilli J, Mukherjee D, Storey RF, Windecker S, ESC Scientific Document Group
Abstract
Cited 19 times since 2015 (2 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 28, Issue 12, 22 4 2015, Pages 1379-89.e1
Quantitative Dobutamine Stress Echocardiography Using Speckle-Tracking Analysis versus Conventional Visual Analysis for Detection of Significant Coronary Artery Disease after ST-Segment Elevation Myocardial Infarction.
Joyce E, Hoogslag GE, Al Amri I, Debonnaire P, Katsanos S, Bax JJ, Delgado V, Marsan NA
Background: Residual ischemia detection after ST-segment elevation myocardial infarction (STEMI) during dobutamine stress echocardiography (DSE) using visual analysis is challenging. The aim of the present study was to investigate the feasibility and accuracy of two-dimensional speckle-tracking strain DSE to detect significant coronary artery disease (CAD) after STEMI. Methods: First STEMI patients (n = 105; mean age, 60 ± 11 years; 86% men) treated with primary percutaneous coronary interventio...
Abstract
Cited 157 times since 2015 (16.4 per year)
source: EuropePMC
European journal of nuclear medicine and molecular imaging,
Volume 42, Issue 12, 21 3 2015, Pages 1929-1940
EANM procedural guidelines for radionuclide myocardial perfusion imaging with SPECT and SPECT/CT: 2015 revision.
Verberne HJ, Acampa W, Anagnostopoulos C, Ballinger J, Bengel F, De Bondt P, Buechel RR, Cuocolo A, van Eck-Smit BL, Flotats A, Hacker M, Hindorf C, Kaufmann PA, Lindner O, Ljungberg M, Lonsdale M, Manrique A, Minarik D, Scholte AJ, Slart RH, Trägårdh E, de Wit TC, Hesse B, European Association of Nuclear Medicine (EANM)
Since the publication of the European Association of Nuclear Medicine (EANM) procedural guidelines for radionuclide myocardial perfusion imaging (MPI) in 2005, many small and some larger steps of progress have been made, improving MPI procedures. In this paper, the major changes from the updated 2015 procedural guidelines are highlighted, focusing on the important changes related to new instrumentation with improved image information and the possibility to reduce radiation exposure, which is fur...
Abstract
Cited 2 times since 2015 (0.2 per year)
source: EuropePMC
European biophysics journal : EBJ,
Volume 44, Issue 7, 19 3 2015, Pages 557-565
Study of light-induced MscL gating by EPR spectroscopy.
Yilmaz D, Dimitrova AI, Walko M, Kocer A
A number of techniques developed to investigate protein structure and function depend on chemically modifying and/or labeling of proteins. However, in the case of homooligomeric proteins, the presence of multiple identical subunits obstructs the introduction of residue-specific labels to only one or several subunits, selectively. Here, in order to study the initial conformational changes of a homopentameric mechanosensitive ion channel during its gating, we developed a method for labeling a defi...
Abstract
Cited 9 times since 2015 (0.9 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 16, Issue 10, 19 3 2015, Pages 1062-1064
Detection of viable myocardium and scar tissue.
Bax JJ, Delgado V
Abstract
Cited 1 times since 2015 (0.1 per year)
source: EuropePMC
Psychiatry research,
Volume 229, Issue 3, 15 3 2015, Pages 678-684
Viral metagenomics in drug-naïve, first-onset schizophrenia patients with prominent negative symptoms.
Canuti M, van Beveren NJ, Jazaeri Farsani SM, de Vries M, Deijs M, Jebbink MF, Zaaijer HL, van Schaik BD, van Kampen AH, van der Kuyl AC, de Haan L, Storosum JG, van der Hoek L
Although several studies suggest a virus or (endogenous) retrovirus involvement at the time of onset of schizophrenia, the unequivocal identification of one or more infectious agents, by means of an undirected catch-all technique, has never been conducted. In this study VIDISCA, a virus discovery method, was used in combination with Roche-454 high-throughput sequencing as a tool to determine the possible presence of viruses (known or unknown) in blood of first-onset drugs-naïve schizophrenic pat...
Abstract
