Research

Publications

Below you can find a list of our published research.

8800 results

European heart journal. Cardiovascular Imaging, Volume 14, Issue 5, 5 1 2012, Pages 507 Rapid aortic aneurysm formation in Marfan patient with dissection of the entire aorta. Scholte AJ, Hilhorst-Hofstee Y, Versteegh MI, Kroft LJ

Abstract

Cited 16 times since 2012 (1.3 per year) source: EuropePMC

Diabetes care, Volume 36, Issue 4, 5 1 2012, Pages 985-991 Influence of diabetes on left ventricular systolic and diastolic function and on long-term outcome after cardiac resynchronization therapy. Höke U, Thijssen J, van Bommel RJ, van Erven L, van der Velde ET, Holman ER, Schalij MJ, Bax JJ, Delgado V, Marsan NA

Objective: The influence of diabetes on cardiac resynchronization therapy (CRT) remains unclear. The aims of the current study were to 1) assess the changes in left ventricular (LV) systolic and diastolic function and 2) evaluate long-term prognosis in CRT recipients with diabetes. Research design and methods: A total of 710 CRT recipients (171 with diabetes) were included from an ongoing registry. Echocardiographic evaluation, including LV systolic and diastolic function assessment, was perform... Abstract

Cited 18 times since 2012 (1.4 per year) source: EuropePMC

Anatomical record (Hoboken, N.J. : 2007), Volume 296, Issue 2, 4 1 2012, Pages 192-197 Steep increase in myonuclear domain size during infancy. Delhaas T, Van der Meer SF, Schaart G, Degens H, Drost MR

We investigated whether myonuclear number increases in proportion to the increase in fiber size during maturational growth of skeletal muscle. Thoraco-abdominal muscle tissue was obtained from twenty 6-day to 15-year-old boys and girls during cardiothoracic surgery. Cross-sections were stained by anti-laminin for the basal lamina and by DAPI to identify nuclei. Basal lamina was traced on digital images to measure the fiber cross-sectional area (FCSA). Nuclei located within the basal lamina were... Abstract

Cited 30 times since 2012 (2.4 per year) source: EuropePMC

Injury, Volume 44, Issue 4, 3 1 2012, Pages 498-503 Re-displacement of stable distal both-bone forearm fractures in children: a randomised controlled multicentre trial. Colaris JW, Allema JH, Biter LU, de Vries MR, van de Ven CP, Bloem RM, Kerver AJ, Reijman M, Verhaar JA

Introduction: Displaced metaphyseal both-bone fractures of the distal forearm are generally reduced and stabilised by an above-elbow cast (AEC) with or without additional pinning. The purpose of this study was to find out if re-displacement of a reduced stable metaphyseal both-bone fracture of the distal forearm in a child could be prevented by stabilisation with Kirschner wires. Methods: Consecutive children aged Abstract

Cited 62 times since 2012 (4.9 per year) source: EuropePMC

Nature structural & molecular biology, Volume 20, Issue 1, 2 1 2012, Pages 73-81 Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay. Hoefig KP, Rath N, Heinz GA, Wolf C, Dameris J, Schepers A, Kremmer E, Ansel KM, Heissmeyer V

The exoRNase Eri1 inhibits RNA interference and trims the 5.8S rRNA 3' end. It also binds to the stem-loop of histone mRNAs, but the functional importance of this interaction remains elusive. Histone mRNAs are normally degraded at the end of S phase or after pharmacological inhibition of replication. Both processes are impaired in Eri1-deficient mouse cells, which instead accumulate oligouridylated histone mRNAs. Eri1 trims the mature histone mRNAs by two unpaired nucleotides at the 3'... Abstract

Cited 2 times since 2012 (0.2 per year) source: EuropePMC

Behavior research methods, Volume 44, Issue 4, 1 1 2012, Pages 1129-1134 Modeling judgment of sequentially presented categories using weighting and sampling without replacement. Kusev P, Tsaneva-Atanasova K, van Schaik P, Chater N

In a series of experiments, Kusev et al. (Journal of Experimental Psychology: Human Perception and Performance 37:1874-1886, 2011) studied relative-frequency judgments of items drawn from two distinct categories. The experiments showed that the judged frequencies of categories of sequentially encountered stimuli are affected by the properties of the experienced sequences. Specifically, a first-run effect was observed, whereby people overestimated the frequency of a given category when that categ... Abstract

Cited 15 times since 2012 (1.2 per year) source: EuropePMC

Molecular diagnosis & therapy, Volume 16, Issue 6, 1 1 2012, Pages 331-345 Pharmacogenetics in kidney transplantation: recent updates and potential clinical applications. Elens L, Hesselink DA, van Schaik RH, van Gelder T

Every month, new releases on the relationship between pharmacogenetic biomarkers and immunosuppressive drug therapy in kidney transplantation are published. However, the systematic clinical application of these discoveries occurs at a very slow pace, and the usefulness of knowing a patient's genotype remains an important matter of debate. This can be partially ascribed to the lack of consistency when looking at the different associations reported across several studies but also the need for... Abstract

Cited 8 times since 2012 (0.6 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 94, Issue 6, 1 1 2012, Pages 2122-2125 Implantation of a left ventricular assist device in patients with a complex apical anatomy. Palmen M, Verwey HF, Haeck ML, Holman ER, Schalij MJ, Klautz RJ

Implantation of a left ventricular assist device can be challenging in patients with an altered apical anatomy after cardiac surgery or as the result of the presence of a calcified apical aneurysm. In this paper we present 2 cases with a challenging apical anatomy and introduce a new surgical technique facilitating left ventricular assist device implantation in these patients. Abstract

Cited 16 times since 2012 (1.3 per year) source: EuropePMC

Expert review of cardiovascular therapy, Volume 10, Issue 12, 1 1 2012, Pages 1517-1531 Surgical versus percutaneous treatment of aortic coarctation: new standards in an era of transcatheter repair. Luijendijk P, Bouma BJ, Groenink M, Boekholdt M, Hazekamp MG, Blom NA, Koolbergen DR, de Winter RJ, Mulder BJ

Aortic coarctation is a common congenital cardiovascular defect, which can be diagnosed over a wide range of ages and with varying degrees of severity. Surgery has proven to be an effective treatment for the management of native aortic coarctation, and remains the treatment of choice in neonates. Balloon angioplasty with or without stenting has evolved rapidly over the past decade. Balloon angioplasty is the treatment of choice in children with re-coarctation, and currently available immediate r... Abstract

Cited 3 times since 2012 (0.2 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 20, Issue 12, 1 1 2012, Pages 509-512 Two cases of aorto-right atrial tunnel: clinical presentation, imaging and percutaneous closure. de Winter RJ, Blom NA, Straver B, Bouma BJ, Backx AP, Clur SA, Kuipers IM, Hoekstra F, Boekholdt SM, Groenink M, Koolbergen DR, Hazekamp MG, Mulder BJ

Communication between the aortic sinus and a cardiac chamber is a rare anomaly that can be diagnosed in children and young adults. We describe two cases with a tunnel between the aortic sinus and right atrium, discuss diagnostic modalities, and review the literature on this anomaly. Abstract

Cited 3 times since 2012 (0.2 per year) source: EuropePMC

Stem cells (Dayton, Ohio), Volume 30, Issue 12, 1 1 2012, Pages 2830-2834 Brief report: Misinterpretation of coculture differentiation experiments by unintended labeling of cardiomyocytes through secondary transduction: delusions and solutions. Ramkisoensing AA, De Vries AA, Schalij MJ, Atsma DE, Pijnappels DA

Cardiomyogenic differentiation of stem cells can be accomplished by coculture with cardiomyocytes (CMCs). To facilitate their identification, stem cells are often labeled through viral transduction with a fluorescent protein. A second marker to distinguish stem cell-derived CMCs from native CMCs is rarely used. This study aimed to investigate the occurrence of secondary transduction of unlabeled neonatal rat (nr) CMCs after coculture with human cells that had been transduced 0, 7, or 14 days ear... Abstract

Cited 37 times since 2012 (2.9 per year) source: EuropePMC

The Journal of urology, Volume 189, Issue 5, 30 5 2012, Pages 1702-1706 Prospective multicenter evaluation of the Beckman Coulter Prostate Health Index using WHO calibration. Loeb S, Sokoll LJ, Broyles DL, Bangma CH, van Schaik RH, Klee GG, Wei JT, Sanda MG, Partin AW, Slawin KM, Marks LS, Mizrahi IA, Shin SS, Cruz AB, Chan DW, Roberts WL, Catalona WJ

Purpose: Reported prostate specific antigen values may differ substantially among assays using Hybritech® or WHO standardization. The Beckman Coulter® Prostate Health Index and [-2]proPSA are newly approved serum markers associated with prostate cancer risk and aggressiveness. We studied the influence of assay standardization on these markers. Materials and methods: Prostate specific antigen, percent free prostate specific antigen and [-2]proPSA were measured using Hybritech calibration in 892 m... Abstract

Cited 17 times since 2012 (1.4 per year) source: EuropePMC

PloS one, Volume 7, Issue 11, 26 4 2012, Pages e49706 Pharmacological activation of the bile acid nuclear farnesoid X receptor is feasible in patients with quiescent Crohn's colitis. van Schaik FD, Gadaleta RM, Schaap FG, van Mil SW, Siersema PD, Oldenburg B, van Erpecum KJ

Background: The bile acid-activated nuclear receptor Farnesoid X Receptor (FXR) is critical in maintaining intestinal barrier integrity and preventing bacterial overgrowth. Patients with Crohn's colitis (CC) exhibit reduced ileal FXR target gene expression. FXR agonists have been shown to ameliorate inflammation in murine colitis models. We here explore the feasibility of pharmacological FXR activation in CC. Methods: Nine patients with quiescent CC and 12 disease controls were treated with... Abstract

Cited 85 times since 2012 (6.8 per year) source: EuropePMC

Radiation oncology (London, England), Volume 7, 24 4 2012, Pages 198 Management of radiation oncology patients with a pacemaker or ICD: a new comprehensive practical guideline in The Netherlands. Dutch Society of Radiotherapy and Oncology (NVRO). Hurkmans CW, Knegjens JL, Oei BS, Maas AJ, Uiterwaal GJ, van der Borden AJ, Ploegmakers MM, van Erven L, Dutch Society of Radiotherapy and Oncology (NVRO)

Current clinical guidelines for the management of radiotherapy patients having either a pacemaker or implantable cardioverter defibrillator (both CIEDs: Cardiac Implantable Electronic Devices) do not cover modern radiotherapy techniques and do not take the patient's perspective into account. Available data on the frequency and cause of CIED failure during radiation therapy are limited and do not converge. The Dutch Society of Radiotherapy and Oncology (NVRO) initiated a multidisciplinary ta... Abstract

Cited 8 times since 2012 (0.6 per year) source: EuropePMC

Cytokine, Volume 61, Issue 2, 24 4 2012, Pages 438-444 A comparative study of the immune modulating properties of antifibrinolytics in cardiac surgery. Later AF, Bruggemans EF, Romijn FP, van Pelt J, Klautz RJ

Purpose: Antifibrinolytics, used in cardiac surgery to abate postoperative blood loss, share anti-inflammatory properties by suppression of pro-inflammatory D-dimer and plasmin levels. Additional drug specific immune modulating qualities are often mentioned in the discussion on which antifibrinolytic can best be used. To determine the extent and relevance of these effects, we investigated cytokine and growth factor plasma levels in cardiac surgery patients randomized to receive either tranexamic... Abstract

Cited 24 times since 2012 (1.9 per year) source: EuropePMC

The American journal of cardiology, Volume 111, Issue 3, 20 3 2012, Pages 382-387 Pregnancy outcomes in women with aortic valve substitutes. Heuvelman HJ, Arabkhani B, Cornette JM, Pieper PG, Bogers AJ, Takkenberg JJ, Roos-Hesselink JW

Young women who require aortic valve replacement need information on the potential cardiac and obstetric complications of pregnancy for the different valve substitutes available. We, therefore, assessed the pregnancy outcomes in women who had received an autograft, homograft, or mechanical valve in the aortic position. Women who were pregnant after surviving aortic valve replacement at our institution from 1987 to 2011 were included. Information on cardiac status and pregnancy outcome was obtain... Abstract

Cited 633 times since 2012 (50.3 per year) source: EuropePMC

mBio, Volume 3, Issue 6, 20 3 2012, Pages e00473-12 Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans. van Boheemen S, de Graaf M, Lauber C, Bestebroer TM, Raj VS, Zaki AM, Osterhaus AD, Haagmans BL, Gorbalenya AE, Snijder EJ, Fouchier RA

Unlabelled: A novel human coronavirus (HCoV-EMC/2012) was isolated from a man with acute pneumonia and renal failure in June 2012. This report describes the complete genome sequence, genome organization, and expression strategy of HCoV-EMC/2012 and its relation with known coronaviruses. The genome contains 30,119 nucleotides and contains at least 10 predicted open reading frames, 9 of which are predicted to be expressed from a nested set of seven subgenomic mRNAs. Phylogenetic analysis of the re... Abstract

Cited 86 times since 2012 (6.8 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 33, Issue 1, 15 3 2012, Pages e1-e10 Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation. Leeper NJ, Raiesdana A, Kojima Y, Kundu RK, Cheng H, Maegdefessel L, Toh R, Ahn GO, Ali ZA, Anderson DR, Miller CL, Roberts SC, Spin JM, de Almeida PE, Wu JC, Xu B, Cheng K, Quertermous M, Kundu S, Kortekaas KE, Berzin E, Downing KP, Dalman RL, Tsao PS, Schadt EE, Owens GK, Quertermous T

Objective: Genomewide association studies have implicated allelic variation at 9p21.3 in multiple forms of vascular disease, including atherosclerotic coronary heart disease and abdominal aortic aneurysm. As for other genes at 9p21.3, human expression quantitative trait locus studies have associated expression of the tumor suppressor gene CDKN2B with the risk haplotype, but its potential role in vascular pathobiology remains unclear. Methods and results: Here we used vascular injury models and f... Abstract

Cited 12 times since 2012 (1 per year) source: EuropePMC

PloS one, Volume 7, Issue 11, 15 3 2012, Pages e49429 Effective population size dynamics and the demographic collapse of Bornean orang-utans. Sharma R, Arora N, Goossens B, Nater A, Morf N, Salmona J, Bruford MW, Van Schaik CP, Krützen M, Chikhi L

Bornean orang-utans experienced a major demographic decline and local extirpations during the Pleistocene and Holocene due to climate change, the arrival of modern humans, of farmers and recent commercially-driven habitat loss and fragmentation. The recent loss of habitat and its dramatic fragmentation has affected the patterns of genetic variability and differentiation among the remaining populations and increased the extinction risk of the most isolated ones. However, the contribution of recen... Abstract

Cited 40 times since 2012 (3.2 per year) source: EuropePMC

The American journal of cardiology, Volume 111, Issue 3, 15 3 2012, Pages 312-318 Influence of gender on ischemic times and outcomes after ST-elevation myocardial infarction. Velders MA, Boden H, van Boven AJ, van der Hoeven BL, Heestermans AA, Cannegieter SC, Umans VA, Jukema JW, Hofma SH, Schalij MJ

Previous studies investigating the influence of gender on ST-segment elevation myocardial infarction have reported conflicting results. The aim of this study was to assess the influence of gender on ischemic times and outcomes after ST-segment elevation myocardial infarction in patients treated with primary percutaneous coronary intervention in modern practice. The present multicenter registry included consecutive patients with ST-segment elevation myocardial infarctions treated with primary per... Abstract