Research

Publications

Below you can find a list of our published research.

6125 results

Stem cell reports, Volume 20, Issue 1, 5 1 2024, Pages 102371 Glycogen synthase kinase-3 inhibition and insulin enhance proliferation and inhibit maturation of human iPSC-derived cardiomyocytes via TCF and FOXO signaling. Yuan Q, Verbueken D, Dinani R, Kim R, Schoger E, Morsink CD, Simkooei SA, Kemna LJM, Hjortnaes J, Kuster DWD, Boon RA, Zelarayan LC, van der Velden J, Buikema JW

Embryonic signaling pathways exert stage-specific effects during cardiac development, yet the precise signals for proliferation or maturation remain elusive. To uncover the cues for proliferation, we performed a combinatory cell-cycle screen for insulin and glycogen synthase kinase-3 (GSK3) inhibition in spontaneously beating human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Our analysis for proliferation, and subsequential downstream sarcomere development, gene expression... Abstract

European heart journal. Cardiovascular Imaging, Volume 26, Issue 1, 1 1 2024, Pages 173-174 Mural thickening of the coronary arteries in a COVID-19 patient. Groen RA, de Graaf MA, Stöger JL, van der Woude D, Antoni ML

Abstract

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 26, Issue 12, 1 1 2024, Pages euae283 Ventricular septal defect characteristics influence presence of septal anatomical isthmuses in patients with repaired tetralogy of Fallot. Wallet J, Kimura Y, Blom NA, Hazekamp MG, Bartelings MM, Jongbloed MRM, Zeppenfeld K

Aims: In repaired tetralogy of Fallot (rTOF), the septal anatomical isthmuses (AI), AI 3, between the ventricular septal defect (VSD) and pulmonary annulus, and AI 4, between the VSD and tricuspid annulus, are important ventricular tachycardia (VT) substrates when slow conducting. Our aim was to assess the influence of VSD characteristics, specifically the presence of muscular or fibrous tissue at its border, on the presence or absence of septal AIs, potentially related to VT. Methods and result... Abstract

Cited 1 times since 2024 (4.3 per year) source: EuropePMC

Current protocols, Volume 4, Issue 12, 1 1 2024, Pages e70068 Cryopreservation of Human Adult Ventricular Tissue for the Preparation of Viable Myocardial Slices. Lodrini AM, Groeneveld EJ, Palmen M, Hjortnaes J, Smits AM, Goumans MJ

Living myocardial slices (LMS) are ultrathin sections of adult myocardium that can be maintained in culture. These slices provide a unique platform for studying interactions between cardiomyocytes (CMs), other cardiac cell types, and the extracellular matrix while maintaining the cytoarchitecture and electrical phenotype of CMs over extended periods. Despite their advantages over other cardiac models, LMS have limitations, particularly their reliance on slice quality. The primary factor influenc... Abstract

Cited 1 times since 2024 (4.3 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 27, Issue 1, 1 1 2024, Pages euae300 Monitoring and modulating cardiac bioelectricity: from Einthoven to end-user. De Coster T, Nobacht A, Oostendorp T, de Vries AAF, Coronel R, Pijnappels DA

In 2024, we celebrate the 100th anniversary of Willem Einthoven receiving the Nobel Prize for his discovery of the mechanism of the electrocardiogram (ECG). Building on Einthoven's legacy, electrocardiography allows the monitoring of cardiac bioelectricity through solutions to the so-called forward and inverse problems. These solutions link local cardiac electrical signals with the morphology of the ECG, offering a reversible connection between the heart's electrical activity and its r... Abstract

Interdisciplinary cardiovascular and thoracic surgery, Volume 40, Issue 1, 1 1 2024, Pages ivae227 Examining the learning curves in robotic cardiac surgery wet lab simulation training. Atroshchenko GV, Navarra E, Valdis M, Sandoval E, Hashemi N, Cerny S, Pereda D, Palmen M, Bjerrum F, Bruun NH, Tolsgaard MG

Background: Simulation-based training has gained distinction in cardiothoracic surgery as robotic-assisted cardiac procedures evolve. Despite the increasing use of wet lab simulators, the effectiveness of these training methods and skill acquisition rates remain poorly understood. Objectives: This study aimed to compare learning curves and assess the robotic cardiac surgical skill acquisition rate for cardiac and noncardiac surgeons who had no robotic experience in a wet lab simulation setting.... Abstract

The Journal of cardiovascular surgery, Volume 66, Issue 1, 29 5 2024, Pages 3-16 Hemodynamic considerations in arteriovenous vascular access modalities for hemodialysis. White NA, Xiao Z, De Winter EP, Li M, De Vries MR, Van Der Bogt KE, Rotmans JI

Arteriovenous fistulas and arteriovenous grafts are the most commonly used vascular access for hemodialysis in patients with end-stage chronic kidney disease. However, both methods face significant challenges due to the hemodynamic disturbances induced by the arteriovenous anastomosis. This causes changes in vascular structure and blood flow velocity near the anastomosis site after the fistula/graft surgery, and introduces abnormal wall shear stress and cyclic stretch. This leads to endothelial... Abstract

Talanta, Volume 285, 29 5 2024, Pages 127293 Flexible 3D nanofiber-based SERS biosensor for detection of miRNA-223-3p in early Laryngeal Cancer diagnosis. Martino S, Yilmaz D, Tammaro C, Misso G, Esposito A, Falco M, Cossu AM, Lombardi A, Amler E, Divin R, Giannetti A, Scrima M, Dardano P, De Stefano L, Rea I, De Luca AC, Caraglia M

MicroRNAs (miRNAs) are small non-coding RNAs (18-22 nucleotides) that regulate gene expression and are associated with various diseases, including Laryngeal Cancer (LCa), which has a high mortality rate due to late diagnosis. Traditional methods for miRNA detection present several drawbacks (time-consuming steps, high cost and high false positive rate). Early-stage diagnosis and selective detection of miRNAs remain challenging. This study proposes a 3D flexible biosensor that combines nanofibers... Abstract

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, Volume 44, Issue 2, 29 5 2024, Pages 333-342 Overview of Pediatric Respiratory Syncytial Virus (RSV) infections: has risk perception for RSV changed in children with comorbid conditions? Yilmaz D, Tasar S, Tuz AE, Eroz NA, Oncel EK, Aksay AK, Yilmaz N

Objective: Respiratory syncytial virus (RSV) is the primary etiology of lower respiratory tract infection in children. The fluctuating incidence of RSV, particularly in light of the COVID-19 pandemic, has shifted the spotlight onto preventive strategies. Our study aims to investigate both the risk factors and clinical symptoms of RSV. Materials and methods: From February 2015 to February 2023, samples were analyzed during all seasons to identify viral respiratory infections. RSV was identified i... Abstract

Scientific reports, Volume 14, Issue 1, 26 4 2024, Pages 29256 Severe and post-COVID-19 are associated with high expression of vimentin and reduced expression of N-cadherin. Yilmaz E, Yilmaz D, Cacan E

SARS-CoV-2 penetrates human cells via its spike protein, which mainly interacts with ACE2 receptors, triggering viral replication and an exacerbated immune response characterized by a cytokine storm. Vimentin III, an intermediate filament protein predominantly found in mesenchymal cells, has garnered considerable attention in recent research due to its multifaceted biological roles and significance in the endothelial-mesenchymal transition (EndMT) during various fibrotic processes. However, the... Abstract

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Volume 105, Issue 2, 24 4 2024, Pages 385-393 Intravascular Lithotripsy in Acute Coronary Syndromes: Procedural and One-Year Clinical Outcomes From the BENELUX-IVL Registry. Oliveri F, van Oort MJH, Al Amri I, Bingen BO, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, van der Van der Kley F, Jukema JW, Montero-Cabezas JM

Background: Despite the excellent success and safety of intravascular lithotripsy (IVL) in heavily calcified lesions, evidence in acute coronary syndromes (ACS) remains limited. Aims: This study aimed to evaluate the procedural and clinical outcomes of IVL in heavily calcified ACS. Methods: Patients who underwent IVL between 2019 and 2024 from the ongoing prospective BENELUX registry were eligible for inclusion. Patients were therefore classified in ACS and chronic coronary syndrome (CCS) groups... Abstract

Annals of vascular surgery, Volume 111, 23 4 2024, Pages 203-211 A Diagnostic Comparison Study between Maximal Systolic Acceleration and Acceleration Time to Detect Peripheral Arterial Disease. Willems SA, van Bennekom OO, Schepers A, van Schaik J, van der Vorst JR, Hamming JF, Brouwers JJWM

Background: Detecting peripheral arterial disease (PAD) can be particularly challenging in patients with diabetes mellitus (DM) or chronic kidney disease (CKD) due to medial arterial calcification (MAC). Current bedside tests, such as the ankle-brachial index, are less accurate in these patient groups. The primary aim of this study is to evaluate the diagnostic accuracy of point-of-care duplex ultrasound parameters maximal systolic acceleration (ACCmax) and acceleration time (AT) to detect PAD,... Abstract

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, Volume 134, Issue 2, 19 3 2024, Pages 223-230 Behavioral feeding problems and parenting stress in toddlers with food protein-induced allergic proctocolitis. Celik P, Yilmaz D, Yuksel F, Akpinar F, Karabag K, Uzun AK, Dibek Misirlioglu E

Background: Food protein-induced allergic proctocolitis (FPIAP) typically develops in infancy, a critical period for taste preference and feeding skill development. Eliminating culprit foods, along with limited food options and the child's distressing symptoms, can significantly impact the mothers' parenting roles. However, research on behavioral feeding problems and parenting stress in toddlers with FPIAP is lacking. Objective: To assess feeding behaviors and parenting stress levels i... Abstract

International journal of cardiology, Volume 420, 15 3 2024, Pages 132712 Unilateral-access vs. bilateral-access in transfemoral transcatheter aortic valve replacement: A slim fit approach. Pereira AR, Al Jaff AAM, Montero-Cabezas J, de Weger A, Candura D, Jukema JW, Arslan F, Regeer MV, Ajmone Marsan N, van-der-Kley F

Background: Vascular complications remain prevalent on transfemoral transcatheter aortic valve replacement (TF-TAVR) with a significant proportion related to the secondary arterial access. We hypothesized that placing the second sheath ipsilateral and distal to the delivery sheath could reduce vascular complications with similar safety and efficacy. Objectives: Comparing vascular complications and clinical outcomes when placing the secondary arterial sheath in the ipsilateral (unilateral-access)... Abstract

The American journal of cardiology, Volume 236, 12 2 2024, Pages 49-55 Sex Differences in a Real-World Registry Examining Coronary Lithotripsy for Calcified Lesions. van Oort MJH, Oliveri F, Ibtihal AA, Bingen BO, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Girgis H, van der Kley F, Jukema JW, Montero-Cabezas JM

Intravascular lithotripsy (IVL) has been established as a safe and effective treatment for coronary artery calcification (CAC). This study aimed to evaluate sex-related differences in the treatment with IVL in a real-world, all-comers international registry. Patients who underwent IVL between May 2019 and February 2024 were enrolled from the BENELUX-IVL registry. Patients were divided into men and women groups. Efficacy end points included device success (delivery of the IVL balloon across the t... Abstract

Cited 1 times since 2024 (3.5 per year) source: EuropePMC

Cardiovascular research, 11 2 2024, Pages cvae243 miR-24-3p secreted as extracellular vesicle cargo by cardiomyocytes inhibits fibrosis in human cardiac microtissues. Senesi G, Lodrini AM, Mohammed S, Mosole S, Hjortnaes J, Veltrop RJA, Kubat B, Ceresa D, Bolis S, Raimondi A, Torre T, Malatesta P, Goumans MJ, Paneni F, Camici GG, Barile L, Balbi C, Vassalli G

Background and aims: Cardiac fibrosis in response to injury leads to myocardial stiffness and heart failure. At the cellular level, fibrosis is triggered by the conversion of cardiac fibroblasts (CF) into extracellular matrix-producing myofibroblasts. miR-24-3p regulates this process in animal models. Here, we investigated whether miR-24-3p plays similar roles in human models. Methods and results: Gain- and loss-of-function experiments were performed using human induced pluripotent stem cell-der... Abstract

The Pediatric infectious disease journal, 8 2 2024 The Prevalence, Serogroup Distribution and Risk Factors of Meningococcal Carriage in Children, Adolescents and Young Adults in Turkey Meningo-Carr-TR Study PART 3: COVID-19 Pandemic Situation. Kizil MC, Kara Y, Karbuz A, Oz FN, Ciftci E, Kurugol Z, Iseri Nepesov M, Celebi S, Cetin BS, Yilmaz D, Dinleyici M, Kizmaz Isancli D, Kilicaslan O, Ozdemir H, Inceli BH, Penezoglu DN, Dortkardesler B, Sezer Yamanel RG, Aksoy FD, Tekin Can S, Agrali Eröz N, Kaya M, Kilic O, Dinleyici EC

Background: The prevalence of meningococcal carriage and serogroup distribution is crucial for assessing the epidemiology of invasive meningococcal disease, forecasting outbreaks and formulating potential immunization strategies. Following the meningococcal carriage studies conducted in Turkey in 2016 and 2018, we planned to re-evaluate meningococcal carriage in children, adolescents and young adults during the COVID-19 pandemic period. Methods: In the MENINGO-CARR-3 study, we collected nasophar... Abstract

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 8 2 2024, Pages 15266028241296490 Diagnostic Value of Maximal Systolic Acceleration Measurements in the Follow-up of Complex Endovascular Aortic Repair: Illustration of a Concept. Willems SA, Brouwers JJWM, Hamming JF, Hinnen JW, van der Vorst JR, van Schaik J

Purpose: After complex endovascular aortic repair (cEVAR), long-term surveillance is advocated to monitor for potential (stent-related) complications. Although various imaging modalities are used, computed tomography angiography remains the standard in current clinical practice worldwide. However, radiopaque markers can cause metal artifacts and scattering, hampering assessment of patency of side branches. The maximal systolic acceleration (ACCmax) is a relatively new duplex ultrasound (DUS) par... Abstract

Nature communications, Volume 15, Issue 1, 7 1 2024, Pages 9652 Preoperative methionine restriction induces perivascular adipose tissue browning and improves vein graft remodeling in male mice. Kip P, Sluiter TJ, MacArthur MR, Tao M, Kruit N, Mitchell SJ, Jung J, Kooijman S, Gorham J, Seidman JG, Quax PHA, Decano JL, Aikawa M, Ozaki CK, Mitchell JR, de Vries MR

Short-term preoperative methionine restriction (MetR) is a promising translatable strategy to mitigate surgical injury response. However, its application to improve post-interventional vascular remodeling remains underexplored. Here we find that MetR protects from arterial intimal hyperplasia in a focal stenosis model and pathologic vascular remodeling following vein graft surgery in male mice. RNA sequencing reveals that MetR enhances browning in arterial (thoracic aorta) perivascular adipose t... Abstract

Journal of cardiology, 6 1 2024, Pages S0914-5087(24)00213-2 Authors' reply. Tomšič A, Palmen M

Abstract