6173 results
Cited 5 times since 1994 (0.2 per year)
source: EuropePMC
Pflugers Archiv : European journal of physiology,
Volume 428, Issue 3-4, 1 1 1994, Pages 296-299
A novel two-compartment culture dish allows microscopic evaluation of two different treatments in one cell culture simultaneously. Influence of external pH on Na+/Ca2+ exchanger activity in cultured rat cardiomyocytes.
Atsma DE, Bastiaanse EM, Ince C, van der Laarse A
A new type of culture dish containing two separate compartments is described, that can be used in high-magnification microscopy. Using the dish, two halves of a single-cell culture, grown on a standard coverslip, can be exposed to different treatments simultaneously, allowing the effect of one treatment to be compared with that of the other treatment in the same culture. This way, the natural variability that might exist between different individual cultures is circumvented. In addition, by simu...
Abstract
Cited 45 times since 1994 (1.5 per year)
source: EuropePMC
The Journal of general virology,
Volume 75 ( Pt 9), 1 1 1994, Pages 2439-2444
Monoclonal antibodies to equine arteritis virus proteins identify the GL protein as a target for virus neutralization.
Deregt D, de Vries AA, Raamsman MJ, Elmgren LD, Rottier PJ
Monoclonal antibodies (MAbs) to equine arteritis virus (EAV) proteins were produced and characterized. The protein specificities of eight MAbs were determined definitively by immunoprecipitation of EAV proteins expressed from vaccinia virus recombinants (VVRs). Included were two new VVRs produced for this study, expressing the M and the GL proteins, respectively. Three MAbs were determined to be N-specific and five MAbs recognized the GL protein. One GL-specific MAb, 17F5, of the IgA class, effi...
Abstract
Cited 6 times since 1994 (0.2 per year)
source: EuropePMC
Der Urologe. Ausg. A,
Volume 33, Issue 5, 1 1 1994, Pages 392-400
[Urologic complications after kidney transplantation. Experiences in a center with 539 recipients].
Conrad S, Schneider AW, Gonnermann D, Ganama A, Tenschert W, Huland H
A total of 539 renal transplantations were performed at the Department of Urology of the University Hospital of Hamburg between 1984 and 1991. 132 (24.5%) patients developed urological complications (by definition, complications occurring as a result of the operative procedure). In 31 cases the transplants had to be removed secondary to urological complications, and 4 patients died of such complications (mortality 0.7%, lethality 3.0%). Urinary tract infections occurred in 13.2% of all patients...
Abstract
Cited 21 times since 1994 (0.7 per year)
source: EuropePMC
The Journal of urology,
Volume 152, Issue 3, 1 1 1994, Pages 906-909
Endo-urological cold-knife incision for ureteral stenosis after renal transplantation.
Conrad S, Schneider AW, Tenschert W, Meyer-Moldenhauer WH, Huland H
Cold-knife incision of stenoses in the transplant ureter was performed in 11 patients with upper urinary tract obstruction in renal transplants. The operations were complicated by bleeding in 2 patients and the graft had to be removed in 1 of them. The stenoses could be treated successfully in 10 of the 11 patients (91%) and the mean serum creatinine concentration decreased significantly from 3.4 to 1.8 mg./dl. After a mean of 26 months only 1 obstruction recurred, so the long-term success rate...
Abstract
Cited 31 times since 1994 (1 per year)
source: EuropePMC
Basic research in cardiology,
Volume 89, Issue 5, 1 1 1994, Pages 411-426
Dependence of anisotropic myocardial electrical resistivity on cardiac phase and excitation frequency.
Steendijk P, van der Velde ET, Baan J
Knowledge of myocardial electrical resistivity is of interest because passive electrical properties govern the electrotonic spread of current through the myocardium and influence the shape and velocity of the excitation wave. In addition, measurements of myocardial resistivity may provide information about tissue structure and components. The aim of the present study was to determine the excitation frequency dependence and the changes during the cardiac cycle of anisotropic myocardial electrical...
Abstract
Cited 13 times since 1994 (0.4 per year)
source: EuropePMC
Arteriosclerosis and thrombosis : a journal of vascular biology,
Volume 14, Issue 9, 1 1 1994, Pages 1459-1465
Tissue-type plasminogen activator and its inhibitor in rat aorta. Effect of endotoxin.
Padró T, Quax PH, van den Hoogen CM, Roholl P, Verheijen JH, Emeis JJ
Plasminogen activator (PA) and PA inhibitor (PAI) antigen, activity, and mRNA were analyzed in the three layers of rat aorta, and the effect of endotoxin on PA and PAI was studied. All PA activity in aorta was identified as tissue-type PA (TPA) activity; no urokinase-type PA was detected. In the tunica adventitia TPA activity, TPA antigen, and TPA mRNA were detected, whereas in the tunica media TPA antigen and TPA mRNA, but no TPA activity, were found. PAI activity was detected in the tunica med...
Abstract
Cited 26 times since 1994 (0.8 per year)
source: EuropePMC
Archives of biochemistry and biophysics,
Volume 313, Issue 1, 1 1 1994, Pages 58-63
The effect of sarcolemmal cholesterol content on intracellular calcium ion concentration in cultured cardiomyocytes.
Bastiaanse EM, Atsma DE, Kuijpers MM, Van der Laarse A
In this study the relationship between sarcolemmal free cholesterol content and intracellular calcium ion concentration ([Ca2+]i) was explored. In cultured neonatal rat cardiomyocytes the cellular free cholesterol content was modulated by treatment with liposomes. Using cholesterol-rich or cholesterol-free liposomes, sarcolemmal free cholesterol content was raised or diminished, respectively. An increased sarcolemmal free cholesterol content resulted in a decreased sarcolemmal fluidity, whereas...
Abstract
Cited 19 times since 1994 (0.6 per year)
source: EuropePMC
Electroencephalography and clinical neurophysiology,
Volume 93, Issue 3, 1 1 1994, Pages 163-168
Fasciculation potentials in foot and leg muscles of healthy young adults.
Van der Heijden A, Spaans F, Reulen J
The occurrence of fasciculation potentials (FPs) was studied in healthy subjects aged 18-25. In 25 males and 25 females 3 intrinsic foot muscles, the tibialis anterior and the gastrocnemius muscles on both sides were monitored with surface electrodes for 2 min periods. Only potentials with a peak-to-peak amplitude of at least 50 microV were counted. The number of FPs per minute (FPs/min) was significantly higher in the abductor hallucis (AH) and significantly lower in the tibialis anterior as co...
Abstract
Cited 32 times since 1994 (1 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 107, Issue 6, 1 1 1994, Pages 1416-1422
Inhibition of the fetal stress response improves cardiac output and gas exchange after fetal cardiac bypass.
Fenton KN, Heinemann MK, Hickey PR, Klautz RJ, Liddicoat JR, Hanley FL
Cardiac bypass in late-gestation fetal lambs causes severe placental vasoconstriction, which leads to fetal death from hypoxemia and respiratory acidosis. This response can be blocked by the administration of indomethacin; however, a fatal metabolic acidosis then gradually develops in the fetus. Because the fetus is known to mount an intensive catecholamine response to stress, and because the fetal myocardium is particularly sensitive to increased afterload, we hypothesized that elevated afterlo...
Abstract
Cited 12 times since 1994 (0.4 per year)
source: EuropePMC
Journal of molecular and cellular cardiology,
Volume 26, Issue 5, 1 1 1994, Pages 639-648
The effect of sarcolemmal cholesterol content on the tolerance to anoxia in cardiomyocyte cultures.
Bastiaanse EM, van der Valk-Kokshoorn LJ, Egas-Kenniphaas JM, Atsma DE, van der Laarse A
To determine whether the sarcolemmal-free cholesterol content influences the tolerance to anoxia in cultured neonatal rat cardiomyocytes, we modulated the free cholesterol content of the cultures, and determined the time course of anoxia-induced cell death. Incubation for 5 h with liposomes having a free cholesterol to phospholipid molar ratio of 2, 0.5 and 0, resulted in a change of cellular free cholesterol content by +54.7 +/- 5.8% (P < 0.001), by -5.2 +/- 6.3% (n.s.), and by -22.1 +/- 4.9...
Abstract
Cited 14 times since 1994 (0.5 per year)
source: EuropePMC
Journal of vascular research,
Volume 31, Issue 3, 1 1 1994, Pages 153-162
In the normal rabbit femoral artery increasing arterial wall injury does not lead to increased intimal hyperplasia.
van Erven L, Post MJ, Velema E, Borst C
Angioplasty inflicts damage to the arterial wall. We studied whether augmented medial smooth muscle cell necrosis leads to augmented intimal hyperplasia and thus aggravates restenosis. Sixty-three normal femoral arteries of New Zealand White rabbits were overstretched with an angioplasty balloon during either maximal vasoconstriction with phenylephrine (32 arteries) or maximal vasodilation with nitroprusside (31 arteries). After 3 days' survival, medial necrosis was determined as percentage...
Abstract
Cited 97 times since 1994 (3.1 per year)
source: EuropePMC
The American journal of physiology,
Volume 266, Issue 4 Pt 2, 1 1 1994, Pages H1565-71
Heart rate and heart rate variability as indexes of sympathovagal balance.
Bootsma M, Swenne CA, Van Bolhuis HH, Chang PC, Cats VM, Bruschke AV
According to the Rosenblueth-Simeone model, the heart rate (HR) is proportional to the sympathovagal balance. The individual proportionality constant is the intrinsic heart rate, which can only be determined invasively. The normalized low-frequency heart rate variability power (LF) has been raised as a calibrated noninvasive alternative. To concrete this assumption, we studied the individual LF-HR relation during incremental head-up tilt (0, 10, 20, 30, 40, 45, 50, 55, 60, 65, 70, 75, and 80 deg...
Abstract
Cited 18 times since 1994 (0.6 per year)
source: EuropePMC
Pharmacological research,
Volume 29, Issue 3, 1 1 1994, Pages 261-272
Endothelial dysfunction and dyslipidemia: possible effects of lipid lowering and lipid modifying therapy.
van Boven AJ, Jukema JW, Paoletti R
Hypercholesterolemic and atherosclerotic coronary endothelial dysfunction consist of a progressive, not irreversible, impairment in reactions to various endothelium dependent relaxing substances in both the epicardial coronary artery and in the resistance vessel. Paradoxical vasoconstriction, dynamic stenoses and dysregulation of the coronary blood flow make this endothelial dysfunction contribute to the pathogenesis of myocardial ischemia. The selectivity of the impairment makes the concept of...
Abstract
Cited 10 times since 1994 (0.3 per year)
source: EuropePMC
FEBS letters,
Volume 343, Issue 2, 1 1 1994, Pages 151-154
Simvastatin-sodium delays cell death of anoxic cardiomyocytes by inhibition of the Na+/Ca2+ exchanger.
Bastiaanse EM, Atsma DE, Kuijpers MM, Van der Laarse A
When incubated under anoxic conditions, cultured neonatal cardiomyocytes undergo cell necrosis. Simvastatin-sodium, the bioactive metabolite of simvastatin (a potent serum cholesterol-lowering drug), delayed the anoxia-induced myocyte necrosis in a dose-dependent manner. This beneficial effect of simvastatin-sodium could not be attributed to its cholesterol-lowering properties. We found that simvastatin-sodium, at concentrations of 20 and 50 microM, attenuated the rise in intracellular Ca2+ conc...
Abstract
Cited 79 times since 1994 (2.5 per year)
source: EuropePMC
Pediatric research,
Volume 35, Issue 3, 1 1 1994, Pages 329-333
Relationship between brain blood flow and carotid arterial flow in the sheep fetus.
van Bel F, Roman C, Klautz RJ, Teitel DF, Rudolph AM
The present study investigates whether changes in total brain blood flow can be reliably estimated by changes in carotid arterial blood flow in fetal and perinatal lambs. We therefore compared carotid arterial blood flow, measured with implanted transit-time ultrasound transducers, with brain blood flow, measured by radioactive microspheres in fetal lambs during normal oxygenation and during pulmonary ventilation with oxygen, with PO2 ranging from levels normal for the healthy fetus to levels no...
Abstract
Cited 1 times since 1994 (0 per year)
source: EuropePMC
The Netherlands journal of medicine,
Volume 44, Issue 2, 1 1 1994, Pages 60-64
Q-fever in a patient with a ventriculo-peritoneal drain. Case report and short review of the literature.
Lohuis PJ, Ligtenberg PC, Diepersloot RJ, de Graaf M
Although Q-fever is still a relatively rare disease in the Netherlands, its incidence seems to be increasing. In this article we describe the case-history of a 65-year-old woman with a Pudenz-drain, who acquired Q-fever pneumonia while manuring her garden. The course of the disease was deviant, which most likely was caused by colonization of the ventriculo-peritoneal drain with Coxiella burnetii. Q-fever usually presents as a self-limiting illness. In the case of chronic Q-fever, complications s...
Abstract
Cited 17 times since 1994 (0.5 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 23, Issue 2, 1 1 1994, Pages 514-524
Nonlinearity of the left ventricular end-systolic wall stress-velocity of fiber shortening relation in young pigs: a potential pitfall in its use as a single-beat index of contractility.
Banerjee A, Brook MM, Klautz RJ, Teitel DF
Objectives: We sought to evaluate in the young heart the primary assumptions on which the current use of the mean "velocity of fiber shortening corrected for heart rate" as a noninvasive index of contractility are based. Background: End-systolic wall stress-velocity of fiber shortening relation has been applied as a single-beat, load-independent index of contractility in children. This use is based on poorly validated assumptions of linearity, parallel shifts with changing contractile...
Abstract
Cited 82 times since 1994 (2.6 per year)
source: EuropePMC
The American journal of pathology,
Volume 144, Issue 1, 1 1 1994, Pages 70-81
Plasminogen activators, their inhibitors, and urokinase receptor emerge in late stages of melanocytic tumor progression.
de Vries TJ, Quax PH, Denijn M, Verrijp KN, Verheijen JH, Verspaget HW, Weidle UH, Ruiter DJ, van Muijen GN
Degradation of the extracellular matrix and other tissue barriers by proteases like plasminogen activators (PAs) is a prerequisite for neoplastic growth and metastasis. Recently, we reported that highly metastatic behavior of human melanoma cells in nude mice correlates with urokinase-type PA (u-PA) expression and activity and with PA inhibitor type 1 and 2 (PAI-1, PAI-2) expression. Here we report on the occurrence of components of the PA system in the various stages of human melanoma tumor pro...
Abstract
Cited 2 times since 1994 (0.1 per year)
source: EuropePMC
Annales de biologie clinique,
Volume 52, Issue 11, 1 1 1994, Pages 775-782
Studies on functional and structural role of urokinase receptor and other components of the plasminogen activation system in malignancy.
Weidle UH, Wöllisch E, Rønne E, Ploug M, Behrendt N, de Vries TJ, Quax PH, Verheijen JH, van Muijen GN, Ruiter DJ
Using immunohistochemistry and in-situ hybridization, we studied the expression of the components of the plasminogen activation system during progression to malignant melanoma with fresh melanocytic lesions. Expression of these components is confined to late stages of melanoma. t-PA expression is limited to rare cases of metastatic melanoma. The other components are frequently expressed concomitantly in the same tumour. Urokinase (u-PA) is expressed in stromal cells and only in tumour cells at i...
Abstract
Cited 6 times since 1994 (0.2 per year)
source: EuropePMC
Magnetic resonance imaging,
Volume 12, Issue 3, 1 1 1994, Pages 531-534
Cardiovascular MR imaging: pressure-gating using the arterial pressure signal from a conventional ferromagnetic micromanometer-tip catheter.
Pattynama PM, van der Velde ET, Steendijk P, Lamb HJ, Baan J, de Roos A
We used the arterial pressure wave as a reliable trigger to synchronize MR imaging to the cardiac cycle. Pressure readings and MR images remained undistorted using a conventional ferromagnetic micromanometer-tip catheter. As a safe alternative to triggering to ventricular pressure, this approach allows varying the time relation between the trigger and the cardiac cycle while maintaining the advantages of pressure-gating.
Abstract
