Research

Publications

Below you can find a list of our published research.

6125 results

Cited 7 times since 1992 (0.2 per year) source: EuropePMC

European journal of nuclear medicine, Volume 19, Issue 9, 1 1 1992, Pages 783-789 The clinical impact of thallium-201 reinjection scintigraphy for detection of myocardial viability. Kuijper AF, Vliegen HW, van der Wall EE, Oosterhuis WP, Zwinderman AH, van Eck-Smit BL, Niemeyer MG, Pauwels EK

In a clinical study, the value of thallium-201 reinjection was studied in 139 patients with suspected or known coronary artery disease who showed one or more persistent defects after conventional stress-redistribution imaging. Fifty-nine (42%) patients had sustained a Q-wave myocardial infarction. Sixty-eight (49%) patients showed a reversible defect in at least one myocardial segment at redistribution, while 71 (51%) had persistent defects only. Following reinjection additional segmental fillin... Abstract

Cited 47 times since 1991 (1.4 per year) source: EuropePMC

Gastroenterology, Volume 101, Issue 6, 1 1 1991, Pages 1522-1528 Imbalance of plasminogen activators and their inhibitors in human colorectal neoplasia. Implications of urokinase in colorectal carcinogenesis. Sier CF, Verspaget HW, Griffioen G, Verheijen JH, Quax PH, Dooijewaard G, De Bruin PA, Lamers CB

Neoplastic growth and metastatic spread of adenocarcinomas is characterized by a marked increase of urokinase-type plasminogen activator (u-PA) and a decrease of tissue-type plasminogen activator (t-PA). In this study, the authors determined the activity and antigen levels of u-PA and t-PA, and their inhibitors, plasminogen-activator inhibitors types 1 and 2 (PAI-1 and PAI-2), in normal mucosa, adenomatous polyps, and adenocarcinomas of the human colon. The decrease in t-PA activity in the neopl... Abstract

Cited 22 times since 1991 (0.7 per year) source: EuropePMC

Journal of cardiothoracic and vascular anesthesia, Volume 5, Issue 6, 1 1 1991, Pages 539-545 Systolic and diastolic pressure-volume relationships during cardiac surgery. Schreuder JJ, Biervliet JD, van der Velde ET, ten Have K, van Dijk AD, Meyne NG, Baan J

Seven patients undergoing elective coronary artery bypass surgery were studied to assess left ventricular (LV) performance by pressure-volume loops. LV pressure was measured by micromanometry and instantaneous LV volume by a conductance catheter. Continuous pressure-volume relationships were determined during preload reduction before and after cardiopulmonary bypass (CPB). End-systolic elastance (Ees), as the slope of the end-systolic pressure-volume relationship (ESPVR), and diastolic elastance... Abstract

Cited 4 times since 1991 (0.1 per year) source: EuropePMC

The Thoracic and cardiovascular surgeon, Volume 39 Suppl 2, 1 1 1991, Pages 166-169 Follow-up of arterial switch operation. Hazekamp MG, Ottenkamp J, Quaegebeur JM, Hardjowijono R, Boot CA, Rohmer J, Huysmans HA

This report describes the experience of the Leiden University Hospital with the arterial switch operation for transposition of the great arteries, with and without ventricular septal defect, and for the Taussig-Bing-anomaly. The longest follow-up was 13 years and 9 months. Follow-up shows good results with almost all surviving patients in functional class I and with a sinus rhythm. Supravalvular pulmonary artery stenosis is noted in some of the patients but is almost always mild and does not sho... Abstract

Cited 89 times since 1991 (2.7 per year) source: EuropePMC

The Journal of cell biology, Volume 115, Issue 1, 1 1 1991, Pages 191-199 Metastatic behavior of human melanoma cell lines in nude mice correlates with urokinase-type plasminogen activator, its type-1 inhibitor, and urokinase-mediated matrix degradation. Quax PH, van Muijen GN, Weening-Verhoeff EJ, Lund LR, Danø K, Ruiter DJ, Verheijen JH

Five out of six human melanoma cell lines tested were able to degrade in vitro a smooth muscle cell extracellular matrix in a plasmin-dependent way. In three of these five cell lines, this process was mediated by tissue-type plasminogen activator (t-PA) and in the other two cell lines by urokinase-type plasminogen activator (u-PA). All melanoma cell lines produced t-PA mRNA and protein, whereas only the two cell lines showing u-PA-mediated matrix degradation produced u-PA mRNA and protein. These... Abstract

Cited 9 times since 1991 (0.3 per year) source: EuropePMC

Pediatric research, Volume 30, Issue 4, 1 1 1991, Pages 375-380 Acceleration of blood flow velocity in the carotid artery and myocardial contractility in the newborn lamb. van Bel F, Schipper IB, Klautz RJ, Teitel DF, Steendijk P, Baan J

We investigated the influence of quantitative changes in myocardial contractile state, reflected by changes in the end-systolic pressure-volume relationship (its slope and volume intercept) and by changes in the slope of the relationship between change in pressure per unit time and end-diastolic volume induced by beta-adrenergic stimulation or inhibition, on the Doppler derived blood flow velocity wave form of the carotid artery, using a newborn lamb model. Acceleration time of the velocity wave... Abstract

Cited 22 times since 1991 (0.7 per year) source: EuropePMC

The Journal of urology, Volume 146, Issue 4, 1 1 1991, Pages 961-965 The cold-knife technique for endourological management of stenoses in the upper urinary tract. Schneider AW, Conrad S, Busch R, Otto U

Between 1985 and October 1989 we managed 13 patients with primary and 43 with secondary obstruction of the upper urinary tract with the endourological cold-knife technique. We treated 26 patients with stenosis of the ureteropelvic junction, 9 with infundibular stenosis, 12 with ureteral obstruction after inflammation or radiation therapy, 7 with stricture of the ureter in kidney transplants and 2 with stenosis of the ureter after ureterosigmoidostomy. Endourological management was successful in... Abstract

Cited 55 times since 1991 (1.6 per year) source: EuropePMC

Cell regulation, Volume 2, Issue 10, 1 1 1991, Pages 793-803 Complementation between urokinase-producing and receptor-producing cells in extracellular matrix degradation. Quax PH, Pedersen N, Masucci MT, Weening-Verhoeff EJ, Danø K, Verheijen JH, Blasi F

The respective roles of urokinase plasminogen activator (u-PA) and the u-PA receptor in extracellular matrix degradation was investigated. Human pro-u-PA and the human u-PA receptor were expressed independently by two different mouse LB6 cell lines. The matrix degradation capacity of these cell lines individually or in coculture was studied. Although pro-u-PA-producing cells alone degrade the matrix in the presence of plasminogen, u-PA-receptor producing cells do not. Cocultivation of a small fr... Abstract

Cited 12 times since 1991 (0.4 per year) source: EuropePMC

The American journal of cardiology, Volume 68, Issue 2, 1 1 1991, Pages 181-186 Systemic neurohumoral activation and vasoconstriction during pacing-induced acute myocardial ischemia in patients with stable angina pectoris. Remme WJ, de Leeuw PW, Bootsma M, Look MP, Kruijssen DA

To identify the effect of myocardial ischemia on systemic neurohormones and vascular resistance, 32 untreated, normotensive patients with coronary artery disease underwent incremental atrial pacing until angina. Arterial and coronary venous lactate and arterial values of catecholamines and angiotensin II were determined at control, at maximal pacing rates, and at 1, 2, 5 and 30 minutes after pacing. Based on pacing-induced ST-segment depression (greater than or equal to 0.1 mV) or myocardial lac... Abstract

Cited 253 times since 1991 (7.5 per year) source: EuropePMC

Journal of virology, Volume 65, Issue 6, 1 1 1991, Pages 2910-2920 Equine arteritis virus is not a togavirus but belongs to the coronaviruslike superfamily. den Boon JA, Snijder EJ, Chirnside ED, de Vries AA, Horzinek MC, Spaan WJ

The nucleotide sequence of the genome of equine arteritis virus (EAV) was determined from a set of overlapping cDNA clones and was found to contain eight open reading frames (ORFs). ORFs 2 through 7 are expressed from six 3'-coterminal subgenomic mRNAs, which are transcribed from the 3'-terminal quarter of the viral genome. A number of these ORFs are predicted to encode structural EAV proteins. The organization and expression of the 3' part of the EAV genome are remarkably similar... Abstract

Cited 3 times since 1991 (0.1 per year) source: EuropePMC

New York state journal of medicine, Volume 91, Issue 5, 1 1 1991, Pages 196-200 A retrospective analysis of the metabolic status of stone formers in the New York City metropolitan areas. Hatch M, Schepers A, Grunberger I, Godec CJ

Eighty stone-forming patients were evaluated as outpatients for risk factors involved in stone formation. Analyses of the major stone risk parameters in the 24-hour collections indicated low volume (less than 2L) in about 79% of these patients. Forty percent of all patients were found to be hypocitraturic, 30% were hyperoxaluric, 18% were hypercalciuric, and 13% were hyperuricosuric. Sixty-one percent of the patients had a normal calcium load study; of these, four patients were uric acid stone f... Abstract

Cited 23 times since 1991 (0.7 per year) source: EuropePMC

Pediatric research, Volume 29, Issue 5, 1 1 1991, Pages 473-482 The end-systolic pressure-volume relationship in the newborn lamb: effects of loading and inotropic interventions. Teitel DF, Klautz R, Steendijk P, van der Velde ET, van Bel F, Baan J

Indices of global systolic performance of the newborn left ventricle exceed those of the adult, despite isolated tissue studies showing immature contractile mechanisms. To evaluate contractility in situ, we investigated the end-systolic pressure-volume relationship (ESPVR) by the conductance technique in nine newborn lambs. After percutaneous placement of catheters, we generated ESPVR by inferior vena cava occlusion, aortic occlusion, and volume infusion in two control states, during three level... Abstract

Cited 101 times since 1991 (3 per year) source: EuropePMC

European heart journal, Volume 12, Issue 4, 1 1 1991, Pages 488-494 Myocardial changes in pressure overload-induced left ventricular hypertrophy. A study on tissue composition, polyploidization and multinucleation. Vliegen HW, van der Laarse A, Cornelisse CJ, Eulderink F

Morphological changes in human myocardium associated with pressure overload-induced left ventricular hypertrophy were studied in 22 normal and 21 hypertrophic hearts obtained at autopsy. Samples were obtained from the left lateral ventricular wall, half way between the apex and the base. Myocyte dimensions, polyploidization, multinucleation and relative volume fractions were studied. Regression analysis in relation to indexed heart weight yielded statistically significant correlation coefficient... Abstract

Journal of cardiovascular pharmacology, Volume 18 Suppl 9, 1 1 1991, Pages S68-72 Improvement of left ventricular function in silent ischemia following myocardial infarction, after administration of diltiazem. van der Wall EE, Niemeyer MG, Vliegen HW, Manger Cats V, Blokland JA, Pauwels EK, Bruschke AV

In a group of 72 patients with acute myocardial infarction who underwent a maximal symptom-limited predischarge exercise test in conjunction with radionuclide angiography, 25 (35%) showed greater than 1 mm asymptomatic ST-T-segment depression during exercise. All 25 patients underwent repeated exercise radionuclide angiography 2 days later, 2 h after oral intake of 120 mg diltiazem. Double product was not significantly different before and after diltiazem both at rest and during exercise. Maxima... Abstract

Cited 14 times since 1991 (0.4 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 5, Issue 6, 1 1 1991, Pages 283-6; discussion 287 One stage repair of aortic arch anomalies and intracardiac defects. Hazekamp MG, Quaegebeur JM, Singh S, Hardjowijono R, Bogers AJ, Ottenkamp J, Rohmer J, Witsenburg M, Hess J, Bos E

Between August 1985 and May 1990, 27 neonates and infants underwent combined correction of intracardiac and aortic arch anomalies through a median sternotomy. Coarctation (CoA) was combined with VSD (6), AVSD (2), Taussig-Bing (TB) heart (5), transposition of the great arteries (TGA) (1), TGA + VSD (2), congenitally corrected TGA + VSD (1) and VSD + myxoid stenotic outlet valves (1). Interrupted aortic arch (IAA) was combined with VSD (10) and TB heart (1). Two patients had IAA type B as well as... Abstract

Cited 76 times since 1991 (2.2 per year) source: EuropePMC

Circulation, Volume 83, Issue 1, 1 1 1991, Pages 315-327 Nonlinearity and load sensitivity of end-systolic pressure-volume relation of canine left ventricle in vivo. van der Velde ET, Burkhoff D, Steendijk P, Karsdon J, Sagawa K, Baan J

The effects of mechanical changes in loading conditions on the left ventricular end-systolic pressure-volume relation (ESPVR) were studied in nine open-chest dogs, including three dogs studied before and after beta-adrenergic blockade. Left ventricular pressure was measured with a micromanometer, and left ventricular volume was measured with a conductance catheter. ESPVRs were obtained by increasing left atrial inflow over wide volume ranges (as much as threefold) under three different condition... Abstract

Cited 10 times since 1991 (0.3 per year) source: EuropePMC

European journal of cancer (Oxford, England : 1990), Volume 27, Issue 10, 1 1 1991, Pages 1315-1316 An unusual cause of diplopia in a cancer patient. van der Heijden A, Twijnstra A, Lamers WP, Hupperets PS, Freling G

A 47-year-old woman with metastatic infiltrating lobular carcinoma of the breast developed diplopia. Computed tomography of the orbits showed enlargement and irregularity of the right inferior rectus and inferior obliques muscles. Biopsies of these muscles contained breast carcinoma cells. This case report discusses the causes of diplopia in cancer patients, with special attention to the diagnostic problems of metastasis in extraocular muscles. The possible combined occurrence of metastasis in t... Abstract

Cited 10 times since 1991 (0.3 per year) source: EuropePMC

Journal of lipid research, Volume 32, Issue 1, 1 1 1991, Pages 173-181 Partial characterization of low density lipoprotein preparations isolated from fresh and frozen plasma after radiolabeling by seven different methods. Atsma DE, Kempen HJ, Nieuwenhuizen W, van 't Hooft FM, Pauwels EK

Four 99mTc and three 123I labeling methods were evaluated for their suitability to label low density lipoproteins (LDL) for the purpose of scintigraphic biodistribution studies. For 99mTc these methods were: direct incorporation in LDL of 99mTcO4- using sodium dithionite (dithionite method); a method using first N,N-dimethylformamide to prepare a 99mTc-complex reacting with LDL in a subsequent step (DMF method); a technique in which 99mTcO4- is first coupled to a diamide dithiolate derivative of... Abstract

Cited 4 times since 1991 (0.1 per year) source: EuropePMC

Journal of cardiovascular pharmacology, Volume 18 Suppl 9, 1 1 1991, Pages S55-60 Long-term efficacy of diltiazem controlled release versus metoprolol in patients with stable angina pectoris. Vliegen HW, van der Wall EE, Niemeyer MG, Holwerda NJ, Bernink PJ, de Weerd P, Bosma AH, van der Wieken LR, Timmermans AJ, Molhoek GP

In a randomized, double-blind, multicenter study, the efficacy of diltiazem controlled-release (CR) 120 mg b.i.d. was compared with metoprolol 100 mg b.i.d. in 56 patients with stable exertional angina pectoris. Fifty-one patients (28 receiving diltiazem CR, 23 receiving metoprolol), completed a follow-up period of 8 weeks. Thirty-nine patients (20 receiving diltiazem CR, 19 receiving metoprolol), completed a follow-up period of 32 weeks. Maximal exercise testing was performed at baseline and af... Abstract

Cited 54 times since 1990 (1.6 per year) source: EuropePMC

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, Volume 9, Issue 12, 1 1 1990, Pages 864-868 Detection of Chlamydia trachomatis in clinical specimens by the polymerase chain reaction. Claas HC, Melchers WJ, de Bruijn IH, de Graaf M, van Dijk WC, Lindeman J, Quint WG

Sequences derived from the endogenous plasmid of Chlamydia trachomatis and from the genes coding for ribosomal 16S RNA of Chlamydia psittaci were used as primers and oligonucleotide probes for detection of chlamydiae by the polymerase chain reaction. The endogenous plasmid primers generated specific amplified products of 517 bp with all known Chlamydia trachomatis serovars. No specific products of Chlamydia psittaci and Chlamydia pneumoniae could be detected using these primers. With the rRNA pr... Abstract