Research

Publications

Below you can find a list of our published research.

6196 results

Cited 28 times since 2011 (2 per year) source: EuropePMC

Clinical genetics, Volume 80, Issue 4, 31 5 2011, Pages 346-353 Critical appraisal of the revised Ghent criteria for diagnosis of Marfan syndrome. Radonic T, de Witte P, Groenink M, de Bruin-Bon RA, Timmermans J, Scholte AJ, van den Berg MP, Baars MJ, van Tintelen JP, Kempers M, Zwinderman AH, Mulder BJ

Marfan syndrome (MFS) is a connective tissue disorder with major features in cardiovascular, ocular and skeletal systems. Recently, diagnostic criteria were revised where more weight was given to the aortic root dilatation. We applied the revised Marfan nosology in an established adult Marfan population to define practical repercussions of novel criteria for clinical practice and individual patients. Out of 180 MFS patients, in 91% (n = 164) the diagnosis of MFS remained. Out of 16 patients with... Abstract

Cited 33 times since 2011 (2.3 per year) source: EuropePMC

Thrombosis research, Volume 128, Issue 1, 30 5 2011, Pages 21-26 A simple non-invasive diagnostic algorithm for ruling out chronic thromboembolic pulmonary hypertension in patients after acute pulmonary embolism. Klok FA, Surie S, Kempf T, Eikenboom J, van Straalen JP, van Kralingen KW, van Dijk AP, Vliegen HW, Bresser P, Wollert KC, Huisman MV

Background: Our aim was to construct a diagnostic model for ruling out chronic thromboembolic pulmonary hypertension (CTEPH) in symptomatic patients after acute pulmonary embolism (PE) that is based on simple, non-invasive tests. Methods: Plasma levels of various CTEPH associated biomarkers and conventional ECG criteria for right ventricular pressure overload were assessed in 82 consecutive patients with confirmed CTEPH and 160 consecutive patients with a history of PE who were suspected to have... Abstract

Cited 30 times since 2011 (2.1 per year) source: EuropePMC

European heart journal, Volume 32, Issue 18, 30 5 2011, Pages 2236-2246 Cardiac resynchronization therapy in paediatric and congenital heart disease patients. van der Hulst AE, Delgado V, Blom NA, van de Veire NR, Schalij MJ, Bax JJ, Roest AA, Holman ER

The number of patients with congenital heart disease (CHD) has significantly increased over the last decades. The CHD population has a high prevalence of heart failure during late follow-up and this is a major cause of mortality. Cardiac resynchronization therapy (CRT) may be a promising therapy to improve the clinical outcome of CHD and paediatric patients with heart failure. However, the CHD and paediatric population is a highly heterogeneous group with different anatomical substrates that may... Abstract

Cited 129 times since 2011 (9.1 per year) source: EuropePMC

European heart journal, Volume 32, Issue 12, 29 5 2011, Pages 1542-1550 Alterations in multidirectional myocardial functions in patients with aortic stenosis and preserved ejection fraction: a two-dimensional speckle tracking analysis. Ng AC, Delgado V, Bertini M, Antoni ML, van Bommel RJ, van Rijnsoever EP, van der Kley F, Ewe SH, Witkowski T, Auger D, Nucifora G, Schuijf JD, Poldermans D, Leung DY, Schalij MJ, Bax JJ

Aims: To identify changes in multidirectional strain and strain rate (SR) in patients with aortic stenosis (AS). Methods and results: A total of 420 patients (age 66.1 ± 14.5 years, 60.7% men) with aortic sclerosis, mild, moderate, and severe AS with preserved left ventricular (LV) ejection fraction [(EF), ≥50%] were included. Multidirectional strain and SR imaging were performed by two-dimensional speckle tracking. Patients were more likely to be older (P < 0.001) and at a worse New York Hea... Abstract

Cited 236 times since 2011 (16.7 per year) source: EuropePMC

Nature reviews. Cardiology, Volume 8, Issue 5, 29 5 2011, Pages 292-300 Innate immune signaling in cardiac ischemia. Arslan F, de Kleijn DP, Pasterkamp G

Despite advances in treatment of patients who suffer from ischemic heart disease, morbidity related to myocardial infarction is increasing in Western societies. Acute and chronic immune responses elicited by myocardial ischemia have an important role in the functional deterioration of the heart. Research on modulation of the inflammatory responses was focused on effector mediators such as leukocytes. However, increasing evidence indicates that various endogenous ligands that act as 'danger... Abstract

Cited 1 times since 2011 (0.1 per year) source: EuropePMC

Journal of the science of food and agriculture, Volume 91, Issue 9, 28 4 2011, Pages 1585-1590 Effect of harvesting hour on some physical and mechanical properties of Rosa damascena Mill. Yilmaz D, Ekinci K, Dilmacunal T, Erbas S

Background: Mechanization of Rosa damascena flower harvest is limited because of the asynchronous flowering period, the necessity for the harvest operation to take place in the early hour of the morning, and a lack of knowledge regarding the physical-mechanical properties of R. damascena. This study investigated the effect of harvesting hour on some physical-mechanical properties of R. damascena. Results: The terminal velocity of the rose flower ranged from 4.00 to 2.38 m s(-1) . The highest pic... Abstract

The international journal of cardiovascular imaging, Volume 28, Issue 3, 26 4 2011, Pages 551-554 Aortic stiffness in type-1 diabetes mellitus; beware of hypertension. van der Wall EE, Siebelink HM, Scholte AJ, Schalij MJ

Abstract

Cited 5 times since 2011 (0.4 per year) source: EuropePMC

The American journal of cardiology, Volume 107, Issue 11, 26 4 2011, Pages 1639-1643 Reaching C-reactive protein and low-density lipoprotein cholesterol goals in dyslipidemic patients (from the Lipid Treatment Assessment Project [L-TAP] 2). Chiang CW, Santos RD, Waters DD, Messig M, Tarasenko L, Jukema JW, Ferrières J, Foody J, Seung KB, Lipid Treatment Assessment Project 2 Investigators

The purpose of the present substudy of the Lipid Treatment Assessment Project 2 was to assess dual C-reactive protein (CRP) and low-density lipoprotein (LDL) cholesterol goal attainment across a spectrum of low-, moderate-, and high-risk patients with dyslipidemia in 8 countries in North America, Latin America, Europe, and Asia. Of the 9,518 patients studied overall, 45% were women, 64% had hypertension, 31% had diabetes, 14% were current smokers, 60% were high risk, and 79% were taking a statin... Abstract

Cited 14 times since 2011 (1 per year) source: EuropePMC

The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons, Volume 50, Issue 3, 25 4 2011, Pages 307-310 Demographics and functional outcome of toe fractures. Van Vliet-Koppert ST, Cakir H, Van Lieshout EM, De Vries MR, Van Der Elst M, Schepers T

Toe fractures are common; however, there are few data on demographics and functional outcome. We studied outcomes in 339 consecutive patients with toe fractures treated between January 2006 and September 2008. Two hundred and sixty-four patients, aged 16 to 75, were mailed an outcome questionnaire, and overall subjective satisfaction with the outcome of treatment was measured using a visual analog scale (VAS). Most frequently affected were the first (38%) and fifth (30%) toes, and most (75.6%) o... Abstract

Cited 31 times since 2011 (2.2 per year) source: EuropePMC

Heart rhythm, Volume 8, Issue 8, 21 3 2011, Pages 1254-1263 Funny current channel HCN4 delineates the developing cardiac conduction system in chicken heart. Vicente-Steijn R, Passier R, Wisse LJ, Schalij MJ, Poelmann RE, Gittenberger-de Groot AC, Jongbloed MR

Background: Hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) in the mouse is expressed in the developing cardiac conduction system (CCS). In the sinoatrial node (SAN), HCN4 is the predominant isoform responsible for the funny current. To date, no data are available on HCN4 expression during chicken CCS development. Objective: The purpose of this study was to provide the full-length sequence of Hcn4 and describe its expression pattern during development in relation to the CCS... Abstract

Cited 70 times since 2011 (5 per year) source: Scopus

The Annals of thoracic surgery, Volume 92, Issue 4, 21 3 2011, Pages 1244-1251 Outcomes after transcatheter aortic valve implantation: transfemoral versus transapical approach. Ewe SH, Delgado V, Ng AC, Antoni ML, van der Kley F, Marsan NA, de Weger A, Tavilla G, Holman ER, Schalij MJ, Bax JJ

Background: Transcatheter aortic valve implantation is commonly implanted through a transfemoral (TFA) or transapical approach (TAA) for patients with severe aortic stenosis. This study aimed to describe the clinical and echocardiographic outcomes of TFA versus TAA. Methods: Clinical and echocardiographic evaluations were performed at baseline, post-TAVI (transcatheter aortic valve implantation), at 6 and 12 months follow-up in 107 consecutive patients who underwent TAVI with balloon-expandable... Abstract

Cited 29 times since 2011 (2.1 per year) source: EuropePMC

Thyroid : official journal of the American Thyroid Association, Volume 21, Issue 5, 21 3 2011, Pages 471-476 Both exogenous subclinical hyperthyroidism and short-term overt hypothyroidism affect myocardial strain in patients with differentiated thyroid carcinoma. Abdulrahman RM, Delgado V, Hoftijzer HC, Ng AC, Ewe SH, Marsan NA, Holman ER, Hovens GC, Corssmit EP, Romijn JA, Bax JJ, Smit JW

Background: The cardiovascular effects of transitions from exogenous subclinical hyperthyroidism to short-term overt hypothyroidism in patients treated for differentiated thyroid carcinoma remain unclear. The present study aims at evaluating the changes in multidirectional myocardial strain using two-dimensional (2D) speckle tracking during this controlled transition from exogenous subclinical hyperthyroidism to overt hypothyroidism. Methods: The study included 14 patients with differentiated th... Abstract

Cited 2 times since 2011 (0.1 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 28, Issue 2, 19 3 2011, Pages 425-428 Reduction of radiation dose using 80 kV tube voltage: a feasible strategy? van der Wall EE, van Velzen JE, de Graaf FR, Jukema JW

Abstract

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 17 3 2011 WITHDRAWN: Predictors of long-term survival in pulmonary hypertension treated with bosentan. Bresser P, Vis JC, Berger RM, Vliegen HW, Vonk MC, Snijder RJ, van den Toorn LM, van Dijk AP, Boomars KA, van Daal GJ, Mulder BJ

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at (http://www.elsevier.com/locate/withdrawalpolicy. Abstract

Cited 13 times since 2011 (0.9 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 142, Issue 3, 12 2 2011, Pages e93-100 Cardiac support device, restrictive mitral valve annuloplasty, and optimized medical treatment: a multimodality approach to nonischemic cardiomyopathy. Braun J, Ciarka A, Versteegh MI, Delgado V, Boersma E, Verwey HF, Schalij MJ, Bax JJ, Dion RA, van de Veire NR, Klautz RJ

Objective: Nonischemic dilated cardiomyopathy with functional mitral regurgitation carries a poor prognosis. Mitral valve surgery with implantation of a cardiac support device can treat mitral regurgitation and promote left ventricular reverse remodeling. This observational study evaluates clinical and echocardiographic outcomes of an individualized medico-surgical approach, focusing on mitral regurgitation recurrence and left ventricular reverse remodeling. Methods: Sixty-nine consecutive patie... Abstract

Cited 138 times since 2011 (9.7 per year) source: EuropePMC

Circulation research, Volume 108, Issue 9, 10 2 2011, Pages 1093-1101 Lack of primary cilia primes shear-induced endothelial-to-mesenchymal transition. Egorova AD, Khedoe PP, Goumans MJ, Yoder BK, Nauli SM, ten Dijke P, Poelmann RE, Hierck BP

Rationale: Primary cilia are cellular protrusions that serve as mechanosensors for fluid flow. In endothelial cells (ECs), they function by transducing local blood flow information into functional responses, such as nitric oxide production and initiation of gene expression. Cilia are present on ECs in areas of low or disturbed flow and absent in areas of high flow. In the embryonic heart, high-flow regime applies to the endocardial cushion area, and the absence of cilia here coincides with the p... Abstract

Cited 13 times since 2011 (0.9 per year) source: Scopus

Logopedics, phoniatrics, vocology, Volume 36, Issue 4, 8 2 2011, Pages 139-144 Informing and supporting partners and children of persons with aphasia: a comparison of supply and demand. Manders E, Mariën A, Janssen V

In this study we investigated how important significant others find it to be informed, supported, and trained by speech-language pathologists (SLPs) and to what extent they perceive their expectations and needs as to these aspects to be fulfilled. Furthermore SLPs were asked about the importance of informing and supporting family members and as to how far they believe they provide adequate care in that field. A questionnaire was completed by 77 relatives of persons with aphasia, a parallel versi... Abstract

Cited 1337 times since 2011 (94.4 per year) source: EuropePMC

Nature genetics, Volume 43, Issue 4, 6 1 2011, Pages 333-338 Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AF, Barbalic M, Gieger C, Absher D, Aherrahrou Z, Allayee H, Altshuler D, Anand SS, Andersen K, Anderson JL, Ardissino D, Ball SG, Balmforth AJ, Barnes TA, Becker DM, Becker LC, Berger K, Bis JC, Boekholdt SM, Boerwinkle E, Braund PS, Brown MJ, Burnett MS, Buysschaert I, Cardiogenics, Carlquist JF, Chen L, Cichon S, Codd V, Davies RW, Dedoussis G, Dehghan A, Demissie S, Devaney JM, Diemert P, Do R, Doering A, Eifert S, Mokhtari NE, Ellis SG, Elosua R, Engert JC, Epstein SE, de Faire U, Fischer M, Folsom AR, Freyer J, Gigante B, Girelli D, Gretarsdottir S, Gudnason V, Gulcher JR, Halperin E, Hammond N, Hazen SL, Hofman A, Horne BD, Illig T, Iribarren C, Jones GT, Jukema JW, Kaiser MA, Kaplan LM, Kastelein JJ, Khaw KT, Knowles JW, Kolovou G, Kong A, Laaksonen R, Lambrechts D, Leander K, Lettre G, Li M, Lieb W, Loley C, Lotery AJ, Mannucci PM, Maouche S, Martinelli N, McKeown PP, Meisinger C, Meitinger T, Melander O, Merlini PA

We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 × 10⁻⁸ and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and we... Abstract

Cited 293 times since 2011 (20.7 per year) source: EuropePMC

European heart journal, Volume 32, Issue 11, 2 1 2011, Pages 1316-1330 A clinical prediction rule for the diagnosis of coronary artery disease: validation, updating, and extension. Genders TS, Steyerberg EW, Alkadhi H, Leschka S, Desbiolles L, Nieman K, Galema TW, Meijboom WB, Mollet NR, de Feyter PJ, Cademartiri F, Maffei E, Dewey M, Zimmermann E, Laule M, Pugliese F, Barbagallo R, Sinitsyn V, Bogaert J, Goetschalckx K, Schoepf UJ, Rowe GW, Schuijf JD, Bax JJ, de Graaf FR, Knuuti J, Kajander S, van Mieghem CA, Meijs MF, Cramer MJ, Gopalan D, Feuchtner G, Friedrich G, Krestin GP, Hunink MG, CAD Consortium

Aims: The aim was to validate, update, and extend the Diamond-Forrester model for estimating the probability of obstructive coronary artery disease (CAD) in a contemporary cohort. Methods and results: Prospectively collected data from 14 hospitals on patients with chest pain without a history of CAD and referred for conventional coronary angiography (CCA) were used. Primary outcome was obstructive CAD, defined as ≥ 50% stenosis in one or more vessels on CCA. The validity of the Diamond-Forrester... Abstract

Cited 13 times since 2011 (0.9 per year) source: EuropePMC

International journal of cardiology, Volume 149, Issue 2, 1 1 2011, Pages 246-247 Wanted! 8000 heart patients: identification of adult patients with a congenital heart defect lost to follow-up. Vis JC, van der Velde ET, Schuuring MJ, Engelfriet-Rijk LCJM, Harms IM, Mantels S, Bouma BJ, Mulder BJM

Abstract