Research

Publications

Below you can find a list of our published research.

6125 results

Ocular immunology and inflammation, Volume 32, Issue 7, 28 4 2023, Pages 1150-1154 Non-Infectious Uveitis Secondary to Dupilumab Treatment in Atopic Dermatitis Patients Shows a Pro-Inflammatory Molecular Profile. Achten R, van Luijk C, Thijs J, Drylewicz J, Delemarre E, Nierkens S, Bakker D, van Wijk F, de Graaf M, de Bruin-Weller M, de Boer J, Kuiper J

Severe uveitis is a rare complication of interleukin-4 receptor alpha blocking by dupilumab in topic dermatitis (AD) patients. The aim of this study was to describe five moderate-to-severe AD patients who developed uveitis during dupilumab treatment and to compare the proteomic profile of aqueous humor (AqH) of dupilumab-associated uveitis (n=3/5 available samples) with non-infectious uveitis (n=27) and cataract controls (n=11). Included patients were treated at the University Medical Center Utr... Abstract

Cited 2 times since 2023 (1 per year) source: EuropePMC

Research and practice in thrombosis and haemostasis, Volume 7, Issue 2, 27 4 2023, Pages 100096 Atrial fibrillation in cancer: thromboembolism and bleeding in daily practice. Chu G, Seelig J, Cannegieter SC, Gelderblom H, Hovens MMC, Huisman MV, van der Hulle T, Trines SA, Vlot AJ, Versteeg HH, Hemels MEW, Klok FA

Background: Cancer is suggested to confer thromboembolic and bleeding risk in patients with atrial fibrillation (AF). Objectives: We aimed to describe current anticoagulant practice in patients with AF and active cancer, present incidences of thromboembolic and bleeding complications, and evaluate the association between cancer type or anticoagulant management strategy with AF-related complications. Methods: This retrospective study identified patients with AF and active cancer in 2 hospitals be... Abstract

Cited 1 times since 2023 (0.5 per year) source: EuropePMC

Internet interventions, Volume 31, 26 4 2023, Pages 100610 Put your money where your feet are: The real-world effects of StepBet gamified deposit contracts for physical activity. de Buisonjé DR, Brosig F, Breeman LD, Bloom EL, Reijnders T, Janssen VR, Kraaijenhagen RA, Kemps HMC, Evers AWM

Background: Gamification and deposit contracts (a financial incentive in which participants pledge their own money) can enhance effectiveness of mobile behavior change interventions. However, to assess their potential for improving population health, research should investigate implementation of gamified deposit contracts outside the research setting. Therefore, we analyzed data from StepBet, a smartphone application originally developed by WayBetter, Inc. Objective: To perform a naturalistic ev... Abstract

Cited 2 times since 2023 (1 per year) source: EuropePMC

Genes, Volume 14, Issue 3, 25 4 2023, Pages 578 Feasibility of Community Pharmacist-Initiated and Point-of-Care <i>CYP2C19</i> Genotype-Guided De-Escalation of Oral P2Y12 Inhibitors. Levens AD, den Haan MC, Jukema JW, Heringa M, van den Hout WB, Moes DJAR, Swen JJ

Tailoring antiplatelet therapy based on CYP2C19 pharmacogenetic (PGx) testing can improve cardiovascular outcomes and potentially reduce healthcare costs in patients on a P2Y12-inhibitor regime with prasugrel or ticagrelor. However, ubiquitous adoption-particularly in an outpatient setting-remains limited. We conducted a proof-of-concept study to evaluate the feasibility of CYP2C19-guided de-escalation of prasugrel/ticagrelor to clopidogrel through point-of-care (POC) PGx testing in the communit... Abstract

Cited 1 times since 2023 (0.5 per year) source: EuropePMC

The International journal of angiology : official publication of the International College of Angiology, Inc, Volume 33, Issue 3, 25 4 2023, Pages 148-155 Validity of Routinely Reported Rutherford Scores Reported by Clinicians as Part of Daily Clinical Practice. van der Heijden LLM, Marang-van de Mheen PJ, Thielman L, Stijnen P, Hamming JF, Fourneau I

Routinely reported structured data from the electronic health record (EHR) are frequently used for secondary purposes. However, it is unknown how valid routinely reported data are for reuse. This study aimed to assess the validity of routinely reported Rutherford scores by clinicians as an indicator for the validity of structured data in the EHR. This observational study compared clinician-reported Rutherford scores with medical record review Rutherford scores for all visits at the vascular surg... Abstract

Cited 1 times since 2023 (0.5 per year) source: EuropePMC

Nutrition, metabolism, and cardiovascular diseases : NMCD, Volume 33, Issue 5, 23 4 2023, Pages 1077-1086 The association between leptin and subclinical cardiovascular disease explained by body fat: Observational and Mendelian randomization analyses. Christen T, de Mutsert R, Smit RA, Willems van Dijk K, Lamb HJ, Rosendaal FR, Jukema JW, Trompet S

Background and aims: Leptin has been associated with adverse effects on cardiovascular disease, but the effect of confounding by body fat in these associations remains unclear. To investigate associations between leptin and heart function and subclinical cardiovascular disease adjusted for total body fat, and to investigate the causal relation between leptin and cardiovascular disease using Mendelian randomisation. Methods and results: Leptin concentrations, total body fat and diverse measures o... Abstract

Cited 1 times since 2023 (0.5 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 109, Issue 6, 23 4 2023, Pages 478-484 Prognostic impact of left ventricular global longitudinal strain in atrial mitral regurgitation. Meucci MC, Stassen J, Tomsic A, Palmen M, Crea F, Bax JJ, Ajmone Marsan N, Delgado V

Objective: Left atrial (LA) and left ventricular (LV) mechanics are impaired in patients with atrial functional mitral regurgitation (AFMR), but their prognostic value in this subset of patients remains unknown. The present study aimed to evaluate the association between LA and LV longitudinal strain and clinical outcomes in patients with AFMR. Methods: A total of 197 patients (mean age 73±10 years, 44% men) with at least moderate AFMR were retrospectively identified. LV global longitudinal stra... Abstract

Cited 1 times since 2023 (0.5 per year) source: EuropePMC

Magma (New York, N.Y.), Volume 36, Issue 5, 23 4 2023, Pages 701-709 A comparison of myocardial magnetic resonance extracellular volume mapping at 3 T against histology of tissue collagen in severe aortic valve stenosis and obstructive hypertrophic cardiomyopathy. Bakermans AJ, Kouwenhoven M, de Vos J, de Vries DK, Reckman YJ, Farag ES, Koolbergen DR, Kluin J, Nederveen AJ, Strijkers GJ, Boekholdt SM

Objective: Quantitative extracellular volume fraction (ECV) mapping with MRI is commonly used to investigate in vivo diffuse myocardial fibrosis. This study aimed to validate ECV measurements against ex vivo histology of myocardial tissue samples from patients with aortic valve stenosis or hypertrophic cardiomyopathy. Materials and methods: Sixteen patients underwent MRI examination at 3 T to acquire native T1 maps and post-contrast T1 maps after gadobutrol administration, from which hematocrit-... Abstract

Cited 3 times since 2023 (1.5 per year) source: EuropePMC

American heart journal plus : cardiology research and practice, Volume 27, 23 4 2023, Pages 100280 Coronary calcium score in COVID-19 survivors: Association with cardiac injury and cardiac function after 6 weeks. Groen RA, de Graaf MA, Stöger JL, van Dijkman PRM, Jukema JW, Schalij MJ, Geelhoed JJM, Antoni ML

Aims: Cardiac manifestations are common in COVID-19, often elevated serum troponin levels or myocardial dysfunction on trans-thoracic echocardiography (TTE) is observed. Both parameters are associated with increased in-hospital mortality. Possibly, subclinical coronary atherosclerosis plays a role, of which severity can be assessed by calculating the coronary artery calcium (CAC) score. This study aims to determine the relation between coronary atherosclerosis and cardiac manifestations in COVID... Abstract

Cited 7 times since 2023 (3.5 per year) source: EuropePMC

JACC. Clinical electrophysiology, Volume 9, Issue 5, 22 4 2023, Pages 715-728 Management of Ventricular Arrhythmias Worldwide: Comparison of the Latest ESC, AHA/ACC/HRS, and CCS/CHRS Guidelines. Könemann H, Ellermann C, Zeppenfeld K, Eckardt L

A new guideline for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death has been published by the European Society of Cardiology (ESC). Beside the 2017 American Heart Association/American College of Cardiology/Heart Rhythm Society (AHA/ACC/HRS) guideline and the 2020 Canadian Cardiovascular Society/Canadian Heart Rhythm Society (CCS/CHRS) position statement, this guideline provides evidence-based recommendations for clinical practice. As these recom... Abstract

Cited 4 times since 2023 (2 per year) source: EuropePMC

JACC. CardioOncology, Volume 5, Issue 1, 21 3 2023, Pages 117-127 Impact of Age at Diagnosis on Cardiotoxicity in High-Grade Osteosarcoma and Ewing Sarcoma Patients. Heemelaar JC, Speetjens FM, Al Jaff AAM, Evenhuis RE, Polomski EAS, Mertens BJA, Jukema JW, Gelderblom H, van de Sande MAJ, Antoni ML

Background: Osteosarcoma and Ewing sarcoma patients face a significant risk of cardiotoxicity as defined by left ventricular dysfunction and heart failure (HF). Objectives: This study sought to evaluate the association between age at sarcoma diagnosis and incident HF. Methods: A retrospective cohort study was performed at the largest sarcoma center in the Netherlands among patients with an osteosarcoma or Ewing sarcoma. All patients were diagnosed and treated over a 36-year period (1982-2018) an... Abstract

Journal of cardiovascular development and disease, Volume 10, Issue 2, 20 3 2023, Pages 89 Intra-Individual Comparison of Sinus and Ectopic Beats Probing the Ventricular Gradient's Activation Dependence. Schoonderwoerd RM, Dik M, Man S, Maan AC, Jukema JW, Swenne CA

Wilson assumed that the ventricular gradient (VG) is independent of the ventricular activation order. This paradigm has often been refuted and was never convincingly corroborated. We sought to validate Wilson's concept by intra-individual comparison of the VG of sinus beats and ectopic beats, thus assessing the effects of both altered ventricular conduction (caused by the ectopic focus) and restitution (caused by ectopic prematurity). We studied standard diagnostic ECGs of 118 patients with... Abstract

Cited 1 times since 2023 (0.5 per year) source: EuropePMC

JAAD international, Volume 11, 18 3 2023, Pages 137-139 Propranolol or atenolol for the management of infantile hemangioma: Implications for long-term health. Hermans MM, Pasmans SGMA, de Laat PCJ, Slieker MG, Mendels EJ, de Graaf M, Langeveld HR, Schappin R, Rietman AB, Breugem CC, Breur JMPJ, de Wildt SN, Raphael MF

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Cited 1 times since 2023 (0.5 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 116, Issue 6, 18 3 2023, Pages 1161-1167 Influenza Season and Outcome After Elective Cardiac Surgery: An Observational Cohort Study. Swets MC, Termorshuizen F, de Keizer NF, van Paassen J, Palmen M, Visser LG, Arbous MS, Groeneveld GH

Background: An asymptomatic respiratory viral infection during cardiac surgery could lead to pulmonary complications and increased mortality. For elective surgery, testing for respiratory viral infection before surgery or vaccination could reduce the number of these pulmonary complications. The aim of this study was to investigate the association between influenzalike illness (ILI) seasons and prolonged mechanical ventilation and inhospital mortality in a Dutch cohort of adult elective cardiac s... Abstract

Cited 2 times since 2023 (1 per year) source: EuropePMC

Prenatal diagnosis, Volume 43, Issue 5, 17 3 2023, Pages 629-638 Short-term outcome after the prenatal diagnosis of right aortic arch. Bet BB, Snoep MC, van Leeuwen E, Linskens IH, Haak MC, Rozendaal L, Knobbe I, van Schuppen J, Hoekstra CEL, Koolbergen DR, Clur SA, Pajkrt E

Objectives: To determine the proportion of children that require surgery in the first year of life and thereafter in order to improve the counseling of parents with a fetus with a right aortic arch (RAA). Methods: Fetuses diagnosed with isolated RAA, defined as the absence of intra- or extracardiac anomalies, between 2007 and 2021 were extracted from the prospective registry PRECOR. Results: In total, 110 fetuses were included, 92 with a prenatal diagnosis of RAA and 18 with double aortic arch (... Abstract

Cited 2 times since 2023 (1 per year) source: EuropePMC

Clinical cardiology, Volume 46, Issue 4, 17 3 2023, Pages 407-415 Addressing current challenges in optimization of lipid management following an ACS event: Outcomes of the ACS EuroPath III initiative. Catapano AL, De Caterina R, Jukema JW, Klempfner R, Landmesser U, Schiele F, Sionis A

Background: Low-density lipoprotein cholesterol (LDL-C) lowering is key to reduce atherosclerotic disease progression and recurrent events for patients after acute coronary syndrome (ACS). However, LDL-C management for post-ACS patients remains challenging in clinical practice. Hypothesis: The ACS EuroPath III project was designed to optimize LDL-C management in post-ACS patients by promoting guideline implementation and translating existing evidence into effective actions. Methods: Three survey... Abstract

Annals of medicine and surgery (2012), Volume 85, Issue 2, 17 3 2023, Pages 130-135 Evaluation of the coexistence of pilonidal sinus disease and hirsutism in female patients: a retrospective cross-sectional study. Akbulut S, Caliskan A, Yilmaz D, Atay A, Garzali IU, Yagmur Y

This study aimed to investigate the coexistence of pilonidal sinus disease (PSD) and hirsutism in female patients. Materials and methods: The demographic and clinical data of 164 female patients who underwent surgery for PSD between January 2007 and May 2014 were evaluated for this retrospective cross-sectional study. Data collected for this study were age, BMI, the modified Ferriman and Gallwey scale (mFGS) for hirsutism, main symptoms, type of surgery, early postoperative complications (wound... Abstract

Cited 6 times since 2023 (3 per year) source: EuropePMC

Acta dermato-venereologica, Volume 103, 16 3 2023, Pages adv00872 Effectiveness of Upadacitinib in Patients with Atopic Dermatitis including those with Inadequate Response to Dupilumab and/or Baricitinib: Results from the BioDay Registry. Boesjes CM, Van der Gang LF, Zuithoff NPA, Bakker DS, Spekhorst LS, Haeck I, Kamsteeg M, De Graaf M, De Bruin-Weller MS

Clinical trials showed that upadacitinib, a selective Janus kinase-1 inhibitor, is effective for treatment of moderate-to-severe atopic dermatitis. However, daily practice studies are limited. This multicentre prospective study evaluated the effectiveness of 16 weeks of upadacitinib treatment for moderate-to-severe atopic dermatitis in adult patients, including those with previous inadequate response to dupilumab and/or baricitinib, in daily practice. A total of 47 patients from the Dutch BioDay... Abstract

Cited 5 times since 2023 (2.5 per year) source: EuropePMC

The Science of the total environment, Volume 873, 14 2 2023, Pages 162209 Rise and fall of SARS-CoV-2 variants in Rotterdam: Comparison of wastewater and clinical surveillance. Izquierdo-Lara RW, Heijnen L, Oude Munnink BB, Schapendonk CME, Elsinga G, Langeveld J, Post J, Prasad DK, Carrizosa C, Been F, van Beek J, Schilperoort R, Vriend R, Fanoy E, de Schepper EIT, Sikkema RS, Molenkamp R, Aarestrup FM, Medema G, Koopmans MPG, de Graaf M

Monitoring of SARS-CoV-2 in wastewater (WW) is a promising tool for epidemiological surveillance, correlating not only viral RNA levels with the infection dynamics within the population, but also to viral diversity. However, the complex mixture of viral lineages in WW samples makes tracking of specific variants or lineages circulating in the population a challenging task. We sequenced sewage samples of 9 WW-catchment areas within the city of Rotterdam, used specific signature mutations from indi... Abstract

Cited 1 times since 2023 (0.5 per year) source: EuropePMC

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Volume 53, Issue 5, 13 2 2023, Pages 582-585 Muscle and joint pain during dupilumab treatment for atopic dermatitis: Lack of association with antinuclear antibodies. Boesjes CM, van Emst M, Bakker DS, Spekhorst LS, van Wijk F, de Graaf M, de Bruin-Weller MS

Abstract