Research

Publications

Below you can find a list of our published research.

9618 results

Cited 11 times since 2011 (0.8 per year) source: EuropePMC

Journal of immunology (Baltimore, Md. : 1950), Volume 186, Issue 9, 18 3 2011, Pages 5236-5243 Anthrax lethal factor activates K(+) channels to induce IL-1β secretion in macrophages. Thomas J, Epshtein Y, Chopra A, Ordog B, Ghassemi M, Christman JW, Nattel S, Cook JL, Levitan I

Anthrax lethal toxin (LeTx) is a virulence factor of Bacilillus anthracis that is a bivalent toxin, containing lethal factor (LF) and protective Ag proteins, which causes cytotoxicity and altered macrophage function. LeTx exposure results in early K(+) efflux from macrophages associated with caspase-1 activation and increased IL-1β release. The mechanism of this toxin-induced K(+) efflux is unknown. The goals of the current study were to determine whether LeTx-induced K(+) efflux from macrophage... Abstract

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 17 3 2011 WITHDRAWN: Predictors of long-term survival in pulmonary hypertension treated with bosentan. Bresser P, Vis JC, Berger RM, Vliegen HW, Vonk MC, Snijder RJ, van den Toorn LM, van Dijk AP, Boomars KA, van Daal GJ, Mulder BJ

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at (http://www.elsevier.com/locate/withdrawalpolicy. Abstract

Cited 294 times since 2011 (20.4 per year) source: EuropePMC

The Journal of urology, Volume 185, Issue 5, 17 3 2011, Pages 1650-1655 A multicenter study of [-2]pro-prostate specific antigen combined with prostate specific antigen and free prostate specific antigen for prostate cancer detection in the 2.0 to 10.0 ng/ml prostate specific antigen range. Catalona WJ, Partin AW, Sanda MG, Wei JT, Klee GG, Bangma CH, Slawin KM, Marks LS, Loeb S, Broyles DL, Shin SS, Cruz AB, Chan DW, Sokoll LJ, Roberts WL, van Schaik RH, Mizrahi IA

Purpose: Prostate specific antigen and free prostate specific antigen have limited specificity to detect clinically significant, curable prostate cancer, leading to unnecessary biopsy, and detection and treatment of some indolent tumors. Specificity to detect clinically significant prostate cancer may be improved by [-2]pro-prostate specific antigen. We evaluated [-2]pro-prostate specific antigen, free prostate specific antigen and prostate specific antigen using the formula, ([-2]pro-prostate s... Abstract

Cited 96 times since 2011 (6.7 per year) source: EuropePMC

BMJ (Clinical research ed.), Volume 342, 16 3 2011, Pages d1250 Effect of statins on atrial fibrillation: collaborative meta-analysis of published and unpublished evidence from randomised controlled trials. Rahimi K, Emberson J, McGale P, Majoni W, Merhi A, Asselbergs FW, Krane V, Macfarlane PW, PROSPER Executive

Objective: To examine whether statins can reduce the risk of atrial fibrillation. Design: Meta-analysis of published and unpublished results from larger scale statin trials, with comparison of the findings against the published results from smaller scale or shorter duration studies. Data sources: Medline, Embase, and Cochrane's CENTRAL up to October 2010. Unpublished data from longer term trials were obtained through contact with investigators. Study selection: Randomised controlled trials... Abstract

Cited 636 times since 2011 (44.1 per year) source: EuropePMC

Clinical pharmacology and therapeutics, Volume 89, Issue 5, 16 3 2011, Pages 662-673 Pharmacogenetics: from bench to byte--an update of guidelines. Swen JJ, Nijenhuis M, de Boer A, Grandia L, Maitland-van der Zee AH, Mulder H, Rongen GA, van Schaik RH, Schalekamp T, Touw DJ, van der Weide J, Wilffert B, Deneer VH, Guchelaar HJ

Currently, there are very few guidelines linking the results of pharmacogenetic tests to specific therapeutic recommendations. Therefore, the Royal Dutch Association for the Advancement of Pharmacy established the Pharmacogenetics Working Group with the objective of developing pharmacogenetics-based therapeutic (dose) recommendations. After systematic review of the literature, recommendations were developed for 53 drugs associated with genes coding for CYP2D6, CYP2C19, CYP2C9, thiopurine-S-methy... Abstract

Cited 36 times since 2011 (2.5 per year) source: EuropePMC

Journal of neurology, Volume 258, Issue 8, 12 2 2011, Pages 1507-1512 Addition of serum-containing medium to cerebrospinal fluid prevents cellular loss over time. de Graaf MT, van den Broek PD, Kraan J, Luitwieler RL, van den Bent MJ, Boonstra JG, Schmitz PI, Gratama JW, Sillevis Smitt PA

Immediately after sampling, leukocyte counts in native cerebrospinal fluid (CSF) start to decrease rapidly. As the time lapse between CSF collection to analysis is not routinely registered, the clinical significance of decreasing cell counts in native CSF is not known. Earlier data suggest that addition of serum-containing medium to CSF directly after sampling prevents this rapid decrease in leukocyte counts and, thus, may improve the accuracy of CSF cell counting and cell characterization. Here... Abstract

Cited 13 times since 2011 (0.9 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 142, Issue 3, 12 2 2011, Pages e93-100 Cardiac support device, restrictive mitral valve annuloplasty, and optimized medical treatment: a multimodality approach to nonischemic cardiomyopathy. Braun J, Ciarka A, Versteegh MI, Delgado V, Boersma E, Verwey HF, Schalij MJ, Bax JJ, Dion RA, van de Veire NR, Klautz RJ

Objective: Nonischemic dilated cardiomyopathy with functional mitral regurgitation carries a poor prognosis. Mitral valve surgery with implantation of a cardiac support device can treat mitral regurgitation and promote left ventricular reverse remodeling. This observational study evaluates clinical and echocardiographic outcomes of an individualized medico-surgical approach, focusing on mitral regurgitation recurrence and left ventricular reverse remodeling. Methods: Sixty-nine consecutive patie... Abstract

Cited 145 times since 2011 (10 per year) source: EuropePMC

Circulation research, Volume 108, Issue 9, 10 2 2011, Pages 1093-1101 Lack of primary cilia primes shear-induced endothelial-to-mesenchymal transition. Egorova AD, Khedoe PP, Goumans MJ, Yoder BK, Nauli SM, ten Dijke P, Poelmann RE, Hierck BP

Rationale: Primary cilia are cellular protrusions that serve as mechanosensors for fluid flow. In endothelial cells (ECs), they function by transducing local blood flow information into functional responses, such as nitric oxide production and initiation of gene expression. Cilia are present on ECs in areas of low or disturbed flow and absent in areas of high flow. In the embryonic heart, high-flow regime applies to the endocardial cushion area, and the absence of cilia here coincides with the p... Abstract

Cited 13 times since 2011 (0.9 per year) source: Scopus

Logopedics, phoniatrics, vocology, Volume 36, Issue 4, 8 2 2011, Pages 139-144 Informing and supporting partners and children of persons with aphasia: a comparison of supply and demand. Manders E, Mariën A, Janssen V

In this study we investigated how important significant others find it to be informed, supported, and trained by speech-language pathologists (SLPs) and to what extent they perceive their expectations and needs as to these aspects to be fulfilled. Furthermore SLPs were asked about the importance of informing and supporting family members and as to how far they believe they provide adequate care in that field. A questionnaire was completed by 77 relatives of persons with aphasia, a parallel versi... Abstract

Cited 1382 times since 2011 (95.6 per year) source: EuropePMC

Nature genetics, Volume 43, Issue 4, 6 1 2011, Pages 333-338 Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AF, Barbalic M, Gieger C, Absher D, Aherrahrou Z, Allayee H, Altshuler D, Anand SS, Andersen K, Anderson JL, Ardissino D, Ball SG, Balmforth AJ, Barnes TA, Becker DM, Becker LC, Berger K, Bis JC, Boekholdt SM, Boerwinkle E, Braund PS, Brown MJ, Burnett MS, Buysschaert I, Cardiogenics, Carlquist JF, Chen L, Cichon S, Codd V, Davies RW, Dedoussis G, Dehghan A, Demissie S, Devaney JM, Diemert P, Do R, Doering A, Eifert S, Mokhtari NE, Ellis SG, Elosua R, Engert JC, Epstein SE, de Faire U, Fischer M, Folsom AR, Freyer J, Gigante B, Girelli D, Gretarsdottir S, Gudnason V, Gulcher JR, Halperin E, Hammond N, Hazen SL, Hofman A, Horne BD, Illig T, Iribarren C, Jones GT, Jukema JW, Kaiser MA, Kaplan LM, Kastelein JJ, Khaw KT, Knowles JW, Kolovou G, Kong A, Laaksonen R, Lambrechts D, Leander K, Lettre G, Li M, Lieb W, Loley C, Lotery AJ, Mannucci PM, Maouche S, Martinelli N, McKeown PP, Meisinger C, Meitinger T, Melander O, Merlini PA

We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 × 10⁻⁸ and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and we... Abstract

Cited 25 times since 2011 (1.7 per year) source: EuropePMC

Journal of bacteriology, Volume 193, Issue 9, 4 1 2011, Pages 2371-2372 Genome sequence of Neisseria meningitidis serogroup B strain H44/76. Piet JR, Huis in 't Veld RA, van Schaik BD, van Kampen AH, Baas F, van de Beek D, Pannekoek Y, van der Ende A

Neisseria meningitidis is an obligate human pathogen. While it is a frequent commensal of the upper respiratory tract, in some individuals the bacterium spreads to the bloodstream, causing meningitis and/or sepsis, which are serious conditions with high morbidity and mortality. Here we report the availability of the genome sequence of the widely used serogroup B laboratory strain H44/76. Abstract

Cited 320 times since 2011 (22.1 per year) source: EuropePMC

European heart journal, Volume 32, Issue 11, 2 1 2011, Pages 1316-1330 A clinical prediction rule for the diagnosis of coronary artery disease: validation, updating, and extension. Genders TS, Steyerberg EW, Alkadhi H, Leschka S, Desbiolles L, Nieman K, Galema TW, Meijboom WB, Mollet NR, de Feyter PJ, Cademartiri F, Maffei E, Dewey M, Zimmermann E, Laule M, Pugliese F, Barbagallo R, Sinitsyn V, Bogaert J, Goetschalckx K, Schoepf UJ, Rowe GW, Schuijf JD, Bax JJ, de Graaf FR, Knuuti J, Kajander S, van Mieghem CA, Meijs MF, Cramer MJ, Gopalan D, Feuchtner G, Friedrich G, Krestin GP, Hunink MG, CAD Consortium

Aims: The aim was to validate, update, and extend the Diamond-Forrester model for estimating the probability of obstructive coronary artery disease (CAD) in a contemporary cohort. Methods and results: Prospectively collected data from 14 hospitals on patients with chest pain without a history of CAD and referred for conventional coronary angiography (CCA) were used. Primary outcome was obstructive CAD, defined as ≥ 50% stenosis in one or more vessels on CCA. The validity of the Diamond-Forrester... Abstract

Cited 51 times since 2011 (3.5 per year) source: EuropePMC

International journal of geriatric psychiatry, Volume 26, Issue 3, 1 1 2011, Pages 239-246 The center for epidemiological studies depression scale (CES-D) is an adequate screening instrument for depressive and anxiety disorders in a very old population living in residential homes. Dozeman E, van Schaik DJ, van Marwijk HW, Stek ML, van der Horst HE, Beekman AT

Objective: The CES-D is an instrument that is commonly used to screen for depression in community-based studies of the elderly, but the characteristics of the CES-D in a residential home population have not yet been studied. The aim of this study was to investigate the criterion validity and the predictive power of the CES-D for both depressive and anxiety disorders in a vulnerable, very old population living in residential homes. Methods: Two hundred seventy seven residents were screened with t... Abstract

Cited 51 times since 2011 (3.5 per year) source: EuropePMC

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, Volume 17, Issue 1, 1 1 2011, Pages 36-48 Y-stent-assisted coil embolization of wide-neck intracranial aneurysms. A single center experience. Akgul E, Aksungur E, Balli T, Onan B, Yilmaz DM, Bicakci S, Erman T

This report evaluated the short and midterm results of the safety and effectiveness of the treatment technique with hybrid and non-hybrid Y-configured, dual stent-assisted coil embolization of wide-neck intracranial aneurysms, and reviewed the literature concerning this technique. Nine patients, eight with unruptured and one with ruptured aneurysms were included in the study. Of aneurysms embolized with a hybrid (with two different stents) and non-hybrid (with two identical stents) technique, th... Abstract

Cited 13 times since 2011 (0.9 per year) source: EuropePMC

International journal of cardiology, Volume 149, Issue 2, 1 1 2011, Pages 246-247 Wanted! 8000 heart patients: identification of adult patients with a congenital heart defect lost to follow-up. Vis JC, van der Velde ET, Schuuring MJ, Engelfriet-Rijk LCJM, Harms IM, Mantels S, Bouma BJ, Mulder BJM

Abstract

Cited 44 times since 2011 (3 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 91, Issue 3, 1 1 2011, Pages 716-723 Automated assessment of the aortic root dimensions with multidetector row computed tomography. Delgado V, Ng AC, Schuijf JD, van der Kley F, Shanks M, Tops LF, van de Veire NR, de Roos A, Kroft LJ, Schalij MJ, Bax JJ

Background: Accurate aortic root measurements and evaluation of spatial relationships with coronary ostia are crucial in preoperative transcatheter aortic valve implantation assessments. Standardization of measurements may increase intraobserver and interobserver reproducibility to promote procedural success rate and reduce the frequency of procedurally related complications. This study evaluated the accuracy and reproducibility of a novel automated multidetector row computed tomography (MDCT) i... Abstract

Cited 5 times since 2011 (0.3 per year) source: EuropePMC

Future cardiology, Volume 7, Issue 2, 1 1 2011, Pages 227-240 Treatment of congenital heart disease: risk-reducing measures in young adults. van der Bom T, Luijendijk P, Bouma BJ, Koolbergen DR, de Groot JR, Mulder BJ

Adults with congenital heart disease form a new and relatively young population, since surgical treatment of heart defects became available three to four decades ago. Owing to improved survival this population is steadily growing in number and age. Little is known regarding long-term survival; however, late complications occur frequently. During adulthood, almost half of the patients have one or more complication, such as endocarditis, stroke, systemic or pulmonary hypertension, aortic aneurysm... Abstract

Cited 163 times since 2011 (11.3 per year) source: EuropePMC

Annals of surgical oncology, Volume 18, Issue 9, 1 1 2011, Pages 2483-2491 Toward optimization of imaging system and lymphatic tracer for near-infrared fluorescent sentinel lymph node mapping in breast cancer. Mieog JS, Troyan SL, Hutteman M, Donohoe KJ, van der Vorst JR, Stockdale A, Liefers GJ, Choi HS, Gibbs-Strauss SL, Putter H, Gioux S, Kuppen PJ, Ashitate Y, Löwik CW, Smit VT, Oketokoun R, Ngo LH, van de Velde CJ, Frangioni JV, Vahrmeijer AL

Background: Near-infrared (NIR) fluorescent sentinel lymph node (SLN) mapping in breast cancer requires optimized imaging systems and lymphatic tracers. Materials and methods: A small, portable version of the FLARE imaging system, termed Mini-FLARE, was developed for capturing color video and two semi-independent channels of NIR fluorescence (700 and 800 nm) in real time. Initial optimization of lymphatic tracer dose was performed using 35-kg Yorkshire pigs and a 6-patient pilot clinical trial.... Abstract

Cited 104 times since 2011 (7.2 per year) source: EuropePMC

Breast cancer research and treatment, Volume 127, Issue 1, 1 1 2011, Pages 163-170 Randomized, double-blind comparison of indocyanine green with or without albumin premixing for near-infrared fluorescence imaging of sentinel lymph nodes in breast cancer patients. Hutteman M, Mieog JS, van der Vorst JR, Liefers GJ, Putter H, Löwik CW, Frangioni JV, van de Velde CJ, Vahrmeijer AL

Near-infrared (NIR) fluorescence imaging has the potential to improve sentinel lymph node (SLN) mapping in breast cancer. Indocyanine green (ICG) is currently the only clinically available fluorophore that can be used for SLN mapping. Preclinically, ICG adsorbed to human serum albumin (ICG:HSA) improves its performance as a lymphatic tracer in some anatomical sites. The benefit of ICG:HSA for SLN mapping of breast cancer has not yet been assessed in a clinical trial. We performed a double-blind,... Abstract

Cited 6 times since 2011 (0.4 per year) source: EuropePMC

Acta chirurgica Belgica, Volume 111, Issue 2, 1 1 2011, Pages 78-82 Outcome of patients with ruptured abdominal aortic aneurysm after cardiopulmonary resuscitation. Greeven AP, Bouwman LH, Smeets HJ, van Baalen JM, Hamming JF

Purpose: Ruptured aneurysm of the abdominal aorta (RAAA) is a condition associated with high mortality rate. If Cardiopulmonary Resuscitation (CPR) is required, outcome is considered even worse. The aim of this study was to assess the effect of CPR on 30-day mortality of RAAA patients. Furthermore the Hardman index was evaluated. Methods: 109 patients with RAAA during a 5 year period (2001-2005) were analysed retrospectively. 30-day mortality, the presence of CPR and Hardman risk factors were re... Abstract