9618 results
Cited 46 times since 2010 (3.1 per year)
source: EuropePMC
Proceedings of the National Academy of Sciences of the United States of America,
Volume 107, Issue 50, 22 4 2010, Pages 21376-21381
Effects of Pleistocene glaciations and rivers on the population structure of Bornean orangutans (Pongo pygmaeus).
Arora N, Nater A, van Schaik CP, Willems EP, van Noordwijk MA, Goossens B, Morf N, Bastian M, Knott C, Morrogh-Bernard H, Kuze N, Kanamori T, Pamungkas J, Perwitasari-Farajallah D, Verschoor E, Warren K, Krützen M
Sundaland, a tropical hotspot of biodiversity comprising Borneo and Sumatra among other islands, the Malay Peninsula, and a shallow sea, has been subject to dramatic environmental processes. Thus, it presents an ideal opportunity to investigate the role of environmental mechanisms in shaping species distribution and diversity. We investigated the population structure and underlying mechanisms of an insular endemic, the Bornean orangutan (Pongo pygmaeus). Phylogenetic reconstructions based on mtD...
Abstract
Cited 45 times since 2010 (3 per year)
source: EuropePMC
Annals of surgical oncology,
Volume 18, Issue 4, 16 3 2010, Pages 1006-1014
Clinical translation of ex vivo sentinel lymph node mapping for colorectal cancer using invisible near-infrared fluorescence light.
Hutteman M, Choi HS, Mieog JS, van der Vorst JR, Ashitate Y, Kuppen PJ, van Groningen MC, Löwik CW, Smit VT, van de Velde CJ, Frangioni JV, Vahrmeijer AL
Background: Sentinel lymph node (SLN) mapping in colorectal cancer may have prognostic and therapeutic significance; however, currently available techniques are not optimal. We hypothesized that the combination of invisible near-infrared (NIR) fluorescent light and ex vivo injection could solve remaining problems of SLN mapping in colorectal cancer. Methods: The FLARE imaging system was used for real-time identification of SLNs after injection of the NIR lymphatic tracer HSA800 in the colon and...
Abstract
Cited 1063 times since 2010 (72 per year)
source: EuropePMC
The New England journal of medicine,
Volume 363, Issue 25, 14 2 2010, Pages 2385-2395
Cardiac-resynchronization therapy for mild-to-moderate heart failure.
Tang AS, Wells GA, Talajic M, Arnold MO, Sheldon R, Connolly S, Hohnloser SH, Nichol G, Birnie DH, Sapp JL, Yee R, Healey JS, Rouleau JL, Resynchronization-Defibrillation for Ambulatory Heart Failure Trial Investigators
Background: Cardiac-resynchronization therapy (CRT) benefits patients with left ventricular systolic dysfunction and a wide QRS complex. Most of these patients are candidates for an implantable cardioverter-defibrillator (ICD). We evaluated whether adding CRT to an ICD and optimal medical therapy might reduce mortality and morbidity among such patients. Methods: We randomly assigned patients with New York Heart Association (NYHA) class II or III heart failure, a left ventricular ejection fractio...
Abstract
Cited 34 times since 2010 (2.3 per year)
source: EuropePMC
Atherosclerosis,
Volume 214, Issue 2, 13 2 2010, Pages 295-300
Atorvastatin inhibits plaque development and adventitial neovascularization in ApoE deficient mice independent of plasma cholesterol levels.
Bot I, Jukema JW, Lankhuizen IM, van Berkel TJ, Biessen EA
Excessive adventitial neovascularization is one of the hallmarks of atherosclerotic plaque progression and is associated with an increased plaque burden by facilitating leukocyte influx and perivascular inflammation. Statins act atheroprotective by reducing plasma cholesterol levels and by quenching inflammation, but recent studies suggest that they may also affect neovascularization. In this study, we aimed to investigate this notion in apoE(-/-) mice. Advanced carotid artery lesions were induc...
Abstract
Cited 447 times since 2010 (30.3 per year)
source: EuropePMC
Circulation. Heart failure,
Volume 4, Issue 1, 12 2 2010, Pages 44-52
Cardiac inflammation contributes to changes in the extracellular matrix in patients with heart failure and normal ejection fraction.
Westermann D, Lindner D, Kasner M, Zietsch C, Savvatis K, Escher F, von Schlippenbach J, Skurk C, Steendijk P, Riad A, Poller W, Schultheiss HP, Tschöpe C
Background: The pathophysiology of heart failure with normal ejection fraction (HFNEF) is still under discussion. Here we report the influence of cardiac inflammation on extracellular matrix (ECM) remodeling in patients with HFNEF. Methods and results: We investigated left ventricular systolic and diastolic function in 20 patients with HFNEF and 8 control patients by conductance catheter methods and echocardiography. Endomyocardial biopsy samples were also obtained, and ECM proteins as well as c...
Abstract
Cited 21 times since 2010 (1.4 per year)
source: EuropePMC
BMC musculoskeletal disorders,
Volume 11, 12 2 2010, Pages 263
Functional treatment versus plaster for simple elbow dislocations (FuncSiE): a randomized trial.
de Haan J, den Hartog D, Tuinebreijer WE, Iordens GI, Breederveld RS, Bronkhorst MW, Bruijninckx MM, De Vries MR, Dwars BJ, Eygendaal D, Haverlag R, Meylaerts SA, Mulder JW, Ponsen KJ, Roerdink WH, Roukema GR, Schipper IB, Schouten MA, Sintenie JB, Sivro S, Van den Brand JG, Van der Meulen HG, Van Thiel TP, Van Vugt AB, Verleisdonk EJ, Vroemen JP, Waleboer M, Willems WJ, Polinder S, Patka P, van Lieshout EM, Schep NW
Background: Elbow dislocations can be classified as simple or complex. Simple dislocations are characterized by the absence of fractures, while complex dislocations are associated with fractures. After reduction of a simple dislocation, treatment options include immobilization in a static plaster for different periods of time or so-called functional treatment. Functional treatment is characterized by early active motion within the limits of pain with or without the use of a sling or hinged brace...
Abstract
Heart (British Cardiac Society),
Volume 97, Issue 1, 11 2 2010, Pages 1-3
Can cardiac [123I]m-iodobenzylguanidine imaging be used for risk stratification of patients with acute myocardial infarction?
Boogers MJ, Bax JJ
Abstract
Cited 25 times since 2010 (1.7 per year)
source: EuropePMC
Toxicology,
Volume 279, Issue 1-3, 10 2 2010, Pages 167-175
Acute respiratory and systemic toxicity of pulmonary exposure to rutile Fe-doped TiO(2) nanorods.
Nemmar A, Melghit K, Al-Salam S, Zia S, Dhanasekaran S, Attoub S, Al-Amri I, Ali BH
Nanomaterials are extensively used in medicines, industry and daily life, but little is known about their possible health effects. Titanium dioxide (TiO₂) nonmaterial-based photocatalysis is useful in the complete mineralization of organic pollutants in waste water and air. While the Fe-doping of TiO₂ enhances their photocatalytic activity, their potential pathophysiologic effects are unknown. Here, rutile Fe-doped (9%) pure titanium dioxide (TiO₂) nanorods were prepared and characterized. Subse...
Abstract
Cited 13 times since 2010 (0.9 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 97, Issue 2, 8 2 2010, Pages 143-150
Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies.
Pons D, Trompet S, de Craen AJ, Thijssen PE, Quax PH, de Vries MR, Wierda RJ, van den Elsen PJ, Monraats PS, Ewing MM, Heijmans BT, Slagboom PE, Zwinderman AH, Doevendans PA, Tio RA, de Winter RJ, de Maat MP, Iakoubova OA, Sattar N, Shepherd J, Westendorp RG, Jukema JW, PROSPER study group, WOSCOPS study group, GENDER study group
Aims: This study was designed to investigate the counterbalancing influence of genetic variation in the promoter of the gene encoding P300/CBP associated factor (PCAF), a lysine acetyltransferase (KAT), on coronary heart disease (CHD) and mortality. Methods and results: The association of genetic variation in the PCAF-gene with CHD, restenosis and mortality was investigated in three large cohorts. The results were combined to examine overall effects on CHD mortality and on restenosis risk. Compa...
Abstract
Cited 48 times since 2010 (3.2 per year)
source: EuropePMC
Blood cells, molecules & diseases,
Volume 46, Issue 1, 5 1 2010, Pages 39-41
A monozygotic twin pair with highly discordant Gaucher phenotypes.
Biegstraaten M, van Schaik IN, Aerts JM, Langeveld M, Mannens MM, Bour LJ, Sidransky E, Tayebi N, Fitzgibbon E, Hollak CE
We describe monozygotic twin sisters, born to consanguineous Moroccan parents, who are highly discordant for the manifestations of Gaucher disease. Both carry Gaucher genotype N188S/N188S. One has severe visceral involvement, epilepsy, and a cerebellar syndrome. Her twin does not manifest any symptoms or signs of Gaucher disease but suffers from type 1 diabetes mellitus. The concurrence of a mild Gaucher mutation with a severe phenotype, as well as the occurrence of highly discordant phenotypes...
Abstract
Cited 30 times since 2010 (2 per year)
source: EuropePMC
The American journal of cardiology,
Volume 106, Issue 12, 4 1 2010, Pages 1675-1679
Impact of clinical presentation and pretest likelihood on the relation between calcium score and computed tomographic coronary angiography.
van Werkhoven JM, de Boer SM, Schuijf JD, Cademartiri F, Maffei E, Jukema JW, Boogers MJ, Kroft LJ, de Roos A, Bax JJ
The purpose of the present study was to assess the impact of clinical presentation and pretest likelihood on the relation between coronary calcium score (CCS) and computed tomographic coronary angiography (CTA) to determine the role of CCS as a gatekeeper to CTA in patients presenting with chest pain. In 576 patients with suspected coronary artery disease (CAD), CCS and CTA were performed. CCS was categorized as 0, 1 to 400, and >400. On CT angiogram the presence of significant CAD (≥50% lumi...
Abstract
Cited 14 times since 2010 (0.9 per year)
source: EuropePMC
European journal of cancer (Oxford, England : 1990),
Volume 46, Issue 17, 1 1 2010, Pages 3109-3119
On the use of prostate-specific antigen for screening of prostate cancer in European Randomised Study for Screening of Prostate Cancer.
Bangma CH, van Schaik RH, Blijenberg BG, Roobol MJ, Lilja H, Stenman UH
Prostate-specific antigen (PSA) has been the main drive for early detection of prostate cancer (PCa), including in population-based screening as in the European Randomised Study for Screening of Prostate Cancer (ERSPC). The specificity of PSA to indicate men with biopsy detectable prostate cancer can be improved by adding information obtained by new biomarkers, such as PSA isoforms. This improvement is needed to increase the efficacy of the screening procedure for the population-based as well as...
Abstract
Cited 30 times since 2010 (2 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 96, Issue 21, 1 1 2010, Pages 1737-1743
Left ventricular rotational mechanics in patients with coronary artery disease: differences in subendocardial and subepicardial layers.
Bertini M, Delgado V, Nucifora G, Ajmone Marsan N, Ng AC, Shanks M, Antoni ML, van de Veire NR, van Bommel RJ, Rapezzi C, Schalij MJ, Bax JJ
Objective: Subendocardial and subepicardial layers have opposite orientation of the myofibres and they are differently affected by coronary artery disease. This study investigated the differences in subendocardial and subepicardial left ventricular (LV) twist in patients with coronary artery disease. Methods: 214 patients were included in the study: 60 with first ST elevation myocardial infarction (STEMI), 111 with chronic ischaemic heart failure (HF) and 43 normal subjects. Real-time three-dime...
Abstract
Cited 62 times since 2010 (4.2 per year)
source: EuropePMC
Plastic and reconstructive surgery,
Volume 126, Issue 5, 1 1 2010, Pages 1472-1481
The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in perforator flap breast reconstruction.
Lee BT, Hutteman M, Gioux S, Stockdale A, Lin SJ, Ngo LH, Frangioni JV
Background: The ability to determine flap perfusion in reconstructive surgery is still primarily based on clinical examination. In this study, the authors demonstrate the use of an intraoperative, near-infrared fluorescence imaging system for evaluation of perforator location and flap perfusion. Methods: Indocyanine green was injected intravenously in six breast cancer patients undergoing a deep inferior epigastric perforator flap breast reconstruction after mastectomy. Three dose levels of indo...
Abstract
Cited 6 times since 2010 (0.4 per year)
source: EuropePMC
Nature reviews. Cardiology,
Volume 7, Issue 11, 1 1 2010, Pages 604-606
Cardiomyopathies: Myocardial fibrosis assessed by CMR to predict events in HCM.
Ajmone Marsan N, Bax JJ
Abstract
Cited 34 times since 2010 (2.3 per year)
source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology,
Volume 6, Issue 5, 1 1 2010, Pages 643-652
Multimodality imaging in transcatheter aortic valve implantation: key steps to assess procedural feasibility.
Delgado V, Ewe SH, Ng AC, van der Kley F, Marsan NA, Schuijf JD, Schalij MJ, Bax JJ
Transcatheter aortic valve implantation (TAVI) has been an important breakthrough in the treatment of patients with symptomatic, severe aortic stenosis and contraindications for surgical aortic valve replacement. Accurate aortic root measurements and evaluation of spatial relationships with the coronary ostia are crucial in pre-operative TAVI assessment. In addition, characterisation of the peripheral artery anatomy and aorta is an important key step in the procedural feasibility evaluation. The...
Abstract
Cited 17 times since 2010 (1.1 per year)
source: EuropePMC
Haemophilia : the official journal of the World Federation of Hemophilia,
Volume 16, Issue 6, 1 1 2010, Pages 888-891
A single centre experience in circumcision of haemophilia patients: Izmir protocol.
Yilmaz D, Akin M, Ay Y, Balkan C, Celik A, Ergün O, Kavakli K
Haemophiliacs and their families consider that circumcision is a very important step to become a member of society and it is a social obligation for men in Turkey. Although bleeding risk is high, almost all haemophiliacs would like to be circumcised in Turkish society. The aim of this study was to evaluate our experience in circumcision of haemophilia patients and define efficacy, safety and complication rates of our protocol, called 'Izmir protocol'. In this study, we retrospectivel...
Abstract
Cited 10 times since 2010 (0.7 per year)
source: EuropePMC
American heart journal,
Volume 160, Issue 5, 1 1 2010, Pages 812-818
Rationale and design of a trial on the effect of angiotensin II receptor blockers on the function of the systemic right ventricle.
van der Bom T, Winter MM, Bouma BJ, Groenink M, Vliegen HW, Pieper PG, van Dijk AP, Sieswerda GT, Roos-Hesslink JW, Zwinderman AH, Mulder BJ
Background: Angiotensin II receptor blockers have been proven to be beneficial in left ventricular failure. In patients with a morphologic right ventricle supporting the systemic circulation, its efficacy has not yet been established. Methods: We designed a multicenter, prospective, randomized, double-blind, placebo-controlled trial studying the effect of valsartan in patients with a systemic right ventricle due to a congenitally or surgically corrected transposition of the great arteries. The p...
Abstract
Cited 32 times since 2010 (2.2 per year)
source: EuropePMC
The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons,
Volume 49, Issue 6, 1 1 2010, Pages 541-545
Chopart joint injury: a study of outcome and morbidity.
van Dorp KB, de Vries MR, van der Elst M, Schepers T
Injuries involving the Chopart joint complex are relatively rare and frequently missed or misdiagnosed, often leading to a poor functional outcome. This study was performed to determine the outcome and morbidity in patients with Chopart joint injuries, and to increase awareness of this severe injury. Patients with a Chopart dislocation or fracture-dislocation, treated between January 2004 and January 2010, were identified using the appropriate diagnosis code and reviewing all radiographs of pati...
Abstract
Cited 20 times since 2010 (1.4 per year)
source: EuropePMC
Journal of cardiovascular electrophysiology,
Volume 21, Issue 11, 1 1 2010, Pages 1284-1292
Electrical activation of sinus venosus myocardium and expression patterns of RhoA and Isl-1 in the chick embryo.
Vicente-Steijn R, Kolditz DP, Mahtab EA, Askar SF, Bax NA, VAN DER Graaf LM, Wisse LJ, Passier R, Pijnappels DA, Schalij MJ, Poelmann RE, Gittenberger-DE Groot AC, Jongbloed MR
Unlabelled: Electrical Activity and RhoA in the Embryo. Introduction: Myocardium at the venous pole (sinus venosus) of the heart has gained clinical interest as arrhythmias can be initiated from this area. During development, sinus venosus myocardium is incorporated to the primary heart tube and expresses different markers than primary myocardium. We aimed to elucidate the development of sinus venosus myocardium, including the sinoatrial node (SAN), by studying expression patterns of RhoA in rel...
Abstract
