9618 results
Cited 37 times since 2010 (2.5 per year)
source: EuropePMC
PloS one,
Volume 5, Issue 10, 19 3 2010, Pages e13482
The population genetics of Pseudomonas aeruginosa isolates from different patient populations exhibits high-level host specificity.
van Mansfeld R, Jongerden I, Bootsma M, Buiting A, Bonten M, Willems R
Objective: To determine whether highly prevalent P. aeruginosa sequence types (ST) in Dutch cystic fibrosis (CF) patients are specifically linked to CF patients we investigated the population structure of P. aeruginosa from different clinical backgrounds. We first selected the optimal genotyping method by comparing pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST) and multilocus variable number tandem-repeat analysis (MLVA). Methods: Selected P. aeruginosa isolates (n =...
Abstract
Cited 72 times since 2010 (4.9 per year)
source: EuropePMC
European journal of nuclear medicine and molecular imaging,
Volume 38, Issue 2, 17 3 2010, Pages 230-238
Optimal left ventricular lead position assessed with phase analysis on gated myocardial perfusion SPECT.
Boogers MJ, Chen J, van Bommel RJ, Borleffs CJ, Dibbets-Schneider P, van der Hiel B, Al Younis I, Schalij MJ, van der Wall EE, Garcia EV, Bax JJ
Purpose: The aim of the current study was to evaluate the relationship between the site of latest mechanical activation as assessed with gated myocardial perfusion SPECT (GMPS), left ventricular (LV) lead position and response to cardiac resynchronization therapy (CRT). Methods: The patient population consisted of consecutive patients with advanced heart failure in whom CRT was currently indicated. Before implantation, 2-D echocardiography and GMPS were performed. The echocardiography was perfor...
Abstract
Cited 22 times since 2010 (1.5 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 27, Issue 6, 16 3 2010, Pages 777-785
Relationship between obstructive coronary artery disease and abnormal stress testing in patients with paroxysmal or persistent atrial fibrillation.
Nucifora G, Schuijf JD, van Werkhoven JM, Trines SA, Kajander S, Tops LF, Turta O, Jukema JW, Schreur JH, Heijenbrok MW, Gaemperli O, Kaufmann PA, Knuuti J, van der Wall EE, Schalij MJ, Bax JJ
Atrial fibrillation (AF) has been linked to the presence of underlying coronary artery disease (CAD). However, whether the higher burden of CAD observed in AF patients translates into higher burden of myocardial ischemia is unknown. In 87 patients (71% male, mean age 61 ± 10 years) with paroxysmal or persistent AF and without history of CAD, MSCT coronary angiography and stress testing (exercise ECG test or myocardial perfusion imaging) were performed. CAD was classified as obstructive (≥50% lum...
Abstract
Cited 77 times since 2010 (5.2 per year)
source: EuropePMC
The EMBO journal,
Volume 29, Issue 23, 15 3 2010, Pages 3967-3978
A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes.
Varier RA, Outchkourov NS, de Graaf P, van Schaik FM, Ensing HJ, Wang F, Higgins JM, Kops GJ, Timmers HT
Histone methylation patterns are correlated with eukaryotic gene transcription. High-affinity binding of the plant homeodomain (PHD) of TFIID subunit TAF3 to trimethylated lysine-4 of histone H3 (H3K4me3) is involved in promoter recruitment of this basal transcription factor. Here, we show that for transcription activation the PHD of TAF3 can be replaced by PHDs of other high-affinity H3K4me3 binders. Interestingly, H3K4me3 binding of TFIID and the TAF3-PHD is decreased by phosphorylation of the...
Abstract
Cited 56 times since 2010 (3.8 per year)
source: EuropePMC
International journal of medical microbiology : IJMM,
Volume 301, Issue 2, 15 3 2010, Pages 165-175
A multiresistance megaplasmid pLG1 bearing a hylEfm genomic island in hospital Enterococcus faecium isolates.
Laverde Gomez JA, van Schaik W, Freitas AR, Coque TM, Weaver KE, Francia MV, Witte W, Werner G
Enterococcus faecium is considered to be a nosocomial pathogen with increasing medical importance. The putative virulence factor, hyl(Efm), encoding a putative hyaluronidase, is enriched among the hospital-associated polyclonal subpopulation of E. faecium.. The hyl(Efm) gene is described to be part of a genomic island and was recently identified to be plasmid-located. Here, we present a description of the structure, localization, and distribution of the putative pathogenicity factor hyl(Efm) and...
Abstract
Cited 40 times since 2010 (2.7 per year)
source: EuropePMC
Environmental microbiology,
Volume 13, Issue 2, 15 3 2010, Pages 518-528
A genetic element present on megaplasmids allows Enterococcus faecium to use raffinose as carbon source.
Zhang X, Vrijenhoek JE, Bonten MJ, Willems RJ, van Schaik W
Enterococcus faecium is a commensal of the gastrointestinal tract of humans and animals. Since the 1990s, it has also emerged as a nosocomial pathogen. Little is known about carbon metabolism of E. faecium even though the ability to utilize different sugars could be an important factor in adapting to different ecological niches. In this study we identify an E. faecium gene cluster that is responsible for the metabolism of the α-galactoside sugar raffinose. Phenotypic testing of seven E. faecium...
Abstract
Cited 23 times since 2010 (1.5 per year)
source: EuropePMC
The American journal of cardiology,
Volume 106, Issue 11, 14 2 2010, Pages 1566-1573
Predictors of death and occurrence of appropriate implantable defibrillator therapies in patients with ischemic cardiomyopathy.
Ng AC, Bertini M, Borleffs CJ, Delgado V, Boersma E, Piers SR, Thijssen J, Nucifora G, Shanks M, Ewe SH, Biffi M, van de Veire NR, Leung DY, Schalij MJ, Bax JJ
Most patients with chronic ischemia and an implantable cardiac defibrillator (ICD) for primary prevention do not experience therapies for ventricular arrhythmias on follow-up. The present study aimed to identify independent clinical, electrocardiographic, and echocardiographic predictors of death and occurrence of ICD therapy in patients with chronic ischemic cardiomyopathy and ICD for primary prevention. A total of 424 patients with chronic ischemic cardiomyopathy, ejection fraction ≤ 35%, and...
Abstract
Cited 66 times since 2010 (4.4 per year)
source: EuropePMC
Arteriosclerosis, thrombosis, and vascular biology,
Volume 31, Issue 1, 14 2 2010, Pages 95-101
Annexin A5 therapy attenuates vascular inflammation and remodeling and improves endothelial function in mice.
Ewing MM, de Vries MR, Nordzell M, Pettersson K, de Boer HC, van Zonneveld AJ, Frostegård J, Jukema JW, Quax PH
Objective: Annexin A5 (AnxA5) has antithrombotic, antiapoptotic, and antiinflammatory properties; we investigated its effectiveness against vascular inflammation, remodeling, and dysfunction in accelerated atherosclerosis. Methods and results: AnxA5 (1 mg/kg per day or vehicle) was investigated in vascular injury models in hypercholesterolemic apolipoprotein E (ApoE)3*Leiden mice. AnxA5 treatment reduced adhesion and infiltration of leukocytes by 71% to 69% (P=0.015, P=0.031) and macrophages by...
Abstract
Cited 235 times since 2010 (15.8 per year)
source: EuropePMC
Circulation,
Volume 122, Issue 17, 11 2 2010, Pages 1674-1682
Electropathological substrate of longstanding persistent atrial fibrillation in patients with structural heart disease: epicardial breakthrough.
de Groot NM, Houben RP, Smeets JL, Boersma E, Schotten U, Schalij MJ, Crijns H, Allessie MA
Background: During persistent atrial fibrillation (AF), waves with a focal spread of activation are frequently observed. The origin of these waves and their relevance for the persistence of AF are unknown. Methods and results: In 24 patients with longstanding persistent AF and structural heart disease, high-density mapping of the right and left atria was performed during cardiac surgery. In a reference group of 25 patients, AF was induced by rapid pacing. For data analysis, a mapping algorithm w...
Abstract
Cited 71 times since 2010 (4.8 per year)
source: EuropePMC
International journal of cardiology,
Volume 154, Issue 2, 8 2 2010, Pages 168-172
Circumstances of death in adult congenital heart disease.
Zomer AC, Vaartjes I, Uiterwaal CS, van der Velde ET, van den Merkhof LF, Baur LH, Ansink TJ, Cozijnsen L, Pieper PG, Meijboom FJ, Grobbee DE, Mulder BJ
Background: Circumstances of death have been described for various cardiovascular diseases, but this study is the first for adults with congenital heart disease (CHD). Methods: Review of medical records and additional information from treating cardiologists and general practitioners, for circumstances of all deaths in a national registry of over 8000 adults with CHD. Results: Of 8595 patients, 231 (2.7%) patients died over 26,500 patient years. Main causes of death were progressive heart failure...
Abstract
Cited 10 times since 2010 (0.7 per year)
source: EuropePMC
The oncologist,
Volume 15, Issue 10, 7 1 2010, Pages 1063-1072
Effects of mannose-binding lectin polymorphisms on irinotecan-induced febrile neutropenia.
van der Bol JM, de Jong FA, van Schaik RH, Sparreboom A, van Fessem MA, van de Geijn FE, van Daele PL, Verweij J, Sleijfer S, Mathijssen RH
Objective: Mannose-binding lectin (MBL) is important in the innate immune response. MBL2 gene polymorphisms affect MBL expression, and genotypes yielding low MBL levels have been associated with an elevated risk for infections in hematological cancer patients undergoing chemotherapy. However, these reported associations are inconsistent, and data on patients with solid tumors are lacking. Here, we investigated the effects of MBL2 genotypes on irinotecan-induced febrile neutropenia in patients wi...
Abstract
Cited 6 times since 2010 (0.4 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 27, Issue 4, 6 1 2010, Pages 635-638
Assessment of left ventricular volumes; reliable by gated SPECT?
van derWall EE, Scholte AJ, Siebelink HM, Bax JJ
Abstract
Cited 2 times since 2010 (0.1 per year)
source: EuropePMC
Pacing and clinical electrophysiology : PACE,
Volume 35, Issue 10, 4 1 2010, Pages e287-90
Anatomical perspective on radiofrequency ablation of AV nodal reentry tachycardia after Mustard correction for transposition of the great arteries.
Jongbloed MR, Kelder TP, DEN Uijl DW, Bartelings MM, Molhoek SG, Tukkie R, Schalij MJ
A case of radiofrequency catheter ablation of atrioventricular (AV) nodal reentry tachycardia, in a patient with transposition of the great arteries after venous rerouting according to Mustard, is described. An electroanatomical map of the His and AV nodal region was created from inside the systemic venous atrium. Retrograde mapping of the pulmonary venous atrium was performed and the arterial catheter retracted to a position in close proximity to the venous catheter inside the intraatrial baffl...
Abstract
Cited 18 times since 2010 (1.2 per year)
source: EuropePMC
American journal of physical anthropology,
Volume 143, Issue 2, 1 1 2010, Pages 175-187
Diet traditions in wild orangutans.
Bastian ML, Zweifel N, Vogel ER, Wich SA, van Schaik CP
This study explores diet differences between two populations of wild Bornean orangutans (Pongo pygmaeus wurmbii) to assess whether a signal of social learning can be detected in the observed patterns. The populations live in close proximity and in similar habitats but are separated by a river barrier that is impassable to orangutans in the study region. We found a 60% between-site difference in diet at the level of plant food items (plant species-organ combinations). We also found that individua...
Abstract
Cited 44 times since 2010 (3 per year)
source: EuropePMC
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
Volume 100, Issue 10, 1 1 2010, Pages 671-674
Earlier HIV diagnosis--are mobile services the answer?
van Schaik N, Kranzer K, Wood R, Bekker LG
Objectives: To assess the age and gender differences of clients accessing mobile HIV counselling and testing (HCT) compared with clients accessing facility-based testing, and to determine the difference in HIV prevalence and baseline CD4 counts. Methods: This was a prospective observational cross-sectional study of 3 different HIV testing services in Cape Town. We compared data on age, sex, HIV status and CD4 counts collected between August and December 2008 from a mobile testing service (known...
Abstract
Cited 38 times since 2010 (2.6 per year)
source: EuropePMC
Pharmacogenomics,
Volume 11, Issue 10, 1 1 2010, Pages 1367-1375
CYP2C19*2 polymorphism is associated with increased survival in breast cancer patients using tamoxifen.
Ruiter R, Bijl MJ, van Schaik RH, Berns EM, Hofman A, Coebergh JW, van Noord C, Visser LE, Stricker BH
Aims: Variant alleles of the CYP2C19 gene were recently associated with survival in breast cancer patients on tamoxifen therapy. CYP2C19 is one of the enzymes involved in the metabolism of tamoxifen into active metabolites. We investigated the hypothesis that CYP2C19*2 and *3 variants, known for their lack of enzyme activity, are associated with an increased breast cancer mortality rate in patients using tamoxifen. Materials & methods: In the prospective population based Rotterdam study, the...
Abstract
Cited 13 times since 2010 (0.9 per year)
source: EuropePMC
Ultrasound in medicine & biology,
Volume 36, Issue 10, 1 1 2010, Pages 1626-1636
Perfusion CT and US of colorectal cancer liver metastases: a correlative study of two dynamic imaging modalities.
Meijerink MR, van Waesberghe JH, van Schaik C, Boven E, van der Veldt AA, van den Tol P, Meijer S, van Kuijk C
The purpose of this study was to evaluate the correlation between dynamic-contrast-enhanced computed tomography (DCE-CT) and first-pass dynamic-contrast-enhanced ultrasound (DCE-US) of normal appearing liver parenchyma and of colorectal cancer liver metastases. Thirty patients with hepatic metastases from colorectal cancer underwent DCE-CT and DCE-US. To obtain DCE-US reproducibility measurements, double contrast-passages (2 × 2.4 mL SonoVue intravenous) were acquired. From several DCE-US-derive...
Abstract
Cited 31 times since 2010 (2.1 per year)
source: EuropePMC
European journal of heart failure,
Volume 12, Issue 10, 1 1 2010, Pages 1101-1110
Prediction of atrial fibrillation in patients with an implantable cardioverter-defibrillator and heart failure.
Bertini M, Borleffs CJ, Delgado V, Ng AC, Piers SR, Shanks M, Antoni ML, Biffi M, Boriani G, Schalij MJ, Bax JJ, Van de Veire NR
Aims: Heart failure and atrial fibrillation (AF) frequently coexist and AF worsens heart failure prognosis. Device-based diagnostics derived from implantable cardioverter-defibrillator (ICD) interrogation provide an accurate method for detecting AF episodes. This study sought to determine clinical and echocardiographic predictors of AF occurrence, including an index of total atrial conduction time derived by tissue Doppler imaging (PA-TDI duration), in patients with heart failure. Moreover, the...
Abstract
Cited 11 times since 2010 (0.7 per year)
source: EuropePMC
American heart journal,
Volume 160, Issue 4, 1 1 2010, Pages 729-736
Longitudinal mechanics of the periinfarct zone and ventricular tachycardia inducibility in patients with chronic ischemic cardiomyopathy.
Bertini M, Ng AC, Borleffs CJ, Delgado V, Wijnmaalen AP, Nucifora G, Ewe SH, Shanks M, Thijssen J, Zeppenfeld K, Biffi M, Leung DY, Schalij MJ, Bax JJ
Background: Quantification of segmental left ventricular (LV) strain by speckle-tracking echocardiography can identify transmural infarcts in patients with chronic ischemic cardiomyopathy. The aim of the study was to explore the relationship between the LV longitudinal peak systolic strain (LPSS) of the infarct, periinfarct, and remote zones and monomorphic ventricular tachycardia (VT) inducibility on electrophysiologic (EP) study. Methods: A total of 134 patients with chronic ischemic cardiomyo...
Abstract
Cited 56 times since 2010 (3.8 per year)
source: EuropePMC
World journal of surgery,
Volume 34, Issue 10, 1 1 2010, Pages 2426-2433
Virtual liver resection and volumetric analysis of the future liver remnant using open source image processing software.
van der Vorst JR, van Dam RM, van Stiphout RS, van den Broek MA, Hollander IH, Kessels AG, Dejong CH
Background: After extended liver resection, a remnant liver that is too small can lead to postresection liver failure. To reduce this risk, preoperative evaluation of the future liver remnant volume (FLRV) is critical. The open-source OsiriX PAC software system can be downloaded for free and used by nonradiologists to calculate liver volume using a stand-alone Apple computer. The purpose of this study was to assess the accuracy of OsiriX CT volumetry for predicting liver resection volume and FLV...
Abstract
