Research

Publications

Below you can find a list of our published research.

6136 results

Cited 28 times since 2013 (2.3 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 99, Issue 10, 12 2 2013, Pages 722-728 Right ventricular function and survival following cardiac resynchronisation therapy. Leong DP, Höke U, Delgado V, Auger D, Witkowski T, Thijssen J, van Erven L, Bax JJ, Schalij MJ, Marsan NA

Objectives: Right ventricular (RV) function is an important prognostic marker in heart failure. However, its impact on all-cause mortality following cardiac resynchronisation therapy (CRT) independent of confounding factors has not been evaluated. Furthermore, evidence concerning the effect of CRT on RV function is limited. The study's aims were to: (1) assess the prognostic importance of RV function among CRT recipients, and (2) characterise RV functional change following CRT and its deter... Abstract

Cited 14 times since 2013 (1.1 per year) source: EuropePMC

American journal of physiology. Lung cellular and molecular physiology, Volume 304, Issue 4, 4 1 2013, Pages L264-75 Ambrisentan reduces pulmonary arterial hypertension but does not stimulate alveolar and vascular development in neonatal rats with hyperoxic lung injury. Wagenaar GT, Laghmani el H, de Visser YP, Sengers RM, Steendijk P, Baelde HJ, Walther FJ

Ambrisentan, an endothelin receptor type A antagonist, may be a novel therapeutic agent in neonatal chronic lung disease (CLD) by blocking the adverse effects of the vasoconstrictor endothelin-1, especially pulmonary arterial hypertension (PAH)-induced right ventricular hypertrophy (RVH). We determined the cardiopulmonary effects of ambrisentan treatment (1-20 mg·kg(-1)·day(-1)) in neonatal rats with CLD in 2 models: early treatment during continuous exposure to hyperoxia for 10 days and late tr... Abstract

Cited 64 times since 2013 (5.3 per year) source: EuropePMC

International orthopaedics, Volume 37, Issue 3, 4 1 2013, Pages 489-494 The timing of ankle fracture surgery and the effect on infectious complications; a case series and systematic review of the literature. Schepers T, De Vries MR, Van Lieshout EM, Van der Elst M

Purpose: Information about the influence of delayed surgery on infectious wound complications is ambiguous. A clinical audit was performed to test the hypothesis that early surgery lowers the rate of infectious wound complications. Secondly we looked at the influence of surgical delay and complications on patient reported functional outcome. Methods: All consecutive, closed distal fibular fractures treated surgically with a plate were included and retrospectively analysed for the delay in operat... Abstract

Cited 24 times since 2013 (2 per year) source: EuropePMC

Trends in cardiovascular medicine, Volume 23, Issue 3, 3 1 2013, Pages 71-79 Visualizing novel concepts of cardiovascular calcification. Hjortnaes J, New SE, Aikawa E

Cardiovascular calcification is currently viewed as an active disease process similar to embryonic bone formation. Cardiovascular calcification mainly affects the aortic valve and arteries and is associated with increased mortality risk. Aortic valve and arterial calcification share similar risk factors, including age, gender, diabetes, chronic renal disease, and smoking. However, the exact cellular and molecular mechanism of cardiovascular calcification is unknown. Late-stage cardiovascular cal... Abstract

Cited 1 times since 2013 (0.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 61, Issue 3, 1 1 2013, Pages 357-385 Highlights of the year in JACC 2012. DeMaria AN, Bax JJ, Feld GK, Greenberg BH, Hall JL, Hlatky MA, Lew WY, Lima JA, Mahmud E, Maisel AS, Narayan SM, Nissen SE, Sahn DJ, Tsimikas S

Abstract

Studies in health technology and informatics, Volume 194, 1 1 2013, Pages 126-132 How to co-develop services, work, and information systems in healthcare: the daisy approach. Korpela M, Ikävalko P, Luukkonen I, Martikainen S, Palmén M, Tiihonen T, Toivanen M, Vainikainen V

Information systems in healthcare need to be designed and developed in a collaborative way. However, existing collaborative methodologies for the parallel development of healthcare work and information systems are vague and fragmented. Furthermore, they neither address people-centred healthcare nor limited-resource contexts. In this paper we introduce an emerging holistic approach, based on a unifying theoretical basis, for co-developing the services, work and information systems in healthcare.... Abstract

Cited 1 times since 2013 (0.1 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 8, Issue 9, 1 1 2013, Pages 1103-1109 How should I treat acute aortic annulus rupture during transcatheter aortic valve implantation? Debonnaire P, Van Herck PL, Katsanos S, van der Kley F, de Weger A, Palmen M, Marsan NA, Schalij MJ, Delgado V

Abstract

Cited 11 times since 2013 (0.9 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 21, Issue 1, 1 1 2013, Pages 6-13 Myocardial bridging: what have we learned in the past and will new diagnostic modalities provide new insights? Bruschke AV, Veltman CE, de Graaf MA, Vliegen HW

The clinical significance of myocardial bridging has been a subject of discussion and controversy since the introduction of coronary arteriography (CAG) in the early 1960s. More recently computed tomography coronary angiography (CTCA) has made it possible to visualise the overlying muscular bands and appears to have a higher sensitivity for detecting myocardial bridging than CAG. Combining CTCA with invasive techniques such as CAG should make it possible to improve our understanding of the patho... Abstract

Nederlands tijdschrift voor geneeskunde, Volume 157, Issue 23, 1 1 2013, Pages A6354 [Feedback during laparoscopic training]. Spruit EN, Band GP, Hamming JF

A recent Danish study showed that instructor feedback significantly reduced the duration of training time needed for acquiring laparoscopic skills. While there is a clear advantage to trainees reaching a predetermined expert level of performance more rapidly, this does not necessarily imply that the skills were also acquired more efficiently. Experiencing continual feedback while undergoing a training task could reduce the level of difficulty in performing it; the presence of an instructor can a... Abstract

Cited 1 times since 2013 (0.1 per year) source: EuropePMC

Nederlands tijdschrift voor geneeskunde, Volume 157, Issue 7, 1 1 2013, Pages A5928 [Adhesiolysis during abdominal surgery: substantial risks]. Hamming JF, Bonsing BA

Surgeons from the Dutch St. Radboud University Medical Centre recently presented the results of a prospective study on adhesiolysis in abdominal surgery. In this methodologically sound study, the authors provided substantial data on the consequences of adhesiolysis. Most patients who have undergone an abdominal operation in the past appear to have adhesions. During an adhesiolysis procedure, 10% of patients suffer intestinal damage, the operating time is prolonged and blood loss is more severe.... Abstract

Cited 18 times since 2013 (1.5 per year) source: EuropePMC

Thrombosis research, Volume 131 Suppl 1, 1 1 2013, Pages S39-41 Venous thromboembolism in neonates and children--update 2013. Nowak-Göttl U, Janssen V, Manner D, Kenet G

Thromboses (VTE) in children were associated with medical diseases with and without acquired or inherited thrombophilic risk factors (IT). Disease recurrence rates vary between 3% in children with a first event during the neonatal period and 21% in children with idiopathic VTE. Recently reported systematic reviews showed significant associations between VTE and factor V G1691A or factor II G20210A mutations, protein C, protein S and antithrombin deficiency, more pronounced when combined IT were... Abstract

Cited 36 times since 2013 (3 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 6, Issue 1, 1 1 2013, Pages 42-52 Real-time integration of MDCT-derived coronary anatomy and epicardial fat: impact on epicardial electroanatomic mapping and ablation for ventricular arrhythmias. van Huls van Taxis CF, Wijnmaalen AP, Piers SR, van der Geest RJ, Schalij MJ, Zeppenfeld K

Objectives: This study aimed to evaluate the feasibility and accuracy of real-time integration of multidetector computed tomography (MDCT) derived coronary anatomy and epicardial fat distribution and its impact on electroanatomical mapping and ablation. Background: Epicardial catheter ablation for ventricular arrhythmias (VA) is an important therapeutic option in patients after endocardial ablation failure. However, epicardial mapping and ablation are limited by the presence of coronary arteries... Abstract

Cited 17 times since 2013 (1.4 per year) source: EuropePMC

The journal of gene medicine, Volume 15, Issue 1, 1 1 2013, Pages 1-11 Development of an AdEasy-based system to produce first- and second-generation adenoviral vectors with tropism for CAR- or CD46-positive cells. Janssen JM, Liu J, Skokan J, Gonçalves MA, de Vries AA

Background: The AdEasy system has acquired preeminence amongst the various methods for producing first-generation, early region 1 (E1)-deleted human adenovirus (HAdV) vectors (AdVs) as a result of the fast and reproducible recovery of full-length AdV genomes via homologous recombination in Escherichia coli. Methods: From the classical AdEasy system, a new production platform was derived to assemble first- and second-generation [i.e. E1- plus early region 2A (E2A)-deleted] AdVs displaying on thei... Abstract

Nederlands tijdschrift voor geneeskunde, Volume 157, Issue 51, 1 1 2013, Pages A7059 [The bionic heart patient: care about aftercare]. Schalij MJ

During the last few decades, care for heart patients has significantly improved. The enormous increase in the number of diagnostic and therapeutic options has resulted in a much better prognosis for many patients with cardiovascular disorders. Implantable cardioverter defibrillators (ICDs) and resynchronization therapy combined with ICDs decrease the risk of sudden death due to ventricular arrhythmias and improve symptoms related to cardiovascular failure. Percutaneous valve implants and percuta... Abstract

Cited 13 times since 2013 (1.1 per year) source: EuropePMC

Asian Pacific journal of cancer prevention : APJCP, Volume 14, Issue 5, 1 1 2013, Pages 3281-3288 Determining the awareness of and compliance with breast cancer screening among Turkish residential women. Yilmaz D, Bebis H, Ortabag T

Background: Breast cancer is the leading cause of cancer-related deaths in women. Despite being associated with high morbidity and mortality, breast cancer is a disease that can be diagnosed and treated early. Materials and methods: In this cross-sectional study of 321 women, data were collected by Questionnaire, Breast Cancer Risk Assessment Form and Champion's Health Belief Model Scale. Mann-Whitney U, Kruskal-Wallis, Chi- squared tests and logistic regression were used in the statistical... Abstract

Cited 44 times since 2013 (3.6 per year) source: EuropePMC

The British journal of dermatology, Volume 168, Issue 1, 1 1 2013, Pages 93-98 Dose optimization for near-infrared fluorescence sentinel lymph node mapping in patients with melanoma. van der Vorst JR, Schaafsma BE, Verbeek FP, Swijnenburg RJ, Hutteman M, Liefers GJ, van de Velde CJ, Frangioni JV, Vahrmeijer AL

Background: Regional lymph node involvement is the most important prognostic factor in cutaneous melanoma. As only 20% of patients with melanoma have occult nodal disease and would benefit from a regional lymphadenectomy, the sentinel lymph node (SLN) biopsy was introduced. Near-infrared (NIR) fluorescence has been hypothesized to improve SLN mapping. Objectives: To assess the potential of intraoperative NIR fluorescence imaging to improve SLN mapping in patients with melanoma and to examine t... Abstract

Cited 3 times since 2013 (0.2 per year) source: EuropePMC

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, Volume 16, Issue Pt 3, 1 1 2013, Pages 147-154 Improved myocardial scar characterization by super-resolution reconstruction in late gadolinium enhanced MRI. Dzyubachyk O, Tao Q, Poot DH, Lamb H, Zeppenfeld K, Lelieveldt BP, van der Geest RJ

Image resolution is an important factor for accurate myocardial scar assessment from late gadolinium enhanced (LGE) MR. It has been shown that the conventionally used short-axis (SA) LGE acquisition with anisotropic resolution may overestimate the scar size due to partial volume effect, undermining the prognostic and diagnostic accuracy of LGE MRI in critical clinical applications. In this work, we present a method for combining three complementary anisotropic orthogonal LGE sequences of the hea... Abstract

Cited 19 times since 2013 (1.6 per year) source: EuropePMC

Indian pacing and electrophysiology journal, Volume 13, Issue 1, 1 1 2013, Pages 14-33 Radiofrequency catheter ablation of idiopathic right ventricular outflow tract arrhythmias. Calvo N, Jongbloed M, Zeppenfeld K

Idiopathic ventricular arrhythmias (VA) consist of various subtypes of VA that occur in the absence of clinically apparent structural heart disease. Affected patients account for approximately 10% of all patients referred for evaluation of ventricular tachycardia (VT). Arrhythmias arising from the outflow tract (OT) are the most common subtype of idiopathic VA and more than 70-80% of idiopathic VTs or premature ventricular contractions (PVCs) originate from the right ventricular (RV) OT. Idiopat... Abstract

Cited 10 times since 2012 (0.8 per year) source: EuropePMC

Journal of molecular and cellular cardiology, Volume 56, 26 4 2012, Pages 116-128 Lack of haptoglobin results in unbalanced VEGFα/angiopoietin-1 expression, intramural hemorrhage and impaired wound healing after myocardial infarction. Arslan F, Smeets MB, Buttari B, Profumo E, Riganò R, Akeroyd L, Kara E, Timmers L, Sluijter JP, van Middelaar B, den Ouden K, Pasterkamp G, Lim SK, de Kleijn DP

Decreased haptoglobin (Hp) functionality due to allelic variations is associated with worsened outcome in patients after myocardial infarction (MI). However, mechanisms through which haptoglobin deficiency impairs cardiac repair remain to be elucidated. In the present study, we identified novel molecular alterations mediated by Hp involved in early and late cardiac repair responses after left coronary artery ligation in Hp(-/-) and wild-type (WT) mice. We observed a higher mortality rate in Hp(-... Abstract

Cited 19 times since 2012 (1.6 per year) source: EuropePMC

Atherosclerosis, Volume 227, Issue 1, 24 4 2012, Pages 95-99 Determinants of calcification growth in atherosclerotic carotid arteries; a serial multi-detector CT angiography study. van Gils MJ, Bodde MC, Cremers LG, Dippel DW, van der Lugt A

Background: Little is known about the natural course of atherosclerotic plaque in the carotid artery bifurcation. This study investigated the growth pattern of calcifications in atherosclerotic carotid arteries and its determinants using serial multi-detector CT angiography (MDCTA). Methods: From a cohort of consecutive patients with TIA or ischemic stroke and a baseline MCDTA scan of the carotid arteries, subjects were invited for a follow-up scan after 4-6 years. Calcification volumes were sco... Abstract