6196 results
Cited 74 times since 2009 (4.7 per year)
source: EuropePMC
American journal of physiology. Heart and circulatory physiology,
Volume 297, Issue 5, 25 4 2009, Pages H1606-16
Allogenic stem cell therapy improves right ventricular function by improving lung pathology in rats with pulmonary hypertension.
Umar S, de Visser YP, Steendijk P, Schutte CI, Laghmani el H, Wagenaar GT, Bax WH, Mantikou E, Pijnappels DA, Atsma DE, Schalij MJ, van der Wall EE, van der Laarse A
Pulmonary arterial hypertension (PAH) is a chronic lung disease that leads to right ventricular (RV) hypertrophy (RVH), remodeling, and failure. We tested treatment with bone marrow-derived mesenchymal stem cells (MSCs) obtained from donor rats with monocrotaline (MCT)-induced PAH to recipient rats with MCT-induced PAH on pulmonary artery pressure, lung pathology, and RV function. This model was chosen to mimic autologous MSC therapy. On day 1, PAH was induced by MCT (60 mg/kg) in 20 female Wist...
Abstract
Cited 77 times since 2009 (4.9 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 26, Issue 1, 16 3 2009, Pages 57-64
Intra-observer and interobserver variability of biventricular function, volumes and mass in patients with congenital heart disease measured by CMR imaging.
Luijnenburg SE, Robbers-Visser D, Moelker A, Vliegen HW, Mulder BJ, Helbing WA
Cardiovascular magnetic resonance (CMR) imaging provides highly accurate measurements of biventricular volumes and mass and is frequently used in the follow-up of patients with acquired and congenital heart disease (CHD). Data on reproducibility are limited in patients with CHD, while measurements should be reproducible, since CMR imaging has a main contribution to decision making and timing of (re)interventions. The aim of this study was to assess intra-observer and interobserver variability of...
Abstract
Cited 6 times since 2009 (0.4 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 26, Issue 1, 16 3 2009, Pages 19-25
Limited value of digital subtraction angiography in the evaluation of cell-based therapy in patients with limb ischemia.
van Tongeren RB, Hamming JF, le Cessie S, van Erkel AR, van Bockel JH
Cell-based therapy has been proposed as a novel strategy for patients with severe peripheral arterial disease by stimulating vascular growth. In clinical studies of this therapy, the emphasis has been on demonstrating recovery of clinical parameters, rather than on evaluation of blood flow recovery. Angiography is still the gold standard for the assessment of lower leg arteries. Therefore, we studied the usefulness of angiography in the evaluation of cell-based therapy. Sixteen patients with cri...
Abstract
Cited 12 times since 2009 (0.8 per year)
source: EuropePMC
Lung cancer (Amsterdam, Netherlands),
Volume 69, Issue 1, 15 3 2009, Pages 60-65
EUS-FNA in the preoperative staging of non-small cell lung cancer.
Talebian M, von Bartheld MB, Braun J, Versteegh MI, Dekkers OM, Rabe KF, Annema JT
Background: According to current guidelines, transesophageal ultrasound-guided fine needle aspiration (EUS-FNA) can be performed as an alternative for surgical staging to confirm mediastinal metastases in patients with non-small cell lung cancer (NSCLC). To date however, data regarding the routine use of EUS-FNA in the preoperative staging of unselected patients with NSCLC are limited. Aims and objectives: (1) To evaluate the diagnostic value of EUS-FNA in consecutive, patients with NSCLC regard...
Abstract
Cited 35 times since 2009 (2.2 per year)
source: EuropePMC
Journal of lipid research,
Volume 51, Issue 5, 14 2 2009, Pages 1201-1207
Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly.
Polisecki E, Peter I, Simon JS, Hegele RA, Robertson M, Ford I, Shepherd J, Packard C, Jukema JW, de Craen AJ, Westendorp RG, Buckley BM, Schaefer EJ, Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) Investigators
Niemann-Pick C1-like 1 protein (NPC1L1) plays a critical role in intestinal cholesterol absorption. Our objective was to examine whether five variants (-133A>G, -18A>C, L272L, V1296V, and U3_28650A>G) at the NPC1L1 gene have effects on lipid levels, prevalence, and incidence of coronary heart disease (CHD) and lipid-lowering response to pravastatin. We studied 5,804 elderly participants from the PROSPER study, who were randomized to prava-statin 40 mg/day or placebo and were followed on...
Abstract
Cited 283 times since 2009 (18.1 per year)
source: EuropePMC
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
Volume 27, Issue 31, 14 2 2009, Pages 5195-5201
Real-time quantitative polymerase chain reaction detection of minimal residual disease by standardized WT1 assay to enhance risk stratification in acute myeloid leukemia: a European LeukemiaNet study.
Cilloni D, Renneville A, Hermitte F, Hills RK, Daly S, Jovanovic JV, Gottardi E, Fava M, Schnittger S, Weiss T, Izzo B, Nomdedeu J, van der Heijden A, van der Reijden BA, Jansen JH, van der Velden VH, Ommen H, Preudhomme C, Saglio G, Grimwade D
Purpose: Risk stratification in acute myeloid leukemia (AML) is currently based on pretreatment characteristics. It remains to be established whether relapse risk can be better predicted through assessment of minimal residual disease (MRD). One proposed marker is the Wilms tumor gene WT1, which is overexpressed in most patients with AML, thus providing a putative target for immunotherapy, although in the absence of a standardized assay, its utility for MRD monitoring remains controversial. Patie...
Abstract
Cited 9 times since 2009 (0.6 per year)
source: EuropePMC
Pacing and clinical electrophysiology : PACE,
Volume 32, Issue 11, 10 2 2009, Pages e18-20
Different mechanisms underlying consecutive, postoperative atrial tachyarrhythmias in a Fontan patient.
De Groot NM, Blom N, Vd Wall EE, Schalij MJ
Introduction: Atrial tachyarrhythmias (AT) frequently develop later after a Fontan operation and can be successfully treated by ablative therapy. However, new arrhythmias often develop. Methods and results: Consecutive AT emerging in a Fontan patient were ablated using three-dimensional electro-anatomical mapping. During a 6-year period, nine different AT were ablated, including intraatrial reentrant AT (N=5), focal AT (N=3), and focal atrial fibrillation (N=1) originating from distinct right at...
Abstract
Cited 28 times since 2009 (1.8 per year)
source: EuropePMC
Acta physiologica (Oxford, England),
Volume 198, Issue 1, 6 1 2009, Pages 37-46
Single-beat estimation of the left ventricular end-systolic pressure-volume relationship in patients with heart failure.
ten Brinke EA, Klautz RJ, Verwey HF, van der Wall EE, Dion RA, Steendijk P
Aim: The end-systolic pressure-volume relationship (ESPVR) constructed from multiple pressure-volume (PV) loops acquired during load intervention is an established method to asses left ventricular (LV) contractility. We tested the accuracy of simplified single-beat (SB) ESPVR estimation in patients with severe heart failure. Methods: Nineteen heart failure patients (NYHA III-IV) scheduled for surgical ventricular restoration and/or restrictive mitral annuloplasty and 12 patients with normal LV f...
Abstract
Cited 32 times since 2009 (2 per year)
source: EuropePMC
The Journal of bone and joint surgery. British volume,
Volume 91, Issue 9, 1 1 2009, Pages 1134-1141
Ceramic-on-metal bearings in total hip replacement: whole blood metal ion levels and analysis of retrieved components.
Isaac GH, Brockett C, Breckon A, van der Jagt D, Williams S, Hardaker C, Fisher J, Schepers A
This study reports on ceramic-on-metal (CoM) bearings in total hip replacement. Whole blood metal ion levels were measured. The median increase in chromium and cobalt at 12 months was 0.08 microg/1 and 0.22 microg/1, respectively, in CoM bearings. Comparable values for metal-on-metal (MoM) were 0.48 microg/1 and 0.32 microg/1. The chromium levels were significantly lower in CoM than in MoM bearings (p = 0.02). The cobalt levels were lower, but the difference was not significant. Examination of t...
Abstract
Cited 47 times since 2009 (3 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 54, Issue 14, 1 1 2009, Pages 1317-1325
Effects of cardiac resynchronization therapy on left ventricular twist.
Bertini M, Marsan NA, Delgado V, van Bommel RJ, Nucifora G, Borleffs CJ, Boriani G, Biffi M, Holman ER, van der Wall EE, Schalij MJ, Bax JJ
Objectives: This study explored the effects of cardiac resynchronization therapy (CRT) on left ventricular (LV) twist, particularly in relation to LV lead position. Background: LV twist is emerging as a comprehensive index of LV function. Methods: Eighty heart failure patients were included. Two-dimensional echocardiography was performed at baseline, immediately after CRT, and at 6-month follow-up. Speckle-tracking analysis was applied to assess LV twist. The LV lead was placed preferably in a (...
Abstract
Cited 50 times since 2009 (3.2 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 54, Issue 14, 1 1 2009, Pages 1238-1245
Paraoxonase variants relate to 10-year risk in coronary artery disease: impact of a high-density lipoprotein-bound antioxidant in secondary prevention.
Regieli JJ, Jukema JW, Doevendans PA, Zwinderman AH, Kastelein JJ, Grobbee DE, van der Graaf Y
Objectives: We investigated the effects of paraoxonase (PON)-1 variants on long-term clinical outcome in patients with coronary artery disease (CAD). Background: PON-1 is a potential therapeutic target to further reduce cardiovascular risk because it is a detoxifying esterase with antioxidant properties. The PON-1 knockout models result in higher susceptibility to atherosclerosis, and PON activity contributes to cardiovascular risk in humans. Human gene variants determine PON activity; however,...
Abstract
Cited 19 times since 2009 (1.2 per year)
source: EuropePMC
Tissue engineering. Part B, Reviews,
Volume 15, Issue 3, 1 1 2009, Pages 307-317
Translating autologous heart valve tissue engineering from bench to bed.
Hjortnaes J, Bouten CV, Van Herwerden LA, Gründeman PF, Kluin J
Tissue engineering is currently being actively investigated to ascertain if it can offer an alternative to prosthetic aortic heart valves that may overcome the current limitations of prosthetic aortic heart valves while at the same time conferring the advantages of a living autologous structure, such as biocompatibility, the capacity to grow, repair, and remodel. In vitro studies have shown tissue-engineered heart valves to have adequate structural and functional properties, indicating a promisi...
Abstract
Cited 2 times since 2009 (0.1 per year)
source: EuropePMC
Pediatric neurology,
Volume 41, Issue 3, 1 1 2009, Pages 179-182
Cerebrospinal fluid nitric oxide levels in subacute sclerosing panencephalitis.
Yilmaz D, Yüksel D, Senbil N, Eminzade S, Kilinç K, Anlar B, Gürer Y
Oxidative damage plays a role in neurodegenerative diseases. Levels of cerebrospinal fluid nitrite and nitrate levels (oxidation products that provide an indirect estimation of nitric oxide) were investigated in relation to clinical and laboratory features in subacute sclerosing panencephalitis (n = 47) and age-matched control (n = 43) groups. Significantly decreased levels of nitrite (median, 4.91 micromol/L) and nitrate (median, 6.14 micromol/L) were found in the patients. Nitrite and nitrate...
Abstract
Cited 7 times since 2009 (0.4 per year)
source: EuropePMC
Expert review of cardiovascular therapy,
Volume 7, Issue 9, 1 1 2009, Pages 1117-1122
Opportunities in pulmonary valve replacement.
Oosterhof T, Hazekamp MG, Mulder BJ
Pulmonary regurgitation is the most important residual lesion after initial surgical correction for pulmonary (sub)valvular stenosis in the early life of patients with tetralogy of Fallot or isolated pulmonary stenosis. Symptomatic or asymptomatic patients with severe right ventricular dilatation due to pulmonary regurgitation may benefit from pulmonary valve replacement. Surgery is ideally performed before the right ventricle becomes irreversibly damaged as a result of longstanding volume overl...
Abstract
Cited 12 times since 2009 (0.8 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 95, Issue 18, 1 1 2009, Pages 1538-1546
Percutaneous aortic valve therapy: clinical experience and the role of multi-modality imaging.
Tops LF, Delgado V, van der Kley F, Bax JJ
Abstract
Cited 150 times since 2009 (9.6 per year)
source: EuropePMC
Journal of magnetic resonance imaging : JMRI,
Volume 30, Issue 3, 1 1 2009, Pages 521-526
Validation and reproducibility of aortic pulse wave velocity as assessed with velocity-encoded MRI.
Grotenhuis HB, Westenberg JJ, Steendijk P, van der Geest RJ, Ottenkamp J, Bax JJ, Jukema JW, de Roos A
Purpose: To validate magnetic resonance imaging (MRI) assessment of aortic pulse wave velocity (PWV(MRI)) with PWV determined from invasive intra-aortic pressure measurements (PWV(INV)) and to test the reproducibility of the measurement by MRI. Materials and methods: PWV(MRI) was compared with PWV(INV) in 18 nonconsecutive patients scheduled for catheterization for suspected coronary artery disease. Reproducibility of PWV(MRI) was tested in 10 healthy volunteers who underwent repeated measuremen...
Abstract
Cited 8 times since 2009 (0.5 per year)
source: EuropePMC
Annals of vascular surgery,
Volume 23, Issue 5, 1 1 2009, Pages 583-597
Morbidity and mortality caused by cardiac adverse events after revascularization for critical limb ischemia.
Flu HC, Lardenoye JH, Veen EJ, Aquarius AE, Van Berge Henegouwen DP, Hamming JF
Background: We assessed cardiac adverse events (AEs) after primary lower extremity arterial revascularization (LEAR) for critical lower limb ischemia (CLI) in order to evaluate the impact of cardiac AEs on the clinical outcome. We created an optimized care protocol concerning CLI patients' preoperative work-up as well as intra- and postoperative surveillance according to recent important literature and guidelines. Methods: We conducted a prospective analysis of clinical outcome after LEAR u...
Abstract
Cited 177 times since 2009 (11.3 per year)
source: EuropePMC
The New England journal of medicine,
Volume 361, Issue 10, 1 1 2009, Pages 980-989
Fluvastatin and perioperative events in patients undergoing vascular surgery.
Schouten O, Boersma E, Hoeks SE, Benner R, van Urk H, van Sambeek MR, Verhagen HJ, Khan NA, Dunkelgrun M, Bax JJ, Poldermans D, Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group
Background: Adverse cardiac events are common after vascular surgery. We hypothesized that perioperative statin therapy would improve postoperative outcomes. Methods: In this double-blind, placebo-controlled trial, we randomly assigned patients who had not previously been treated with a statin to receive, in addition to a beta-blocker, either 80 mg of extended-release fluvastatin or placebo once daily before undergoing vascular surgery. Lipid, interleukin-6, and C-reactive protein levels were me...
Abstract
Cited 127 times since 2009 (8.1 per year)
source: EuropePMC
European heart journal,
Volume 30, Issue 20, 30 5 2009, Pages 2470-2477
Characteristics of heart failure patients associated with good and poor response to cardiac resynchronization therapy: a PROSPECT (Predictors of Response to CRT) sub-analysis.
van Bommel RJ, Bax JJ, Abraham WT, Chung ES, Pires LA, Tavazzi L, Zimetbaum PJ, Gerritse B, Kristiansen N, Ghio S
Aims: Predictors of Response to Cardiac Resynchronization Therapy (CRT) (PROSPECT) was the first large-scale, multicentre clinical trial that evaluated the ability of several echocardiographic measures of mechanical dyssynchrony to predict response to CRT. Since response to CRT may be defined as a spectrum and likely influenced by many factors, this sub-analysis aimed to investigate the relationship between baseline characteristics and measures of response to CRT. Methods and results: A total of...
Abstract
Cited 19 times since 2009 (1.2 per year)
source: EuropePMC
International journal of cardiology,
Volume 147, Issue 1, 28 4 2009, Pages 52-57
Can we use the end systolic volume index to monitor intrinsic right ventricular function after repair of tetralogy of Fallot?
Uebing A, Fischer G, Schlangen J, Apitz C, Steendijk P, Kramer HH
Background: After tetralogy of Fallot (ToF) repair the right ventricle (RV) is commonly exposed to abnormal volume load resulting from pulmonary regurgitation (PR) leading to progressive RV dilatation. The objective of this study was to assess the relationship between RV volumes, especially the end systolic volume index (ESVi), and RV contractility in patients after ToF repair and significant PR and to determine whether RV dilatation reflects intrinsic RV dysfunction in these patients. Methods:...
Abstract
