Research

Publications

Below you can find a list of our published research.

6886 results

Cited 6 times since 2024 (4.7 per year) source: EuropePMC

Journal of dentistry, Volume 144, 14 2 2024, Pages 104941 Fabrication trueness and marginal quality of additively manufactured resin-based definitive laminate veneers with different restoration thicknesses. Çakmak G, Donmez MB, Yılmaz D, Yoon HI, Kahveci Ç, Abou-Ayash S, Yilmaz B

Objectives: To evaluate how restoration thickness (0.5 mm and 0.7 mm) affects the fabrication trueness of additively manufactured definitive resin-based laminate veneers, and to analyze the effect of restoration thickness and margin location on margin quality. Methods: Two maxillary central incisors were prepared either for a 0.5 mm- or 0.7 mm-thick laminate veneer. After acquiring the partial-arch scans of each preparation, laminate veneers were designed and stored as reference data. By using t... Abstract

Journal of dairy science, Volume 107, Issue 8, 14 2 2024, Pages 5754-5778 A Living Lab approach to understanding dairy farmers' technology and data needs to improve herd health: Focus groups from 6 European countries. Doidge C, Ånestad LM, Burrell A, Frössling J, Palczynski L, Pardon B, Veldhuis A, Bokma J, Carmo LP, Hopp P, Guelbenzu-Gonzalo M, Meunier NV, Ordell A, Santman-Berends I, van Schaik G, Kaler J

For successful development and adoption of technology on dairy farms, farmers need to be included in the innovation process. However, the design of agricultural technologies usually takes a top-down approach with little involvement of end-users at the early stages. Living Labs offer a methodology that involve end-users throughout the development process and emphasize the importance of understanding users' needs. Currently, exploration of dairy farmers' technology needs has been limited... Abstract

Cited 2 times since 2024 (1.6 per year) source: EuropePMC

Frontiers in veterinary science, Volume 11, 14 2 2024, Pages 1337661 Review state-of-the-art of output-based methodological approaches for substantiating freedom from infection. Meletis E, Conrady B, Hopp P, Lurier T, Frössling J, Rosendal T, Faverjon C, Carmo LP, Hodnik JJ, Ózsvári L, Kostoulas P, van Schaik G, Comin A, Nielen M, Knific T, Schulz J, Šerić-Haračić S, Fourichon C, Santman-Berends I, Madouasse A

A wide variety of control and surveillance programmes that are designed and implemented based on country-specific conditions exists for infectious cattle diseases that are not regulated. This heterogeneity renders difficult the comparison of probabilities of freedom from infection estimated from collected surveillance data. The objectives of this review were to outline the methodological and epidemiological considerations for the estimation of probabilities of freedom from infection from surveil... Abstract

Communications biology, Volume 7, Issue 1, 13 2 2024, Pages 314 A platform-independent AI tumor lineage and site (ATLAS) classifier. Rydzewski NR, Shi Y, Li C, Chrostek MR, Bakhtiar H, Helzer KT, Bootsma ML, Berg TJ, Harari PM, Floberg JM, Blitzer GC, Kosoff D, Taylor AK, Sharifi MN, Yu M, Lang JM, Patel KR, Citrin DE, Sundling KE, Zhao SG

Histopathologic diagnosis and classification of cancer plays a critical role in guiding treatment. Advances in next-generation sequencing have ushered in new complementary molecular frameworks. However, existing approaches do not independently assess both site-of-origin (e.g. prostate) and lineage (e.g. adenocarcinoma) and have minimal validation in metastatic disease, where classification is more difficult. Utilizing gradient-boosted machine learning, we developed ATLAS, a pair of separate AI T... Abstract

Cited 1 times since 2024 (0.8 per year) source: EuropePMC

Kidney international reports, Volume 9, Issue 6, 13 2 2024, Pages 1849-1859 Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure. Ganji-Arjenaki M, Kamali Z, International Consortium of Blood Pressure, Sardari S, de Borst M, Snieder H, Vaez A

Introduction: Blood pressure (BP) is a highly heritable trait with over 2000 underlying genomic loci identified to date. Although the kidney plays a key role, little is known about specific cell types involved in the genetic regulation of BP. Methods: Here, we applied stratified linkage disequilibrium score (LDSC) regression to connect BP genome-wide association studies (GWAS) results to specific cell types of the mature human kidney. We used the largest single-stage BP genome-wide analysis to d... Abstract

Journal of cardiovascular development and disease, Volume 11, Issue 3, 13 2 2024, Pages 90 Incremental Value of Biventricular Strain in Patients with Severe Aortic Stenosis. Sarrazyn C, Galloo X, Meucci MC, Butcher SC, Hirsawa K, Myagmardorj R, van der Kley F, De Backer T, Bax JJ, Ajmone Marsan N

(1) Background: Left ventricular global longitudinal (LVGLS) and right ventricular free wall strain (RVFWS) demonstrated separate prognostic values in patients with severe aortic stenosis (AS). However, studies evaluating the combined assessment of LVGLS and RVFWS have shown contradictory results. This study explored the prognostic value of combining LVGLS and RVFWS in a large group of severe AS patients referred for transcatheter aortic valve implantation. (2) Methods: Patients were classified... Abstract

Cited 11 times since 2024 (8.5 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 17, Issue 8, 13 2 2024, Pages 894-906 Development and Validation of a Quantitative Coronary CT Angiography Model for Diagnosis of Vessel-Specific Coronary Ischemia. Nurmohamed NS, Danad I, Jukema RA, de Winter RW, de Groot RJ, Driessen RS, Bom MJ, van Diemen P, Pontone G, Andreini D, Chang HJ, Katz RJ, Stroes ESG, Wang H, Chan C, Crabtree T, Aquino M, Min JK, Earls JP, Bax JJ, Choi AD, Knaapen P, van Rosendael AR, CREDENCE and PACIFIC-1 Investigators

Background: Noninvasive stress testing is commonly used for detection of coronary ischemia but possesses variable accuracy and may result in excessive health care costs. Objectives: This study aimed to derive and validate an artificial intelligence-guided quantitative coronary computed tomography angiography (AI-QCT) model for the diagnosis of coronary ischemia that integrates atherosclerosis and vascular morphology measures (AI-QCTISCHEMIA) and to evaluate its prognostic utility for major adver... Abstract

Cited 3 times since 2024 (2.3 per year) source: EuropePMC

iScience, Volume 27, Issue 4, 12 2 2024, Pages 109496 Oleic acid triggers metabolic rewiring of T cells poising them for T helper 9 differentiation. Reilly NA, Sonnet F, Dekkers KF, Kwekkeboom JC, Sinke L, Hilt S, Suleiman HM, Hoeksema MA, Mei H, van Zwet EW, Everts B, Ioan-Facsinay A, Jukema JW, Heijmans BT

T cells are the most common immune cells in atherosclerotic plaques, and the function of T cells can be altered by fatty acids. Here, we show that pre-exposure of CD4+ T cells to oleic acid, an abundant fatty acid linked to cardiovascular events, upregulates core metabolic pathways and promotes differentiation into interleukin-9 (IL-9)-producing cells upon activation. RNA sequencing of non-activated T cells reveals that oleic acid upregulates genes encoding key enzymes responsible for cholestero... Abstract

Cited 7 times since 2024 (5.4 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 17, Issue 3, 12 2 2024, Pages e016143 Interaction of AI-Enabled Quantitative Coronary Plaque Volumes on Coronary CT Angiography, FFRCT, and Clinical Outcomes: A Retrospective Analysis of the ADVANCE Registry. Dundas J, Leipsic J, Fairbairn T, Ng N, Sussman V, Guez I, Rosenblatt R, Hurwitz Koweek LM, Douglas PS, Rabbat M, Pontone G, Chinnaiyan K, de Bruyne B, Bax JJ, Amano T, Nieman K, Rogers C, Kitabata H, Sand NPR, Kawasaki T, Mullen S, Huey W, Matsuo H, Patel MR, Norgaard BL, Ahmadi A, Tzimas G

Background: Luminal stenosis, computed tomography-derived fractional-flow reserve (FFRCT), and high-risk plaque features on coronary computed tomography angiography are all known to be associated with adverse clinical outcomes. The interactions between these variables, patient outcomes, and quantitative plaque volumes have not been previously described. Methods: Patients with coronary computed tomography angiography (n=4430) and one-year outcome data from the international ADVANCE (Assessing Dia... Abstract

Cited 5 times since 2024 (3.8 per year) source: EuropePMC

FEMS microbes, Volume 5, 9 2 2024, Pages xtae009 Interactions between commensal Enterococcus faecium and Enterococcus lactis and clinical isolates of Enterococcus faecium. Wagner TM, Pöntinen AK, Fenzel CK, Engi D, Janice J, Almeida-Santos AC, Tedim AP, Freitas AR, Peixe L, van Schaik W, Johannessen M, Hegstad K

Enterococcus faecium (Efm) is a versatile pathogen, responsible for multidrug-resistant infections, especially in hospitalized immunocompromised patients. Its population structure has been characterized by diverse clades (A1, A2, and B (reclassified as E. lactis (Ela)), adapted to different environments, and distinguished by their resistomes and virulomes. These features only partially explain the predominance of clade A1 strains in nosocomial infections. We investigated in vitro interaction of... Abstract

Cited 4 times since 2024 (3.1 per year) source: EuropePMC

Gastrointestinal endoscopy, Volume 100, Issue 4, 8 2 2024, Pages 703-709.e4 Interobserver agreement of current and new proposed endoscopic scores for postoperative recurrence in Crohn's disease. Bak MTJ, Hammoudi N, Allez M, Silverberg MS, Schellekens IM, Erler NS, Dijkstra G, Romberg-Camps M, de Boer NKH, Jansen SV, van der Marel S, Horjus CS, Visschedijk MC, Goetgebuer RL, van Dop WA, Hoekstra J, Bodelier AGL, Molendijk I, Derikx LAAP, van Schaik FDM, West RL, Duijvestein M, Janneke van der Woude C, van Ruler O, de Vries AC, Dutch Initiative on Crohn and Colitis and the RAP-CD study group

Background and aims: The modified Rutgeerts score (mRS) is widely used for the assessment of endoscopic postoperative recurrence (ePOR) in Crohn's disease (CD) after ileocolic resection to guide therapeutic decisions. To improve the validity and prognostic value of this endoscopic assessment, 2 new scores have been proposed. This study assessed the interobserver agreement of the current score (mRS) and the new endoscopic score for ePOR in CD. Methods: Sixteen Dutch academic and nonacademic... Abstract

Respiratory research, Volume 25, Issue 1, 7 1 2024, Pages 117 MUC5AC concentrations in lung lavage fluids are associated with acute lung injury after cardiac surgery. van Paassen J, Hiemstra PS, van der Linden AC, de Jonge E, Zwaginga JJ, Klautz RJM, Arbous MS

Heart surgery may be complicated by acute lung injury and adult respiratory distress syndrome. Expression and release of mucins MUC5AC and MUC5B in the lungs has been reported to be increased in acute lung injury. The aim of our study was to [1] investigate the perioperative changes of MUC5AC, MUC5B and other biomarkers in mini-bronchoalveolar lavage (minBAL), and [2] relate these to clinical outcomes after cardiac surgery. In this prospective cohort study in 49 adult cardiac surgery patients pr... Abstract

Cited 2 times since 2024 (1.5 per year) source: EuropePMC

International journal of cardiology, Volume 405, 7 1 2024, Pages 131940 The impact of patient-reported frailty on cardiovascular outcomes in elderly patients after non-ST-acute coronary syndrome. van den Broek WWA, Gimbel ME, Hermanides RS, Runnett C, Storey RF, Knaapen P, Emans ME, Oemrawsingh RM, Cooke J, Galasko G, Walhout R, Stoel MG, von Birgelen C, van Bergen PFMM, Brinckman SL, Aksoy I, Liem A, Van't Hof AWJ, Jukema JW, Heestermans AACM, Nicastia D, Alber H, Austin D, Nasser A, Deneer V, Ten Berg JM

Background: As life expectancy increases, the population of older individuals with coronary artery disease and frailty is growing. We aimed to assess the impact of patient-reported frailty on the treatment and prognosis of elderly early survivors of non-ST-elevation acute coronary syndrome (NSTE-ACS). Methods: Frailty data were obtained from two prospective trials, POPular Age and the POPular Age Registry, which both assessed elderly NSTE-ACS patients. Frailty was assessed one month after admiss... Abstract

Comprehensive psychiatry, Volume 132, 7 1 2024, Pages 152467 When a test is more than just a test: Findings from patient interviews and survey in the trial of a technology to measure antidepressant medication response (the PReDicT Trial). Brown S, Ploeger C, Guo B, Petersen JJ, Beckenstrom AC, Browning M, Dawson GR, Deckert J, Dias R, Dourish CT, Gorwood P, Kingslake J, Menke A, Sola VP, Reif A, Ruhe H, Simon J, Stäblein M, van Schaik A, Veltman DJ, Morriss R, PReDicT Group

Background: A RCT of a novel intervention to detect antidepressant medication response (the PReDicT Test) took place in five European countries, accompanied by a nested study of its acceptability and implementation presented here. The RCT results indicated no effect of the intervention on depression at 8 weeks (primary outcome), although effects on anxiety at 8 weeks and functioning at 24 weeks were found. Methods: The nested study used mixed methods. The aim was to explore patient experiences o... Abstract

Cited 1 times since 2024 (0.8 per year) source: EuropePMC

Animal : an international journal of animal bioscience, Volume 18, Issue 4, 7 1 2024, Pages 101124 A qualitative survey approach to investigating beef and dairy veterinarians' needs in relation to technologies on farms. Doidge C, Burrell A, van Schaik G, Kaler J

Globally, farmers are being increasingly encouraged to use technologies. Consequently, veterinarians often use farm data and technologies to provide farmers with advice. Yet very few studies have sought to understand veterinarians' perceptions of data and technologies on farms. The aim of this study was to understand veterinarians' experiences and opinions on data and technology on beef and dairy farms. An online qualitative survey was conducted with a convenience sample of 36 and 24 v... Abstract

Cited 89 times since 2024 (68 per year) source: EuropePMC

Nature, Volume 628, Issue 8006, 6 1 2024, Pages 130-138 Genome-wide characterization of circulating metabolic biomarkers. Karjalainen MK, Karthikeyan S, Oliver-Williams C, Sliz E, Allara E, Fung WT, Surendran P, Zhang W, Jousilahti P, Kristiansson K, Salomaa V, Goodwin M, Hughes DA, Boehnke M, Fernandes Silva L, Yin X, Mahajan A, Neville MJ, van Zuydam NR, de Mutsert R, Li-Gao R, Mook-Kanamori DO, Demirkan A, Liu J, Noordam R, Trompet S, Chen Z, Kartsonaki C, Li L, Lin K, Hagenbeek FA, Hottenga JJ, Pool R, Ikram MA, van Meurs J, Haller T, Milaneschi Y, Kähönen M, Mishra PP, Joshi PK, Macdonald-Dunlop E, Mangino M, Zierer J, Acar IE, Hoyng CB, Lechanteur YTE, Franke L, Kurilshikov A, Zhernakova A, Beekman M, van den Akker EB, Kolcic I, Polasek O, Rudan I, Gieger C, Waldenberger M, Asselbergs FW, China Kadoorie Biobank Collaborative Group, Estonian Biobank Research Team, FinnGen, Hayward C, Fu J, den Hollander AI, Menni C, Spector TD, Wilson JF, Lehtimäki T, Raitakari OT, Penninx BWJH, Esko T, Walters RG, Jukema JW, Sattar N, Ghanbari M, Willems van Dijk K, Karpe F, McCarthy MI, Laakso M, Järvelin MR, Timpson NJ, Perola M, Kooner

Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1-7. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8-11. Here we present a genome-wide association study for 233 circulating metabolic traits quantified by nuclear magnetic resonance spectroscopy in up to 136,016 participants... Abstract

Cited 1 times since 2024 (0.8 per year) source: EuropePMC

Journal of cardiovascular development and disease, Volume 11, Issue 3, 5 1 2024, Pages 86 Atypical Progeria Primarily Manifesting as Premature Cardiac Valvular Disease Segregates with LMNA-Gene Variants. Wu HW, Van de Peppel IP, Rutten JW, Jukema JW, Aten E, Jazet IM, Koopmann TT, Barge-Schaapveld DQCM, Ajmone Marsan N

Mutations in the LMNA-gene can cause a variety of 'laminopathies'. These laminopathies are associated with a range of phenotypes, including disorders affecting the adipose tissue, peripheral nerves, the heart, such as dilated cardiomyopathy and conduction system abnormalities, and less commonly, progeroid disorders. This case series describes two families in which two novel LMNA-gene variants were identified, and who presented with an atypical progeroid phenotype with primarily prematu... Abstract

Cited 2 times since 2024 (1.5 per year) source: EuropePMC

Journal of translational medicine, Volume 22, Issue 1, 3 1 2024, Pages 234 CRISPR/Cas9-edited ROS1 + non-small cell lung cancer cell lines highlight differential drug sensitivity in 2D vs 3D cultures while reflecting established resistance profiles. Terrones M, Deben C, Rodrigues-Fortes F, Schepers A, de Beeck KO, Van Camp G, Vandeweyer G

Introduction: The study of resistance-causing mutations in oncogene-driven tumors is fundamental to guide clinical decisions. Several point mutations affecting the ROS1 kinase domain have been identified in the clinical setting, but their impact requires further exploration, particularly in improved pre-clinical models. Given the scarcity of solid pre-clinical models to approach rare cancer subtypes like ROS1 + NSCLC, CRISPR/Cas9 technology allows the introduction of mutations in patient-derived... Abstract

Cited 2 times since 2024 (1.5 per year) source: EuropePMC

Animal cognition, Volume 27, Issue 1, 2 1 2024, Pages 5 The proximate regulation of prosocial behaviour: towards a conceptual framework for comparative research. Kopp KS, Kanngiesser P, Brügger RK, Daum MM, Gampe A, Köster M, van Schaik CP, Liebal K, Burkart JM

Humans and many other animal species act in ways that benefit others. Such prosocial behaviour has been studied extensively across a range of disciplines over the last decades, but findings to date have led to conflicting conclusions about prosociality across and even within species. Here, we present a conceptual framework to study the proximate regulation of prosocial behaviour in humans, non-human primates and potentially other animals. We build on psychological definitions of prosociality and... Abstract

Arthroplasty today, Volume 26, 2 1 2024, Pages 101343 Perioperative Differences Between Outpatient and Inpatient Pathways Following Hip and Knee Arthroplasty. Keulen MHF, Bemelmans YFL, Boonen B, Hendrickx RPM, Heyligers IC, Schotanus MGM

Background: Optimization of clinical pathways and logistics led to the introduction of outpatient joint arthroplasty of the hip and knee. Nevertheless, little is known about what these current protocols look like and how they differ from "standard" inpatient protocols. This study aimed to find preoperative, intraoperative, and postoperative differences between outpatient and inpatient pathways. Methods: A questionnaire (ranging between 23 and 37 items) was developed and administered by... Abstract