Research

Publications

Below you can find a list of our published research.

6173 results

Cited 7 times since 2022 (2.3 per year) source: EuropePMC

Clinical oral investigations, Volume 26, Issue 7, 21 3 2022, Pages 4897-4904 Salivary levels of hBDs in children and adolescents with type 1 diabetes mellitus and gingivitis. Yilmaz D, Yilmaz N, Polat R, Nissilä V, Aydın EG, Rautava J, Gürsoy M, Gürsoy UK

Objectives: Type 1 diabetes mellitus (T1DM), a chronic autoimmune disease characterized by insulin deficiency, is related to periodontal diseases in children and adolescents. Our aim was to profile salivary human beta-defensin (hBD)-2 and hBD-3 concentrations in relation to periodontal and T1DM status in children and adolescent populations. Material and methods: Unstimulated saliva samples were collected from 66 participants including periodontally healthy T1DM patients (T1DM + C; n = 18), T1DM... Abstract

Cited 4 times since 2022 (1.3 per year) source: EuropePMC

The American journal of cardiology, Volume 172, 19 3 2022, Pages 54-61 The Quantity of Epicardial Adipose Tissue in Patients Having Ablation for Atrial Fibrillation With and Without Heart Failure. Wang X, Butcher SC, Kuneman JH, Lustosa RP, Fortuni F, Ajmone Marsan N, Knuuti J, Bax JJ, Delgado V

The distribution of epicardial adipose tissue (EAT) across the spectrum of heart failure (HF) has yet to be fully elucidated. The present study investigated the distribution of EAT in an HF spectrum and its association with clinical and echocardiographic parameters. A total of 326 patients who underwent contrast-enhanced computed tomography before transcatheter atrial fibrillation ablation with and without HF symptoms, and a wide range of left ventricular (LV) ejection fractions (LVEF) were incl... Abstract

Cited 5 times since 2022 (1.6 per year) source: EuropePMC

Molecular therapy. Nucleic acids, Volume 28, 19 3 2022, Pages 307-327 Extracellular vesicles enriched with an endothelial cell pro-survival microRNA affects skin tissue regeneration. Fernandes H, Zonnari A, Abreu R, Aday S, Barão M, Albino I, Lino M, Branco A, Seabra C, Barata T, Leal EC, Tralhão JG, Gonçalves L, de Jong A, Peters HAB, de Vries MR, da Costa Martins P, Quax PHA, Ferreira L

Endothelial cell (EC) activity is essential for tissue regeneration in several (patho)physiological contexts. However, our capacity to deliver in vivo biomolecules capable of controlling EC fate is relatively limited. Here, we screened a library of microRNA (miR) mimics and identified 25 miRs capable of enhancing the survival of ECs exposed to ischemia-mimicking conditions. In vitro, we showed that miR-425-5p, one of the hits, was able to enhance EC survival and migration. In vivo, using a mouse... Abstract

Cited 34 times since 2022 (11 per year) source: EuropePMC

BMJ quality & safety, Volume 31, Issue 5, 18 3 2022, Pages 402-408 The problem with making Safety-II work in healthcare. Verhagen MJ, de Vos MS, Sujan M, Hamming JF

Abstract

Cited 11 times since 2022 (3.6 per year) source: EuropePMC

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Volume 52, Issue 6, 18 3 2022, Pages 801-805 Ocular surface disease is common in moderate-to-severe atopic dermatitis patients. Achten RE, Bakker DS, van Luijk CM, van der Wal M, de Graaf M, van Wijk F, Zuithoff NPA, van der Rijst LP, Boesjes CM, Thijs JL, de Boer JH, de Bruin-Weller MS

Abstract

Cited 11 times since 2022 (3.6 per year) source: EuropePMC

Life (Basel, Switzerland), Volume 12, Issue 3, 17 3 2022, Pages 446 Near-Infrared Fluorescence Tumor-Targeted Imaging in Lung Cancer: A Systematic Review. Neijenhuis LKA, de Myunck LDAN, Bijlstra OD, Kuppen PJK, Hilling DE, Borm FJ, Cohen D, Mieog JSD, Steup WH, Braun J, Burggraaf J, Vahrmeijer AL, Hutteman M

Lung cancer is the most common cancer type worldwide, with non-small cell lung cancer (NSCLC) being the most common subtype. Non-disseminated NSCLC is mainly treated with surgical resection. The intraoperative detection of lung cancer can be challenging, since small and deeply located pulmonary nodules can be invisible under white light. Due to the increasing use of minimally invasive surgical techniques, tactile information is often reduced. Therefore, several intraoperative imaging techniques... Abstract

Cited 5 times since 2022 (1.6 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 9, 17 3 2022, Pages 845359 The Prognostic Value of Right Atrial and Right Ventricular Functional Parameters in Systemic Sclerosis. Vos JL, Butcher SC, Fortuni F, Galloo X, Rodwell L, Vonk MC, Bax JJ, van Leuven SI, de Vries-Bouwstra JK, Snoeren M, El Messaoudi S, Marsan NA, Nijveldt R

Introduction: Right ventricular (RV) function is of particular importance in systemic sclerosis (SSc), since common SSc complications, such as interstitial lung disease and pulmonary hypertension may affect RV afterload. Cardiovascular magnetic resonance (CMR) is the gold standard for measuring RV function. CMR-derived RV and right atrial (RA) strain is a promising tool to detect subtle changes in RV function, and might have incremental value, however, prognostic data is lacking. Therefore, the... Abstract

Cited 9 times since 2022 (2.9 per year) source: EuropePMC

Advanced drug delivery reviews, Volume 184, 16 3 2022, Pages 114184 Pharmaceutical applications of a nanospectroscopic technique: Surface-enhanced Raman spectroscopy. Yilmaz H, Yilmaz D, Taskin IC, Culha M

Surface-enhanced Raman spectroscopy (SERS) is a very sensitive technique offering unique opportunities for detection and identification of molecules and molecular structures at extremely low concentrations even in complex sample matrixes. Since a nanostructured noble metal surface is required for the enhancement of Raman scattering, the acquired spectral information naturally originates from nanometer size domains making it a nanospectroscopic technique by breaking the diffraction limit of light... Abstract

Cited 2 times since 2022 (0.6 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 8, 15 3 2022, Pages 779075 Continuum of Care: Positioning of the Virtual Hospital. van der Lande ACMH, Treskes RW, Beeres SLMA, Schalij MJ

Introduction: Patients with multiple chronic diseases suffer from reduced life expectancy. Care for these patients is often divided over multiple healthcare professionals. eHealth might help to integrate care for these patients and create a continuum. It is the primary purpose of this paper to describe an intervention that integrates first, second, and third line care in patients with multiple chronic conditions using remote monitoring, remote therapy and data automatization, all integrated in a... Abstract

Cited 15 times since 2022 (4.8 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 35, Issue 8, 15 3 2022, Pages 791-800.e4 Left Ventricular Global Longitudinal Strain in Patients with Moderate Aortic Stenosis. Stassen J, Pio SM, Ewe SH, Singh GK, Hirasawa K, Butcher SC, Cohen DJ, Généreux P, Leon MB, Marsan NA, Delgado V, Bax JJ

Moderate aortic stenosis (AS) is associated with an increased risk for adverse events. Although reduced left ventricular (LV) global longitudinal strain (GLS) is associated with worse outcomes in patients with severe AS, its prognostic value in patients with moderate AS is unknown. The aim of this study was to investigate the prognostic implications of LV GLS in patients with moderate AS. Methods: LV GLS was evaluated using speckle-tracking echocardiography in patients with moderate AS (aortic v... Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

Medical sciences (Basel, Switzerland), Volume 10, Issue 1, 15 3 2022, Pages 19 Parathyroid Allotransplantation: A Systematic Review. Zhang JLH, Appelman-Dijkstra NM, Schepers A

Background: To date, there is no satisfactory treatment for patients with calcium and vitamin D supplementation refractive hypoparathyroidism. Parathyroid allotransplantation by design is a one-time cure through its restoration of the parathyroid function and, therefore, could be the solution. A systematic literature review is conducted in the present paper, with the aim of outlining the possibilities of parathyroid allotransplantation and to calculate its efficacy. Additionally, various transpl... Abstract

The American journal of medicine, Volume 135, Issue 7, 14 2 2022, Pages 915-918 Effect of Alirocumab on Incidence of Atrial Fibrillation After Acute Coronary Syndromes: Insights from the ODYSSEY OUTCOMES Trial. Lopes RD, Guimarães PO, Schwartz GG, Bhatt DL, Bittner VA, Budaj A, Dalby AJ, Diaz R, Goodman SG, Harrington RA, Jukema JW, Kiss RG, Loy M, Pordy R, Poulouin Y, Szarek M, White HD, Steg PG, ODYSSEY OUTCOMES Investigators

Background: Using data from the ODYSSEY OUTCOMES trial (NCT01663402), we sought to identify factors associated with the development of incident atrial fibrillation in patients with recent acute coronary syndrome without prior atrial fibrillation and to determine whether alirocumab treatment influenced risk of incident atrial fibrillation. Methods: ODYSSEY OUTCOMES compared alirocumab treatment with placebo in 18,924 patients with recent acute coronary syndrome and dyslipidemia despite high-inten... Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

European journal of nutrition, Volume 61, Issue 5, 14 2 2022, Pages 2761-2773 Adherence to the Dutch healthy diet index and change in glycemic control and cardiometabolic markers in people with type 2 diabetes. Bartels ECM, den Braver NR, Borgonjen-van den Berg KJ, Rutters F, van der Heijden A, Beulens JWJ

Purpose: To investigate whether adherence to the Dutch Healthy Diet index 2015 (DHD15-index) is associated with change in glycemic control and cardio-metabolic markers over two-year follow-up in people with type 2 diabetes (T2D). Methods: This prospective cohort study included 1202 individuals with T2D (mean age 68.7 ± 9.0 years; 62.5% male; mean HbA1c 53.8 ± 11.7 mmol/mol) from the Diabetes Care System cohort. Baseline dietary intake was assessed using a validated food frequency questionnaire,... Abstract

Cited 16 times since 2022 (5.1 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 9, 11 2 2022, Pages 854314 Pirfenidone Has Anti-fibrotic Effects in a Tissue-Engineered Model of Human Cardiac Fibrosis. Bracco Gartner TCL, Crnko S, Leiteris L, van Adrichem I, van Laake LW, Bouten CVC, Goumans MJ, Suyker WJL, Sluijter JPG, Hjortnaes J

A fundamental process in the development and progression of heart failure is fibrotic remodeling, characterized by excessive deposition of extracellular matrix proteins in response to injury. Currently, therapies that effectively target and reverse cardiac fibrosis are lacking, warranting novel therapeutic strategies and reliable methods to study their effect. Using a gelatin methacryloyl hydrogel, human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) and human fetal cardiac fibr... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 30, Issue 9, 11 2 2022, Pages 431-435 Emergency Heart failure Mortality Risk Grade may help to reduce heart failure admissions. van Hattem NE, Beeres SLMA, Mertens BJA, Antoni ML, Atsma DE, Schalij MJ, den Haan MC

Introduction: Hospital admissions for heart failure (HF) are frequent and pose a heavy burden on health care resources. Currently, the decision to hospitalise is based on clinical judgement rather than on prognostic risk stratification. The Emergency Heart failure Mortality Risk Grade (EHMRG) was recently developed to identify high-risk HF patients in the emergency department (ED). Objective: To assess the ability of the EHMRG to predict 30-day mortality in Dutch HF patients visiting the ED and... Abstract

Cited 10 times since 2022 (3.2 per year) source: EuropePMC

Acta dermato-venereologica, Volume 102, 11 2 2022, Pages adv00666 Identification of Risk Factors for Dupilumab-associated Ocular Surface Disease in Patients with Atopic Dermatitis. Achten RE, Van Luijk C, Van der Rijst L, Bakker D, Spekhorst L, Zuithoff N, Schuttelaar M, Romeijn G, Voorberg A, Kamsteeg M, Haeck I, De Graaf M, Thijs J, De Boer J, De Bruin-Weller M

This study identified risk factors for the development of dupilumab-associated ocular surface disease in patients with moderate-to-severe atopic dermatitis in a large prospective daily practice cohort. Data from the Dutch BioDay Registry were used to assess the risk of developing dupilumab-associated ocular surface disease, by performing univariate and multivariate logistic regression analyses. A total of 469 patients were included, of which 152/469 (32.4%) developed dupilumab-associated ocular... Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

Journal of lipid research, Volume 63, Issue 5, 10 2 2022, Pages 100193 Apolipoprotein A-V is a potential target for treating coronary artery disease: evidence from genetic and metabolomic analyses. Ibi D, Boot M, Dollé MET, Jukema JW, Rosendaal FR, Christodoulides C, Neville MJ, Koivula R, Rensen PCN, Karpe F, Noordam R, Willems van Dijk K

Triglyceride (TG)-lowering LPL variants in combination with genetic LDL-C-lowering variants are associated with reduced risk of coronary artery disease (CAD). Genetic variation in the APOA5 gene encoding apolipoprotein A-V also strongly affects TG levels, but the potential clinical impact and underlying mechanisms are yet to be resolved. Here, we aimed to study the effects of APOA5 genetic variation on CAD risk and plasma lipoproteins through factorial genetic association analyses. Using data fr... Abstract

Cited 10 times since 2022 (3.2 per year) source: EuropePMC

Diagnostics (Basel, Switzerland), Volume 12, Issue 3, 9 2 2022, Pages 669 Sclerodermic Cardiomyopathy-A State-of-the-Art Review. Giucă A, Gegenava T, Mihai CM, Jurcuţ C, Săftoiu A, Gȋrniţă DM, Popescu BA, Ajmone Marsan N, Jurcuț R

Systemic sclerosis (SSc) is a chronic autoimmune disorder with unknown triggering factors, and complex pathophysiologic links which lead to fibrosis of skin and internal organs, including the heart, lungs, and gut. However, more than 100 years after the first description of cardiac disease in SSc, sclerodermic cardiomyopathy (SScCmp) is an underrecognized, occult disease with important adverse long-term prognosis. Laboratory tests, electrocardiography (ECG) and cardiovascular multimodality imagi... Abstract

Cited 13 times since 2022 (4.2 per year) source: EuropePMC

ESC heart failure, Volume 9, Issue 3, 9 2 2022, Pages 1597-1607 Right ventricular-pulmonary artery coupling in cardiac resynchronization therapy: evolution and prognosis. Stassen J, Galloo X, Hirasawa K, Chimed S, Marsan NA, Delgado V, van der Bijl P, Bax JJ

Aims: Chronic pressure overload and right ventricular (RV) dysfunction can lead to RV-pulmonary artery (PA) uncoupling in patients with heart failure. The evolution and prognostic values of RV-PA coupling assessed by echocardiography in patients undergoing cardiac resynchronization therapy (CRT) have not been thoroughly investigated. The aim of this study was to evaluate the evolution and prognostic value of tricuspid annular plane systolic excursion (TAPSE)/pulmonary artery systolic pressure (P... Abstract

Cited 2 times since 2022 (0.6 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 9, 7 1 2022, Pages 870390 Corrigendum: Robotic Cardiac Surgery in Europe: Status 2020. Cerny S, Oosterlinck W, Onan B, Singh S, Segers P, Bolcal C, Alhan C, Navarra E, Pettinari M, Van Praet F, De Praetere H, Vojacek J, Cebotaru T, Modi P, Doguet F, Franke U, Ouda A, Melly L, Malapert G, Labrousse L, Gianoli M, Agnino A, Philipsen T, Jansens JL, Folliguet T, Palmen M, Pereda D, Musumeci F, Suwalski P, Cathenis K, Van den Eynde J, Bonatti J

[This corrects the article DOI: 10.3389/fcvm.2021.827515.]. Abstract