8892 results
Cited 52 times since 2022 (14.3 per year)
source: EuropePMC
Diabetes care,
Volume 45, Issue 3, 1 1 2022, Pages 674-683
Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 Individuals Across 13 Cohorts.
DiCorpo D, LeClair J, Cole JB, Sarnowski C, Ahmadizar F, Bielak LF, Blokstra A, Bottinger EP, Chaker L, Chen YI, Chen Y, de Vries PS, Faquih T, Ghanbari M, Gudmundsdottir V, Guo X, Hasbani NR, Ibi D, Ikram MA, Kavousi M, Leonard HL, Leong A, Mercader JM, Morrison AC, Nadkarni GN, Nalls MA, Noordam R, Preuss M, Smith JA, Trompet S, Vissink P, Yao J, Zhao W, Boerwinkle E, Goodarzi MO, Gudnason V, Jukema JW, Kardia SLR, Loos RJF, Liu CT, Manning AK, Mook-Kanamori D, Pankow JS, Picavet HSJ, Sattar N, Simonsick EM, Verschuren WMM, Willems van Dijk K, Florez JC, Rotter JI, Meigs JB, Dupuis J, Udler MS
Objective: Type 2 diabetes (T2D) has heterogeneous patient clinical characteristics and outcomes. In previous work, we investigated the genetic basis of this heterogeneity by clustering 94 T2D genetic loci using their associations with 47 diabetes-related traits and identified five clusters, termed β-cell, proinsulin, obesity, lipodystrophy, and liver/lipid. The relationship between these clusters and individual-level metabolic disease outcomes has not been assessed. Research design and methods:...
Abstract
Cited 15 times since 2022 (4.1 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 23, Issue 4, 1 1 2022, Pages 515-523
Orientation of the right superior pulmonary vein affects outcome after pulmonary vein isolation.
Szegedi N, Vecsey-Nagy M, Simon J, Szilveszter B, Herczeg S, Kolossváry M, Idelbi H, Osztheimer I, Klaudia Nagy V, Tahin T, Széplaki G, Delgado V, Bax JJ, Maurovich-Horvat P, Merkely B, Gellér L
Aims: Controversial results have been published regarding the influence of pulmonary vein (PV) anatomical variations on outcomes after pulmonary vein isolation (PVI). However, no data are available on the impact of PV orientation on the long-term success rates of point-by-point PVI. We sought to determine the impact of PV anatomy and orientation on atrial fibrillation (AF)-free survival in patients undergoing PVI using the radiofrequency point-by-point technique. Methods and results: We retrospe...
Abstract
Cited 11 times since 2022 (3 per year)
source: EuropePMC
American journal of epidemiology,
Volume 191, Issue 5, 1 1 2022, Pages 886-899
Evaluation of the Value of Waist Circumference and Metabolomics in the Estimation of Visceral Adipose Tissue.
Boone SC, van Smeden M, Rosendaal FR, le Cessie S, Groenwold RHH, Jukema JW, van Dijk KW, Lamb HJ, Greenland P, Neeland IJ, Allison MA, Criqui MH, Budoff MJ, Lind LL, Kullberg J, Ahlström H, Mook-Kanamori DO, de Mutsert R
Visceral adipose tissue (VAT) is a strong prognostic factor for cardiovascular disease and a potential target for cardiovascular risk stratification. Because VAT is difficult to measure in clinical practice, we estimated prediction models with predictors routinely measured in general practice and VAT as outcome using ridge regression in 2,501 middle-aged participants from the Netherlands Epidemiology of Obesity study, 2008-2012. Adding waist circumference and other anthropometric measurements on...
Abstract
Cited 6 times since 2022 (1.7 per year)
source: EuropePMC
The Journal of cardiovascular nursing,
Volume 37, Issue 2, 1 1 2022, Pages 192-196
Type D Personality Associated With Increased Risk for Mortality in Adults With Congenital Heart Disease.
Kauw D, Schoormans D, Sieswerda GT, Van Melle JP, Vliegen HW, Van Dijk APJ, Hulsbergen-Zwarts MS, Post MC, Ansink TJ, Mulder BJM, Bouma BJ, Schuuring MJ
Background: Type D personality has been previously shown to increase the risk for mortality in patients with acquired heart disease. Objective: We aimed to compare mortality in adult patients with congenital heart disease (CHD) with and without type D. Methods: Survival was assessed using prospective data from the Dutch national Congenital Corvitia registry for adults with CHD. Patients were randomly selected from the registry and characterized at inclusion in 2009 for the presence of type D usi...
Abstract
Cited 27 times since 2022 (7.4 per year)
source: EuropePMC
JAMA cardiology,
Volume 7, Issue 3, 1 1 2022, Pages 309-319
Association of Plaque Location and Vessel Geometry Determined by Coronary Computed Tomographic Angiography With Future Acute Coronary Syndrome-Causing Culprit Lesions.
Han D, Lin A, Kuronuma K, Tzolos E, Kwan AC, Klein E, Andreini D, Bax JJ, Cademartiri F, Chinnaiyan K, Chow BJW, Conte E, Cury RC, Feuchtner G, Hadamitzky M, Kim YJ, Leipsic JA, Maffei E, Marques H, Plank F, Pontone G, Villines TC, Al-Mallah MH, de Araújo Gonçalves P, Danad I, Gransar H, Lu Y, Lee JH, Lee SE, Baskaran L, Al'Aref SJ, Yoon YE, Van Rosendael A, Budoff MJ, Samady H, Stone PH, Virmani R, Achenbach S, Narula J, Chang HJ, Min JK, Lin FY, Shaw LJ, Slomka PJ, Dey D, Berman DS
Importance: Distinct plaque locations and vessel geometric features predispose to altered coronary flow hemodynamics. The association between these lesion-level characteristics assessed by coronary computed tomographic angiography (CCTA) and risk of future acute coronary syndrome (ACS) is unknown. Objective: To examine whether CCTA-derived adverse geometric characteristics (AGCs) of coronary lesions describing location and vessel geometry add to plaque morphology and burden for identifying culpr...
Abstract
Cited 17 times since 2022 (4.7 per year)
source: EuropePMC
Human molecular genetics,
Volume 31, Issue 7, 1 1 2022, Pages 1051-1066
C/D box snoRNA SNORD113-6/AF357425 plays a dual role in integrin signalling and arterial fibroblast function via pre-mRNA processing and 2'O-ribose methylation.
van Ingen E, van den Homberg DAL, van der Bent ML, Mei H, Papac-Milicevic N, Kremer V, Boon RA, Quax PHA, Wojta J, Nossent AY
We have previously shown that C/D box small nucleolar RNAs (snoRNAs) transcribed from the DLK1-DIO3 locus on human chromosome 14 (14q32) are associated with cardiovascular disease. DLK1-DIO3 snoRNAs are 'orphan snoRNAs' that have no known targets. We aimed to identify RNA targets and elucidate the mechanism-of-action of human SNORD113-6 (AF357425 in mice). As AF357425-knockout cells were non-viable, we induced overexpression or inhibition of AF357425 in primary murine fibroblasts and p...
Abstract
Cited 20 times since 2022 (5.5 per year)
source: EuropePMC
Microbiology spectrum,
Volume 10, Issue 2, 28 4 2022, Pages e0213421
Phenotypic and Genotypic Characterization of a Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae ST17-KL38 Clinical Isolate Harboring the Carbapenemase IMP-4.
He J, Du X, Zeng X, Moran RA, van Schaik W, Zou Q, Yu Y, Zhang J, Hua X
Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is a threat to global public health. We characterized a sequence type 17 (ST17) K. pneumoniae clinical isolate that was resistant to carbapenems and belonged to serotype KL38/O2. Its complete genome is comprised of a 5.1-Mb chromosome and two conjugative plasmids. The 52,578-bp N-type plasmid pXH210-IMP contains the blaIMP-4 carbapenemase gene and the quinolone resistance gene qnrS1. The 272,742-bp FII(K)-9:FIB(K)-10 plasmid pXH2...
Abstract
Cited 12 times since 2022 (3.3 per year)
source: EuropePMC
The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland,
Volume 21, Issue 1, 28 4 2022, Pages 1-7
Exploring the surgical personality.
Sier VQ, Schmitz RF, Schepers A, van der Vorst JR
Surgery is a demanding field, requiring determination and emotional stability. This review explores the surgical personality, addressing international personality differences between surgical and non-surgical specialties. Across the globe, surgically-interested individuals (i.e., medical students, residents, surgeons) generally scored higher on conscientiousness, open mindedness, and extraversion, and lower on neuroticism compared to non-surgically-interested contemporaries. Extraversion was inv...
Abstract
Cited 2 times since 2022 (0.6 per year)
source: EuropePMC
Biomedicines,
Volume 10, Issue 3, 28 4 2022, Pages 565
Blood M2-like Monocyte Polarization Is Associated with Calcific Plaque Phenotype in Stable Coronary Artery Disease: A Sub-Study of SMARTool Clinical Trial.
Sbrana S, Cecchettini A, Bastiani L, Di Giorgi N, Mazzone A, Ceccherini E, Vozzi F, Caselli C, Neglia D, Clemente A, Scholte AJHA, Parodi O, Pelosi G, Rocchiccioli S
Background: Atherosclerosis is a chronic inflammatory disease. The balance between pro- and anti-inflammatory factors, acting on the arterial wall, promotes less or more coronary plaque macro-calcification, respectively. We investigated the association between monocyte phenotypic polarization and CTCA-assessed plaque dense-calcium volume (DCV) in patients with stable coronary artery disease (CAD). Methods: In 55 patients, individual DCV component was assessed by quantitative CTCA and normalized...
Abstract
The international journal of cardiovascular imaging,
Volume 38, Issue 5, 26 4 2022, Pages 927-929
Patterns of cardiac involvement characterized by strain echocardiography in amyloidosis.
Tjahjadi C, Fortuni F, Stassen J, Marsan NA, Delgado V, Bax JJ
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 30, Issue 6, 24 4 2022, Pages 338-339
Multiple culprit lesions in ST-segment elevation myocardial infarction with cardiogenic shock: a case of simultaneous thrombosis of two infarct-related arteries.
Caliskan R, Ince H, Arslan F
Abstract
Cited 3 times since 2022 (0.8 per year)
source: EuropePMC
British journal of pharmacology,
Volume 179, Issue 13, 23 4 2022, Pages 3382-3402
In vivo and cellular antiarrhythmic and cardiac electrophysiological effects of desethylamiodarone in dog cardiac preparations.
Kohajda Z, Virág L, Hornyik T, Husti Z, Sztojkov-Ivanov A, Nagy N, Horváth A, Varga R, Prorok J, Szlovák J, Tóth N, Gazdag P, Topal L, Naveed M, Árpádffy-Lovas T, Pászti B, Magyar T, Koncz I, Déri S, Demeter-Haludka V, Aigner Z, Ördög B, Patfalusi M, Tálosi L, Tiszlavicz L, Földesi I, Jost N, Baczkó I, Varró A
Background and purpose: The aim of the present study was to study the antiarrhythmic effects and cellular mechanisms of desethylamiodarone (DEA), the main metabolite of amiodarone (AMIO), following acute and chronic 4-week oral treatments (25-50 mg·kg-1 ·day-1 ). Experimental approach: The antiarrhythmic effects of acute iv. (10 mg·kg-1 ) and chronic oral (4 weeks, 25 mg·kg-1 ·day-1 ) administration of DEA were assessed in carbachol and tachypacing-induced dog atrial fibrillation models. Action...
Abstract
Cited 18 times since 2022 (4.9 per year)
source: EuropePMC
JMIR cardio,
Volume 6, Issue 1, 22 4 2022, Pages e29473
A Preoperative Virtual Reality App for Patients Scheduled for Cardiac Catheterization: Pre-Post Questionnaire Study Examining Feasibility, Usability, and Acceptability.
Aardoom JJ, Hilt AD, Woudenberg T, Chavannes NH, Atsma DE
Background: Pre- and postoperative anxiety is a common phenomenon associated with negative postoperative outcomes. Symptoms of posttraumatic stress disorder, such as fear, nightmares, and sleep deprivation, are prevalent in approximately 30% to 50% of patients following discharge from intensive care units after cardiac surgery. Preliminary evidence suggests a promising role of virtual reality (VR) in preventing stress-related reactions using stress inoculation training. Such training enables cog...
Abstract
Cited 1 times since 2022 (0.3 per year)
source: EuropePMC
Frontiers in psychiatry,
Volume 13, 22 4 2022, Pages 774251
Incorporating Baseline Outcome Data in Individual Participant Data Meta-Analysis of Non-randomized Studies.
Syrogiannouli L, Wildisen L, Meuwese C, Bauer DC, Cappola AR, Gussekloo J, den Elzen WPJ, Trompet S, Westendorp RGJ, Jukema JW, Ferrucci L, Ceresini G, Åsvold BO, Chaker L, Peeters RP, Imaizumi M, Ohishi W, Vaes B, Völzke H, Sgarbi JA, Walsh JP, Dullaart RPF, Bakker SJL, Iacoviello M, Rodondi N, Del Giovane C
Background: In non-randomized studies (NRSs) where a continuous outcome variable (e.g., depressive symptoms) is assessed at baseline and follow-up, it is common to observe imbalance of the baseline values between the treatment/exposure group and control group. This may bias the study and consequently a meta-analysis (MA) estimate. These estimates may differ across statistical methods used to deal with this issue. Analysis of individual participant data (IPD) allows standardization of methods acr...
Abstract
Cited 5 times since 2022 (1.4 per year)
source: EuropePMC
Evolutionary human sciences,
Volume 4, 21 3 2022, Pages e11
Four levers of reciprocity across human societies: concepts, analysis and predictions.
Lehmann L, Powers ST, van Schaik CP
This paper surveys five human societal types - mobile foragers, horticulturalists, pre-state agriculturalists, state-based agriculturalists and liberal democracies - from the perspective of three core social problems faced by interacting individuals: coordination problems, social dilemmas and contest problems. We characterise the occurrence of these problems in the different societal types and enquire into the main force keeping societies together given the prevalence of these. To address this,...
Abstract
Cited 1 times since 2022 (0.3 per year)
source: EuropePMC
The American journal of cardiology,
Volume 170, 21 3 2022, Pages 1-9
Prognostic Relevance of Right Ventricular Remodeling after ST-Segment Elevation Myocardial Infarction in Patients Treated With Primary Percutaneous Coronary Intervention.
Chimed S, van der Bijl P, Lustosa RP, Hirasawa K, Yedidya I, Fortuni F, van der Velde E, Montero-Cabezas JM, Marsan NA, Gersh BJ, Delgado V, Bax JJ
ST-segment elevation myocardial infarction (STEMI) often leads to changes in right ventricular (RV) function and size over time. The prognostic implications of RV remodeling after STEMI, however, are unknown. RV remodeling in patients who underwent STEMI with primary percutaneous coronary intervention (PCI) was defined by RV end-systolic area (RV ESA) change at 6 months after STEMI compared with baseline. The optimal threshold of RV ESA change (≥40%) to define RV remodeling was derived from spli...
Abstract
Cited 4 times since 2022 (1.1 per year)
source: EuropePMC
International journal of cardiology,
Volume 355, 18 3 2022, Pages 65-71
Prognostic implications of staging cardiac remodeling in patients undergoing cardiac resynchronization therapy.
Stassen J, Khidir M, Galloo X, Hirasawa K, Knuuti J, Marsan NA, Delgado V, van der Bijl P, Bax JJ
Background: Cardiac resynchronization therapy (CRT) candidates often present with significant mitral and tricuspid regurgitation, pulmonary hypertension and right ventricular dysfunction when referred for device implantation. This study investigated the prognostic value of a novel cardiac staging system, based on the extent of cardiac remodeling prior to implantation. Methods: Data were collected from an ongoing registry of CRT recipients. Patients were divided into 4 groups according to the ext...
Abstract
Cited 8 times since 2022 (2.2 per year)
source: EuropePMC
Heart rhythm,
Volume 19, Issue 6, 18 3 2022, Pages 927-936
Impact of baseline left ventricular volume on left ventricular reverse remodeling after cardiac resynchronization therapy.
Galloo X, Stassen J, Hirasawa K, Chimed S, Cosyns B, Ajmone Marsan N, Delgado V, van der Bijl P, Bax JJ
Background: Left ventricular (LV) dilatation may limit LV reverse remodeling after cardiac resynchronization therapy (CRT). Objective: The purpose of this study was to evaluate the impact of baseline LV volumes on LV reverse remodeling after CRT and whether this is associated with improved survival. Methods: Patients were stratified into quintiles according to baseline LV end-diastolic volume indexed for body surface area (LVEDVi). LV reverse remodeling was defined as ≥15% reduction in LV end-sy...
Abstract
European heart journal. Case reports,
Volume 6, Issue 3, 17 3 2022, Pages ytac087
Successful hybrid cardiac resynchronization therapy in a patient with failing systemic right ventricle and significant tricuspid regurgitation in transposition of the great arteries after atrial switch procedure according to Mustard.
Nederend M, Zeppenfeld K, Jongbloed MRM, Egorova AD
Background: Patients with a systemic right ventricle (sRV) in the context of transposition of the great arteries (TGA) late after atrial switch are prone to heart failure. Complications like tricuspid valve regurgitation (TR) can further aggravate sRV dysfunction. Tricuspid valve regurgitation is usually secondary to annular dilatation and restriction. Criteria for cardiac resynchronization therapy (CRT) in this patient group are not well defined and should be considered on a case-by-case basis....
Abstract
Cited 18 times since 2022 (4.9 per year)
source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 63, Issue 3, 16 3 2022, Pages 390-399
Editor's Choice - Post-operative Surveillance and Long Term Outcome after Endovascular Aortic Aneurysm Repair in Patients with an Initial Post-operative Computed Tomography Angiogram Without Abnormalities: the Multicentre Retrospective ODYSSEUS Study.
Geraedts ACM, Mulay S, Vahl AC, Verhagen HJM, Wisselink W, de Mik SML, van Dieren S, Koelemay MJW, Balm R, ODYSSEUS study group
Objective: Lifelong imaging surveillance is recommended following endovascular aneurysm repair (EVAR). This study aimed to examine the association between adherence to post-operative surveillance and survival and secondary interventions in patients with an initial post-operative computed tomography angiogram (CTA) without abnormalities. Methods: All consecutive patients undergoing EVAR for intact abdominal aortic aneurysm (AAA) in 16 hospitals between 2007 and 2012 were identified retrospectivel...
Abstract
