7494 results
Cited 437 times since 2021 (101.6 per year)
source: EuropePMC
European journal of preventive cardiology,
Volume 28, Issue 11, 1 1 2021, Pages 1279-1289
EU-Wide Cross-Sectional Observational Study of Lipid-Modifying Therapy Use in Secondary and Primary Care: the DA VINCI study.
Ray KK, Molemans B, Schoonen WM, Giovas P, Bray S, Kiru G, Murphy J, Banach M, De Servi S, Gaita D, Gouni-Berthold I, Hovingh GK, Jozwiak JJ, Jukema JW, Kiss RG, Kownator S, Iversen HK, Maher V, Masana L, Parkhomenko A, Peeters A, Clifford P, Raslova K, Siostrzonek P, Romeo S, Tousoulis D, Vlachopoulos C, Vrablik M, Catapano AL, Poulter NR, DA VINCI study
Aims: To provide contemporary data on the implementation of European guideline recommendations for lipid-lowering therapies (LLTs) across different settings and populations and how this impacts low-density lipoprotein cholesterol (LDL-C) goal achievement. Methods and results: An 18 country, cross-sectional, observational study of patients prescribed LLT for primary or secondary prevention in primary or secondary care across Europe. Between June 2017 and November 2018, data were collected at a si...
Abstract
Cited 18 times since 2021 (4.2 per year)
source: EuropePMC
Proceedings of the National Academy of Sciences of the United States of America,
Volume 118, Issue 39, 1 1 2021, Pages e2106332118
The discrete-time Kermack-McKendrick model: A versatile and computationally attractive framework for modeling epidemics.
Diekmann O, Othmer HG, Planqué R, Bootsma MCJ
The COVID-19 pandemic has led to numerous mathematical models for the spread of infection, the majority of which are large compartmental models that implicitly constrain the generation-time distribution. On the other hand, the continuous-time Kermack-McKendrick epidemic model of 1927 (KM27) allows an arbitrary generation-time distribution, but it suffers from the drawback that its numerical implementation is rather cumbersome. Here, we introduce a discrete-time version of KM27 that is as general...
Abstract
Cited 11 times since 2021 (2.6 per year)
source: EuropePMC
Open heart,
Volume 8, Issue 2, 1 1 2021, Pages e001772
Comparative evaluation of coronary disease burden: bicuspid valve disease is not atheroprotective.
Dolmaci OB, Driessen AHG, Klautz RJM, Poelmann R, Lindeman JHN, Grewal N
Objective: Bicuspid aortic valve (BAV) has been associated with less atherosclerosis as compared with tricuspid aortic valve (TAV) patients. It, however, remains unclear whether this reflects the older age of TAV patients and/or accumulation of atherosclerotic risk factors or that the BAV phenotype is atheroprotective. Therefore, we compared the atherosclerotic disease burden of BAV and TAV patients, with that of the general (age-matched) population. Methods: The prevalence of coronary artery di...
Abstract
Cited 1 times since 2021 (0.2 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 60, Issue 3, 1 1 2021, Pages 481-496
Summary: international consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes.
Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Edwards WD, Roman MJ, Devereux RB, Fernández B, Asch FM, Barker AJ, Sierra-Galan LM, De Kerchove L, Fernandes SM, Fedak PWM, Girdauskas E, Delgado V, Abbara S, Lansac E, Prakash SK, Bissell MM, Popescu BA, Hope MD, Sitges M, Thourani VH, Pibarot P, Chandrasekaran K, Lancellotti P, Borger MA, Forrest JK, Webb J, Milewicz DM, Makkar R, Leon MB, Sanders SP, Markl M, Ferrari VA, Roberts WC, Song JK, Blanke P, White CS, Siu S, Svensson LG, Braverman AC, Bavaria J, Sundt TM, Khoury GE, De Paulis R, Enriquez-Sarano M, Bax JJ, Otto CM, Schäfers HJ
This International evidence-based nomenclature and classification consensus on the congenital bicuspid aortic valve and its aortopathy recognizes 3 types of bicuspid aortic valve: 1. Fused type, with 3 phenotypes: right-left cusp fusion, right-non cusp fusion and left-non cusp fusion; 2. 2-sinus type with 2 phenotypes: Latero-lateral and antero-posterior; and 3. Partial-fusion or forme fruste. This consensus recognizes 3 bicuspid-aortopathy types: 1. Ascending phenotype; root phenotype; and 3. e...
Abstract
Cited 11 times since 2021 (2.6 per year)
source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 62, Issue 4, 31 5 2021, Pages 630-641
Towards Patient Centred Outcomes for Elective Abdominal Aortic Aneurysm Repair: A Scoping Review of Quality of Life Scales.
Bulder RMA, Hamming JF, van Schaik J, Lindeman JHN
Objective: In order to better incorporate the patient's perspective in medical decision making, core outcome sets (COS) are being defined. In the field of abdominal aortic aneurysm (AAA), efforts to capture the patient's perspective focus on generic quantitative quality of life (QoL) scales. The question arises whether these quantitative scales adequately reflect the patient's perspective on QoL, and whether they can be included in the QoL aspect of COS. A scoping review of QoL as...
Abstract
Cited 9 times since 2021 (2.1 per year)
source: EuropePMC
Frontiers in cardiovascular medicine,
Volume 8, 30 5 2021, Pages 687885
Radiation Induces Valvular Interstitial Cell Calcific Response in an <i>in vitro</i> Model of Calcific Aortic Valve Disease.
Meerman M, Driessen R, van Engeland NCA, Bergsma I, Steenhuijsen JLG, Kozono D, Aikawa E, Hjortnaes J, Bouten CVC
Background: Mediastinal ionizing radiotherapy is associated with an increased risk of valvular disease, which demonstrates pathological hallmarks similar to calcific aortic valve disease (CAVD). Despite advances in radiotherapy techniques, the prevalence of comorbidities such as radiation-associated valvular disease is still increasing due to improved survival of patients receiving radiotherapy. However, the mechanisms of radiation-associated valvular disease are largely unknown. CAVD is conside...
Abstract
Cited 7 times since 2021 (1.6 per year)
source: EuropePMC
Turkish journal of medical sciences,
Volume 51, Issue 4, 30 5 2021, Pages 1640-1646
Impact of COVID-19 on serum melatonin levels and sleep parameters in children
Yayıcı Köken Ö, Gültutan P, Güngören MS, Bayhan Gİ, Yılmaz D, Gürkaş E, Özyürek H, Çıtak Kurt AN
Background/aim: This study aimed to analyze the serum melatonin levels and changes in sleep patterns in pediatric patients with
coronavirus disease 2019 (COVID-19). Materials and methods: This study was designed as a descriptive, cross-sectional study. Serum melatonin levels and sleep parameters of children with the diagnosis of COVID-19 who had mild and moderate disease (i.e., COVID-19 group) were compared with those of children admitted with non-COVID-19 nonspecific upper respiratory tract inf...
Abstract
Cited 1 times since 2021 (0.2 per year)
source: EuropePMC
JMIR cardio,
Volume 5, Issue 2, 30 5 2021, Pages e27867
Financial Incentives for Healthy Living for Patients With Cardiac Disease From the Perspective of Health Care Professionals: Interview Study.
de Buisonjé D, Van der Geer J, Keesman M, Van der Vaart R, Reijnders T, Wentzel J, Kemps H, Kraaijenhagen R, Janssen V, Evers A
Background: A promising new approach to support lifestyle changes in patients with cardiovascular disease (CVD) is the use of financial incentives. Although financial incentives have proven to be effective, their implementation remains controversial, and ethical objections have been raised. It is unknown whether health care professionals (HCPs) involved in CVD care find it acceptable to provide financial incentives to patients with CVD as support for lifestyle change. Objective: This study aims...
Abstract
Cited 16 times since 2021 (3.7 per year)
source: EuropePMC
Clinical research in cardiology : official journal of the German Cardiac Society,
Volume 110, Issue 11, 28 4 2021, Pages 1734-1742
Echocardiography-derived total atrial conduction time (PA-TDI duration): risk stratification and guidance in atrial fibrillation management.
Müller P, Weijs B, Bemelmans NMAA, Mügge A, Eckardt L, Crijns HJGM, Bax JJ, Linz D, den Uijl DW
Atrial fibrillation (AF) is a major cause of cardiovascular morbidity and mortality. To early detect and to avoid AF-related complications, several cardiac imaging modalities and approaches aim to quantify the severity of the underlying atrial cardiomyopathy (i.e., the extent of atrial remodeling). However, most established cardiac imaging modalities just incorporate single components of atrial remodeling and do not reflect the complete multifactorial process, which may contribute to their limit...
Abstract
European heart journal. Case reports,
Volume 5, Issue 8, 27 4 2021, Pages ytab288
4D flow MRI of type B dissection with later retrograde progression to type A dissection in Marfan: a case report.
van Hout MJP, Juffermans JF, Scholte AJ, Lamb HJ
Background: Due to the malfunction of connective tissue, Marfan patients are at increased risk of aortic dissection. Uncomplicated acute type B dissection is usually managed with medical therapy. Retrograde progression or new type A dissection is a relatively rare but often fatal complication that occur most frequently in the first 6 months after acute type B dissection. Case summary: We present a 31-year-old male with Marfan syndrome and a recent uncomplicated type B dissection from the left su...
Abstract
Cited 21 times since 2021 (4.9 per year)
source: EuropePMC
BMC medicine,
Volume 19, Issue 1, 27 4 2021, Pages 211
Interventions to control nosocomial transmission of SARS-CoV-2: a modelling study.
Pham TM, Tahir H, van de Wijgert JHHM, Van der Roest BR, Ellerbroek P, Bonten MJM, Bootsma MCJ, Kretzschmar ME
Background: Emergence of more transmissible SARS-CoV-2 variants requires more efficient control measures to limit nosocomial transmission and maintain healthcare capacities during pandemic waves. Yet the relative importance of different strategies is unknown. Methods: We developed an agent-based model and compared the impact of personal protective equipment (PPE), screening of healthcare workers (HCWs), contact tracing of symptomatic HCWs and restricting HCWs from working in multiple units (HCW...
Abstract
Cited 12 times since 2021 (2.8 per year)
source: EuropePMC
Journal of cardiovascular development and disease,
Volume 8, Issue 9, 26 4 2021, Pages 102
The Coronary Arteries in Adults after the Arterial Switch Operation: A Systematic Review.
Engele LJ, Mulder BJM, Schoones JW, Kiès P, Egorova AD, Vliegen HW, Hazekamp MG, Bouma BJ, Jongbloed MRM
Coronary artery status in adults long after the arterial switch operation (ASO) is unclear. We conducted a systematic review to provide an overview of coronary complications during adulthood and to evaluate the value of routine coronary imaging in adults after ASO, in light of current guidelines. Articles were screened for the inclusion of adult ASO patients and data on coronary complications and findings of coronary imaging were collected. A total of 993 adults were followed with a median avail...
Abstract
JTCVS open,
Volume 8, 25 4 2021, Pages 249-250
Reply from authors: Prosthesis-patient mismatch is not synonymous with elevated transvalvular pressure gradient.
Vriesendorp MD, Klautz RJM
Abstract
Cited 20 times since 2021 (4.6 per year)
source: EuropePMC
Angiogenesis,
Volume 25, Issue 1, 25 4 2021, Pages 129-143
PFKFB3 gene deletion in endothelial cells inhibits intraplaque angiogenesis and lesion formation in a murine model of venous bypass grafting.
Perrotta P, de Vries MR, Peeters B, Guns PJ, De Meyer GRY, Quax PHA, Martinet W
Vein grafting is a frequently used surgical intervention for cardiac revascularization. However, vein grafts display regions with intraplaque (IP) angiogenesis, which promotes atherogenesis and formation of unstable plaques. Graft neovessels are mainly composed of endothelial cells (ECs) that largely depend on glycolysis for migration and proliferation. In the present study, we aimed to investigate whether loss of the glycolytic flux enzyme phosphofructokinase-2/fructose-2,6-bisphosphatase 3 (PF...
Abstract
Cited 16 times since 2021 (3.7 per year)
source: EuropePMC
Scientific reports,
Volume 11, Issue 1, 24 4 2021, Pages 17121
Differential progression of coronary atherosclerosis according to plaque composition: a cluster analysis of PARADIGM registry data.
Yoon YE, Baskaran L, Lee BC, Pandey MK, Goebel B, Lee SE, Sung JM, Andreini D, Al-Mallah MH, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Chun EJ, Conte E, Gottlieb I, Hadamitzky M, Kim YJ, Lee BK, Leipsic JA, Maffei E, Marques H, de Araújo Gonçalves P, Pontone G, Shin S, Narula J, Bax JJ, Lin FY, Shaw L, Chang HJ
Patient-specific phenotyping of coronary atherosclerosis would facilitate personalized risk assessment and preventive treatment. We explored whether unsupervised cluster analysis can categorize patients with coronary atherosclerosis according to their plaque composition, and determined how these differing plaque composition profiles impact plaque progression. Patients with coronary atherosclerotic plaque (n = 947; median age, 62 years; 59% male) were enrolled from a prospective multi-national re...
Abstract
Cited 3 times since 2021 (0.7 per year)
source: EuropePMC
ACS chemical biology,
Volume 16, Issue 9, 24 4 2021, Pages 1770-1778
Identification of NQO2 As a Protein Target in Small Molecule Modulation of Hepatocellular Function.
Schepers AG, Shan J, Cox AG, Huang A, Evans H, Walesky C, Fleming HE, Goessling W, Bhatia SN
The utility of in vitro human disease models is mainly dependent on the availability and functional maturity of tissue-specific cell types. We have previously screened for and identified small molecules that can enhance hepatocyte function in vitro. Here, we characterize the functional effects of one of the hits, FH1, on primary human hepatocytes in vitro, and also in vivo on primary hepatocytes in a zebrafish model. Furthermore, we conducted an analogue screen to establish the structure-activit...
Abstract
Cited 4 times since 2021 (0.9 per year)
source: EuropePMC
Frontiers in physiology,
Volume 12, 23 4 2021, Pages 710020
The Effects of Repetitive Use and Pathological Remodeling on Channelrhodopsin Function in Cardiomyocytes.
Ördög B, Teplenin A, De Coster T, Bart CI, Dekker SO, Zhang J, Ypey DL, de Vries AAF, Pijnappels DA
Aim: Channelrhodopsins (ChRs) are a large family of light-gated ion channels with distinct properties, which is of great importance in the selection of a ChR variant for a given application. However, data to guide such selection for cardiac optogenetic applications are lacking. Therefore, we investigated the functioning of different ChR variants in normal and pathological hypertrophic cardiomyocytes subjected to various illumination protocols. Methods and Results: Isolated neonatal rat ventricul...
Abstract
Cited 25 times since 2021 (5.8 per year)
source: EuropePMC
European journal of heart failure,
Volume 23, Issue 10, 22 4 2021, Pages 1597-1609
Guidance on the management of left ventricular assist device (LVAD) supported patients for the non-LVAD specialist healthcare provider: executive summary.
Ben Gal T, Ben Avraham B, Milicic D, Crespo-Leiro MG, Coats AJS, Rosano G, Seferovic P, Ruschitzka F, Metra M, Anker S, Filippatos G, Altenberger J, Adamopoulos S, Barac YD, Chioncel O, de Jonge N, Elliston J, Frigerio M, Goncalvesova E, Gotsman I, Grupper A, Hamdan R, Hammer Y, Hasin T, Hill L, Itzhaki Ben Zadok O, Abuhazira M, Lavee J, Mullens W, Nalbantgil S, Piepoli MF, Ponikowski P, Potena L, Ristic A, Ruhparwar A, Shaul A, Tops LF, Tsui S, Winnik S, Jaarsma T, Gustafsson F
The accepted use of left ventricular assist device (LVAD) technology as a good alternative for the treatment of patients with advanced heart failure together with the improved survival of patients on the device and the scarcity of donor hearts has significantly increased the population of LVAD supported patients. Device-related, and patient-device interaction complications impose a significant burden on the medical system exceeding the capacity of LVAD implanting centres. The probability of an L...
Abstract
Cited 3 times since 2021 (0.7 per year)
source: EuropePMC
JTCVS open,
Volume 8, 21 3 2021, Pages 668-676
Incidence and risk factors of unplanned emergency department visits following thoracic surgery.
Hazewinkel MHJ, Berendsen RR, van Klink RCJ, Dik H, Wink J, Braun J, de Lind van Wijngaarden RAF
Background: Unplanned visits for care following a surgical procedure can represent a lapse in quality of care. The purpose of this study was to define the proportion of patients undergoing thoracic surgery who return to the emergency department (ED) within 6 months after discharge and the reasons for the returns. In addition, the risk factors for ED visits after thoracic surgery were identified. Methods: All adult patients undergoing thoracic surgery at the Leiden University Medical Center betwe...
Abstract
Cited 10 times since 2021 (2.3 per year)
source: EuropePMC
International journal of cardiology. Heart & vasculature,
Volume 36, 20 3 2021, Pages 100858
Referral and participation in cardiac rehabilitation of patients following acute coronary syndrome; lessons learned.
Rodrigo SF, Van Exel HJ, Van Keulen N, Van Winden L, Beeres SLMA, Schalij MJ
Purpose: Cardiac rehabilitation (CR) after hospitalization for acute coronary syndrome (ACS) has shown to reduce mortality, readmissions, and improve quality of life. CR is recommended by international guidelines but previous studies have shown low participation rates. Systematic CR referral might improve CR participation. Methods: The present study evaluates CR referral and CR participation of patients hospitalized for ACS in 2017 and treated according to local protocol, which includes systemat...
Abstract
