6125 results
Cited 33 times since 2005 (1.7 per year)
source: EuropePMC
Current opinion in lipidology,
Volume 16, Issue 4, 1 1 2005, Pages 434-441
Surrogate markers for atherosclerotic disease.
Sankatsing RR, de Groot E, Jukema JW, de Feyter PJ, Pennell DJ, Schoenhagen P, Nissen SE, Stroes ES, Kastelein JJ
Purpose of review: Novel treatment modalities for cardiovascular prevention are emerging rapidly. Since it is virtually impossible to evaluate all these new compounds in long-term trials using clinical end points, there is an urgent need for validated surrogate markers of atherosclerosis to save both time and costs. Over the last decade, the use of imaging markers has been widely introduced into drug-development strategies. Here we will discuss the most commonly used techniques. Recent findings:...
Abstract
Cited 10 times since 2005 (0.5 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 130, Issue 2, 1 1 2005, Pages 265-271
Dexamethasone reduces gut permeability in pediatric cardiac surgery.
Malagon I, Onkenhout W, Klok M, Linthorst L, van der Poel PF, Bovill JG, Hazekamp MG
Objectives: Little attention has been paid to the effect of the systemic inflammatory response syndrome on intestinal dysfunction in the postoperative period. Several proinflammatory cytokines have been reported to increase the permeability of intestinal mucosa in vitro. We investigated the effect of dexamethasone on gut permeability in pediatric patients undergoing cardiac surgery by using the dual sugar permeability test and absorption of 2 other saccharides. Methods: Thirty-four patients sche...
Abstract
Cited 100 times since 2005 (5.1 per year)
source: EuropePMC
Circulation,
Volume 112, Issue 9 Suppl, 1 1 2005, Pages I212-8
Right atrial and ventricular adaptation to chronic right ventricular pressure overload.
Gaynor SL, Maniar HS, Bloch JB, Steendijk P, Moon MR
Background: Increased mortality in patients with chronic pulmonary hypertension has been associated with elevated right atrial (RA) pressure. However, little is known about the effects of chronic right ventricular (RV) pressure overload on RA and RV dynamics or the adaptive response of the right atrium to maintain RV filling. Methods and results: In 7 dogs, RA and RV pressure and volume (conductance catheter) were recorded at baseline and after 3 months of progressive pulmonary artery banding. R...
Abstract
Cited 63 times since 2005 (3.2 per year)
source: EuropePMC
Cardiovascular research,
Volume 67, Issue 2, 1 1 2005, Pages 245-255
Activation of cardiac and smooth muscle-specific genes in primary human cells after forced expression of human myocardin.
van Tuyn J, Knaän-Shanzer S, van de Watering MJ, de Graaf M, van der Laarse A, Schalij MJ, van der Wall EE, de Vries AA, Atsma DE
Objective: Myocardin is a recently discovered transcriptional regulator of cardiac and smooth muscle development. Its ability to transactivate smooth muscle-specific genes has been firmly established in animal cells but its effect on heart muscle genes has been investigated less extensively and the consequences of ectopic myocardin expression in human cells are unknown. Methods: In this study, primary human mesenchymal stem cells and foreskin fibroblasts were transduced with human adenovirus vec...
Abstract
Cited 16 times since 2005 (0.8 per year)
source: EuropePMC
European journal of endocrinology,
Volume 153, Issue 2, 1 1 2005, Pages 231-238
Persistent diastolic dysfunction despite successful long-term octreotide treatment in acromegaly.
van Thiel SW, Bax JJ, Biermasz NR, Holman ER, Poldermans D, Roelfsema F, Lamb HJ, van der Wall EE, Smit JW, Romijn JA, Pereira AM
Introduction: This study was designed to evaluate potential reversibility of left-ventricular (LV) dysfunction in patients with acromegaly following long-term control of disease. It is unknown whether the cardiac changes induced by acromegaly can be reversed completely by long-term strict control of growth hormone excess by octreotide. Patients and methods: We compared LV systolic and diastolic function in inactive patients with acromegaly (n = 22), who were divided into patients with long-term...
Abstract
Cited 6 times since 2005 (0.3 per year)
source: EuropePMC
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie,
Volume 15, Issue 4, 1 1 2005, Pages 243-247
Outcome of primary peritoneal drainage for perforated necrotizing enterocolitis: comparison between laparotomy and drainage.
Zenciroğlu A, Cakmak O, Demirel N, Baş AY, Yilmaz D, Karaman I, Erdoğan D
Perforation of the gastrointestinal tract in neonates is still associated with high mortality rates. Laparotomy is usually required to treat gastrointestinal perforation, however peritoneal drainage under local anesthesia has been also described as an alternative mode of treatment. In our institute, laparotomy was the first choice for the management of gastrointestinal perforation in neonates until 1999. Because of the high mortality rates in this group of patients, our policy has since changed...
Abstract
Cited 3 times since 2005 (0.2 per year)
source: EuropePMC
Coronary artery disease,
Volume 16, Issue 5, 1 1 2005, Pages 309-313
Long-term prognostic value of ejection fraction changes during dobutamine-atropine stress echocardiography.
Pedone C, Bax JJ, van Domburg RT, Rizzello V, Biagini E, Schinkel AF, Krenning B, Vourvouri EC, Poldermans D
Objective: Dobutamine stress echocardiography (DSE), using subjective wall motion scoring, provides incremental prognostic information over clinical data. The aim of the study was to test the additional prognostic value of left ventricular ejection fraction (LVEF) changes during DSE at different stages. Methods: The study population comprised 106 consecutive patients (mean age 60+/-11 years, 73% men) with suspected or known coronary artery disease referred for DSE. Stress-induced ischemia was de...
Abstract
Cited 4 times since 2005 (0.2 per year)
source: EuropePMC
The American journal of cardiology,
Volume 96, Issue 3, 1 1 2005, Pages 386-389
Relation of improvement in left ventricular ejection fraction versus improvement in heart failure symptoms after coronary revascularization in patients with ischemic cardiomyopathy.
Rizzello V, Poldermans D, Biagini E, Schinkel AF, Elhendy A, Leone AM, Crea F, Maat A, Roelandt JR, Bax JJ
In the present study, the relation between improvement in the left ventricular ejection fraction (LVEF) and heart failure symptoms was evaluated in 100 patients with ischemic cardiomyopathy undergoing coronary revascularization. In patients with viable myocardium, the improvement in the LVEF after revascularization was accompanied by improvement in heart failure symptoms in most patients (80%); most viable patients (75%) without improvement in LVEF also showed an improvement in New York Heart As...
Abstract
Cited 5 times since 2005 (0.3 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 46, Issue 4, 1 1 2005, Pages 730-732
Risk stratification of patients with classic angina pectoris and no history of coronary artery disease by dobutamine stress echocardiography.
Biagini E, Elhendy A, Schinkel AF, Bax JJ, Rizzello V, van Domburg RT, Rapezzi C, Simoons ML, Poldermans D
Abstract
Cited 19 times since 2005 (1 per year)
source: EuropePMC
The American journal of cardiology,
Volume 96, Issue 4, 1 1 2005, Pages 469-473
Effect of myocardial ischemia during dobutamine stress echocardiography on cardiac mortality in patients with heart failure secondary to ischemic cardiomyopathy.
Elhendy A, Sozzi F, van Domburg RT, Bax JJ, Schinkel AF, Roelandt JR, Poldermans D
This study assessed the effect of ischemia during dobutamine stress echocardiography (DSE) on cardiac mortality in patients with heart failure. We studied 528 patients (62 +/- 11 years of age, 402 men) who had heart failure and previous myocardial infarction or known coronary artery disease and underwent DSE. Ischemia was defined as new or worsening wall motion abnormalities or a biphasic response. End point during follow-up was cardiac death. Mean ejection fraction was 35 +/- 12%. Ischemia was...
Abstract
Cited 29 times since 2005 (1.5 per year)
source: EuropePMC
Circulation,
Volume 112, Issue 9 Suppl, 1 1 2005, Pages I437-42
MRI to evaluate left atrial and ventricular reverse remodeling after restrictive mitral annuloplasty in dilated cardiomyopathy.
Westenberg JJ, van der Geest RJ, Lamb HJ, Versteegh MI, Braun J, Doornbos J, de Roos A, van der Wall EE, Dion RA, Reiber JH, Bax JJ
Background: Data on reverse remodeling of the left atrium (LA) and left ventricle (LV) after restrictive annuloplasty in patients with dilated cardiomyopathy are scarce, and follow-up studies are performed with echocardiography. Methods and results: Twenty patients with dilated cardiomyopathy and severe mitral regurgitation selected for restrictive mitral annuloplasty underwent serial MRI studies (within 1 week before surgery, and 2 months [n =18] and 1 year [n =13] after surgery). Early mortali...
Abstract
Cited 38 times since 2005 (1.9 per year)
source: EuropePMC
The American journal of cardiology,
Volume 96, Issue 3, 1 1 2005, Pages 420-422
Comparison of effectiveness of cardiac resynchronization therapy in patients <70 versus > or =70 years of age.
Bleeker GB, Schalij MJ, Molhoek SG, Boersma E, Steendijk P, van der Wall EE, Bax JJ
In the present study, the effects of cardiac resynchronization therapy (CRT) in elderly patients were evaluated. The study included 170 consecutive patients whose clinical and echocardiographic improvements were evaluated after 6 months of follow-up. Survival was evaluated up to 2 years. The effects of CRT in elderly patients (age > or =70 years) were compared with those in younger patients (age
Abstract
Cited 1 times since 2005 (0.1 per year)
source: EuropePMC
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
Volume 65, Issue 4, 1 1 2005, Pages 478-483
Early administration of abciximab in patients with acute myocardial infarction improves angiographic and clinical outcome after primary angioplasty.
Beeres SL, Oemrawsingh PV, Warda HM, Bechan R, Atsma DE, Jukema JW, van der Wall EE, Schalij MJ
Adjunctive use of abciximab during percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) improves clinical outcome. This study addresses the outcome of patients with AMI treated with abciximab, initiated either before transport to a PCI center (early group) or immediately upon arrival at the catheterization laboratory (late group) for primary PCI. Of 446 consecutive patients with AMI, angiographic data and clinical complications were evaluated up to 6 months after primar...
Abstract
Cited 5 times since 2005 (0.3 per year)
source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology,
Volume 1, Issue 2, 1 1 2005, Pages 236-243
Inhibition of intimal hyperplasia by the tetracycline derived mmp inhibitor doxycycline in vein graft disease in vitro and in vivo.
Lardenoye JH, de Vries MR, Deckers M, van Lent N, Hanemaaijer R, van Bockel JH, Quax PH
Aims: Intimal hyperplasia, characterised by smooth muscle cell migration and proliferation, requires extracellular matrix degradation which is mediated by matrix metalloproteinases (MMPs). In this study, the effect of tetracycline derived doxycycline, a specific MMP inhibitor of both activity and synthesis, on intimal hyperplasia in vitro and in vivo was assessed. Methods and results: Segments of human saphenous veins were cultured for 4 weeks in absence or presence of doxycycline (10microg/ml)...
Abstract
Cited 38 times since 2005 (1.9 per year)
source: EuropePMC
Human molecular genetics,
Volume 14, Issue 18, 27 4 2005, Pages 2607-2618
Functional interaction between -629C/A, -971G/A and -1337C/T polymorphisms in the CETP gene is a major determinant of promoter activity and plasma CETP concentration in the REGRESS Study.
Frisdal E, Klerkx AH, Le Goff W, Tanck MW, Lagarde JP, Jukema JW, Kastelein JJ, Chapman MJ, Guerin M
Cholesteryl ester transfer protein (CETP) plays a key role in the determination of high-density lipoprotein (HDL) levels via its action on intravascular HDL metabolism. The TaqIB polymorphism of the CETP gene is associated with plasma CETP and high-density lipoprotein cholesterol (HDL-C) levels and with premature coronary artery disease. Such associations appear to result from linkage disequilibrium between TaqIB and other functional polymorphisms. To date, only one functional promoter variant,...
Abstract
Cited 16 times since 2005 (0.8 per year)
source: EuropePMC
Cardiovascular research,
Volume 68, Issue 3, 15 3 2005, Pages 415-424
Histopathologic alterations following local delivery of dexamethasone to inhibit restenosis in murine arteries.
Pires NM, Schepers A, van der Hoeven BL, de Vries MR, Boesten LS, Jukema JW, Quax PH
Objective: Dexamethasone-eluting stents are currently under evaluation to prevent post-angioplasty restenosis. The efficacy and safety of dexamethasone as an anti-restenotic agent is still unclear. We assess the effect of perivascular delivery of dexamethasone on vascular pathology in a mouse model of restenosis. Methods and results: In this study we investigate the ability of both systemic and local dexamethasone treatment to inhibit neointima formation after cuff placement around C57BL/6 mouse...
Abstract
Cited 37 times since 2005 (1.9 per year)
source: EuropePMC
Diabetes care,
Volume 28, Issue 7, 1 1 2005, Pages 1668-1674
The effect of statin therapy on endothelial function in type 2 diabetes without manifest cardiovascular disease.
Beishuizen ED, Tamsma JT, Jukema JW, van de Ree MA, van der Vijver JC, Meinders AE, Huisman MV
Objective: Cardiovascular disease (CVD) is the most important cause of mortality in patients with type 2 diabetes and is preceded by endothelial dysfunction. Flow-mediated dilation (FMD) is a noninvasive technique for measuring endothelial dysfunction. We aimed to determine the effect of long-term statin therapy versus placebo on FMD in patients with type 2 diabetes without manifest CVD. Research design and methods: A randomized, placebo-controlled, double-blind trial was performed with 250 type...
Abstract
Cited 11 times since 2005 (0.6 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 130, Issue 1, 1 1 2005, Pages 33-40
Acute hemodynamic effects of restrictive mitral annuloplasty in patients with end-stage heart failure: analysis by pressure-volume relations.
Tulner SA, Steendijk P, Klautz RJ, Bax JJ, Versteegh MI, van der Wall EE, Dion RA
Objective: Recent studies show beneficial long-term effects of restrictive mitral annuloplasty in patients with end-stage heart failure. However, concerns are raised about possible adverse effects on early postoperative systolic and diastolic function, which might limit application of this approach in patients with heart failure. Therefore we evaluated the acute effects of restrictive mitral annuloplasty on left ventricular function by using load-independent pressure-volume relations. Methods: I...
Abstract
Cited 8 times since 2005 (0.4 per year)
source: EuropePMC
Diabetes care,
Volume 28, Issue 7, 1 1 2005, Pages 1675-1679
No effect of statin therapy on silent myocardial ischemia in patients with type 2 diabetes without manifest cardiovascular disease.
Beishuizen ED, Jukema JW, Tamsma JT, van de Ree MA, van der Vijver JC, Putter H, Maan AC, Meinders AE, Huisman MV
Objective: Coronary artery disease is the most important cause of mortality in patients with type 2 diabetes. We aimed to determine the prevalence of silent myocardial ischemia (SMI) and the effect of statin therapy on SMI in type 2 diabetic patients without manifest cardiovascular disease. Research design and methods: A randomized, placebo-controlled, double-blind trial was performed in 250 patients with type 2 diabetes without manifest cardiovascular disease. Patients were given either 0.4 mg...
Abstract
Cited 16 times since 2005 (0.8 per year)
source: EuropePMC
The American journal of cardiology,
Volume 96, Issue 1, 1 1 2005, Pages 22-24
Effect of intracoronary aqueous oxygen on left ventricular remodeling after anterior wall ST-elevation acute myocardial infarction.
Warda HM, Bax JJ, Bosch JG, Atsma DE, Jukema JW, van der Wall EE, van der Laarse A, Schalij MJ, Oemrawsingh PV
The present report describes outcomes of randomized selective intracoronary aqueous oxygen versus standard care in patients who had acute anterior wall myocardial infarction within 6 hours of onset (n = 50). Left ventricular (LV) dimensions and function were assessed by contrast echocardiography at baseline and 1 month. It is demonstrated that aqueous oxygen prevents LV remodeling and preserves LV ejection fraction.
Abstract
